Nicotine pouches put to the test: can they replace cigarettes?
NCT ID NCT05335915
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tested how tobacco-free nicotine pouches affect the body and mind compared to regular cigarettes. Seventy-one adult smokers tried different doses and flavors of pouches, as well as their own cigarettes, in a controlled setting. Researchers measured nicotine levels in the blood and asked participants about cravings and satisfaction. The goal is to see if these pouches could be a less harmful option for people who smoke.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Nicotine pouches (tobacco-free) and cigarettes
What this could lead to
If successful, this could help understand whether nicotine pouches are a less harmful alternative to smoking for adults who already smoke.
What could go wrong
This is a small, early-phase study in healthy smokers, so results may not apply to everyone. It measures short-term effects only, not long-term health outcomes or addiction risk.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for NICOTINE ADDICTION are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Johns Hopkins Behavioral Pharmacology Research Unit
Baltimore, Maryland, 21224, United States