Can Ultra-Low nicotine cigarettes help pregnant smokers cut down?

NCT ID NCT04033237

Completed Disease control Sponsor: University of Vermont Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether giving pregnant smokers cigarettes with very low nicotine (0.4 mg per gram of tobacco) helps them smoke less over 12 weeks. Thirty women were randomly assigned to either their usual brand or the low-nicotine cigarettes. The main goal was to see if they smoked fewer cigarettes per day.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: very low nicotine cigarettes (0.4 mg nicotine/g tobacco)
What this could lead to: If successful, this could show that reducing nicotine in cigarettes helps pregnant women smoke less, potentially leading to safer tobacco policies.
What could go wrong: This is a small early-phase study with only 30 participants, so results may not apply to all pregnant smokers. The intervention still involves smoking, which carries health risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

nicotine dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TOBACCO USE DISORDER

Contacts and locations

Locations

University of Kentucky

Lexington, Kentucky, 40536, United States
University of Vermont

Burlington, Vermont, 05401, United States

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