New cancer drug combo trial launches for Hard-to-Treat tumors

NCT ID NCT04777994

Recruiting now Disease control Sponsor: Calico Life Sciences LLC Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase trial is testing an experimental oral drug called ABBV-CLS-484, either alone or combined with other cancer treatments, in people with advanced solid tumors that have spread or cannot be removed by surgery. The study aims to find safe and tolerable doses and to see if the drug can shrink tumors. About 248 participants will take part across multiple cancer types, including head and neck, lung, and kidney cancers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ABBV-CLS-484 (oral drug)
What this could lead to: If it works, this could point toward a new treatment option for people with advanced solid tumors that have not responded to other therapies.
What could go wrong: This is an early Phase 1 trial, so the main goals are safety and dosing, not yet proving effectiveness. Many experimental cancer drugs do not succeed in later trials.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cancer head and neck squamous cell carcinoma neoplasm non-small cell lung carcinoma nonpapillary renal cell carcinoma Recurrence renal cell carcinoma Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMOR CANCER

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Beth Israel Deaconess Medical Center /ID# 252009
RECRUITING

Boston, Massachusetts, 02215-5400, United States
Carolina BioOncology Institute /ID# 225704
COMPLETED

Huntersville, North Carolina, 28078, United States
Centre Antoine-Lacassagne /ID# 252606
RECRUITING

Nice, Provence-Alpes-Côte d'Azur Region, 06189, France
Dana-Farber Cancer Institute /ID# 249642
RECRUITING

Boston, Massachusetts, 02215, United States
Duke Cancer Center /ID# 251975
RECRUITING

Durham, North Carolina, 27710, United States
Hadassah Medical Center /ID# 252366
RECRUITING

Jerusalem, Jerusalem, 91120, Israel
Hopital Foch /ID# 252607
RECRUITING

Suresnes, 92151, France
Hospital Universitario 12 de Octubre /ID# 257374
RECRUITING

Madrid, Madrid, 28041, Spain
Hospital Universitario HM Sanchinarro /ID# 228034
RECRUITING

Madrid, Madrid, 28050, Spain
IUCT Oncopole /ID# 252673
RECRUITING

Toulouse, Occitanie, 31059, France
Institut Català d'Oncologia (ICO) - L'Hospitalet /ID# 252524
RECRUITING

L'Hospitalet de Llobregat, Barcelona, 08907, Spain
Institut Paoli-Calmettes /ID# 260956
RECRUITING

Marseille, Bouches-du-Rhone, 13009, France
Johns Hopkins Hospital /ID# 254056
RECRUITING

Baltimore, Maryland, 21287, United States
Lifespan Cancer Institute at Rhode Island Hospital /ID# 225705
RECRUITING

Providence, Rhode Island, 02903-4923, United States
NEXT Oncology /ID# 225708
COMPLETED

San Antonio, Texas, 78229, United States
NYU Laura and Isaac Perlmutter Cancer Center - 34th Street /ID# 257869
RECRUITING

New York, New York, 10016, United States
National Cancer Center Hospital /ID# 225884
RECRUITING

Chuo-ku, Tokyo, 104-0045, Japan
Perelman Center for Advanced Medicine /ID# 250188
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Rabin Medical Center /ID# 263631
RECRUITING

Petah Tikva, Central District, 4941492, Israel
Samsung Medical Center /ID# 260664
RECRUITING

Seoul, Seoul Teugbyeolsi, 06351, South Korea
Seoul National University Hospital /ID# 254635
RECRUITING

Seoul, Seoul Teugbyeolsi, 03080, South Korea
The Chaim Sheba Medical Center /ID# 226756
RECRUITING

Ramat Gan, Tel Aviv, 5265601, Israel
UPMC Hillman Cancer Ctr /ID# 225706
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
University of Arizona Cancer Center - Tucson /ID# 262698
RECRUITING

Tucson, Arizona, 85724, United States
University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 252010
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Texas MD Anderson Cancer Center /ID# 252004
RECRUITING

Houston, Texas, 77030, United States
University of Texas Southwestern Medical Center /ID# 251974
RECRUITING

Dallas, Texas, 75390-7208, United States
Wakayama Medical University Hospital /ID# 252988
RECRUITING

Wakayama, Wakayama, 641-8510, Japan
Yale University School of Medicine /ID# 225707
RECRUITING

New Haven, Connecticut, 06510, United States
Yonsei University Health System Severance Hospital /ID# 260665
RECRUITING

Seoul, 03722, South Korea

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