New drug hopes to shrink Hard-to-Treat tumors
NCT ID NCT05954312
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase study tests a new drug called VVD-130037 in people with advanced solid tumors that have stopped responding to standard treatments. The drug aims to activate a protein (KEAP1) to fight cancer. Researchers will check safety, side effects, and whether the drug works alone or with other cancer drugs. About 290 participants will take part.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Asan Medical Center
RECRUITINGSeoul, South Korea
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Clinica Universitaria de Navarra
RECRUITINGPamplona, Spain
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Florida Cancer Specialists
RECRUITINGSarasota, Florida, 34232, United States
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Gachon University Gil Medical Center
RECRUITINGIncheon, South Korea
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Hospital Clinico Universitario de Valencia
RECRUITINGValencia, Spain
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Hospital Universitario 12 de Octubre
RECRUITINGMadrid, Spain
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Hospital Universitario Ramon y Cajal
RECRUITINGMadrid, Spain
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Hospital Vall d'Hebron
RECRUITINGBarcelona, Spain
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MDACC
RECRUITINGHouston, Texas, 77030, United States
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Mayo Clinic Jacksonville
RECRUITINGJacksonville, Florida, 32224, United States
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Mayo Clinic Rochester
RECRUITINGRochester, Minnesota, 55905, United States
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Moffitt Cancer Center
RECRUITINGTampa, Florida, 33612, United States
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NEXT Dallas
RECRUITINGIrving, Texas, 75039, United States
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NEXT Madrid
RECRUITINGMadrid, Spain
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NEXT Virginia
RECRUITINGFairfax, Virginia, 22031, United States
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National Cancer Center
RECRUITINGGoyang, South Korea
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START Barcelona Hospital HM Nou Delfos
RECRUITINGBarcelona, Spain
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START Madrid CIOCC
RECRUITINGMadrid, Spain
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Samsung Medical Center
RECRUITINGSeoul, South Korea
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Sarah Cannon Research Institute
RECRUITINGNashville, Tennessee, 37203, United States
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Seoul National University Hospital
RECRUITINGSeoul, South Korea
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Seoul National University; Bundang Hospital
RECRUITINGSeongnam, South Korea
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Severance Hospital; Yonsei University Health System
RECRUITINGSeoul, South Korea
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Start Madrid-FJD, Hospital Fundacion Jimenez Diaz
RECRUITINGMadrid, Spain
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The Catholic University of Korea, St. Vincent's Hospital
RECRUITINGGoyang, South Korea
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The Catholic University of Korea, St. Vincent's Hospital
RECRUITINGSuwon, South Korea
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Other studies related to the condition(s) this trial covers.
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- Can a new drug combo shrink Hard-to-Treat tumors?
- Can a pill outsmart Tumors' defenses?