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New hope for tough cancers? early trial launches for ABBV-711

NCT ID NCT07241039

Recruiting now Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase study tests an experimental drug called ABBV-711, alone or with another drug (budigalimab), in adults with advanced squamous tumors (like certain lung or head and neck cancers). The main goals are to check safety and see if the tumors shrink. About 220 people will take part worldwide. Because it is a Phase 1 trial, the focus is on finding the right dose and watching for side effects, not yet on proving a cure.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
ABBV-711 (oral tablet) and budigalimab (intravenous infusion)
What this could lead to
If successful, this could lead to a new treatment option for people with advanced squamous tumors who have run out of standard therapies.
What could go wrong
This is a very early Phase 1 trial, so the drugs may not work or could cause serious side effects. It is small and not yet proven to help patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

head and neck squamous cell carcinoma non-small cell squamous lung carcinoma Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SQUAMOUS TUMORS

Contacts and locations

Locations

  • Carolina BioOncology Institute /ID# 272380

    RECRUITING

    Huntersville, North Carolina, 28078, United States

  • City Of Hope Comprehensive Cancer Center /ID# 276550

    RECRUITING

    Duarte, California, 91030, United States

  • City of Hope - Orange County Lennar Foundation Cancer Center /ID# 278432

    RECRUITING

    Irvine, California, 92618, United States

  • Hadassah Medical Center-Hebrew University /ID# 276800

    RECRUITING

    Jerusalem, 91120, Israel

  • Kansai Medical University Hospital /ID# 276586

    RECRUITING

    Hirakata-shi, Osaka, 573-1191, Japan

  • National Cancer Center Hospital East /ID# 276585

    RECRUITING

    Kashiwa-shi, Chiba, 277-8577, Japan

  • Next Oncology - Irving /ID# 276659

    RECRUITING

    Irving, Texas, 75039, United States

  • Princess Margaret Cancer Centre /ID# 276852

    RECRUITING

    Toronto, Ontario, M5G 2M9, Canada

  • Rambam Health Care Campus- Haifa /ID# 276799

    RECRUITING

    Haifa, 3109601, Israel

  • START Midwest /ID# 272505

    RECRUITING

    Grand Rapids, Michigan, 49546, United States

  • The Chaim Sheba Medical Center /ID# 276798

    RECRUITING

    Ramat Gan, Tel Aviv, 5265601, Israel

  • University of Chicago Medical Center /ID# 276638

    RECRUITING

    Chicago, Illinois, 60637, United States

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