Nicotine dependence

This study tested a treatment called CPT-SMART that combines PTSD therapy, smoking cessation counseling, medication, and financial incentives to help veterans quit smoking. 120 veteran smokers with PTSD were randomly assigned to either the full program or a control group. The goa…

This study tested whether offering smokers more frequent and personalized outreach, plus more treatment choices like nicotine patches and text support, helps more people quit compared to standard care. Over 12,000 adult smokers from 10 primary care clinics took part. The goal was…

This study tested whether text message reminders and rewards could help people who smoke to stick with their quitline counseling and take their medication. Twenty adults who smoked daily took part. They received a prescription for a stop-smoking drug and were referred to a quitli…

This study tested different ways to help daily smokers quit by comparing two medications (varenicline and nicotine patches/lozenges), how long to take them before quitting, how long to continue after quitting, and the level of counseling. Over 500 smokers from primary care partic…

This study tested whether offering small gift cards for quitting smoking helps low-income smokers stay smoke-free. 320 uninsured or Medicaid patients received either standard care (counseling and medication) or standard care plus financial rewards for verified abstinence. The mai…

This study tested whether giving rewards like gift cards can help Native American women quit smoking and lose weight. 125 women who smoked daily and were overweight or obese took part. They earned prizes for staying smoke-free and losing a half to one pound per week. The goal was…

This study tests whether measuring tobacco smoke exposure in children, using a simple blood test, can help parents quit smoking. About 865 parents of young children (12 or younger) who smoke will be enrolled. The goal is to see if this approach, combined with support, leads to mo…

This study tests whether a 15-week aerobic exercise program at the YMCA can help smokers who are highly sensitive to stress quit smoking. Participants work with a personal trainer three times a week and also receive support from a national quitline. The goal is to see if exercise…

This completed trial in Xishui, China, tested a community-based program for 3,571 adults aged 35 and older who were at high risk for COPD and had mental health symptoms. The program included lung function tests, digital mental health support, smoking cessation help, and health ed…

This study looked at whether e-cigarettes or nicotine lozenges help people on methadone switch from smoking tobacco. 183 smokers were randomly assigned to use either JUUL e-cigarettes or nicotine lozenges for 6 weeks. Researchers measured nicotine exposure, lung function, and smo…

This study tested three different ways to help people living with HIV stop smoking. Over 670 patients from 13 HIV clinics in Hanoi took part. Nurses either referred patients to a quitline, provided counseling, or offered counseling plus nicotine gum. The goal was to see which met…

This pilot study looked at whether giving e-cigarettes to adults aged 50 and older who are in treatment for opioid use disorder could help them cut down on smoking. The 36 participants were not trying to quit smoking at the start. Researchers measured how many people switched to …

This study looked at whether adult smokers who switch to heated tobacco products have lower levels of harmful chemicals in their bodies compared to those who keep smoking regular cigarettes. Over 900 healthy smokers aged 22 to 65 took part. Researchers measured various biomarkers…

This study tested a web-based addiction treatment program that was culturally adapted for American Indians and Alaska Natives. 53 adults in outpatient treatment used the program for 12 weeks. The goal was to see if it helped them stay away from drugs and alcohol and to decide if …

This study tested a mobile phone-based wellness program (WISH) to help veterans with HIV quit smoking. 234 participants were split into two groups: one received the WISH program, the other got standard care (quitline and text support). The goal was to see if the wellness program …

This study tested whether giving pregnant smokers cigarettes with very low nicotine (0.4 mg per gram of tobacco) helps them smoke less over 12 weeks. Thirty women were randomly assigned to either their usual brand or the low-nicotine cigarettes. The main goal was to see if they s…

This study tested whether offering financial incentives through a smartphone app could help pregnant women stop smoking. 150 women who smoked were randomly assigned to either earn rewards for submitting breath and saliva tests showing no smoking, or to receive standard care. The …

This completed phase 4 pilot trial tested whether varenicline (Chantix) works better than nicotine patches and lozenges for helping smokers quit. Over 600 smokers who smoked at least 5 cigarettes daily took part. The study measured how many people stayed smoke-free for 7 days, ve…

This study looked at whether switching from regular cigarettes to either low or high wattage e-cigarettes changes smoking behavior and reduces exposure to harmful chemicals. 372 daily smokers who were not planning to quit were given e-cigarettes to use freely for 12 weeks, then c…

This study tested whether N-acetylcysteine (NAC), an over-the-counter supplement, can help people who use both tobacco and cannabis quit both substances. Fifty-nine regular smokers who also used cannabis took either NAC or a placebo for 8 weeks. Researchers tracked how often they…

This pilot study tested a program called 'Nudges to Quit' that sends encouraging messages to people with serious mental illness who smoke. The goal was to see if these messages could help them start smoking cessation treatments like counseling or medication. The study involved 59…

This study tested a simple, low-cost program to help adults stop using tobacco in busy community health centers in Mumbai, India. Nearly 4,700 participants received either brief advice from trained health workers or usual care. The program used a mobile app and WhatsApp to suppor…

This study tested whether a smartphone app designed for people with serious mental illness can help them quit smoking better than standard methods. Researchers enrolled 343 adults with conditions like bipolar disorder or schizophrenia who wanted to quit. Participants used either …

QuitBet is a digital social game that helps people stop smoking by letting them bet $30 of their own money. Players submit daily breath tests to prove they haven't smoked. Those who succeed split the pot of money from those who fail. This study tested QuitBet in 245 adults who sm…

This study compared four different smoking cessation programs to see which one works best for underserved smokers who are getting lung cancer screening. Over 3,200 participants from four U.S. health systems took part. The goal was to help them quit smoking for at least six months…

This study tested a mobile app designed to help nursing students who smoke change their attitudes and reduce their smoking. Forty-three students used the app, which sent reminders and educational content. Researchers measured changes in smoking intention, attitudes, and decision-…

This study looked at whether smokers who want to cut down can switch to a special research e-cigarette and smoke fewer regular cigarettes. Over 12 weeks, researchers tracked how many cigarettes people smoked and if any quit completely. The goal was to see if e-cigarettes are a he…

This study tested a program called CareConnect that uses automated phone calls to help cancer patients stop smoking. About 400 cancer patients who smoked took part. The program gave them educational messages and connected them to resources like quitlines or websites. The goal was…

This study looked at whether smokers who quickly respond to nicotine alternatives (like patches, e-cigarettes, or pouches) can keep smoking less or stop entirely for 6 months. 150 healthy adult smokers who reduced their smoking by at least half within 2 weeks were followed. The g…

This study tested an enhanced tobacco cessation program for retired FDNY firefighters who smoke. The program automatically enrolled participants in counseling, tailored the advice based on their lung scans and breathing tests, and started a quit-smoking medication (varenicline) e…

This study tested a pill called cytisinicline, made from a plant compound, to see if it helps adults stop using nicotine e-cigarettes. 160 daily vapers took either the drug or a placebo for 12 weeks, along with brief counseling. The main goal was to see if more people could quit …

This pilot study looked at whether giving free e-cigarettes to smokers who hadn't quit after lung cancer screening could help them smoke fewer regular cigarettes. Fifteen people who smoked at least 5 cigarettes a day were given NJOY ACE e-cigarettes for 4 weeks and asked to switc…

This study tested a mindfulness program designed for women in residential treatment for substance use disorders. The program, called Mindfulness-Based Relapse Prevention for Women (MBRP-W), teaches stress management skills to help women stay in treatment and avoid relapse. Resear…

This study tested different ways to help people living with HIV quit smoking. Participants received nicotine replacement therapy (like patches or gum), the medications varenicline or bupropion, and financial rewards for staying smoke-free. The goal was to see if these approaches …

This study tested whether peer recovery coaches in emergency departments can help people with substance use disorders connect to treatment and support. 144 adults were randomly assigned to get in-person coaching, coaching via video call, or just a list of resources. Researchers f…

This study tested a program to help people with mental illness quit smoking. The program included brief advice from their mental health provider and phone calls offering support. Researchers enrolled 94 daily smokers from community mental health centers and measured how many quit…

This study tested a personalized approach to help people quit smoking by matching medication to their nicotine metabolism. 606 adults on Medicaid or Medicare who smoked daily took part. The goal was to see if tailoring treatment improves quit rates.

This study tested a computer program called C-Raven that uses an interactive avatar to help people quit smoking. Participants used an iPad for two 20-minute sessions and could get nicotine replacement therapy and support from a community health worker. The study was small (18 peo…

This study tested a telephone program called Be Smoke Free that uses guided imagery (a relaxation technique) to help people stop smoking. Over 1,200 daily smokers from Arizona, New York, and West Virginia took part. Participants received coaching calls and were checked at 3 and 6…

This study tested whether topiramate, a seizure medication, can help people who are dependent on both alcohol and nicotine. 236 adults received either a low or high dose of topiramate or a placebo, plus behavioral therapy. The goal was to see if the drug could reduce heavy drinki…

This study tested whether a special group therapy program called Positively Smoke Free helps people living with HIV quit smoking better than standard care. 450 HIV-positive smokers who wanted to quit took part. The main goal was to see if more people stayed smoke-free for 6 month…

This study tested a digital pill and smartphone app to help people with substance use disorders take their HIV prevention medication (PrEP) consistently. Thirty HIV-negative men who have sex with men and have moderate to severe substance use disorder participated. They used a dig…

This pilot study tested whether a virtual counselor program, combined with support from a community health worker, could help people in public housing quit smoking and get screened for lung cancer. Five participants were offered nicotine replacement therapy and two counseling ses…

This completed study tested whether a Mediterranean diet could improve metabolic syndrome markers in 30 hospitalized adults with psychiatric conditions. Participants followed either a Mediterranean diet or a standard hospital diet for 8 weeks, then switched. Researchers measured …

This study looked at whether omega-3 supplements (fish oil) could help pregnant women who smoke have healthier pregnancies and possibly smoke less. About 237 pregnant smokers took either omega-3 pills or a placebo. The goal was to see if the supplements could reduce preterm labor…

This study tested a 45-minute classroom program called UP2UTobacco for 9th graders. The goal was to help students quit or avoid tobacco and nicotine products, including e-cigarettes. Nearly 600 students took part, and researchers checked if the program led to more teens being tob…

This study tested whether anti-vaping and anti-smoking ads on social media can prevent tobacco use in young adults ages 18-24. Researchers randomly assigned 2,800 participants to see different amounts of digital ads and measured their vaping and smoking habits over 30 days. The g…

This small pilot study tested an 8-week mindfulness and meditation program in 3 adults with substance use disorders. Participants reported lower stress and improved mindfulness after the program. One person stayed sober long-term, while two relapsed within a year. The study shows…

This pilot study tested a smartphone app called SiS-H, designed to help people with HIV quit smoking. 66 participants were randomly assigned to use either SiS-H or a standard quit guide app. The study measured how often people used the app and how acceptable it was, rather than d…

This study tested whether a digital mindfulness app is practical and acceptable for people in early recovery from substance use disorders. 36 participants were randomly assigned to standard group therapy alone or standard therapy plus the app for 8 weeks. The main goal was to see…

This study tested whether a simple computer task, called the Approach Avoidance Task (AAT), could help smokers quit. The task aims to change automatic, unconscious thoughts that make people want to smoke. 52 daily smokers who wanted to quit took part. Researchers measured changes…

This study tested whether a computer joystick task that trains people to avoid smoking-related images can help them quit smoking when added to standard care. 96 daily smokers who wanted to quit participated. The training aimed to change automatic, unconscious tendencies to approa…

This study investigates whether an 8-week yoga program can help female smokers manage stress and nicotine withdrawal when trying to quit. Participants attend two 60-minute yoga sessions per week and provide hair and saliva samples to measure stress hormones. The goal is to see if…

This study tested whether a drug called isradipine, combined with virtual reality scenes of smoking, could lower cigarette cravings. 78 daily smokers took part. The goal was to see if this approach could help people quit smoking by reducing their urge to smoke when faced with tri…

This study tested whether a chatbot providing instant messaging support via WhatsApp could help adult smokers in Hong Kong quit. Over 1,000 participants received either brief advice plus chatbot support or brief advice alone. The goal was to see if the chatbot led to higher quit …

This study tested a type of group therapy called Resilience-Oriented Therapy (RoT) for adults in Rwanda who were struggling with mental health issues like trauma, depression, anxiety, or anger. 427 people took part, and the therapy was tailored to each person's main problem, such…

This study tested a new type of counseling called behavioral activation problem solving (BAPS) against standard smoking cessation counseling for people with HIV in Botswana. 651 participants were split into two groups to see which approach helped more people quit smoking. The goa…

This study tested whether a 4-week program using active video games (exergames) on the Nintendo Switch could help adults with mental illness feel better and stay motivated. Twelve participants were split into two groups: one played exergames, the other continued their usual routi…

This study tested whether a smartphone app could help people with PTSD quit smoking and avoid starting again. Participants received counseling, stop-smoking medications, and rewards for not smoking, plus the app. The goal was to see if the app made it easier to stay smoke-free co…

This study tested whether adding a personalized therapy scale to standard treatment helps reduce cravings in people with substance use disorders or behavioral addictions like gambling. 151 adults seeking outpatient care participated. The approach aimed to tailor treatment to each…

This study tested a video-based program to help university students quit smoking. Participants recorded short videos about their reasons for quitting and received feedback from researchers. The goal was to see if this approach could reduce nicotine dependence and increase motivat…

This study tested whether offering payments for low carbon monoxide readings can help homeless smokers quit. Twenty-five homeless Veterans received nicotine replacement therapy, counseling, and a mobile phone to record their breath tests. The goal was to see if this reward-based …

This study looked at whether a 4-week circuit training program could improve heart and lung fitness in men recovering from drug addiction. Sixty men were split into two groups: one did circuit training (like push-ups, stair climbing, and high knees) three times a week, and the ot…

This study tested a smoking cessation program for caregivers of children admitted to American Family Children's Hospital. 23 caregivers received a 20-minute counseling session and used nicotine patches and lozenges for 2 weeks. The goal was to see if caregivers would use the prog…

This study tested a program to help lung cancer patients stop smoking and avoid starting again. 21 adults with lung cancer who smoked took part. The program included counseling, a web video, and support calls. The goal was to see if the program was easy to use and if patients lik…

This study tested a breathing and meditation program called SKY Recovery in 100 people recovering from substance use disorder at a residential center. Participants either took the program right away or after a delay. Researchers measured changes in emotion regulation, cravings, a…

This study looked at whether an online cognitive behavioral therapy program, called Breaking Free Online, helps people with substance use disorder cut back on their drug or alcohol use. About 200 adults from an outpatient addiction program took part. Some got standard care with g…

This study tested whether cytisine, a plant-based medication, is safe and helpful for quitting smoking in people who also have alcohol use disorder. Twenty adults who smoked daily and wanted to quit took part. The main goal was to see if the drug was well-tolerated and if partici…

This study tested whether transcranial magnetic stimulation (TMS) can help smokers quit by reducing cravings and preventing relapse. 88 adults who had failed previous quit attempts received daily TMS sessions for a week, followed by maintenance sessions. The goal was to see if th…

This study tested a special type of talk therapy (cognitive-behavioral therapy, or CBT) delivered over telehealth to help veterans who feel lonely and struggle with substance use. The goal was to see if the program was practical and well-liked by participants. Thirty-six veterans…

This study tested a 9-session program that uses cognitive-behavioral techniques to help people living with HIV quit smoking by reducing anxiety and depression. 131 daily smokers who were motivated to quit took part. The goal was to see if the program led to more people staying sm…

This study created and tested a program to help teens and young adults (ages 14-21) who vape or smoke quit while they are in the hospital. 144 participants took part, and the program focused on helping them stop for at least 30 days. The goal was to see if this hospital-based sup…

This study tested whether a non-invasive brain stimulation technique called rTMS could reduce tobacco cravings in heavy smokers who had already failed multiple quit attempts. 39 highly nicotine-dependent adults received either real or fake rTMS to a brain region linked to craving…

This study tested whether adding virtual reality (VR) to standard smoking cessation treatment helps people quit. 74 smokers who wanted to stop received nicotine patches and either usual counseling or VR-enhanced therapy. The goal was to see if VR could reduce cravings and improve…

This study tested whether inhaling lemongrass (as a vapor or from an inhaler) could reduce nicotine dependence and improve health markers in 200 adult smokers aged 18–30. Participants used lemongrass products or nothing (control) and provided blood samples and questionnaires. The…

This study tested a mindfulness-based treatment (MBRP) combined with cognitive behavioral therapy to help people reduce alcohol use and quit smoking. 67 adults who smoked and drank heavily participated. The goal was to see if the program was practical and satisfying for patients,…

This study tested whether providing overnight infant care and parenting support helps new mothers with substance use disorder living in residential treatment programs. 41 mothers participated, and researchers measured how many enrolled, completed the program, and gave feedback. T…

This study tested a new smoking cessation program for veterans who are at high risk for suicide. The program combines standard tobacco treatment with Dialectical Behavior Therapy (DBT), a therapy proven to reduce suicide risk. 67 veterans participated, and researchers measured ho…

This study tested a type of talk therapy called Positive Psychotherapy (PPT) to help people with serious mental illness quit smoking. Sixteen adults who smoked at least 10 cigarettes a day and wanted to quit took part. The goal was to see if at least 20% could stop smoking comple…

This completed study looked at whether combining exercise with music can help people recovering from drug addiction. 92 adults in a Chinese rehab center were split into groups: exercise only, exercise with fast music, exercise with slow music, or a control group. Over six months,…

This study tested if chewing gum can help people smoke less or quit. 80 adults in Hong Kong who wanted to quit or cut down either used chewing gum or tried to quit on their own for one week. Researchers measured how much they smoked and checked their saliva to confirm if they had…

This study tested a mobile app called Support2Quit that uses a psychological technique called cognitive dissonance to help people stop smoking. The study enrolled 437 adult smokers who wanted to quit. Researchers measured how many people stopped smoking and how much they reduced …

This study tested whether a chatbot could help young smokers (up to age 25) quit tobacco. Over 150 participants used the chatbot as part of a youth quitline program. Researchers checked how many joined, stayed, and found it useful, and measured quit rates with saliva tests. The g…

This study tested a smartphone app that uses augmented reality to help reduce cravings to smoke. 14 adults who recently quit smoking tried the app and rated how easy it was to use and how much they liked it. The goal was to see if the app could be a helpful tool for quitting smok…

This study tested whether adding a specific breathing technique called diaphragmatic proprioceptive neuromuscular facilitation to aerobic exercise could improve lung function and exercise capacity in young adults (ages 20-29) who smoke heavily. Forty participants were split into …

This study tested whether a type of brain stimulation called theta burst stimulation (TBS) could reduce cravings and attention to drug-related cues in 23 people with both opioid and tobacco use disorders. Participants received four sessions of real or fake TBS in one day while th…

This study tested a smartphone app called OKquit to help smokers quit. About 500 adults who wanted to stop smoking were split into two groups: one got standard helpline support plus daily check-ins, and the other got that plus the OKquit app. The goal was to see if the app helped…

This study tested whether suvorexant, a sleep aid, could help smokers manage cravings, withdrawal, and stress that often lead to relapse. Fourteen non-treatment-seeking smokers took the drug or a placebo and were monitored for stress reactions, smoking urges, and sleep quality. T…

This study tested a mobile app called CoQuit that uses cognitive dissonance—the mental discomfort of holding conflicting beliefs—to motivate smokers to quit. 72 adult daily smokers used the app for 25 days, completing activities like writing a letter to a young person about smoki…

This study tested how different warning labels (pictorial vs. text-only) and flavor descriptors (sweet vs. none) on little cigar and cigarillo packages affect people's attention and emotional reactions. Researchers used eye tracking and skin sensors on 90 adult tobacco users. The…

This study aims to create and improve cognitive tasks used during functional MRI scans to better understand how drugs affect the brain. It involves 525 healthy volunteers, including both drug users and non-users, aged 18 to 65. Participants perform tasks like memory tests or reac…

This completed study looked at how genes influence addiction and related behaviors. Researchers collected blood samples and had 847 adults (healthy volunteers, smokers, drug users, and people with psychiatric disorders) complete questionnaires and computer tasks. The goal was to …

This study explored whether experiencing subtle racial slights (microaggressions) makes Latinx smokers want to smoke more or makes it harder to quit. Thirty daily smokers who identified as Hispanic or Latino took part. Researchers measured their smoking behavior, withdrawal sympt…

This study looked at how nicotine affects brain activity and genes in smokers and non-smokers. Researchers used brain scans and genetic tests to understand why some people find it harder to quit smoking. The goal was to find biological markers that could predict quitting success …

This study from Yale University looked at how menthol flavor in e-cigarettes affects smoking behavior and nicotine levels in people who smoke menthol cigarettes. Fourteen adult smokers participated in lab sessions where they used e-cigarettes with menthol or non-menthol flavor. R…

This study tested whether a 10-week recovery program, co-led by a peer with mental illness and a professional, is feasible for people with mental illness in Taiwan. Twenty participants completed the program, which focused on recovery concepts, strengths, and goal setting. Researc…

This study looked back at the records of 652 patients who were seen in the emergency department of a French hospital and then referred to a special addiction liaison team. The goal was to understand the social and medical backgrounds of these patients. The findings could help hos…

This completed early-phase study at Yale University tested how different doses and delivery rates of IV nicotine affect its abuse potential and its ability to reduce smoking urges. Twenty daily smokers received low and high doses of nicotine at various speeds. The goal was to bet…

This completed study surveyed over 1,500 adults in Nyakabare Parish, Uganda, to learn how people perceive tobacco and alcohol use in their community. Participants answered questions about how often they think others smoke or drink. The goal was to understand perceived norms, whic…

This completed study examined how African American and white male smokers respond to stress and how that affects their smoking habits. Researchers used a psychological stress test and measured daily cortisol patterns to understand biological differences. The goal is to learn why …

This study combined brain imaging with real-world data from mobile devices to explore how addiction affects the brain. Researchers scanned the brains of 107 people with alcohol, cannabis, or nicotine dependence, along with healthy controls. They also tracked cravings and daily fu…

This study looked at how different labels on vaping devices (like 'contains nicotine' or 'high potency') affect teens' interest in trying them, their views on health risks, and what effects they expect. Over 3,000 high school students viewed images of vaping devices with various …

This study tested whether a mobile app could help people on probation or parole who are receiving treatment for substance use disorder. 31 adults used the app alongside their usual care. Researchers measured how easy the app was to use and how satisfied participants were with it.

This study looked at how thinking skills and brain activity differ in people who self-harm compared to those who don't. Researchers interviewed 316 adults and gave them thinking tests, with some also having brain scans. The goal was to better understand self-harm to help create m…

This study looked at how a specific way of thinking, called high-level construal (focusing on the big picture), affects smoking habits. Researchers studied 300 low-income adults aged 25-55 who wanted to quit but had failed before. They used brain scans and surveys to see if this …

This study involved 24 adult smokers who used three different nicotine products: a tobacco-free nicotine stick, a heated tobacco stick, and regular cigarettes. Researchers measured how much nicotine entered the blood and how the body processed it. The goal was to understand the d…

This study looked at how the price of nicotine pouches affects whether people choose them over cigarettes. Researchers surveyed over 1,300 tobacco users online to see how much they would use pouches at different price points. The goal was to understand if nicotine pouches could b…

This study involved 440 daily smokers and dual users (smokers who also vape) to understand how price changes affect their choices between cigarettes and other nicotine products like e-cigarettes, nicotine pouches, and heated tobacco. Participants completed a simulated shopping ta…

This study tested a program called Recovery Bridge, where trained peer specialists (people with lived experience of mental illness) helped veterans leaving a psychiatric hospital connect to outpatient care and community life. Fifteen veterans took part to see if the program was f…

This study tested whether an anti-stigma training program for healthcare providers improves attitudes toward people with mental illness or substance use problems. About 485 staff and clients from six health centers took part, with three centers receiving the training and three no…

This study looked at the best ways to bring FDA-approved digital treatments (reSET and reSET-O) for opioid and other substance use disorders into primary care clinics. Over 18,000 adults who screened positive for substance use took part. Researchers tested whether health coaching…

This study looked at how often insomnia occurs in people hospitalized for psychiatric conditions. Researchers checked 427 patients at 11 hospitals in Switzerland and Germany. They also explored whether age, gender, or type of disorder made insomnia more likely.

This small, early-phase study tested whether a single dose of sedatives like ketamine, midazolam, or dexmedetomidine could reduce cigarette cravings and smoking in 20 daily smokers. Participants received one of these drugs or a placebo (saline) and reported their cravings, withdr…

This study looked at how nicotine is absorbed and affects the body when using a standardized research e-cigarette compared to a person's usual brand e-cigarette. Thirty-two regular e-cigarette users participated in a crossover study where they used both types. Researchers measure…

This study measured how much nicotine gets into the blood and how smokers feel after using heated tobacco products, regular cigarettes, or nicotine gum. Eighty adult smokers took part in a six-day clinic stay where they tried each product. The goal was to understand the appeal an…

This study looked at how smoking affects a brain chemical called glutamate in men versus women. Researchers scanned the brains of 58 smokers after not smoking overnight and after their first cigarette of the day. They also measured hormone levels in women to see if hormones influ…

This study looked at 385 adults diagnosed with their first lung or head & neck cancer to see how many continued using tobacco or alcohol over the next year. Researchers tracked smoking and drinking habits, as well as how long patients lived without the cancer getting worse. The g…

This study explored whether how addicted a person is to nicotine affects their awareness of having gum disease. Researchers examined 350 smokers with gingivitis or periodontitis, measuring their nicotine dependence with a standard test and asking about their gum health. The goal …

This study looked at whether little cigars and cigarillos (LCCs) are addictive, especially when flavored like fruit, and if addiction differs between men and women. Researchers studied 65 young adults aged 18-34 who smoke both LCCs and cigarettes. They measured how much people wo…

This study looked at how the amount of sugar in cigarette tobacco affects how much people enjoy smoking and how addictive the cigarettes seem. Thirty adult smokers tested cigarettes with different sugar levels and answered questionnaires about their experience. The goal was to se…

This study measured harmful chemicals in the air after adults used either a heated tobacco product (ploom) or regular cigarettes in a sealed room. Researchers tracked over 20 pollutants like nicotine, formaldehyde, and benzene. The goal was to see how the two products differ in s…

This study looked at whether a questionnaire called the Behavioral Activation for Depression Scale (BADS) is a good tool for measuring depression-related behaviors in people with substance use disorders. Researchers analyzed answers from 289 adults receiving treatment for substan…

This completed study with 65 adult smokers and vapers tested how different rules and penalties affect whether people buy illegal tobacco products. Participants used a simulated store to see how promotion factors and mitigation strategies like fines changed their buying choices. T…

This study tested an 8-month program called 'Meaningful Activities and Recovery' (MA&R) for people with mental illness. The program helps people take part in activities that matter to them. 139 adults took part to see if the program improves activity engagement, recovery, and qua…

This pilot study tested whether a computer avatar that delivers a smoking cessation program, combined with help from a community health worker, could help people in Baltimore public housing quit smoking and get screened for lung cancer. Ten adults aged 50 or older who smoked took…

This study looked at how different marketing messages about tobacco-free nicotine pouches affect what people think about them. Over 5,000 participants in the US, including smokers and young non-users, answered survey questions after seeing ads. The goal was to understand how word…

This completed study at Yale University looked at how 66 adult smokers (ages 21-44) perceive sweet, cooling, and unflavored e-cigarette liquids. Participants tried each flavor and rated its appeal, sensory effects, and how much they wanted it compared to money. The goal was to se…

This study tested a Spanish-language electronic screening tool called TAPS-ESP to identify tobacco, alcohol, prescription drug, and illicit substance use in primary care. About 1,000 Spanish-speaking adults from a clinic participated. The goal was to see if the tool accurately de…

This study tested a new way to help addiction treatment clinics use an AI platform that coaches counselors in evidence-based techniques. Researchers worked with 479 leaders and staff from state agencies and clinics in Oregon and Indiana. The goal was to see if this strategy impro…

This study tested whether a remote, telehealth approach can work to study how cigarette filter ventilation (the tiny holes in the filter) affects smoking behavior and exposure to harmful chemicals. 64 adult smokers participated from home, using their own devices for video visits …

This study tested whether a genetic biomarker called the Nicotine Metabolite Ratio (NMR) can help doctors choose the best FDA-approved smoking cessation medication for each person. 82 daily smokers were assigned to varenicline, bupropion, or nicotine patches based on their NMR re…

This study looked at how warning labels on little cigars and cigarillos (LCCs) affect teens aged 15-20 who have used or might try them. Researchers surveyed 928 participants to measure their willingness to use LCCs and how often they used them. The goal is to help the FDA create …

This completed study looked at how 53 young adults (ages 21-34) who regularly vape perceive and react to e-cigarettes containing a new substance called metatine (6-methyl nicotine). Researchers measured how the body processes metatine, puffing behavior, sensory experiences, and a…

This completed study worked with 65 African American/Black adults who use cocaine or other illicit substances to develop a manual called I-DREM. The goal was to gather their feedback on how to improve recruitment and retention in substance use disorder clinical trials. Participan…

This completed study looked at whether six new nicotine oral products (pouches in flavors like cool mint and dragon fruit) are less addictive than regular cigarettes. Forty adult smokers tried each product in a controlled clinic setting. Researchers measured how much participants…

This study looked at how flavors in e-cigarettes affect how much adult smokers like and want them. It included 130 smokers aged 21-50 who used only e-cigarettes for two weeks. The goal was to measure their reactions, not to treat or cure any condition.

This study tested two types of brain stimulation (TMS) in 90 people who smoke, half with schizophrenia and half without. The goal was to see if TMS could change brain connections and reduce nicotine cravings. Participants completed thinking tasks and reported their cravings befor…

This study looked at whether sending text messages to smokers could get them to sign up for free quitline services. Over 4,000 patients from a large health system were sent texts offering either free counseling or free nicotine patches. The goal was to see which offer led more pe…

This study looked at how the strength and form of nicotine in e-cigarettes affect how fast and how much nicotine gets into the blood. Thirty-six adults who vape regularly took puffs from different e-cigarette setups while their blood was sampled through a small tube in their arm.…

This study tested a program called Care Coordination after Preterm Birth (CCAPB) to see if it helps mothers who had a preterm baby. The program provides extra support with healthcare access and well-being for six months. Researchers measured how acceptable the program was and its…

This completed study looked at how nicotine salt-based vaping products compare to free-base nicotine e-liquids. Fifteen daily vapers tried different flavors and nicotine levels, and researchers measured nicotine levels in their blood and asked about harshness and satisfaction. Th…

This completed study looked at 224 adults who already had at least one psychiatric condition to see how many also had undiagnosed ADHD. Researchers measured how often ADHD was missed and tracked quality of life in those diagnosed. The goal is to highlight the need for better dete…

This study looked at how adults who smoke cigarettes daily or only some days might react if certain tobacco products were no longer available. Researchers created a pretend online store where participants could shop for cigarettes and other nicotine products under different rules…

This study tested whether combining a policy change with professional training can reduce stigma toward substance use in mental health clinics. Twelve providers from two sites participated. The goal was to see if the combined approach improves how often substance use is addressed…

This study tested how limiting flavors in cigarettes and e-cigarettes changes what people choose to buy. 302 adult smokers completed a single online session where they made purchases in a simulated tobacco marketplace. Researchers measured how much of their budget they spent on c…

This study looked at whether flavored filtered cigars are more addictive than unflavored ones in young adults (ages 21-34) who smoke both cigarettes and cigars. Participants used flavored cigars for one week and unflavored for another, then reported their cravings and smoking hab…

This study tested whether regular support calls can help veterans who are not ready to quit smoking to eventually stop. Over 500 veterans received either four calls a year (enhanced care) or one call a year (standard care). The goal was to see if more calls led to more quit attem…

This study looked at whether flavor chemicals in e-cigarettes can make them more addictive by changing brain function. 36 regular tobacco users (ages 21-60) had their brain activity measured while vaping, and their puffing behavior was tracked over 10 days. The goal was to unders…

This completed study tested whether targeted brain stimulation (TMS) could affect attention and nicotine cravings in 15 people with schizophrenia or schizoaffective disorder who smoke. Researchers applied different types of TMS to a brain network linked to attention and measured …

This study looked at whether using very low nicotine cigarettes along with nicotine-containing e-cigarettes can reduce harmful chemical exposure in smokers with mental health conditions. 88 participants were assigned to different combinations of cigarettes and e-cigarettes. The m…

This study tested how tobacco-free nicotine pouches affect the body and mind compared to regular cigarettes. Seventy-one adult smokers tried different doses and flavors of pouches, as well as their own cigarettes, in a controlled setting. Researchers measured nicotine levels in t…