New biosimilar RPH-002 takes on erbitux in head and neck cancer showdown

NCT ID NCT07435324

Completed Disease control Sponsor: R-Pharm Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 15, 2026 · Updated 3 times

Summary

This phase 3 trial compares a new drug, RPH-002, to the standard treatment Erbitux in 161 patients with advanced head and neck cancer that cannot be removed by surgery. Both drugs are given with chemotherapy. The main goal is to see if RPH-002 works as well as Erbitux in shrinking tumors. The study is active but no longer recruiting participants.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: RPH-002 (a biosimilar to cetuximab)
What this could lead to: If successful, this could offer a more affordable or equally effective alternative to Erbitux for treating advanced head and neck cancer.
What could go wrong: This is a phase 3 trial, but it's still early to know if RPH-002 works as well as Erbitux. Side effects may include infusion reactions and other drug-related risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

head and neck squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEAD AND NECK SQUAMOUS CELL CARCINOMA

Contacts and locations

Locations

Branch of the Limited Liability Company "Hadassah Medical Ltd." (LLC Branch "Hadassah Medical")

Moscow, 121205, Russia
Budgetary Healthcare Institution of Omsk Region "Clinical Oncological Dispensary"

Omsk, 644013, Russia
Budgetary Healthcare Institution of the Udmurt Republic "Sergey Grigoryevich Primushko Republican Clinical Oncological Dispensary" of the Ministry of Health of the Udmurt Republic

Izhevsk, 571207, Russia
Federal State Autonomous Educational Institution of Higher Education First Moscow State Medical University named after I.M. Sechenov of the Ministry of Health of the Russian Federation (Sechenov University)

Moscow, 119435, Russia
Federal State Autonomous Institution "National Medical Research Center 'Medical and Rehabilitation Center'" of the Ministry of Health of the Russian Federation

Moscow, 125367, Russia
Federal State Budgetary Educational Institution of Higher Education "Siberian State Medical University" of the Ministry of Health of the Russian Federation

Tomsk, 634028, Russia
Federal State Budgetary Institution "N.N. Burdenko Main Military Clinical Hospital" of the Ministry of Defense of the Russian Federation

Moscow, 105094, Russia
Federal State Budgetary Institution "National Medical Research Center of Oncology" of the Ministry of Health of the Russian Federation

Rostov-on-Don, 344037, Russia
Federal State Budgetary Institution "National Medical Research Center of Radiology" of the Ministry of Health of the Russian Federation, Branch: A.F. Tsyba Medical Radiological Research Center

Obninsk, 249036, Russia
Federal State Budgetary Institution "National Medical Research Center of Radiology" of the Ministry of Health of the Russian Federation, Branch: P.A. Herzen Moscow Research Oncology Institute

Obninsk, 249036, Russia
Joint-Stock Company "Medsi Group of Companies"

Moscow, 143442, Russia
Kirov Regional State Clinical Budgetary Healthcare Institution "Center of Oncology and Medical Radiology"

Kirov, 610045, Russia
Limited Liability Company "EuroCityClinic"

Saint Petersburg, 197022, Russia
Limited Liability Company Medical and Sanitary Unit "Clinician-Pretor Clinic"

Novosibirsk, 630091, Russia
Private Healthcare Institution "RZD-Medicine Clinical Hospital" of Saint Petersburg

Saint Petersburg, 195271, Russia
Private Medical Institution "Euromedservice"

Pushkin, 196603, Russia
Regional Budgetary Healthcare Institution "Ivanovo Regional Oncological Dispensary"

Ivanovo, 153040, Russia
Republican Specialized Scientific and Practical Medical Center of Oncology and Radiology, Tashkent Regional Branch

Tashkent, 100128, Uzbekistan
Saint Petersburg State Budgetary Healthcare Institution "City Clinical Oncological Dispensary"

Saint Petersburg, 197022, Russia
State Autonomous Healthcare Institution "Republican Clinical Oncological Dispensary" of the Ministry of Health of the Republic of Bashkortostan

Ufa, 450054, Russia
State Autonomous Healthcare Institution "Republican Clinical Oncology Dispensary of the Ministry of Health of the Republic of Tatarstan named after Professor M.Z. Sigal"

Kazan', 420029, Russia
State Autonomous Healthcare Institution of Sverdlovsk Region "Sverdlovsk Regional Oncology Dispensary"

Yekaterinburg, 620036, Russia
State Autonomous Healthcare Institution of the Nizhny Novgorod Region "Research Institute of Clinical Oncology 'Nizhny Novgorod Regional Clinical Oncology Dispensary'"

Nizhny Novgorod, 603081, Russia
State Budgetary Healthcare Institution "Clinical Oncological Dispensary No. 1" of the Ministry of Health of Krasnodar Krai

Krasnodar, 350040, Russia
State Budgetary Healthcare Institution "Kuzbass Clinical Oncology Dispensary named after M.S. Rappoport" (SBHI "KCOD")

Kemerovo, 650036, Russia
State Budgetary Healthcare Institution "Leningrad Regional Clinical Hospital"

Kuz'molovskiy, 191104, Russia
State Budgetary Healthcare Institution "Regional Oncological Dispensary"

Irkutsk, 664035, Russia
State Budgetary Healthcare Institution of Arkhangelsk Region "Arkhangelsk Clinical Oncological Dispensary"

Arkhangelsk, 163045, Russia
State Budgetary Healthcare Institution of Kaluga Region "Kaluga Regional Clinical Oncology Dispensary"

Kaluga, 248007, Russia
State Budgetary Healthcare Institution of Moscow "A.S. Loginov Moscow Clinical Scientific and Practical Center" of the Moscow Department of Health

Moscow, 111123, Russia
State Budgetary Healthcare Institution of Moscow "City Clinical Hospital named after S.S. Yudin, Department of Health of Moscow"

Moscow, 129090, Russia
State Budgetary Healthcare Institution of Moscow "Moscow City Oncological Hospital No. 62, Department of Health of Moscow"

Istra, 143515, Russia
State Budgetary Healthcare Institution of Stavropol Krai "Pyatigorsk Interdistrict Oncology Dispensary"

Pyatigorsk, Russia
State Budgetary Healthcare Institution of Yaroslavl Region "Regional Clinical Oncological Hospital"

Yaroslavl, 150054, Russia

More trials for these conditions

Other studies related to the condition(s) this trial covers.