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Bee glue lozenges could fight gum disease

NCT ID NCT06888453

Disease control Sponsor: Al-Mustansiriyah University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether lozenges made from propolis (a substance bees produce) can improve gum health in 100 young adults with mild to moderate gingivitis. Participants chewed the lozenges twice daily for a week while keeping their normal brushing routine. Researchers measured gum inflammation, plaque buildup, and immune markers in saliva to see if the lozenges helped control gum disease.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
propolis lozenges
What this could lead to
If it works, this could point toward a simple, natural way to reduce gum inflammation and plaque without changing brushing habits.
What could go wrong
This is a small, early-phase trial with only 100 participants over 7 days. Results may not apply to everyone, and long-term effects are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

100 people

The number who actually took part.

Started

Mar 2025

Finished

Apr 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 to 24 years

Sex

Male participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age of patients (19\_24) who volunteered to participate. 2. Apparently, good general health. With no systemic diseases. 3. plaque and gingival indices were ranged from (1.1\_2.0) Exclusion Criteria: * 1\. Individuals with chronic illnesses, immunocompromised individuals, pregnant women, those on contraceptive medications, and breastfeeding mothers. 2\. People who use mouthwash at the moment or any preventive modalities. 3. Those taking anti-inflammatory drugs and antibiotics both during the study and in the final four weeks prior. 4\. Individuals have a history of hypersensitivity to any substance utilized in the current investigation. 5\. Individuals who have undergone a recent tooth extraction. 6. Individuals with Periodontal pocket depth Equal or less than 4 or attachment loss. 7\. Individuals who smoke. 8. Individuals with orthodontic equipment, removable dentures, implants.

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Conditions

The condition(s) this trial relates to.

gingivitis mouth disorder periodontal disorder Plaque, Amyloid

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mouth diseases Periodontal diseases Plaque-induced gingivitis

Contacts and locations

Locations

  • Almustansiriyah University

    Baghdad, Iraq

More trials for these conditions

Other studies related to the condition(s) this trial covers.