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Nicotine dependence
MONDO:0008575Physical and psychological dependence on nicotine.
Also known as: nicotine addiction, tobacco use disorder
465 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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Flavored vapes tested as smoking cessation aid – but study ends early
Disease control TerminatedThis study aimed to see if giving smokers access to different e-cigarette flavors (menthol, non-tobacco, or tobacco) helps them stop smoking regular cigarettes. Over 600 adult smokers were assigned to different flavor groups and tracked for 13 weeks. However, the trial was termin…
Phase: NA • Sponsor: RAI Services Company • Aim: Disease control
Last updated Jun 27, 2026 09:08 UTC
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New approach aims to boost HIV prevention in LGBTQ+ individuals struggling with addiction
Prevention TerminatedThis study tested a program to help HIV-negative transgender women and men who have sex with men who also have a substance use disorder stick with PrEP, a daily pill or shot that prevents HIV. Participants received counseling and text support, with extra help for those who strugg…
Phase: NA • Sponsor: Friends Research Institute, Inc. • Aim: Prevention
Last updated Jun 27, 2026 09:04 UTC
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Mental health sessions may boost vaccine uptake in latinx communities
Prevention TerminatedThis study tested whether adding vaccine discussions to routine behavioral health visits could reduce hesitancy and increase COVID-19 and flu shots among Latinx adults with mental illness. Clinicians used motivational interviewing and could offer a warm handoff to a nurse for vac…
Phase: NA • Sponsor: Boston College • Aim: Prevention
Last updated Jun 26, 2026 17:00 UTC
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Mental health study aims to uncover Long-Term heart risks
Knowledge-focused TerminatedThis study followed 167 adults with mental health issues like anxiety, depression, or sleep problems who visited their primary care doctor. Researchers used health conversations and a blood test to track lifestyle changes and heart disease risks over up to 20 years. The goal was …
Phase: NA • Sponsor: Region Skane • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:28 UTC
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Brain zapping study targets smoking in schizophrenia
Knowledge-focused TerminatedThis study tested whether a non-invasive brain stimulation technique called deep rTMS could change brain activity and reduce smoking in people with schizophrenia. Researchers used brain scans to measure changes in brain connections and smoking behavior. The study was small and en…
Phase: NA • Sponsor: Stony Brook University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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New program aims to help moms after preterm birth
Knowledge-focused TerminatedThis study tested a care coordination and motivational interviewing program for women who recently had a preterm birth. The goal was to see if the program was feasible and acceptable to participants. Only 13 women enrolled before the study was terminated, so the findings are very…
Phase: NA • Sponsor: Children's Hospital of Philadelphia • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC