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Can hyaluronic acid and bone graft make dental implants stronger?

NCT ID NCT07665281

Disease control Sponsor: Al-Mustansiriyah University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 08, 2026 · Updated 5 times

Summary

This study tests whether adding hyaluronic acid gel and bone graft during dental implant surgery improves the quality of the surrounding gum and bone. Thirty-six adults needing implants are split into three groups: one gets hyaluronic acid, one gets both hyaluronic acid and bone graft, and one gets standard implants. Researchers will measure changes in gum thickness, bone width, and pain over 16 weeks to see if these additions help.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
hyaluronic acid gel (Gengigel) and particulate bone graft
What this could lead to
If it works, this could point toward a simple way to improve gum and bone healing around dental implants, potentially reducing implant failure.
What could go wrong
This is a small, early-stage trial with only 36 participants, so results may not apply to everyone. The benefits of hyaluronic acid and bone graft for implant outcomes are still uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

36 people

The number who actually took part.

Started

Dec 2025

Finished

Jul 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults ≥ 18 years old. * Partially edentulous patients requiring dental implant placement. * Good oral hygiene (Calibrated Gingival Bleeding Index (GBI) \< 10%, O'Leary ---Plaque Index (PI) \< 10%). * Sufficient bone volume for implant placement. Exclusion Criteria: * Systemic conditions affecting bone healing (e.g., uncontrolled diabetes). * Smoking \> 10 cigarettes/day. * Medications affecting bone metabolism (e.g., bisphosphonates). * Active periodontal disease. * Pregnant or lactating women.

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Conditions

The condition(s) this trial relates to.

Alveolar Bone Loss Jaw, Edentulous, Partially periodontal disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alveolar bone loss Dental implant Partially edentulous jaw

Contacts and locations

Locations

  • College of Dentistry, University of Babylon

    Hillah, Babylon, Iraq

  • Private specialized dental center

    Hillah, Babylon, Iraq

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