Periodontal disorder

This study tests whether watching a video about brushing and flossing is as effective as a hands-on demonstration with a 3D model for people with gingivitis (early gum disease). Eighty adults with gingivitis will receive either a video link or a live demo, and their gum health wi…

This study tested a procedure that uses a patient's own growth factors to help rebuild lost jawbone. Eleven people with severe bone loss in the upper jaw received a bone graft mixed with plasma rich in growth factors. After 6-9 months, enough bone had grown to place dental implan…

This trial tests whether adding a laser procedure to standard deep cleaning improves gum health and quality of life in people with periodontitis. Researchers will compare two groups: one receiving scaling and root planing alone, and another receiving the same cleaning plus laser-…

This trial tests whether a deep dental cleaning, called non-surgical periodontal therapy, can reduce inflammation in people who have received a heart transplant. Heart transplant recipients often have low-level inflammation that may harm the new heart, and gum disease can be a hi…

This trial tests whether taking a probiotic supplement alongside standard deep cleaning of the tooth roots improves gum health in adults with advanced periodontitis. Researchers will compare two groups: one receiving deep cleaning alone and another receiving deep cleaning plus th…

This trial tests whether a graft made from a patient's own extracted tooth can preserve the jawbone that normally shrinks after tooth removal. Researchers compare four approaches: no graft, dentin graft alone, dentin graft combined with platelet-rich fibrin (PRF) from the patient…

This trial tests whether rinsing with coconut oil can reduce plaque and gum inflammation as effectively as a standard chlorhexidine mouthwash. Eighty adults with plaque-induced gingivitis will be split into two groups: one using coconut oil daily and the other using chlorhexidine…

This trial tests whether herbal mouthwashes containing tea tree oil, thyme hydrosol, or essential oils can reduce the plaque and gum inflammation seen in gingivitis. About 52 adults with gingivitis will use one of these mouthwashes or a placebo twice daily for three months, along…

This trial tests whether using artificial intelligence and computer guidance to lift the sinus floor and place dental implants immediately, along with a graft made from the patient's own tooth, improves outcomes compared to the traditional free-hand method. The study includes peo…

This trial tests whether treating gum disease can reduce bacteria that cause lung infections in people with bronchiectasis. Participants with both conditions will receive either basic cleaning, deep cleaning, or deep cleaning plus light therapy. Researchers will measure bacteria …

This trial tests whether adding an interdental brush, water flosser, or rubber toothpick to twice-daily toothbrushing reduces plaque and gum bleeding more than brushing alone. Twenty-nine dental students with gingivitis will use each method in different sections of their mouth fo…

This study tests whether adding photodynamic therapy (PDT) to standard deep cleaning (scaling and root planing) improves gum disease treatment more than cleaning alone. The trial includes both smokers and non-smokers to see if the extra treatment helps smokers, who often have wor…

This study compares two types of dental implant connections — internal hexagon and conical — to see which one leads to better bone preservation, fewer complications, and healthier gums. Twenty adults needing two implant-supported crowns will receive one of each connection type, a…

This study tests whether a gel made from Centella asiatica (a herb) can improve standard treatment for gum disease. Adults with periodontitis receive either standard deep cleaning alone or cleaning plus the gel applied to the gums once a week for three months. Researchers measure…

This study tests whether non-surgical gum treatment (deep cleaning) can improve oral health and quality of life in adults with hemophilia A or B. Researchers compare changes in gum health and daily comfort (using a questionnaire) between hemophilia patients and healthy individual…

This study tests whether adding hyaluronic acid gel and bone graft during dental implant surgery improves the quality of the surrounding gum and bone. Thirty-six adults needing implants are split into three groups: one gets hyaluronic acid, one gets both hyaluronic acid and bone …

This study tested two ways to widen a narrow lower jawbone so dental implants can be placed. One method used AI and computer guidance to make tiny holes in the bone, while the other did the same procedure by hand. The goal was to see which approach is safer and more effective. Tw…

This study looks at whether adding hyaluronic acid gel or a special blood product (Alb-PRF) to standard deep-cleaning treatment helps people with advanced gum disease (periodontitis). 51 adults aged 30-60 with Stage III periodontitis will be randomly assigned to one of three grou…

This study tests whether a gel made from spirulina (a type of algae) can improve the treatment of stage II gum disease when used alongside standard deep cleaning. Researchers will compare different ways of preparing the spirulina gel and measure gum health and inflammation levels…

This study tested whether a hands-on teaching method called Touch-to-Teach helps people with dental crowns clean between their teeth better than standard advice. 36 adults with at least one crown took part and were split into two groups: one got personalized brush training, the o…

This early-phase study tested whether an ozonated sunflower seed oil gel could improve gum disease treatment when used alongside standard deep cleaning. Sixty adults with stage II periodontitis were divided into groups receiving either cleaning alone or cleaning plus a regular or…

This study tested two types of bone graft materials—alloplastic (man-made) and xenograft (from animals)—to rebuild jaw bone in 20 people who needed dental implants. Each person received both materials in different sides of their jaw so the results could be directly compared. The …

This study tested whether a melatonin gel applied to the gums can improve the results of standard deep-cleaning treatment for gum disease. Thirty adults with periodontitis received either the melatonin gel or a placebo gel alongside their regular dental cleaning. Researchers meas…

This study compared a liquorice nanogel to a diode laser as extra treatments for advanced gum disease (stage III). 27 adults with deep gum pockets received one of the two treatments alongside standard care. The goal was to see which approach better reduced harmful bacteria and im…

This study looked at whether adding probiotics or antibiotics to standard non-surgical gum disease treatment helps improve gum health. Sixty adults with severe periodontitis took part. The goal was to see if probiotics could be a safer alternative to antibiotics, which can cause …

This study tested whether a new mouthwash called MicroRepair ABX works as well as the standard chlorhexidine mouthwash for treating plaque-induced gingivitis (gum inflammation). Forty adults with gum disease used one of the two mouthwashes twice daily for 14 days after a professi…

This study tested whether using a calibrated interdental brush (sized to fit each gap) reduces gum bleeding better than a non-calibrated brush in 51 healthy young adults aged 18-30. Participants used one type of brush daily for three months. The main goal was to compare gum infla…

This study tested whether taking antibiotics along with standard deep-cleaning treatment (scaling and root planing) improves gum health in adults with periodontitis. 236 participants from dental practices across the U.S. were randomly assigned to receive either antibiotics (amoxi…

This study tested two daily-use mouth rinses containing chlorhexidine (CHX) plus either hydrogen peroxide or cetylpyridinium chloride against a placebo rinse. Over 3 months, 81 adults used the rinse twice daily alongside normal brushing. Researchers measured plaque buildup, gum i…

This study tested whether a hyaluronic acid gel or a chlorhexidine mouthwash works better as a follow-up home treatment after deep cleaning for gum disease. Forty adults with periodontitis used one of the two products for 15 days after their dental cleaning. Researchers measured …

This study tested whether applying hyaluronic acid gel after gum surgery helps the gums heal better. 26 patients with deep gum pockets were randomly given either the gel or a saltwater placebo during surgery. Researchers measured healing, pocket depth, and patient comfort over 3 …

This study tested a new ultrasonic device with root polishing against standard scaling and root planing for treating gum disease. Forty adults with moderate to severe gum disease were treated and followed for 6 months. The goal was to see which method better reduced pocket depths…

This study looked at whether adding a special light therapy (antimicrobial photodynamic therapy) to standard deep cleaning helps treat gum disease. Twenty adults with deep gum pockets and bleeding were treated on both sides of the mouth—one side got the light therapy, the other d…

This study tested whether adding laser therapy to standard deep cleaning improves gum health in people with severe periodontitis. Twenty adults received either antimicrobial photodynamic therapy (using a blue dye and laser) or photobiomodulation (red or infrared laser) alongside …

This study tested whether a probiotic called TCI188 (Pediococcus acidilactici) can improve oral health in adults with serious gum disease. Fifty-five participants took either the probiotic or a placebo daily. Researchers measured gum pocket depth and bleeding to see if the probio…

This study tested a new combination treatment for gum disease-related bone loss. Thirty adults with deep gum pockets received a graft made from zinc-substituted nano-hydroxyapatite (a bone-like material) mixed with advanced platelet-rich fibrin (a blood-derived healing scaffold).…

This study tested whether adding enamel matrix proteins (Emdogain) and a bovine bone graft to a minimally invasive gum surgery (M-MIST) helps heal deep gum defects better than surgery alone. Forty-five adults with at least one deep gum pocket were treated and followed. The main g…

This study tested whether adding a 980nm diode laser to standard deep-cleaning gum treatment improves gum health and reduces body-wide inflammation in people who recently had a heart attack. Forty participants with gum disease (some healthy, some heart attack survivors) received …

This study tested three methods to preserve the jawbone after removing an infected front tooth. Fifty-four adults received either a dentin graft alone, a dentin graft with a special platelet-rich fibrin (PRF) mix, or a dentin graft with PRF plus an antibiotic. The goal was to see…

This study tested a mobile app called NutriDent4Mom in 264 pregnant women to see if it could improve their diet and gum health. Half the women used the app to track food and read health tips, while the other half received standard care. The app was designed to help women meet nut…

This study looked at whether using a piece of a patient's own tooth can help repair bone gaps around new dental implants placed right after a tooth is pulled. 63 adults aged 20 to 45 with a damaged front tooth were treated. Some got the standard implant, some got an extra tooth g…

This study tested whether placing a thin bone layer (cortical lamina) over the extraction site helps preserve the jawbone's shape and size. Forty adults needing a tooth pulled were randomly assigned to get the lamina or standard care. After six months, bone changes were measured …

This study tested a gum surgery that combines a connective tissue graft with a special protein gel (enamel matrix derivative) to help regrow bone and gum tissue in people with advanced gum disease. Seventeen adults with deep gum pockets received the treatment, and researchers mea…

This study tested whether adding a diode laser to standard deep cleaning helps smokers with severe gum disease. 33 smokers were split into two groups: one got standard cleaning alone, the other got cleaning plus laser. After 3 months, the laser group had shallower gum pockets, le…

This study tested whether taking a daily probiotic (Bifidobacterium Lactis HN019) can reduce plaque buildup and gum bleeding in people undergoing orthodontic treatment with braces or clear aligners. Sixty participants, aged 10 to 30, took the probiotic or a placebo for a period w…

This study tested whether a chewing gum containing dietary nitrate (a natural compound found in leafy greens and beets) could improve gum health and heart health in adults with mild gum disease. Thirty participants were randomly assigned to use either the nitrate gum or a placebo…

This study tested whether lozenges made from propolis (a substance bees produce) can improve gum health in 100 young adults with mild to moderate gingivitis. Participants chewed the lozenges twice daily for a week while keeping their normal brushing routine. Researchers measured …

This study tested two treatments for deep gum bone defects caused by periodontitis: platelet-rich fibrin (PRF), made from the patient's own blood, and enamel matrix derivative (EMD), a protein gel. Twenty-six patients received one of the treatments after surgery, and their gum he…

This completed study tested a surgical technique called Entire Papilla Preservation (EPPT) alone or with added enamel matrix derivative and bone graft for repairing bone defects from gum disease. Fifty-eight adults with moderate to severe periodontitis took part. The goal was to …

This study looked at whether smokers who switch to combustion-free nicotine products (like e-cigarettes or heated tobacco) see improvements in their gum health and tooth appearance. 460 smokers with mild gum disease were randomly assigned to keep smoking, switch to these products…

This study tested a special dental floss coated with a probiotic (good bacteria) to see if it could reduce harmful mouth germs and improve gum health. Thirty-three healthy men used the probiotic floss and a placebo floss for two weeks each, with a break in between. Researchers me…

This study tests whether a 3D intraoral scanner can accurately measure dental plaque compared to the traditional method of applying a dye and visually scoring. Twenty adults with at least 20 natural teeth and visible plaque will be scanned before and after plaque disclosure and a…

This study looked at whether certain proteins in saliva can help tell the difference between healthy gums, gingivitis (mild gum inflammation), and periodontitis (serious gum disease). Researchers collected saliva from 60 people and measured three specific biomarkers. The goal is …

This study explores whether gas samples from the mouth can be collected and analyzed up to 7 days later to diagnose halitosis (bad breath). Researchers will take breath samples from 100 adults with gum disease and measure volatile sulfur compounds—the molecules responsible for ba…

This study tests an artificial intelligence system that measures the width of keratinized gingiva (a type of gum tissue) from smartphone photos. Researchers will compare the AI's measurements to those made by dental experts to see how accurate the tool is. The goal is to make gum…

This study tested a new high-frequency ultrasound probe to measure the depth of gum pockets, a key sign of periodontal disease. Researchers compared the ultrasound measurements to standard manual probing in 39 adults. The goal was to see if the ultrasound could accurately detect …

This study tested a non-invasive optical device that uses different types of light to detect and diagnose various mouth conditions, including oral cancer, gum disease, and dry mouth. Over 1,000 participants with and without oral lesions were imaged, and the results were compared …

This study compared a mobile app (Peribrain) to traditional manual methods for classifying the stage and grade of periodontitis (gum disease) in 122 patients. A student, a clinical student, and a clinician each classified the disease using either the app or manual measurements. T…

This study looked at whether measuring a substance called pentraxin in the fluid around teeth can help detect early gum disease in people who have fixed dentures. Researchers studied 90 patients to see if pentraxin levels could reveal inflammation that isn't visible during a regu…

This study looked at whether certain proteins and metals in saliva can signal the start of gum disease before teeth are damaged. Researchers measured these markers in 106 adults with healthy gums or various stages of gum disease. The goal was to find a way to predict gum disease …

Researchers compare three ways to preserve the jawbone after a tooth is removed. Participants are randomly assigned to receive no bone graft, a graft made from their own extracted tooth, or a synthetic bone substitute called beta-tricalcium phosphate. The trial measures changes i…

This trial tests whether stem cells from children's shed baby teeth can replace the standard hip bone graft for repairing a cleft in the upper jaw. Twenty children aged 7 to 12 with cleft lip and palate will receive either the stem cell graft or a traditional bone graft from thei…

This trial tests whether a long-acting anesthetic called liposomal bupivacaine can reduce pain after gum surgery better than the standard medium-acting anesthetic. Adults scheduled for gum surgery on 2 to 5 teeth will receive one of the two anesthetics injected near the surgical …

This study looked at how satisfied patients were and how much pain they felt after getting All-on-Four dental implants under sedation. 30 adults were followed for three days after surgery. Researchers measured pain, swelling, and how much pain medicine they used. The goal was to …

This study tested whether a special ultrasonic handpiece that sprays hydroxyapatite (a natural enamel mineral) can reduce tooth sensitivity during dental cleanings for people with gum disease. Forty adults with moderate to severe periodontitis had half their mouth cleaned with th…

This study tested two different tools—a magnetic mallet and a piezotome—to widen a thin upper jawbone so dental implants could be placed. Twenty patients with missing front teeth and narrow bone received the procedure along with a bone graft. The goal was to see which tool gave b…

This study looked at 30 adults with braces and gum inflammation (gingivitis). Each person received two different cleanings—one side of the mouth got a newer method called Guided Biofilm Therapy (using air and powder), and the other side got the standard ultrasonic cleaning and po…

This study tested whether adding a substance made from the patient's own blood (L-PRF) to standard gum surgery improves healing and reduces pain. Twenty-one adults with gum disease had both types of surgery on different sides of their mouth. Researchers measured pocket depth and …

This study tested a program where care partners helped people with mild dementia brush their teeth better. The program included a personalized oral care plan and tips for communication and cueing. Researchers measured plaque and gum health in 60 participants. The goal was to prev…

This study tested whether a special 5-day fasting-mimicking diet (plant-based soups, bars, and drinks) could reduce inflammation after deep cleaning for advanced gum disease. Twenty-eight adults with stage III-IV periodontitis were randomly assigned to either follow the diet or e…

This study looks at how oral hygiene habits and gum health affect quality of life in 160 adults. Participants will have a dental exam and fill out a questionnaire about how their mouth feels day-to-day. No treatment is given—the goal is simply to understand the connection between…

This study looks at how smoking cigarettes, e-cigarettes, or a water pipe (narghile) affects the gums and teeth of university students aged up to 25. Researchers will measure plaque, gum inflammation, pocket depth, and other signs of gum disease in 90 smokers. The goal is to see …

This study investigates whether proteins from the Hippo signaling pathway—known to control cell growth and bone health—are present at different levels in the gum fluid of people with healthy gums, gingivitis, or periodontitis. Researchers will collect fluid samples from 75 partic…

This study looked at three substances in saliva—Adseverin, 1-alpha defensin, and sRANKL—to see if they differ between people with healthy gums, gingivitis, or periodontitis. Researchers collected saliva from 60 non-smoking, systemically healthy adults and measured these biomarker…

This study tests whether the way a clear aligner's edge meets the gumline changes the types of bacteria living in the gum pocket. 36 people in the finishing phase of orthodontic treatment wore aligners with two different edge designs at the same time—one covering a bit of gum, th…

This study looks at why gum disease (gingivitis) develops at different rates in different people. Healthy adults aged 18 to 35 will stop brushing and flossing for 3 weeks to allow mild gum inflammation to develop, then resume normal hygiene to recover. Researchers will take clini…

This study examined 318 adults to see if coffee drinking habits are linked to gum health. Participants were grouped by gum condition (healthy, gingivitis, or periodontitis) and asked about their coffee intake. Researchers measured plaque, bleeding, and gum pocket depth to find an…

This observational study investigates whether levels of certain enzymes (ACE and ACE2) in saliva and blood are linked to the severity of gum disease in adults with cardiovascular disease. Researchers will compare these enzyme levels across different stages of gum disease—from gin…

This study compares two popular ways to straighten teeth in adults with mild-to-moderate crowding: clear aligners and traditional fixed braces. The main question is whether the two methods differ in how they affect the bone that surrounds the teeth. Using 3D X-ray scans and digit…

This study looks at two different ways clear aligners are trimmed—one that sits on the gums and one that stops at the gum line—to see which leads to less plaque and healthier gums. Twenty adults with mild to moderate crowding will wear both designs at the same time (one on top, o…

This observational study investigates how different levels of gum health influence asprosin (a hormone) and total oxidant/antioxidant levels in people with type 2 diabetes. Researchers will collect fluid from around the gums and blood samples from 67 participants to compare these…

This study explored the connection between gum disease severity and levels of certain antibodies (ACPAs) in people with rheumatoid arthritis. Researchers measured these antibodies in fluid from the gums before and after non-surgical gum treatment. The goal was to better understan…

This study looked at whether certain amino acids in saliva differ between people with healthy gums, gingivitis, and periodontitis. Researchers also tracked how these amino acids changed after standard non-surgical gum treatment in 32 periodontitis patients. The goal is to see if …

This study looked at 76 children aged 3 to 15 getting dental care with nitrous oxide (laughing gas). Researchers watched for signs that kids wanted to keep the mask on longer, like hand gestures or asking to keep it. The goal was to see if there's a risk of children misusing the …

This study looked back at records of 200 adults who had heart valve surgery to see if treating gum disease beforehand lowered their risk of infection or death after the operation. Researchers checked dental X-rays and medical charts from 2015 to 2024. The goal is to understand if…

This completed study looked at 160 healthy adults to see if a blood test marker called Pan-Immune-Inflammation Value (PIV) is linked to the severity of gum disease. Researchers measured gum inflammation and compared it to PIV from routine blood work. The goal was to explore if th…

This study looked at how diet affects gum inflammation in healthy people. Researchers compared vegans and omnivores by temporarily stopping their oral hygiene to see how their gums reacted. The goal was to understand if a vegan diet might reduce gum inflammation compared to an om…

This study looks at proteins that help parts of cells communicate—specifically mitochondria and the endoplasmic reticulum—in people with healthy gums, gingivitis, or advanced gum disease. Researchers measure these proteins in saliva and gum fluid to see if they relate to inflamma…

This study looked at immune cells in a non-cancerous gum growth called peripheral giant cell granuloma (PGCG) and compared them to healthy gum tissue from the same 28 patients. Researchers used special staining to count different types of immune cells. The goal was to better unde…

This pilot study tested two different bone grafting methods for people needing dental implants after tooth loss. Forty implants were placed in 21 patients, using either a collagen-based graft alone or a mix of synthetic bone and the patient's own bone. Both methods used a special…

This study looked at levels of a hormone called prolactin in the gum fluid of 26 people with obesity and gum disease (stage II or III). Researchers measured prolactin before and after non-surgical gum treatment to see if it changed. The goal was to better understand the link betw…

This completed study looked at 227 people with HIV who are on antiretroviral therapy. Researchers examined their oral health—including cavities, gum disease, and dry mouth—and checked for links to metabolic problems and ongoing inflammation. The goal was to understand if poor ora…

This small pilot study tested a new way to place dental implants in the upper jaw when there is not enough bone height. Surgeons used a special drill and a tiny camera to watch the sinus membrane during the procedure. The goal was to see how often the membrane gets torn, which ca…

This study tested whether custom-made orthodontic molar bands, created using digital scans and 3D printing, lead to better gum health than standard pre-made metal bands. 180 teenagers getting braces were randomly assigned to one type of band. Researchers checked plaque buildup, g…

This study measured how often adults with gum disease have atypical swallowing (abnormal tongue movements). Researchers checked 125 adults for tongue posture and other mouth signs. The goal was to see if this swallowing pattern is linked to worse gum problems.

This study tested two types of special membranes used to help grow new jawbone in areas where bone has been lost. Fourteen people who needed bone rebuilding before getting dental implants took part. Researchers measured how much bone grew over 12 months using 3D X-rays and checke…

This study measured levels of a protein called IL-36α in saliva and gum fluid from 80 people with gum disease, gingivitis, or healthy gums. The goal was to see if this protein is linked to gum inflammation and damage. No treatment was given; it was purely an observational study t…

This completed study looked at how radiation therapy for head and neck cancers affects viruses in the mouth, specifically the Epstein-Barr virus (EBV), and how this might relate to gum disease. Researchers collected samples from 25 patients to measure virus levels. The goal was t…

This completed study from Cairo University looked at whether people with multiple sclerosis (MS) are more likely to have gum disease. Researchers examined 293 Egyptian adults with MS using standard dental check-ups. The goal was to see if there is a link between MS and periodonta…

This study measured two proteins, Dkk-1 and sFRP5, in the gum fluid of 99 people with healthy gums, gingivitis, or periodontitis. Researchers collected samples before and after non-surgical periodontal treatment (deep cleaning) to see if these proteins change with treatment. The …

This study compared gum health and levels of inflammatory substances in the mouth and blood of 25 people with non-infectious uveitis (an eye inflammation) and 27 healthy individuals. Researchers measured gum pocket depth, bleeding, and cytokines like TNF-α and IL-10. The goal was…

This study looked at whether bone grafts used before dental implants cause the body to make antibodies that might affect healing. Twenty healthy adults needing bone augmentation received either animal or human donor bone, and half also got laser therapy. Blood and bone samples we…

This study explored whether how addicted a person is to nicotine affects their awareness of having gum disease. Researchers examined 350 smokers with gingivitis or periodontitis, measuring their nicotine dependence with a standard test and asking about their gum health. The goal …

This completed observational study looked at 61 people with peripheral artery disease to see if their gum health was linked to levels of a substance called TMAO in their blood and saliva. Researchers compared TMAO levels among those with healthy gums, gum disease, or no teeth. Th…

This observational study looked at 400 dental and medical students to see how their oral health affects their quality of life. Researchers measured plaque, gum health, and cavities, and asked students about their oral health-related well-being. The goal was to understand if diffe…

This completed study looked at 73 children aged 6-12 to see if sleep problems and certain chemicals in saliva are linked to cavities and gum health. Researchers measured things like saliva flow, pH, and stress hormones, and compared them to the severity of tooth decay. The goal w…

This study looked at whether adding einkorn, an ancient cereal, to the diet could change the types of bacteria in the mouth. Researchers focused on bacteria linked to gum disease and cancer risk. Thirty-one healthy adults ate einkorn and had their oral bacteria measured over time…

This completed study examined the mouth bacteria of 30 people, some with gastritis (stomach inflammation) and some without, to see if gum disease and stomach issues are connected. Researchers collected saliva samples and used advanced DNA technology to compare the types and amoun…

This study tested whether a custom 3D-printed surgical guide helps dentists place bone grafts more accurately in the upper jaw compared to doing it free-hand. Thirty people with thin jawbones received bone taken from their chin. The main goal was to measure how much bone width an…

This study tested whether placing a gel made from a patient's own blood into the socket after wisdom tooth removal, along with low-level laser therapy, can improve healing. 122 adults had their impacted wisdom teeth removed and were assigned to different combinations of these tre…

This completed study looked at 108 Turkish adults to see if understanding dental health information is linked to gum health. Participants took a reading test about dentistry and had a dental exam. The goal was to find out if people with lower health literacy have worse gum diseas…

This study looked at 100 people with gum disease, some also with obesity, to see how non-surgical gum cleaning affects the body's immune system. Researchers measured changes in inflammation and immune cells before and after treatment, comparing men and women. The goal was to find…

This study measured levels of three metals—chromium, nickel, and magnesium—in the blood of 74 adults. Some had type 2 diabetes and gum disease, some had only one condition, and some were healthy. The goal was to see if these metals are connected to gum health in people with diabe…

This study looked at 56 extracted teeth to see which polishing method — bristle brush, rubber cup, or air polishing — makes the tooth surface smoothest after scaling. Smoother teeth may help prevent plaque buildup and improve oral health. Researchers used a powerful microscope to…

This study examined how smoking influences immune cells (macrophages) in gum disease. Researchers compared gum tissue from 80 smokers and non-smokers with and without periodontitis. They measured specific markers to see how smoking shifts the balance of immune responses, which ma…

This completed study looked at how smoking affects gum health in 484 adults. Researchers compared current smokers to non-smokers by measuring plaque, gum bleeding, pocket depth, and gum recession. The goal was to better understand the link between smoking and periodontal disease.

This study examined 80 postmenopausal women to see if there is a connection between gum (periodontal) disease and osteoporosis. Researchers measured two substances in blood and gum fluid called sclerostin and TNF-α, which may help explain how these conditions affect each other. T…

This study looked at whether gum disease (periodontitis) and Parkinson's disease are connected through inflammation. Researchers collected saliva and blood samples from 60 people—some with both conditions, some with only gum disease, and some healthy. They found that certain subs…

This study examined how gum disease (periodontitis) and type 2 diabetes affect each other. Researchers measured immune markers, bacteria, and other health signs in 226 adults aged 30-70. The goal was to better understand the connection between these two conditions, not to test a …

This completed study looked at two ways to clean below the gumline in 80 adults with early-stage gum disease. One group received Guided Biofilm Therapy, a newer technique, while the other got conventional cleaning with hand tools and an ultrasonic device. Researchers measured gum…

This completed study analyzed blood test results from 100 people over age 50 to see if there is a connection between gum inflammation and Alzheimer's disease. Researchers measured gum health and looked at various blood cell counts. The goal was to find blood markers that might li…

This study looked at a new way to fix horizontal jawbone loss by placing a dental implant at the same time as a bone graft. Sixteen patients were treated and followed to see how well the implants and grafts healed. The results showed high implant survival and good bone integratio…

This study looked at certain proteins in the saliva and gum fluid of people with and without gum disease. The goal was to see if these proteins could help explain how gum disease develops. 44 healthy adults took part, and no treatments were given.

This completed study examined 160 children aged 3-14 to see if a Mediterranean-style diet and physical activity habits are linked to better oral health, including less tooth decay and healthier gums. Researchers checked children's teeth and gums and compared them to their eating …

This completed study tested two devices—a special drill (Densah Bur) and a magnetic hammer (Magnetic Mallet)—to see which better prepares a narrow jawbone for dental implants. Only 5 people took part, all with partial tooth loss and enough bone height but not enough width. The ma…

This completed study examined whether people with psoriasis have worse gum health and how it affects their daily lives. Researchers compared 226 adults with and without psoriasis through oral exams and questionnaires. The goal was to understand if the chronic skin condition also …