Could less radiation be enough for HPV-Positive throat cancer?
NCT ID NCT03396718
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study is testing whether a lower dose of radiation after surgery can safely treat HPV-positive head and neck cancer while reducing long-term side effects. About 304 participants will receive either standard or reduced radiation, with or without chemotherapy. The goal is to see if the lower dose still prevents cancer from coming back.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- radiation therapy (reduced dose)
- What this could lead to
- If successful, this could show that a lower radiation dose is safe and effective for HPV-positive head & neck cancer, reducing long-term side effects without compromising disease control.
- What could go wrong
- This is an early-phase study, so the reduced dose might not control the cancer as well as standard treatment. Long-term results are not yet known, and side effects could still occur.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Charité - Universitätsmedizin Berlin
NOT_YET_RECRUITINGBerlin, 13353, Germany
Contact Email: •••••@•••••
Contact
Contact
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LMU Munich University Hospital
RECRUITINGMünchen, 81377, Germany
Contact Email: •••••@•••••
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TUM University Hospital
RECRUITINGMünchen, 81675, Germany
Contact Email: •••••@•••••
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University Clinic Dresden
RECRUITINGDresden, Saxony, 01307, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University Clinic Essen
RECRUITINGEssen, North Rhine-Westphalia, 45147, Germany
Contact Email: •••••@•••••
Contact
Contact
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University Clinic Frankfurt
RECRUITINGFrankfurt am Main, 60590, Germany
Contact Email: •••••@•••••
Contact
Contact
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University Clinic Freiburg
RECRUITINGFreiburg im Breisgau, 79106, Germany
Contact
Contact Email: •••••@•••••
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University Clinic Heidelberg
RECRUITINGHeidelberg, 69120, Germany
Contact Email: •••••@•••••
Contact
Contact
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University Clinic Regensburg
RECRUITINGRegensburg, 93053, Germany
Contact Email: •••••@•••••
Contact
Contact Email: •••••@•••••
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University Clinic Tübingen
RECRUITINGTübingen, Baden-Wurttemberg, 72016, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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