Nicotine dependence

This study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…

This trial tests whether a counseling method called motivational interviewing, based on the Transtheoretical Model, can help nursing students who smoke to change their smoking habits and quit. Participants will receive two to six face-to-face sessions tailored to their readiness …

This study compares how adult smokers experience IQOS heated tobacco products versus their usual cigarettes. Participants use both products and rate them on appeal, taste, harshness, and satisfaction. Researchers also measure puffing behavior and nicotine withdrawal symptoms. The…

This trial tests whether switching to cigarettes with very low nicotine content can reduce how much people smoke and their nicotine exposure. Adult daily smokers in South Korea will be randomly assigned to either very low nicotine or normal nicotine cigarettes for 12 weeks. Resea…

This trial tests whether a text message-based program called Text2Quit-Kenya can help current tobacco users who visit the emergency department at Kenyatta National Hospital in Kenya quit smoking. Participants receive automated, interactive texts timed around their quit date to tr…

This trial tests a program called ROOTS that places substance use counselors and peer recovery specialists directly in rural schools. The goal is to see if this approach helps teens who are referred or seek help on their own to engage in treatment and reduce their substance use. …

This study looks at whether a program called EMPOWER, led by trained peer supporters, can help homeless veterans with substance use or mental health issues stay engaged in care and avoid repeated hospital stays or emergency visits. About 278 veterans in permanent supportive housi…

This trial tests whether adding a relational health enhanced parenting support (RHEP) program to standard family-focused peer recovery services helps parents with substance use disorders. The study compares outcomes like parenting satisfaction, treatment retention, and substance …

This study tests whether the drug varenicline (Chantix) can help veterans who smoke at least 5 cigarettes a day but aren't ready to quit. Participants will either take varenicline or use nicotine lozenges to reduce smoking over 12 weeks. The goal is to see if this approach leads …

This study in Nairobi, Kenya, will test whether a drug called cytisine, combined with counseling, can help 300 people with HIV quit smoking and reduce heavy drinking. Participants will receive either cytisine or a placebo, plus either intensive counseling or standard advice. The …

This study will test whether a smartphone app can help people with HIV in Laos quit smoking. About 1,200 smokers from eight HIV clinics will be split into two groups: one gets the app with tailored messages and videos, the other gets printed self-help materials. The goal is to se…

This trial tests whether integrating tobacco cessation tools into electronic health records can increase the number of smokers who receive a prescription for nicotine replacement therapy (NRT) like patches or gum. Researchers will compare a new workflow at one primary care clinic…

This study tests whether a 6-month program delivered through the Telegram messaging app can help people stop smoking after a heart attack. 142 adult smokers who use Telegram will either get the chatbot support or standard advice. The goal is to see if more people quit with the ch…

This trial tests whether a digital medical device called Quitoxil®, which offers cognitive behavioral therapy and connects users with trained patient experts, can improve smoking cessation rates when added to standard nicotine replacement therapy. About 600 adults who smoke at le…

This study tests a smoking cessation program designed for veterans who have chronic pain. Participants receive counseling over the phone plus nightly automated calls to report their smoking and pain levels. The goal is to see if this approach helps more veterans quit smoking comp…

This study tests a program called Abstinence Reinforcement Therapy (ART+) to help veterans who are homeless quit smoking. The program combines telehealth counseling, nicotine replacement therapy, and financial rewards for staying smoke-free. Researchers will compare ART+ to stand…

This study tests whether a program called CourtConnect, where peer recovery specialists meet with people in courthouses, can increase substance use disorder treatment and reduce overdose and incarceration. The program provides information, referrals, and up to three months of fol…

This pilot study investigates whether adding Dialectical Behavior Therapy (DBT)-informed principles to standard short-term inpatient substance abuse treatment helps patients better manage emotions and reduce symptoms. About 70 adults in a 12-week program will either receive usual…

This study tests a new eight-session group therapy program for adults hospitalized with substance use disorders. The program combines motivational interviewing, acceptance and commitment therapy, and behavioral activation to help participants manage cravings and develop alternati…

Coal miners in Central Appalachia use tobacco at very high rates and face serious lung diseases like cancer and black lung. This study tests a new approach: lawyers handling black-lung compensation cases identify miners who use tobacco and connect them to community pharmacists. T…

This early-stage study at Yale is testing whether a combination of two medications (naltrexone and bupropion) plus cognitive-behavioral therapy can help people who are considering bariatric surgery lose weight and stop smoking. Twenty participants will receive the treatment for f…

This study tests a program that combines medication (Naltrexone + Bupropion) with behavior therapy to help adults lose weight and quit smoking before bariatric surgery. Researchers will compare this approach to standard care in 64 participants aged 18-65 who smoke and have obesit…

This pilot study tests whether offering rewards for taking smoking cessation medication and completing counseling calls helps people quit smoking. Participants receive varenicline and referrals to a state quitline, with some also getting incentives tracked by a smart pill dispens…

This study tests whether a smart chatbot can help adults quit smoking as effectively as human support. About 1,000 smokers in Hong Kong will use a WhatsApp chatbot for 12 weeks, receiving personalized advice and encouragement. The goal is to see if the chatbot can boost quit rate…

This study tests whether peer recovery coaches—people who have personally overcome opioid addiction—can help others with opioid use disorder quit smoking. About 60 adults on medication for opioid use disorder who smoke daily will receive either coaching from a peer coach or stand…

This study tests whether a new four-session group program, called the First Step Program, can be delivered in hospital settings and help people with substance use disorders. The program combines motivational interviewing, acceptance and commitment therapy, and group support to bo…

This study tests a very brief smoking cessation intervention called 3A-OR in family health centers across Turkey. About 2,400 smokers aged 15 and older will be randomly assigned to receive the intervention or usual care. The intervention involves asking about tobacco use, assessi…

This study will test whether e-cigarettes or a natural supplement called cytisine can help people who smoke at least 5 cigarettes a day and haven't been able to quit with standard treatments like nicotine patches or counseling. Over 4 years, 6,000 participants will be randomly as…

This study will test an app called JomCare that sends personalized support to men who have sex with men when they are most likely to engage in chemsex (using drugs before or during sex). The goal is to reduce risky behaviors and prevent new HIV infections. About 482 HIV-negative …

This study will create and test a smartphone app designed to help teenagers in Indonesia stop smoking. About 110 teens aged 13-15 who smoke will be split into two groups: one using the new app and the other using paper materials. Researchers will check if the app helps them stay …

This study will bring medication for addiction and cognitive behavioral therapy to homeless veterans living in VA supportive housing. The goal is to help them stay housed and reduce substance use. About 8,000 veterans across multiple VA sites will take part.

This study tests if adding a safe dye to a drink can prove that urine samples are real and not tampered with. About 114 adults with substance use disorder will drink Gatorade with or without the dye, then provide a urine sample 15 minutes later. Researchers will check for the dye…

This trial tests whether higher doses of nicotine replacement therapy (NRT) can help adults who use both cigarettes and e-cigarettes quit both products. Participants are randomly assigned to receive either standard-dose NRT, augmented-dose NRT, or no NRT, with all groups getting …

This study tests LaunchPad, an online program designed to help high school seniors avoid drug and alcohol problems as they leave school. Researchers will randomly assign 5,000 students to different lessons and measure changes in their attitudes, confidence, and intentions around …

This study tests whether a brief digital program can help teenagers ages 12-17 who vape reduce their e-cigarette use and lower their risk of starting to smoke cigarettes. About 150 teens in California will take online surveys over 12 weeks, and some will also do a virtual intervi…

This study tests whether giving financial rewards to pregnant women who smoke—and to their smoking partners—helps them quit. About 180 pregnant women and their partners will be split into three groups: one where only the woman gets money for quitting, one where both get money, an…

This study tests whether a social network approach can encourage people who inject drugs to start HIV prevention medication (PrEP) and addiction treatment (MOUD). About 398 participants will be assigned to either the LINKED intervention or a control group. The goal is to see if p…

This study tests whether a smartphone app with AI can help adolescents aged 14-20 quit e-cigarettes. Participants use the app to set goals, track progress, and get real-time support during cravings. Researchers compare an immediate-use group with a delayed-start group to see if t…

This study will test a new multilingual chatbot called LIFT-UP designed to help people living in poverty quit smoking. Researchers will interview 22 adults who smoke at least 3 cigarettes daily and are motivated to quit. The goal is to see if the chatbot is easy to use and helpfu…

This trial tests whether Narrative Enhancement and Cognitive Therapy (NECT), a 12-session group program, can help adults with severe mental health disorders — including substance use disorders — overcome self-stigma and promote personal recovery. About 106 participants receiving …

This pilot trial tests whether a brief, culturally adapted support message sent to a smartphone during moments of high stress can reduce the urge to smoke, vape, or eat in response to stress. About 115 gender and sexual minority adults in Dhaka will receive up to five check-ins p…

This study tests whether a compound from cannabis called THCV can help people who smoke daily to resist cigarettes and smoke less. 32 smokers will receive either THCV or a placebo and then take a test measuring how long they can delay smoking and how many cigarettes they smoke. T…

This study tests a mindfulness program designed to help sexual assault survivors reduce alcohol misuse and tobacco use. Researchers will enroll 120 college students aged 18-24 who have experienced sexual violence and drank alcohol recently. Participants will take online surveys a…

This study tests a new 8-session group program designed to help people with substance use disorder better understand and regulate their emotions. About 20 adults receiving inpatient care at two hospitals in Korea will take part. The program combines motivational interviewing and …

This pilot study tests a program to help construction workers in Hong Kong quit smoking. Participants will get nicotine gum, a week of nicotine replacement therapy samples, and 12 weeks of support from a chatbot via WhatsApp. The study will see if this combined approach is practi…

This pilot study tests a new program for young adults (25 or under) in Hong Kong who recently quit smoking. The program combines personalized counseling with an AI chatbot that sends supportive messages for 30 days. Researchers want to see if this approach is practical and accept…

This study tests whether an intelligent chatbot can help people quit smoking by joining their private online support groups. 120 adult smokers who are ready to quit within 10 days will be split into two groups: one with a chatbot that responds when no human does, and one with a s…

This study tests a smoking cessation program delivered via telemedicine and wearable devices. About 102 adult smokers will either get the program with remote monitoring or standard in-person support. The goal is to see if the tech-based approach helps more people quit and stay sm…

This study tests a smoking cessation program that combines a smartphone app with support from a psychologist. 429 adult smokers who want to quit will be placed into one of three groups: eight sessions with a psychologist plus the app, four sessions plus the app, or the app alone.…

This study tests whether a behavioral method called Emotional Brain Training (EBT) can help people in recovery from addiction manage stress, anxiety, and cravings. About 54 adults receiving standard addiction treatment will either continue their usual care or also attend weekly E…

This study tests whether equine-assisted therapy (working with horses) can improve mental health and reduce cravings in people recovering from addiction. Twenty-two adults who have completed detox will be randomly assigned to either receive 22 sessions of equine therapy over 24 w…

This study aims to help Native Hawaiian adults quit smoking by testing nicotine gum, group counseling, or both. About 75 participants from public housing sites on O'ahu will be assigned to one of three groups. Researchers will check which method works best for quitting and is mos…

This study tests whether daily motivational text messages can help people in rural Mississippi quit smoking or smokeless tobacco. Researchers will recruit 150 tobacco users who want to quit and have tried before. Half will get encouraging texts, the other half non-specific messag…

This pilot study tests whether adding music therapy to nicotine replacement therapy (patches and gum) helps healthcare professionals reduce smoking cravings more than nicotine therapy alone. 80 participants will be split into two groups and followed for 3 months. The study also l…

This study tests whether daridorexant, a recently FDA-approved sleep medication, can improve sleep quality and daytime alertness in smokers who struggle with insomnia during quit attempts. About 44 adult smokers who smoke at least 10 cigarettes daily will take the drug or a place…

This study tests whether a virtual reality app, used alongside standard counseling, can help people stop vaping nicotine. Ninety participants aged 16 and older who vape at least weekly and want to quit will use the VR app at home for 12 weeks. The app is designed to make practici…

This study tests whether adding a structured exercise program to cognitive-behavioral therapy (CBT) helps smokers quit more effectively than CBT alone or general health advice. Sixty-six adult smokers will be randomly assigned to one of three groups and followed for 12 weeks. Res…

This study tests whether a special breathing technique called Wim Hof breathing can improve lung function in young men who smoke e-cigarettes. Forty-two participants will practice deep breathing and breath-holding exercises. Researchers will measure lung capacity, oxygen levels, …

This trial asks how different e-cigarette products compare to regular cigarettes in terms of nicotine delivery and appeal. About 50 adult smokers who also use e-cigarettes will try eight different products in a random order during a supervised stay. The study measures nicotine le…

This study tests whether adding a career counseling program called Purposeful Pathways to standard job training helps veterans with mental health and substance use disorders find and keep quality jobs. About 254 veterans from three VA sites will take part. The goal is to improve …

This study looks at whether new types of menthol cigarettes are more addictive than a person's usual menthol brand. About 48 daily smokers will test different cigarettes in a lab and at home. Researchers will measure nicotine levels in the blood and ask about how much participant…

This study looks at how men and women differ in their attraction to and addiction risk from menthol-flavored e-cigarettes, both with and without nicotine. Researchers will measure choices and effort to get the product in 60 adult smokers who already use e-cigarettes. The goal is …

This study compares the immediate effects of inhaling cannabis (either smoked or vaporized) versus tobacco cigarettes on lung health. Researchers will measure breath biomarkers—such as exhaled nitric oxide, volatile organic compounds, and other substances—to see how each substanc…

This study looks at whether four new oral nicotine products (like pouches) are less appealing and addictive than traditional cigarettes and moist snuff. About 50 healthy adults who smoke and use smokeless tobacco will try each product in a clinic setting. Researchers will measure…

This study looks at how changing the temperature and liquid in e-cigarettes affects the amount of harmful chemicals (oxidants) users breathe in. Researchers will measure markers of cell damage in breath, cheek cells, and blood from 50 adult e-cigarette users. The goal is to under…

This study aims to find better ways to help Veterans quit smoking when they come in for lung cancer screening. Since smoking causes most lung cancers, combining screening with stop-smoking support could save more lives. The project will test new processes at a few VA sites and me…

This study looks at whether adding a clinical pharmacist to community mental health teams (called FACT teams) helps people with severe mental illness and substance use disorders feel better and manage their medications more effectively. About 160 adults will take part, and the st…

This study will check how addictive two new nicotine pouches are by measuring their effects on the body and how much nicotine gets into the blood. About 40 healthy adults who smoke and also use smokeless tobacco will try the pouches in a clinic. The goal is to understand the abus…

This study will observe 60 adults in residential therapeutic communities in Mexico to understand how recovery from substance use unfolds over time. Participants will answer quick mobile surveys several times a day about cravings, mood, and social interactions for 8 to 12 weeks. T…

This study tests if a 12-week one-on-one support program is easy to complete and acceptable for people supporting a loved one who recently finished substance use treatment. About 18 participants will attend weekly telehealth sessions and complete surveys and interviews. The goal …

This study will examine 212 regular smokers to see how their level of nicotine addiction relates to breathing strength, physical fitness, memory, pain, sleep, and overall well-being. Participants will answer questionnaires and perform simple tests like a 6-minute walk. No treatme…

This study tests a program to help mental health providers prescribe smoking cessation medications to veterans with serious mental illness. Researchers will work with 65 providers and veterans to see if the program is acceptable and practical. The goal is to overcome barriers tha…

This study will enroll 70 adult smokers to compare how appealing and addictive different e-cigarettes are versus their usual cigarettes and nicotine gum. Participants will try each product in a random order during an 8-day stay at a clinic. Researchers will measure how much nicot…

This study will measure how much nicotine enters the bloodstream when adult smokers use eight different e-cigarette products with various flavors (menthol, mint, tobacco, fruit). Forty healthy smokers, aged 21 to 60, will try each product in a random order while staying at a clin…

This study will enroll 40 healthy adult smokers to compare how much they crave different tobacco products. Participants will try heated tobacco devices, their usual cigarettes, and nicotine gum in a clinic setting. Researchers will measure their desire to smoke and nicotine level…

This study tests whether community health workers can help more eligible people get screened for lung cancer and quit smoking. The workers will reach out to patients, help them make informed decisions, offer smoking cessation counseling, and navigate barriers to care. The study w…

This study will enroll 16,000 people invited to colorectal cancer screening in Norway. Participants will fill out a diet and lifestyle questionnaire and receive personalized digital feedback on how their habits compare to health recommendations. Some groups get extra support like…