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Can a 'gentle' gum surgery plus enamel proteins rebuild bone? small study hints at yes.

NCT ID NCT07310732

Disease control Sponsor: Rungta College of Dental Sciences and Research Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding enamel matrix proteins (Emdogain) and a bovine bone graft to a minimally invasive gum surgery (M-MIST) helps heal deep gum defects better than surgery alone. Forty-five adults with at least one deep gum pocket were treated and followed. The main goal was to see if the combination improved pocket depth and gum attachment levels.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
enamel matrix derivative (Emdogain) and bovine bone mineral xenograft
What this could lead to
If successful, this combination could offer a better way to repair bone and gum damage from periodontal disease, potentially reducing the need for more invasive surgery.
What could go wrong
This is a small, completed study (45 people) without a later-phase follow-up. Results may not apply to everyone, and the added benefit of the extra materials over surgery alone may be modest.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

45 people

The number who actually took part.

Started

Mar 2022

Finished

Mar 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * at least one site associated with an intrabony defect of ≥3 mm involving predominantly the interdental space of the tooth * patients with optimal compliance Exclusion Criteria: * Patients with uncontrolled or poorly controlled diabetes * history of long-term use of medications * allergic to medications * pregnant or lactating women * smokers/users of other tobacco products

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Conditions

The condition(s) this trial relates to.

Alveolar Bone Loss periodontal disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontal bone loss Periodontal diseases

Contacts and locations

Locations

  • Department of Periodontics, Rungta College of Dental Sciences and Research

    Bhilai, Chhattisgarh, 490023, India

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