HEAD AND NECK SQUAMOUS CELL CARCINOMA

This early-stage trial tested a new type of cell therapy for cancers caused by HPV, a common virus. Researchers gave patients specially engineered immune cells designed to find and attack cancer cells. The main goal was to find the safest and most effective dose of these cells, t…

This study tested whether combining an experimental drug (sEphB4-HSA) with an approved immunotherapy (pembrolizumab) could help control advanced lung or head/neck cancers that had worsened after standard chemotherapy. It involved 42 patients who received both drugs by IV infusion…

This study compared a new drug called RPH-002 to an existing drug, Erbitux®, for people with advanced head and neck cancer that had returned or spread. The main goals were to see if the body processed the two drugs similarly and to check their safety when given with standard chem…

This first-in-human study tested a new oral drug called JAB-3312 in 40 adults with advanced solid tumors that had progressed despite standard treatments. The main goals were to find the safest dose and see how the body processes the drug. Researchers also looked for early signs t…

This large, completed Phase 3 trial tested whether adding the drug lenvatinib to the immunotherapy pembrolizumab works better than pembrolizumab alone for people with advanced head and neck cancer that has returned or spread. The study involved 511 participants and aimed to see i…

This study tested whether combining two existing drugs—pembrolizumab (an immunotherapy) and tadalafil—could be safe and more effective for people with advanced head and neck cancer that has returned or spread. The idea was to boost the body's immune system in two different ways t…

This trial tested if adding a newer immunotherapy drug (durvalumab) to radiation therapy works better than the standard combination of radiation with an older drug (cetuximab). It was for patients with advanced head and neck cancer who could not safely take the usual chemotherapy…

This study tested a new way to deliver radiation therapy for head and neck cancer. Doctors used artificial intelligence (AI) tools to focus radiation only on cancerous lymph nodes, instead of treating large areas of the neck. The goal was to see if this more precise method could …

This study tested whether combining two existing cancer drugs, cetuximab and nivolumab, could help people with advanced head and neck cancer that had returned or spread. The first part aimed to find the safest dose of the combination. The second part aimed to see if this combinat…

This study tested whether combining two existing cancer drugs, pembrolizumab and cetuximab, could help control advanced head and neck cancer that had returned or spread. It involved 78 patients at four US cancer centers, grouped based on their prior treatments. The main goal was …

This completed Phase 3 trial tested whether adding the drug lenvatinib to the immunotherapy pembrolizumab works better than pembrolizumab alone for people with advanced head and neck cancer that has returned or spread. It involved 112 participants whose cancer had a specific mark…

This study tested whether an intensive smoking cessation program could help head and neck or lung cancer patients quit smoking. The program included counseling, medications, and nicotine replacement therapy, and was compared to standard doctor advice. Researchers wanted to see if…

This trial tested a new immunotherapy approach for Epstein-Barr virus (EBV)-positive head and neck cancers that have returned or spread. Researchers collected patients' own immune cells, engineered them to recognize EBV proteins on cancer cells, and added a component to block can…

This study tested whether a special type of MRI scan, done soon after patients finished chemoradiation treatment for head and neck cancer, could predict if the cancer would come back. Researchers followed 59 patients to see if changes seen on this scan matched up with later cance…

This study tested new blood tests designed to detect cancer biomarkers in patients with recurrent or metastatic head & neck, lung, or skin cancer. The goal was to validate if these 'liquid biopsies' could accurately track cancer changes over time by analyzing genetic material in …

This study collected and stored tumor tissue samples from 419 patients with head and neck cancer to create a research biobank. The goal is to enable future scientists to analyze these samples to find genetic markers that might better predict a patient's chance of survival or canc…

This study tested whether a personalized blood test could detect tiny bits of cancer DNA in the blood of patients with advanced head and neck cancer. Researchers created a unique test for each of the 40 participants based on their specific tumor. They tracked the cancer DNA level…