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New cancer drug combo trial launches for Hard-to-Treat tumors

NCT ID NCT04777994

Recruiting now Disease control Sponsor: Calico Life Sciences LLC Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase trial is testing an experimental oral drug called ABBV-CLS-484, either alone or combined with other cancer treatments, in people with advanced solid tumors that have spread or cannot be removed by surgery. The study aims to find safe and tolerable doses and to see if the drug can shrink tumors. About 248 participants will take part across multiple cancer types, including head and neck, lung, and kidney cancers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

ABBV-CLS-484 (oral drug)

What this could lead to

If it works, this could point toward a new treatment option for people with advanced solid tumors that have not responded to other therapies.

What could go wrong

This is an early Phase 1 trial, so the main goals are safety and dosing, not yet proving effectiveness. Many experimental cancer drugs do not succeed in later trials.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

cancer head and neck squamous cell carcinoma neoplasm non-small cell lung carcinoma nonpapillary renal cell carcinoma Recurrence renal cell carcinoma Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMOR CANCER

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Beth Israel Deaconess Medical Center /ID# 252009

    RECRUITING

    Boston, Massachusetts, 02215-5400, United States

  • Carolina BioOncology Institute /ID# 225704

    COMPLETED

    Huntersville, North Carolina, 28078, United States

  • Centre Antoine-Lacassagne /ID# 252606

    RECRUITING

    Nice, Provence-Alpes-Côte d'Azur Region, 06189, France

  • Dana-Farber Cancer Institute /ID# 249642

    RECRUITING

    Boston, Massachusetts, 02215, United States

  • Duke Cancer Center /ID# 251975

    RECRUITING

    Durham, North Carolina, 27710, United States

    Contact Phone: •••-•••-••••

  • Hadassah Medical Center /ID# 252366

    RECRUITING

    Jerusalem, Jerusalem, 91120, Israel

  • Hopital Foch /ID# 252607

    RECRUITING

    Suresnes, 92151, France

  • Hospital Universitario 12 de Octubre /ID# 257374

    RECRUITING

    Madrid, Madrid, 28041, Spain

  • Hospital Universitario HM Sanchinarro /ID# 228034

    RECRUITING

    Madrid, Madrid, 28050, Spain

  • IUCT Oncopole /ID# 252673

    RECRUITING

    Toulouse, Occitanie, 31059, France

  • Institut Català d'Oncologia (ICO) - L'Hospitalet /ID# 252524

    RECRUITING

    L'Hospitalet de Llobregat, Barcelona, 08907, Spain

  • Institut Paoli-Calmettes /ID# 260956

    RECRUITING

    Marseille, Bouches-du-Rhone, 13009, France

  • Johns Hopkins Hospital /ID# 254056

    RECRUITING

    Baltimore, Maryland, 21287, United States

    Contact Phone: •••-•••-••••

  • Lifespan Cancer Institute at Rhode Island Hospital /ID# 225705

    RECRUITING

    Providence, Rhode Island, 02903-4923, United States

  • NEXT Oncology /ID# 225708

    COMPLETED

    San Antonio, Texas, 78229, United States

  • NYU Laura and Isaac Perlmutter Cancer Center - 34th Street /ID# 257869

    RECRUITING

    New York, New York, 10016, United States

    Contact Phone: •••-•••-••••

  • National Cancer Center Hospital /ID# 225884

    RECRUITING

    Chuo-ku, Tokyo, 104-0045, Japan

  • Perelman Center for Advanced Medicine /ID# 250188

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

    Contact Phone: •••-•••-••••

  • Rabin Medical Center /ID# 263631

    RECRUITING

    Petah Tikva, Central District, 4941492, Israel

  • Samsung Medical Center /ID# 260664

    RECRUITING

    Seoul, Seoul Teugbyeolsi, 06351, South Korea

  • Seoul National University Hospital /ID# 254635

    RECRUITING

    Seoul, Seoul Teugbyeolsi, 03080, South Korea

  • The Chaim Sheba Medical Center /ID# 226756

    RECRUITING

    Ramat Gan, Tel Aviv, 5265601, Israel

  • UPMC Hillman Cancer Ctr /ID# 225706

    RECRUITING

    Pittsburgh, Pennsylvania, 15232, United States

  • University of Arizona Cancer Center - Tucson /ID# 262698

    RECRUITING

    Tucson, Arizona, 85724, United States

  • University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 252010

    RECRUITING

    Ann Arbor, Michigan, 48109, United States

  • University of Texas MD Anderson Cancer Center /ID# 252004

    RECRUITING

    Houston, Texas, 77030, United States

    Contact Phone: •••-•••-••••

  • University of Texas Southwestern Medical Center /ID# 251974

    RECRUITING

    Dallas, Texas, 75390-7208, United States

  • Wakayama Medical University Hospital /ID# 252988

    RECRUITING

    Wakayama, Wakayama, 641-8510, Japan

  • Yale University School of Medicine /ID# 225707

    RECRUITING

    New Haven, Connecticut, 06510, United States

  • Yonsei University Health System Severance Hospital /ID# 260665

    RECRUITING

    Seoul, 03722, South Korea