NICOTINE ADDICTION

This study tests a new, non-invasive treatment using low-intensity focused ultrasound (LIFU) to help people quit smoking. It targets deep brain areas linked to nicotine addiction without surgery or needles. The study will enroll 100 adults who have smoked for at least 5 years and…

This study compares two ways to help people stop smoking and lower their cancer risk. About 5,000 adults who smoke and visit a participating clinic will be assigned to either a program that uses personalized reminders and support (ELEVATE-S) or standard quit-focused care (ELEVATE…

This study tests whether semaglutide, a drug used for diabetes, can help people with type 2 diabetes quit smoking. About 100 adults in Ontario who smoke at least 5 cigarettes daily will receive the drug alongside nicotine replacement therapy. The main goal is to see if a larger s…

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can help people with schizophrenia spectrum disorder quit or reduce smoking. Fifty participants will receive active rTMS using either an F8 coil or an H …

This study looks at how stopping smoking for six weeks affects the body's chemistry and gut bacteria in people being treated for substance use disorders. Researchers will compare 100 participants who quit smoking with 50 healthy controls, using blood and stool samples along with …

This study looks at whether virtual reality (VR) can measure how smokers pay attention to smoking-related cues, which may help understand nicotine addiction. Two hundred daily smokers will take either a medication (varenicline) or a placebo, and their eye movements and cravings w…

This study looks at how the amount of nicotine and the pH level in nicotine pouches influence how appealing and addictive they feel to young adult users. Researchers will have 84 participants try different pouches and rate their experience. The goal is to help regulators understa…