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New study tests simpler bone grafts for stronger dental implants

NCT ID NCT07572643

Knowledge-focused Sponsor: Nicola Alberto Valente, DDS, MS, PhD Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study tested two different bone grafting methods for people needing dental implants after tooth loss. Forty implants were placed in 21 patients, using either a collagen-based graft alone or a mix of synthetic bone and the patient's own bone. Both methods used a special collagen membrane to guide new bone growth. The goal was to see if the simpler graft works just as well, which could make the procedure easier for patients.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Collagenated porcine cortical bone lamina and collagenated xenograft bone materials
What this could lead to
If successful, this study could show that simpler, collagen-based grafts work as well as those using the patient's own bone, reducing pain and recovery time for dental implant patients.
What could go wrong
This is a small pilot study with only 40 implants, so results may not apply to everyone. It measures bone changes on scans, not long-term implant success, and different graft materials may perform differently in real-world use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Jul 2022

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healed type II post-extraction sockets according to the Elian classification * Age between 18 and 80 years * Good periodontal control, defined as treated periodontitis with plaque index \<25% and bleeding on probing \<25% * ASA I or ASA II systemic status * Ability and willingness to provide written informed consent * Ability and willingness to attend scheduled follow-up visits Exclusion Criteria: * Smoking more than 10 cigarettes per day * Active oral infections * Mucosal diseases, including erosive lichen planus * History of radiotherapy in the head and neck region * Systemic diseases affecting bone metabolism or contraindicating oral surgery * Non-compliance or inability to complete follow-up * Extraction sockets with intact bone walls

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Conditions

The condition(s) this trial relates to.

Alveolar Bone Loss periodontal disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alveolar bone loss

Contacts and locations

Locations

  • Università di Cagliari

    Cagliari, Cagliari, 09125, Italy

More trials for these conditions

Other studies related to the condition(s) this trial covers.