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Gum fluid proteins may reveal hidden clues about periodontitis

NCT ID NCT06727929

Knowledge-focused Sponsor: Cumhuriyet University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study measured two proteins, Dkk-1 and sFRP5, in the gum fluid of 99 people with healthy gums, gingivitis, or periodontitis. Researchers collected samples before and after non-surgical periodontal treatment (deep cleaning) to see if these proteins change with treatment. The goal was to explore whether these proteins could serve as markers for gum disease activity.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
non-surgical periodontal treatment (scaling and root planing)
What this could lead to
If successful, this could point toward a new way to diagnose or monitor gum disease using protein levels in gum fluid.
What could go wrong
This is a small, completed study that only measured protein levels; it does not test a new treatment. The results may not apply to broader populations or lead to a diagnostic test.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

99 people

The number who actually took part.

Started

Mar 2024

Finished

Jan 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

A total of 99 patients (44 males and 55 females) between 20-50 years of age were included and were divided into three groups as follows: periodontally healthy, patients with gingivitis, and patients with stage 3 grade B periodontitis. Participants were selected from the patients who presented for periodontal treatment between March 2024 and August 2024 at Department of Periodontology, Faculty of Dentistry, Sivas Cumhuriyet University, Sivas, Turkey.

Ages

20 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Being between 20-50 years old * Meeting the criteria for the working groups Exclusion Criteria: * having any systemic or metabolic diseases or insturition of effected bone metabolism, * having bruksizm habits, * pregnant or lactating, * received periodontal/peri-implant treatment within the last 6 months, * the history of antibiotics or antiinflamatuars use regularly within the last 6 months, * having \< 20 teeth (except for 3rd molars), * smokers or consumed alcohol.

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Conditions

The condition(s) this trial relates to.

Alveolar Bone Loss gingivitis periodontal disorder periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alveolar bone loss Periodontal diseases Periodontal inflammation

Contacts and locations

Locations

  • Sivas Cumhuriyet University

    Sivas, Turkey (Türkiye)

More trials for these conditions

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