Nicotine dependence

This study tests whether combining home food delivery with video-based smoking cessation counseling helps rural smokers quit more than counseling or food delivery alone. Participants are adults aged 21-75 who smoke regularly and live in certain Arkansas counties. The goal is to s…

This study tests whether personalized text messages can motivate people living with HIV in Vietnam to quit smoking. Participants receive motivational texts over six months and are encouraged to use a free government quitline that provides nicotine patches. The goal is to see if t…

This study tests a smoking cessation program called All Nations Breath of Life, designed specifically for American Indian communities. It involves 576 participants at four sites—two on reservations and two in urban areas. The program includes counseling and support, and success i…

This study tests a telephone-based version of the All Nations Breath of Life program, designed specifically for American Indians who smoke. Participants receive coaching calls over the phone and are compared to those in a general smoking cessation program. The main goal is to see…

This study tested whether adding a special type of talk therapy (CBASP) to standard smoking cessation treatment helps depressed smokers quit and feel better. About 91 adults with depression who smoked at least 5 cigarettes a day took part. The goal was to see if the combined appr…

This study tests whether a smoking cessation medication (varenicline) combined with tools to help people stick with treatment can improve quit rates for smokers living with HIV. About 340 participants will be followed for 6 months to see if they stop smoking, confirmed by breath …

This study tests whether a personalized letter and proactive phone calls can help veterans with a newly diagnosed lung nodule quit smoking. The program uses the diagnosis as a 'teachable moment' to motivate quitting. Researchers will compare how many veterans use cessation servic…

This study tests a program called Just Care for Families, designed to help parents in rural Oregon who are involved with child welfare services and struggle with opioid or methamphetamine use. The program combines substance use treatment, mental health support, parenting training…

This study looks at whether sending reminders (nudges) to doctors, patients, or both can increase the number of people with HIV who smoke getting help to quit. About 500 patients and their doctors are involved. The goal is to see if these nudges lead to more referrals and partici…

This study looks at whether helping both patients and their household members quit smoking together works better than helping patients alone. About 231 patients who smoke and live with other smokers will get nicotine replacement therapy and support. Researchers will check quit ra…

This study tests a simple alert built into hospital electronic health records. When a doctor writes a note for a patient who smokes, the alert automatically suggests prescribing nicotine replacement therapy and ordering lung cancer screening. The goal is to see if this reminder h…

This study is testing a special kiosk placed in rural Appalachian Kentucky that provides clean syringes and harm reduction supplies to people who inject drugs. The goal is to see if the kiosk helps reduce the spread of HIV and hepatitis C, and lowers the risk of drug overdose. Ab…

This study tests whether intensive home-based psychiatric treatment can help children and teens with mental health disorders as an alternative to being in the hospital. Over 3 months, participants receive 3 to 7 home visits per week from a team of doctors, therapists, and other s…

This study looks at whether offering money can help hospitalized smokers quit. Over 1,000 adult smokers will be given different types of financial rewards to see which approach works best. The goal is to find a cost-effective way to help people stop smoking for good.

This study tests whether an online training program helps people who recently quit smoking stay smoke-free and also support others in their social network to quit. About 940 adults who have been smoke-free for 2 to 8 weeks will take part. They will complete online surveys and pro…

This pilot study tests whether giving the smoking-cessation drug varenicline to people with HIV who also have alcohol use disorder is practical and safe. Thirty participants will receive the medication along with support from a pharmacist and psychiatrist. The goal is to see if t…

This study tests a proactive, culturally tailored outreach program to help BIPOC adults who smoke quit tobacco. Researchers will enroll 700 participants from two health systems and provide personalized materials and support to connect them with proven cessation treatments. The go…

This study compares two ways to help people with both substance use and mental health disorders: a full team-based program called MISSION that provides counseling, peer support, and community outreach for 6 months, versus just linking them with a peer specialist. Researchers hope…

This study compares two approaches to helping smokers quit: an opt-out method where everyone is automatically referred unless they say no, versus an opt-in method where people must actively sign up. Over 1,300 veterans at VA clinics in New York are taking part. The goal is to see…

This study compares two approaches to help people who are homeless or at risk of homelessness quit smoking: cytisine (a plant-based pill) versus nicotine replacement therapy (like mouth spray, patches, or gum). Both groups also get counseling. The goal is to see which strategy wo…

This study tests whether offering financial incentives through a mobile phone app can help low-income adults quit smoking. 532 participants will receive either standard care (phone counseling and nicotine patches/gum) or standard care plus mobile rewards for verified abstinence. …

This study tests whether a daily kava drink can help active smokers who don't plan to quit reduce their smoking and lower their risk of lung cancer. Twenty adult smokers will take kava daily for several months. Researchers will check how well participants stick with the regimen, …

This study looks at whether varenicline (a prescription drug) or nicotine patches help people quit smoking more effectively, depending on their natural levels of emotion and attention. About 204 smokers aged 18-75 who smoke at least 5 cigarettes daily will receive behavioral coun…

This study looks at whether having a trained peer (someone with similar experiences) as a case manager can help people with HIV who also have mental health or substance use problems get the care they need. About 405 adults from an HIV clinic will be randomly assigned to either us…

This study tests a program to help people living with HIV in Botswana stop smoking. It combines counseling with a medication called varenicline. The goal is to see if this approach helps them quit and improves their health. The study involves 750 participants who are daily smoker…

This study tests a program called the Bridge Model that provides social support, volunteering, and job opportunities to help people with nicotine or substance use disorders who are homeless or low-income. Researchers want to see if this approach improves quality of life and helps…

This trial tests a digital program designed to help people quit tobacco. Over 2,200 participants will use the program or receive usual care. The main goal is to see if the program helps people stop using their primary tobacco product for at least 30 days.

This study is creating and testing a program to help Hispanic/Latino high school students stop using e-cigarettes. Researchers will work with 120 teens to see if the program is practical and helps reduce vaping. The goal is to support a group that is often overlooked in quitting …

This study tests whether referring Veterans in early recovery from substance use disorder to work-focused programs (like supported employment) helps them stay sober and function better. About 100 Veterans will be randomly assigned to get the work referral or usual treatment alone…

This study tests a program called BAT-CS that combines smoking cessation counseling with mood management for people who have had a heart attack (acute coronary syndrome). The goal is to help them quit smoking and reduce depression symptoms, which could lower their risk of dying f…

This trial tests whether a school-based program can help parents stop smoking. About 700 families with a smoking parent will take part. The program includes education, motivation support, and relapse prevention delivered both in person and online. Success is measured by whether p…

This study aims to eliminate hepatitis C among people who use drugs in Paris, Marseille, Lyon, and Fort-de-France. Researchers will screen participants, provide immediate treatment, and use a peer-referral system to reach more people. The goal is to see if this community-based ap…

This study tests whether special lights and cameras can help find early signs of mouth cancer in people at high risk. About 338 participants with precancerous spots or conditions like Fanconi anemia will have their mouths examined with fluorescence imaging, which makes abnormal c…

This study tests a program called Journey of Transformation for Native American tenth graders at an off-reservation boarding school. The program uses traditional storytelling, cultural arts, and outdoor activities to teach leadership and healthy decision-making around substance u…

This study tests whether a robot-assisted escape room game can help 5th and 6th graders learn about the harms of tobacco and e-cigarettes. About 200 students in Taiwan will either play the game or receive standard classroom lessons. Researchers will measure changes in knowledge, …

This study tests a free online program called Healthy Futures: Alternative-to-Suspension, designed to teach high school students about the risks of tobacco and nicotine and provide resources to quit. About 2,540 students from schools that agree to use the program or continue thei…

This study tests whether a type of counseling called behavioral activation therapy, combined with a nicotine patch, helps people quit smoking. It focuses on smokers who have low reward sensitivity, meaning they get less pleasure from rewards. About 85 participants will receive ei…

This study tests a program called Omnis Salutis for recent veterans with PTSD, depression, anxiety, or substance use disorders. The program teaches veterans to identify their health goals and communicate them to doctors and family. Researchers want to see if it improves social an…

This study tests whether a smartphone app designed for people with serious mental illness can help them quit smoking. About 64 adults who smoke heavily and have a mental illness will use one of two special apps or a standard app for 5 weeks. All participants also get nicotine pat…

This study tests a 6-session virtual program called Future Self-BD for adults with bipolar disorder who want to quit smoking. Participants are guided to vividly imagine positive future events that could result from quitting, combined with brief smoking cessation counseling. The t…

This pilot study tests whether two smartphone apps can help current smokers quit. 24 participants will use either the KickAsh app (to track mood and activity) or the Breathe2Relax app (for relaxation). Researchers will check if the apps improve mood, increase activity, and lead t…

This study aimed to see if adding dexmedetomidine to a standard painkiller could improve pain control and comfort after lung surgery in smokers. It planned to enroll 102 men with high nicotine dependence. However, the study was withdrawn before any participants were enrolled, so …

This pilot study tests a specific type of drama therapy for people who have both a mental health condition (like depression or bipolar disorder) and a substance use disorder. Ten participants will attend weekly group drama therapy sessions for 12 weeks, then put on a performance.…

This study is testing whether a smartphone app, combined with nicotine patches, can help people reduce or quit smoking. The app guides users to smoke on a schedule and tracks their progress. The study involves 56 adult smokers who smoke at least 10 cigarettes a day. The goal is t…

This study tests a program that combines mood management with health and wellness coaching to help pregnant smokers who are depressed quit smoking and stay smoke-free after their baby is born. About 26 participants will take part during pregnancy and after birth. The goal is to s…

This study tests a group therapy called Awareness, Courage, and Love (ACL) for older adults with psychiatric disorders who feel lonely. The therapy focuses on mindfulness, sharing feelings, and building connections. Researchers want to see if the program is practical and helpful …

This small pilot study tests whether using a mobile app can help adults quit smoking. About 24 smokers from MD Anderson's Tobacco Treatment Program will use either a positive psychology app or a relaxation app alongside their usual care. The main goal is to see how well people st…

This study tests whether a pharmacist-led program can help low-income smokers use nicotine patches or lozenges to quit or reduce smoking. About 100 adults from community health centers will receive counseling sessions and text support. The goal is to see if this approach is pract…

This study tests whether a short group therapy program (CBT) can help men in prison stop smoking. 202 participants will be randomly assigned to CBT, a health education session, or a waitlist. Researchers will check if they quit by measuring carbon monoxide levels at 1 and 3 month…

This study looks at how proposed tobacco regulations might affect the buying and use habits of people in Appalachian Kentucky. About 473 adults who use tobacco daily will take online surveys and shop in a pretend online store where prices change. The goal is to see if rules like …

This study looks at how synthetic cooling additives (like WS-3 and WS-23) in e-cigarettes change how young adults perceive and use them. About 158 current e-cigarette users aged 21-29 will try different flavored e-liquids and report their satisfaction, sensory experiences, and pu…

This study tests a 10-week program called 'Grow to Recovery' for people with mental illness. The program is co-led by a peer (someone who also has a mental illness) and a professional. Researchers want to see if it helps participants feel more hopeful and capable. 138 people are …

This study tests whether doing clinical trial visits remotely (from home) works as well as coming into a clinic. About 200 adults will be randomly assigned to remote or in-person groups for intake and follow-up over 3 months. The goal is to see which method is better at keeping p…

This study looks at how long-term exposure to secondhand tobacco smoke changes the lungs of never-smoking flight attendants who worked on planes before smoking was banned. Researchers want to see if a bronchodilator, a medicine that opens airways, can help with breathing problems…

This study from Mayo Clinic tests whether a smartphone app called Senyo Health can help connect people with substance use disorders to treatment through their primary care doctor. Sixty participants will use the app for 12 weeks, which includes therapy modules, weekly check-ins w…

This study looks at how Salvation Army staff can help people who smoke learn about and use free quit-smoking services, like the Wisconsin Tobacco Quit Line. Researchers will train staff to offer a short survey that gives feedback on smoking risks and treatment options. The goal i…

This study uses data from over 30,000 Swedish adults to see if using snus (including newer white nicotine pouches) is linked to heart disease, metabolic problems, and poor mental health, independent of smoking. Researchers will compare current, former, and never-users using advan…

This study examines how nicotine buildup in gum tissue influences the results of non-surgical periodontitis treatment. Researchers will measure nicotine and cotinine levels in the gums of 56 smokers and non-smokers with periodontitis. The goal is to understand if nicotine intoxic…

This study tests a machine-learning tool that gives doctors a pop-up alert when they prescribe opioids to a patient at high risk of overdose. The alert explains why the patient is at risk and suggests safer options, like prescribing naloxone or referring to pain therapy. Research…

This study aimed to understand how a person's socioeconomic status (like income and education) affects their recovery from substance use disorder. Researchers planned to follow adults in early recovery for up to 3 years, measuring changes in social functioning, quality of life, a…

This study tests a program called ENHANCE-TTS that trains pharmacists at HIV clinics to provide tobacco treatment. Researchers will see if the program helps pharmacists offer more smoking cessation services and if it helps patients quit. About 172 people from six clinics will tak…

This study is developing and testing a smartphone app called R-Assist for people recently released from jail who have both substance use and mental health disorders. The app tracks symptoms, connects users to resources like housing and recovery groups, and measures how easy it is…

This study was designed to understand how cigarette direct mail marketing influences smoking beliefs and behavior in young adults ages 18 to 29. Researchers planned to compare responses between smokers from higher and lower income backgrounds. However, the study was withdrawn bef…

This study looks at tobacco, cannabis, and other drug use among homeless and at-risk youth in downtown Ottawa. Researchers will follow 520 participants aged 16 and older who are homeless or insecurely housed and have a history of cannabis use and mental illness. The goal is to un…

This study follows 100 head and neck or lung cancer patients who are current or former smokers and receive radiation therapy. Researchers track who stays smoke-free at 1, 6, and 12 months after treatment ends, and what factors help or hinder abstinence. The goal is to learn how t…

This study tests whether a "Care Navigator" — a personal guide — can help people with substance use problems start and stay in treatment. About 360 adults who call a mental health access center will be randomly assigned to get usual care or extra help from a navigator. The goal i…

This study looks at how different tobacco products, like cigarettes, e-cigarettes, and smokeless tobacco, affect the way skin wounds heal. Researchers will measure skin temperature, blood flow, and signs of inflammation in 60 participants, including a non-smoking group. The goal …

This observational study follows 120 adult e-cigarette users for two weeks to see if those who use lower nicotine e-liquids have less nicotine exposure and fewer harmful chemicals compared to those using higher nicotine e-liquids. Participants will use their usual devices at home…

This study follows 192 teens aged 12 to 20 who are already receiving either Cognitive Behavioral Therapy (CBT) or Brief Strategic Therapy (BST) for anxiety, depression, or OCD. Researchers will track their progress using questionnaires and interviews over 9 months. The goal is to…

This early study is testing whether focused ultrasound, a non-invasive technique that uses sound waves to target specific brain areas, is safe and feasible for people with opioid or other substance use disorders. The study involves 20 adults aged 22-60 who are currently in treatm…