Nicotine pouches put to the test: can they replace cigarettes?

NCT ID NCT05335915

Completed Knowledge-focused Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 24, 2026 · Updated 2 times

Summary

This study tested how tobacco-free nicotine pouches affect the body and mind compared to regular cigarettes. Seventy-one adult smokers tried different doses and flavors of pouches, as well as their own cigarettes, in a controlled setting. Researchers measured nicotine levels in the blood and asked participants about cravings and satisfaction. The goal is to see if these pouches could be a less harmful option for people who smoke.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Nicotine pouches (tobacco-free) and cigarettes
What this could lead to: If successful, this could help understand whether nicotine pouches are a less harmful alternative to smoking for adults who already smoke.
What could go wrong: This is a small, early-phase study in healthy smokers, so results may not apply to everyone. It measures short-term effects only, not long-term health outcomes or addiction risk.

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Conditions

The condition(s) this trial relates to.

nicotine dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DRUG EFFECT NICOTINE ADDICTION NICOTINE WITHDRAWAL

Contacts and locations

Locations

Johns Hopkins Behavioral Pharmacology Research Unit

Baltimore, Maryland, 21224, United States

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