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Good bacteria floss could fight gum disease

NCT ID NCT07149493

Disease control Sponsor: St. Anne's University Hospital Brno, Czech Republic Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tested a special dental floss coated with a probiotic (good bacteria) to see if it could reduce harmful mouth germs and improve gum health. Thirty-three healthy men used the probiotic floss and a placebo floss for two weeks each, with a break in between. Researchers measured plaque, gum bleeding, and levels of harmful bacteria.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Ligilactobacillus salivarius (probiotic) infused into nanofiber dental floss
What this could lead to
If it works, this could point toward a simple way to improve gum health and reduce harmful bacteria using everyday dental floss.
What could go wrong
This is a small, early-stage trial with only 33 healthy men, so results may not apply to everyone. The effect on actual gum disease is still unclear.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

33 people

The number who actually took part.

Started

Feb 2022

Finished

Jun 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Male participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male adults (≥18 years) of Czech or Slovak nationality * ≥20 own teeth * Good oral hygiene * Maximum Stage 2 periodontitis Exclusion Criteria: * Immunocompromised status * Systemic illness * Antibiotic use within 2 months * Smoking * Probiotic use during study

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Conditions

The condition(s) this trial relates to.

dental caries gingivitis periodontal disorder periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dental hygiene Gingivitis and periodontal diseases Oral microbiome Periodontal health Prevention of dental caries Probiotics, periodontitis

Contacts and locations

Locations

  • St. Anne's University Hospital

    Brno, 65691, Czechia

More trials for these conditions

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