Nicotine dependence

This study tests whether a smart chatbot can help adults quit smoking as effectively as human support. About 1,000 smokers in Hong Kong will use a WhatsApp chatbot for 12 weeks, receiving personalized advice and encouragement. The goal is to see if the chatbot can boost quit rate…

This study tests whether peer recovery coaches—people who have personally overcome opioid addiction—can help others with opioid use disorder quit smoking. About 60 adults on medication for opioid use disorder who smoke daily will receive either coaching from a peer coach or stand…

This study tests a smoking cessation program designed for veterans who have chronic pain. Participants receive counseling over the phone plus nightly automated calls to report their smoking and pain levels. The goal is to see if this approach helps more veterans quit smoking comp…

This study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…

This study tests whether a new four-session group program, called the First Step Program, can be delivered in hospital settings and help people with substance use disorders. The program combines motivational interviewing, acceptance and commitment therapy, and group support to bo…

This study tests whether the drug varenicline (Chantix) can help veterans who smoke at least 5 cigarettes a day but aren't ready to quit. Participants will either take varenicline or use nicotine lozenges to reduce smoking over 12 weeks. The goal is to see if this approach leads …

This study tests a very brief smoking cessation intervention called 3A-OR in family health centers across Turkey. About 2,400 smokers aged 15 and older will be randomly assigned to receive the intervention or usual care. The intervention involves asking about tobacco use, assessi…

This study tests a program called CONNECT Multilingual, designed to help Spanish and Cantonese speakers quit smoking while they undergo lung cancer screening. About 439 current smokers aged 50-80 will receive personalized video doctor messages, text support, and help getting nico…

This study tests a short case management program for people who have been involuntarily admitted to a psychiatric hospital. The program, designed with input from people who have experienced coercion, provides up to five sessions with a nurse or social worker starting during the h…

This study tests whether a virtual session with a peer recovery coach can help incarcerated adults with substance use disorders connect to addiction treatment and recovery resources. About 550 participants in jail will either get the coaching or just standard information. Researc…

This study will test whether a smartphone app can help people with HIV in Laos quit smoking. About 1,200 smokers from eight HIV clinics will be split into two groups: one gets the app with tailored messages and videos, the other gets printed self-help materials. The goal is to se…

This study tests two types of non-invasive brain stimulation (rTMS) to help veterans stop smoking. About 56 veterans who smoke at least 10 cigarettes a day will receive either standard or precision-guided rTMS over three weeks. Researchers will measure how much smoking decreases …

This study looks at whether a program called EMPOWER, led by trained peer supporters, can help homeless veterans with substance use or mental health issues stay engaged in care and avoid repeated hospital stays or emergency visits. About 278 veterans in permanent supportive housi…

This study tests whether a 6-month program delivered through the Telegram messaging app can help people stop smoking after a heart attack. 142 adult smokers who use Telegram will either get the chatbot support or standard advice. The goal is to see if more people quit with the ch…

This study tests a program that combines medication (Naltrexone + Bupropion) with behavior therapy to help adults lose weight and quit smoking before bariatric surgery. Researchers will compare this approach to standard care in 64 participants aged 18-65 who smoke and have obesit…

This study will test whether e-cigarettes or a natural supplement called cytisine can help people who smoke at least 5 cigarettes a day and haven't been able to quit with standard treatments like nicotine patches or counseling. Over 4 years, 6,000 participants will be randomly as…

This study will test an app called JomCare that sends personalized support to men who have sex with men when they are most likely to engage in chemsex (using drugs before or during sex). The goal is to reduce risky behaviors and prevent new HIV infections. About 482 HIV-negative …

This study will create and test a smartphone app designed to help teenagers in Indonesia stop smoking. About 110 teens aged 13-15 who smoke will be split into two groups: one using the new app and the other using paper materials. Researchers will check if the app helps them stay …

This study tests whether adding accelerated transcranial magnetic stimulation (aTMS) to the standard smoking-cessation drug varenicline helps adults quit nicotine products like cigarettes and vapes. Thirty participants will take varenicline daily for 12 weeks and receive either r…

This study in Nairobi, Kenya, will test whether a drug called cytisine, combined with counseling, can help 300 people with HIV quit smoking and reduce heavy drinking. Participants will receive either cytisine or a placebo, plus either intensive counseling or standard advice. The …

This study will bring medication for addiction and cognitive behavioral therapy to homeless veterans living in VA supportive housing. The goal is to help them stay housed and reduce substance use. About 8,000 veterans across multiple VA sites will take part.

This study tests if adding a safe dye to a drink can prove that urine samples are real and not tampered with. About 114 adults with substance use disorder will drink Gatorade with or without the dye, then provide a urine sample 15 minutes later. Researchers will check for the dye…

This study tests LaunchPad, an online program designed to help high school seniors avoid drug and alcohol problems as they leave school. Researchers will randomly assign 5,000 students to different lessons and measure changes in their attitudes, confidence, and intentions around …

This study tests whether a brief digital program can help teenagers ages 12-17 who vape reduce their e-cigarette use and lower their risk of starting to smoke cigarettes. About 150 teens in California will take online surveys over 12 weeks, and some will also do a virtual intervi…

This study tests whether giving financial rewards to pregnant women who smoke—and to their smoking partners—helps them quit. About 180 pregnant women and their partners will be split into three groups: one where only the woman gets money for quitting, one where both get money, an…

This study tests whether a social network approach can encourage people who inject drugs to start HIV prevention medication (PrEP) and addiction treatment (MOUD). About 398 participants will be assigned to either the LINKED intervention or a control group. The goal is to see if p…

This study tests whether a smartphone app with AI can help adolescents aged 14-20 quit e-cigarettes. Participants use the app to set goals, track progress, and get real-time support during cravings. Researchers compare an immediate-use group with a delayed-start group to see if t…

This pilot study tests a program to help construction workers in Hong Kong quit smoking. Participants will get nicotine gum, a week of nicotine replacement therapy samples, and 12 weeks of support from a chatbot via WhatsApp. The study will see if this combined approach is practi…

This early-phase study at Yale will test whether a single 25mg dose of psilocybin is safe and well-tolerated in 10 veterans who smoke daily and have chronic pain. Researchers will monitor side effects and explore whether the drug can improve pain and boost motivation to quit smok…

This study tests whether a compound from cannabis called THCV can help people who smoke daily to resist cigarettes and smoke less. 32 smokers will receive either THCV or a placebo and then take a test measuring how long they can delay smoking and how many cigarettes they smoke. T…

This study will test a new multilingual chatbot called LIFT-UP designed to help people living in poverty quit smoking. Researchers will interview 22 adults who smoke at least 3 cigarettes daily and are motivated to quit. The goal is to see if the chatbot is easy to use and helpfu…

This pilot study tests a new program for young adults (25 or under) in Hong Kong who recently quit smoking. The program combines personalized counseling with an AI chatbot that sends supportive messages for 30 days. Researchers want to see if this approach is practical and accept…

This study tests whether a program that helps people notice and manage smoking triggers can help light smokers (10 or fewer cigarettes per day) quit. About 60 adults will either get standard counseling or counseling plus a cue-based tool where they text about cravings. The goal i…

This study tests whether an intelligent chatbot can help people quit smoking by joining their private online support groups. 120 adult smokers who are ready to quit within 10 days will be split into two groups: one with a chatbot that responds when no human does, and one with a s…

This study tests a smoking cessation program delivered via telemedicine and wearable devices. About 102 adult smokers will either get the program with remote monitoring or standard in-person support. The goal is to see if the tech-based approach helps more people quit and stay sm…

This study tests a smoking cessation program that combines a smartphone app with support from a psychologist. 429 adult smokers who want to quit will be placed into one of three groups: eight sessions with a psychologist plus the app, four sessions plus the app, or the app alone.…

This study tests whether a behavioral method called Emotional Brain Training (EBT) can help people in recovery from addiction manage stress, anxiety, and cravings. About 54 adults receiving standard addiction treatment will either continue their usual care or also attend weekly E…

This study tests whether a type of cognitive training called Action-Based Cognitive Remediation (ABCR) can improve thinking skills in people with various psychiatric conditions like depression, schizophrenia, anxiety, PTSD, and autism. Participants will complete computer exercise…

This study tests a mindfulness program designed to help sexual assault survivors reduce alcohol misuse and tobacco use. Researchers will enroll 120 college students aged 18-24 who have experienced sexual violence and drank alcohol recently. Participants will take online surveys a…

This study tests whether equine-assisted therapy (working with horses) can improve mental health and reduce cravings in people recovering from addiction. Twenty-two adults who have completed detox will be randomly assigned to either receive 22 sessions of equine therapy over 24 w…

This study aims to help Native Hawaiian adults quit smoking by testing nicotine gum, group counseling, or both. About 75 participants from public housing sites on O'ahu will be assigned to one of three groups. Researchers will check which method works best for quitting and is mos…

This study is for pregnant people who use tobacco and cannabis and want to quit. Researchers will test a program that helps with depressive symptoms to make quitting easier. The study involves 25 participants and will measure how well the program works and if people stick with it…

This study tests whether daily motivational text messages can help people in rural Mississippi quit smoking or smokeless tobacco. Researchers will recruit 150 tobacco users who want to quit and have tried before. Half will get encouraging texts, the other half non-specific messag…

This pilot study tests whether adding music therapy to nicotine replacement therapy (patches and gum) helps healthcare professionals reduce smoking cravings more than nicotine therapy alone. 80 participants will be split into two groups and followed for 3 months. The study also l…

This study tests whether daridorexant, a recently FDA-approved sleep medication, can improve sleep quality and daytime alertness in smokers who struggle with insomnia during quit attempts. About 44 adult smokers who smoke at least 10 cigarettes daily will take the drug or a place…

This study tests whether a virtual reality app, used alongside standard counseling, can help people stop vaping nicotine. Ninety participants aged 16 and older who vape at least weekly and want to quit will use the VR app at home for 12 weeks. The app is designed to make practici…

This study tests whether adding a structured exercise program to cognitive-behavioral therapy (CBT) helps smokers quit more effectively than CBT alone or general health advice. Sixty-six adult smokers will be randomly assigned to one of three groups and followed for 12 weeks. Res…

This study tests whether a special breathing technique called Wim Hof breathing can improve lung function in young men who smoke e-cigarettes. Forty-two participants will practice deep breathing and breath-holding exercises. Researchers will measure lung capacity, oxygen levels, …

This study aims to adapt and validate a French version of the Recovery Assessment Scale (RAS), a questionnaire that measures how people feel about their own recovery from mental health conditions. Researchers will ask 260 adult psychiatric patients in France to fill out the RAS a…

This study looks at how changing the temperature and liquid in e-cigarettes affects the amount of harmful chemicals (oxidants) users breathe in. Researchers will measure markers of cell damage in breath, cheek cells, and blood from 50 adult e-cigarette users. The goal is to under…

This study looks at whether new types of menthol cigarettes are more addictive than a person's usual menthol brand. About 48 daily smokers will test different cigarettes in a lab and at home. Researchers will measure nicotine levels in the blood and ask about how much participant…

This study aims to find better ways to help Veterans quit smoking when they come in for lung cancer screening. Since smoking causes most lung cancers, combining screening with stop-smoking support could save more lives. The project will test new processes at a few VA sites and me…

This study looks at whether adding a clinical pharmacist to community mental health teams (called FACT teams) helps people with severe mental illness and substance use disorders feel better and manage their medications more effectively. About 160 adults will take part, and the st…

This study will check how addictive two new nicotine pouches are by measuring their effects on the body and how much nicotine gets into the blood. About 40 healthy adults who smoke and also use smokeless tobacco will try the pouches in a clinic. The goal is to understand the abus…

This study looks at how men and women differ in their attraction to and addiction risk from menthol-flavored e-cigarettes, both with and without nicotine. Researchers will measure choices and effort to get the product in 60 adult smokers who already use e-cigarettes. The goal is …

This study will observe 60 adults in residential therapeutic communities in Mexico to understand how recovery from substance use unfolds over time. Participants will answer quick mobile surveys several times a day about cravings, mood, and social interactions for 8 to 12 weeks. T…

This study tests whether a special team of doctors, nurses, and peer supporters can help people with substance use disorders get the follow-up care they need after a hospital stay. The team meets patients in the hospital and provides support and treatment after they leave, helpin…

This study tests whether adding a career counseling program called Purposeful Pathways to standard job training helps veterans with mental health and substance use disorders find and keep quality jobs. About 254 veterans from three VA sites will take part. The goal is to improve …

This study tests if a 12-week one-on-one support program is easy to complete and acceptable for people supporting a loved one who recently finished substance use treatment. About 18 participants will attend weekly telehealth sessions and complete surveys and interviews. The goal …

This study will compare how synthetic nicotine and a nicotine analogue (6-methylnicotine) behave in the body versus traditional tobacco-derived nicotine. Twenty-four regular vapers will vape e-liquids containing these substances, and researchers will measure their levels in the b…

This study will test a tool called the Health Improvement Profile (HIP) in a mental health inpatient unit. The HIP is a checklist that helps clinicians spot physical health problems like high blood pressure or poor diet in people being treated for mental illness. Researchers will…

This study will examine 212 regular smokers to see how their level of nicotine addiction relates to breathing strength, physical fitness, memory, pain, sleep, and overall well-being. Participants will answer questionnaires and perform simple tests like a 6-minute walk. No treatme…

This study tests a program to help mental health providers prescribe smoking cessation medications to veterans with serious mental illness. Researchers will work with 65 providers and veterans to see if the program is acceptable and practical. The goal is to overcome barriers tha…

This study aims to better understand psychiatric disorders, thinking problems, and treatment side effects in 2000 cancer patients and their close relatives. Researchers will compare those with and without mental health issues to find patterns and improve care. No new treatments a…

This study will check how much psychiatric clients know about occupational therapy (OT) and whether their expectations are realistic. It will also evaluate how well OT interns explain health information and conduct interviews. Researchers will develop new tools to measure these s…

This study will enroll 70 adult smokers to compare how appealing and addictive different e-cigarettes are versus their usual cigarettes and nicotine gum. Participants will try each product in a random order during an 8-day stay at a clinic. Researchers will measure how much nicot…

This study will measure how much nicotine enters the bloodstream when adult smokers use eight different e-cigarette products with various flavors (menthol, mint, tobacco, fruit). Forty healthy smokers, aged 21 to 60, will try each product in a random order while staying at a clin…

This study will enroll 40 healthy adult smokers to compare how much they crave different tobacco products. Participants will try heated tobacco devices, their usual cigarettes, and nicotine gum in a clinic setting. Researchers will measure their desire to smoke and nicotine level…

This study tests whether community health workers can help more eligible people get screened for lung cancer and quit smoking. The workers will reach out to patients, help them make informed decisions, offer smoking cessation counseling, and navigate barriers to care. The study w…

This study will enroll 16,000 people invited to colorectal cancer screening in Norway. Participants will fill out a diet and lifestyle questionnaire and receive personalized digital feedback on how their habits compare to health recommendations. Some groups get extra support like…