Gene test could help smokers quit by matching them to the right drug
NCT ID NCT03227679
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether a genetic biomarker called the Nicotine Metabolite Ratio (NMR) can help doctors choose the best FDA-approved smoking cessation medication for each person. 82 daily smokers were assigned to varenicline, bupropion, or nicotine patches based on their NMR result. The goal was to see if this personalized approach is feasible and acceptable to patients.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Nicotine Metabolite Ratio (NMR) testing, varenicline, bupropion, nicotine patch
What this could lead to
If successful, this approach could help doctors personalize smoking cessation treatments, making them more effective for each individual.
What could go wrong
This is a small pilot study with only 82 participants, so results may not apply to everyone. It tested feasibility, not long-term quit rates.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.