Could Low-Nicotine smokes plus E-Cigs cut harm for mentally ill smokers?

NCT ID NCT04058717

Completed Knowledge-focused Sponsor: Milton S. Hershey Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looked at whether using very low nicotine cigarettes along with nicotine-containing e-cigarettes can reduce harmful chemical exposure in smokers with mental health conditions. 88 participants were assigned to different combinations of cigarettes and e-cigarettes. The main goal was to measure a cancer-related chemical in urine and other markers of smoke exposure.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Very low nicotine cigarettes and nicotine-containing e-cigarettes
What this could lead to: If successful, this could point toward ways to reduce harmful chemical exposure in smokers who cannot or will not quit.
What could go wrong: This is a small, early-stage study with only 88 participants, so results may not apply to all smokers. It does not test quitting or long-term health outcomes.

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Conditions

The condition(s) this trial relates to.

anxiety disorder bipolar disorder eating disorder major depressive disorder nicotine dependence psychotic disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TOBACCO DEPENDENCE

Contacts and locations

Locations

Penn State College of Medicine

Hershey, Pennsylvania, 17033, United States

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