Diabetes mellitus

This study tests whether a 6-week self-management program, done with a caregiver's help, can improve diabetes control and thinking skills in adults aged 55+ who have both diabetes and mild cognitive impairment. About 309 participants will attend weekly group sessions and provide …

This trial tests whether a single daily pill that combines treatments for high blood pressure, high cholesterol, and type 2 diabetes can lower the risk of heart disease and dementia. The study involves over 8,000 adults aged 50 to 75 in China who have all three conditions. Partic…

This study tests whether tirzepatide, a drug used for type 2 diabetes, can help people with type 1 diabetes. Researchers will measure how the body responds to insulin and meals before and after 6 weeks of treatment. 44 adults with type 1 diabetes who use an automated insulin pump…

This study tests a procedure called pulsENDO that uses mild electric pulses to regenerate the lining of the first part of the small intestine (duodenum) in people recently diagnosed with type 2 diabetes. The goal is to see if this can help control blood sugar levels without needi…

This study tests a new medicine called UBT251, given as a weekly shot, in 300 adults with type 2 diabetes. Some participants will get UBT251, others will get a placebo or an existing drug (semaglutide). The goal is to see if UBT251 can safely lower blood sugar and help with weigh…

This study tests a new drug, CNP-103, in people aged 12 to 35 who were diagnosed with stage 3 type 1 diabetes within the last 6 months. The goal is to see if the drug is safe and can help control the disease. Participants will receive either the drug or a placebo, and researchers…

This study tests a new once-weekly injection called NNC0662-0419 in 270 adults with type 2 diabetes. It compares the drug against a placebo and an approved medication, semaglutide, to see how well it controls blood sugar and promotes weight loss. The trial is currently recruiting…

This study tests a next-generation automated insulin delivery system (Omnipod M) in up to 40 adults with type 1 diabetes. The goal is to see if the system safely improves blood sugar control by reducing dangerously low and high levels. Participants will use the device during hote…

This study looks at whether people who take GLP-1 receptor agonists (like Ozempic or Wegovy) should continue them after having bariatric surgery. Researchers will compare weight loss, blood sugar control, gut health, and hunger in 150 adults who either keep taking the drug or sto…

This study tests whether montelukast, a medicine used for asthma, can help protect the kidneys and blood vessels in 50 teens and young adults (ages 14-24) with type 2 diabetes. The drug works by blocking harmful inflammatory chemicals linked to diabetes complications. Researchers…

This study compares two telehealth approaches—digital health coaching and remote patient monitoring—to see which works better for managing type 2 diabetes in people with physical disabilities and at least one other chronic condition. About 5,000 participants will be randomly assi…

Researchers are testing whether low-dose interleukin-2 (IL-2) can help people recently diagnosed with type 1 diabetes preserve their own insulin production. The trial enrolls 24 people aged 16 to 45 who still make some insulin. Participants first receive a two-month course of cyc…

This study follows about 1,875 people aged 6 and older with type 1 diabetes who use the iLet Bionic Pancreas, an automated insulin delivery system. Over 12 months, researchers will track serious events like severe low blood sugar and diabetic ketoacidosis to see how the device pe…

This study tests a once-daily pill called orforglipron in adults with type 2 diabetes who plan to fast during Ramadan. The goal is to see if the drug helps control blood sugar and weight without causing harm. About 130 participants will take the pill for up to 48 weeks, with clin…

This study tests whether a four-week education program can help adults with type 1 diabetes dose mealtime insulin using continuous glucose monitor (CGM) data instead of traditional carbohydrate counting. Participants are randomly assigned to either the C-Carbs program or usual ca…

This study looks at whether SGLT2 inhibitors, a class of diabetes and kidney drugs, can improve blood flow through the heart's small arteries in women with HIV who also have diabetes or chronic kidney disease. Eighty women aged 45-75 will be randomly assigned to health education …

This study tests a once-monthly injection called berobenatide to help adults with overweight or obesity lose weight. About 954 participants will receive either the drug or a placebo for 20 months. The goal is to see if the drug is safe and effective for weight loss, including in …

This study tests whether a structured, goal-directed care plan can help people with diabetic kidney disease better manage their kidney and heart health. About 100 adults with type 2 diabetes and kidney disease will either receive this focused care or standard treatment. The goal …

This phase 2 trial tests whether photobiomodulation, a type of light therapy, can improve healing of foot ulcers in people with diabetes. Researchers will compare standard wound care alone against standard care plus light therapy applied to the ulcer and to blood vessels. The stu…

This study tests a once-weekly injection called NNC0487-0111 in 630 adults who are overweight or obese and have type 2 diabetes. Participants receive either the active drug or a placebo for about a year. The main goal is to see how much weight they lose, with additional checks on…

This Phase 3 trial tests a new drug called KAI-9531, given as a weekly injection, in 1700 adults who are overweight or obese and have type 2 diabetes. The study compares KAI-9531 to a placebo to see if it leads to greater weight loss and better blood sugar control over 76 weeks. …

This trial is testing whether an investigational wound gel called VES-0-D can help heal mild-to-moderate diabetic foot ulcers better than standard wound care. Adults with type 1 or type 2 diabetes and a foot ulcer will receive either the gel or a standard dressing, applied every …

This trial tests whether trained community health workers can help adults with high blood pressure, diabetes, or high cholesterol address social needs like transportation, healthy food, housing, and job opportunities. Participants from clinics will be connected to a health worker…

This trial tests whether applying perinatal tissue allografts to chronic diabetic foot ulcers, along with standard wound care, leads to more ulcers healing completely within 12 weeks compared to standard care alone. Adults with type 1 or 2 diabetes who have a nonhealing foot ulce…

This study tests whether group care—where patients meet together with health workers for education and check-ups—can improve control of high blood pressure and diabetes in Nepal. Over 1,100 adults from 37 health facilities will be assigned to standard care, low-intensity group ca…

This study follows 630 people with type 1 diabetes in Japan who are already prescribed Awiqli, a once-weekly injection. Researchers will track side effects and blood sugar control over one year to see how the drug works in everyday life. The goal is to manage diabetes, not cure i…

This early-phase study tests a new treatment called OPF-310, which uses pig islet cells enclosed in a protective capsule, for people with unstable type 1 diabetes who still experience severe low blood sugar episodes despite using an automated insulin pump and continuous glucose m…

This study tests whether an internet-based depression treatment called cognitive behavioral therapy (iCBT-D) can prevent insulin resistance from getting worse in adults with HIV who are on antiretroviral therapy and have depression. Researchers will compare the online therapy pro…

This study tests a 6-month digital care program for adults aged 50+ with type 2 diabetes and at least one other chronic condition like high blood pressure or kidney disease. The program combines online education, phone support, a mobile health app, home visits, and personalized c…

This trial tests whether remote monitoring can help people with diabetes better control their blood sugar. Participants will either use a connected glucose meter that sends readings to a platform for remote management, or receive standard care. The study will compare changes in b…

This study tests a new, long-acting form of semaglutide (a diabetes drug) that is given once every four weeks instead of weekly. The goal is to see if it is safe and works well for controlling blood sugar and weight in 24 adults with type 2 diabetes. Participants must already be …

This trial tests whether starting a comprehensive, guideline-based treatment plan immediately after a heart attack can reduce the chance of another heart attack, stroke, or death. The plan targets key risk factors like high cholesterol, high blood pressure, and diabetes using a c…

This study tests whether using a diabetes management app alongside personalized nutrition counseling from a dietitian can help adults with insulin-requiring diabetes improve their blood sugar control, cholesterol, physical activity, and overall quality of life. Participants will …

This study tests a new approach for teens (ages 10-17) recently diagnosed with type 1 diabetes. They will use an inhaled insulin called Afrezza along with a long-acting injected insulin. The goal is to see if this combination helps keep blood sugar in a healthy range and is safe …

This study tests whether a 12-week program of supervised foot and ankle exercises can help people with diabetes who have nerve damage in their feet. The exercises are done in groups at primary care clinics. Researchers will measure changes in symptoms, foot movement, and quality …

This study tests a new digital tool called P3-EX that helps doctors create personalized exercise plans for patients with heart disease risk factors like high blood pressure, diabetes, and obesity. Researchers will recruit 24 doctors and 48 patients to compare the new tool with a …

This study tests a drug called CSL300 in people with end-stage kidney disease who are on dialysis and have signs of inflammation. The goal is to see if it can reduce the risk of heart attacks or heart-related death. About 3110 adults will take part, and half will get the drug whi…

This study looks at whether wearing a continuous glucose monitor (CGM) for two weeks after leaving the hospital helps people with diabetes who are starting insulin for the first time. About 150 adults with type 1 or type 2 diabetes will be randomly assigned to use either a CGM or…

This trial tests a new model of care called PEN-Plus, which brings specialized treatment for severe chronic diseases like diabetes, heart conditions, and sickle cell disease to first-level hospitals in Zambia. The goal is to train local health workers and set up clinics to manage…

This study tests whether personalized marketing messages and discounts can encourage people with prediabetes or type 2 diabetes to switch from refined grains to whole grains when shopping for groceries online. About 216 adults aged 45-70 from the Philadelphia area who already sho…

This study tests whether helping people with diabetes find local resources (like food or housing help) and pairing them with a peer supporter can improve blood sugar and blood pressure. About 694 adults with diabetes who have trouble controlling their condition will be randomly a…

This study tests a treatment called physiologic insulin resensitization (PIR) in 120 adults with advanced chronic kidney disease and type 2 diabetes. The goal is to see if PIR can improve kidney function better than standard care. Participants will be randomly assigned to receive…

This study looks at how well the Omnipod 5 Automated Insulin Delivery System works in real-world settings for people with type 1 diabetes. About 152 participants aged 2 and older will use the system for the first time. The goal is to see if it helps keep blood sugar levels in a h…

This study tests two diabetes medications, pioglitazone and empagliflozin, to see which one better controls blood sugar in people whose diabetes is caused by chronic or recurrent acute pancreatitis. About 40 adults aged 18-80 with this type of diabetes will take one of the drugs,…

This study tests whether a hybrid closed-loop insulin pump (MiniMed 780) can help people with diabetes after pancreas removal achieve better blood sugar control. About 24 adults will use the pump for 3 months and then their usual treatment for 3 months, with results compared. The…

This study will test a new experimental automated insulin delivery system (called NMX8) in 116 people with type 1 or type 2 diabetes who need insulin. The goal is to see if the new system is safe and works as well as the current Medtronic 780G system at keeping blood sugar in a h…

Black individuals often have lower levels of natriuretic peptides, heart hormones that help regulate metabolism. This trial tests whether raising those hormone levels with a drug called sacubitril/valsartan can improve insulin sensitivity and energy expenditure. About 200 Black a…

This study will test whether a 4-month digital coaching program (Noom) helps adults who recently started GLP-1 medications improve their diet and physical activity. About 220 participants will use the app to track food and exercise, get coaching, and learn about managing challeng…

This study tests a program that uses artificial intelligence to guide exercise and continuous glucose monitors to help people with both knee osteoarthritis and obesity. The goal is to see if it can improve blood sugar control, reduce knee pain, and lower the need for knee replace…

This study looks at whether adding support from a pharmacist or a community health worker helps adults with type 2 diabetes better manage their blood sugar. About 376 people will be placed into one of four groups: usual care, pharmacist help, community health worker help, or both…

This study tests whether empagliflozin (Jardiance), a drug used for type 2 diabetes, can improve blood sugar control in people who have had an islet transplant and still have partial islet function. About 40 adults will receive either a placebo, 10 mg, or 25 mg of empagliflozin d…

This trial tests whether adding an antibiotic-impregnated bone graft substitute (Cerament G) to standard surgery improves healing of heel bone infections (calcaneal osteomyelitis) in people with diabetes. Thirty participants will be randomly assigned to receive either partial rem…

This study tests a web-based program called Web-SUCCEED that helps veterans with chronic illness and their informal caregivers work together to manage the condition. The program includes three weekly online modules and brief phone calls with staff, focusing on stress coping and c…

This study tests a smartphone program called Smart Walk, designed specifically for African American women who are not very active. The program includes an app, virtual coaching, and text messages to encourage more physical activity. Researchers want to see if it helps women exerc…

This study will look at whether a remote patient monitoring system, called Steno Detektor, helps people with diabetes control their blood sugar. About 12,000 patients will be monitored as part of their regular care. Researchers will compare blood sugar levels and hospital visits …

This small pilot study is testing whether eating Greek bottarga (grey mullet fish roe) every day can improve blood sugar, cholesterol, and inflammation in adults with prediabetes, diabetes, or obesity. About 20 participants will compare the effects of bottarga against a dairy pro…

This study offers a free 3-month diabetes education program at a local faith-based organization for adults with diabetes or prediabetes in Jefferson County, Alabama. Participants attend group sessions on diet, exercise, and coping, and are paired with a community health worker fo…

This study looks at whether using a patient's own continuous glucose monitor (CGM) during a hospital stay can help doctors manage diabetes more safely. About 150 adults with diabetes who already use a CGM at home will be enrolled. The goal is to reduce dangerous high and low bloo…

This study tests whether a 6-month program of problem-solving training, community health worker support, and exercise coaching at a YMCA can improve fitness and heart health in 210 adults with type 2 diabetes, obesity, and low income. Participants are compared to those who receiv…

This study tests a program to help new mothers with chronic conditions like high blood pressure, diabetes, or depression transition smoothly from obstetric to primary care after giving birth. The program includes automatically scheduling a primary care visit, sending personalized…

This study compares a new injectable medicine called iGlarLixi with standard diabetes treatments in adults with type 2 diabetes whose blood sugar is not well controlled by pills alone. About 1,300 people in China will take part. The goal is to see if iGlarLixi helps lower blood s…

This phase 2 trial is testing whether mirabegron, a drug currently used for overactive bladder, can improve glucose tolerance and activate brown fat in people with prediabetes. Researchers will enroll 65 adults with a BMI of 27-45 and prediabetes. Participants will take mirabegro…

This early-stage trial tests a drug called CSL300 (clazakizumab) in 24 Chinese adults with end-stage kidney disease who are on dialysis. The drug is an antibody that blocks interleukin-6, a protein involved in inflammation. The main goal is to see how the drug moves through the b…

This 12-month pilot study tests whether a nurse-led smartphone app can help Medicaid patients with insulin-treated type 2 diabetes improve their blood sugar control. The program combines educational messages, phone-based problem-solving with a nurse, and remote monitoring via a d…

This study tests a program for adults with type 2 diabetes who are leaving the hospital. Participants will work with a patient navigator to address unmet social needs like food, housing, or transportation. The goal is to see if this support reduces emergency visits and readmissio…

This study tests a faster version of a procedure called renal denervation, which uses energy to calm overactive nerves in the kidneys to lower blood pressure. About 130 adults with uncontrolled high blood pressure will receive the quicker procedure. The goal is to see if it works…

This study compares continuous glucose monitoring (CGM) to standard fingerstick testing for pregnant women with type 2 diabetes. Researchers want to see if CGM leads to better blood sugar control and fewer complications for both mother and baby. Participants wear a CGM device or …

This study tests whether semaglutide, a diabetes drug, is safe and tolerable for people with type 2 diabetes who are on dialysis. About 100 participants will either receive weekly semaglutide injections or standard care for 26 weeks. The goal is to see if patients can stick with …

This study tests whether a minimally invasive procedure called endoscopic sleeve gastroplasty (ESG), which reduces stomach size by 70%, can help reverse fatty liver disease (MASH) in people with obesity. Researchers will compare ESG plus lifestyle changes to lifestyle changes alo…

This study compares two advanced heart procedures—stenting guided by imaging and blood flow tests (PCI) versus bypass surgery (CABG)—in 1,500 people with diabetes and three blocked coronary arteries. The goal is to see which approach better prevents major events like death, heart…

This study compares two treatments for gestational diabetes: oral metformin pills and injectable insulin. Researchers want to see if metformin is as good as insulin at preventing problems for mothers and babies, like high birth weight or low blood sugar. About 1,500 pregnant wome…

This study tests a device that uses radiofrequency energy to disrupt nerve signals in the kidney and liver arteries, aiming to lower blood pressure in people with uncontrolled hypertension. About 175 adults aged 18-80 with high blood pressure despite medication will be enrolled. …

This study compares two digital approaches—live video classes and simple text messages—against traditional in-person classes to help 150 Hispanic/Latino adults with type 2 diabetes better manage their condition. The goal is to see if these digital tools can improve blood sugar co…

This study will test if a 'produce prescription' program, called Eat Well, helps veterans with high blood pressure and food insecurity. About 1,500 veterans in North Carolina will either get money for fruits and vegetables for 6 or 12 months, or standard care. Researchers will tr…

This study compares the iLet Bionic Pancreas, an automated insulin delivery system, to standard care for adults with type 1 or type 2 diabetes who use insulin. About 240 participants will use the device for 13 weeks or continue their usual routine. The goal is to see if the devic…

This study tests whether a program called Sisters for Heart Health can help farmworker women ages 18-50 reduce stress, feel less isolated, and improve their heart health. Participants will join weekly peer support groups led by trained community health workers for 10 weeks. The s…

This study is tracking 145 adults with type 2 diabetes in Argentina who are starting semaglutide (either as a pill or injection) as part of their normal care. Researchers will measure changes in blood sugar, weight, waist size, and grip strength over 12 months, along with how sat…

This study tests whether a continuous glucose monitor (CGM) helps control blood sugar better than standard finger-stick checks for people with diabetes who are recovering at home through Mayo Clinic's Advanced Care at Home program. About 100 participants will use the Dexcom G6 PR…

This study tests whether screening for social needs like housing and food access, combined with referrals to community resources, can improve chronic disease outcomes for patients of color. Researchers will track blood pressure, cholesterol, blood sugar, depression, and asthma co…

This study compares two ways to place heart stents in people with diabetes: one using special imaging (IVUS or OCT) and the other using standard X-ray. The goal is to see if the imaging method reduces heart-related deaths, heart attacks, or the need for repeat procedures. About 1…

This study looks at why some people diagnosed with diabetes in the emergency room don't follow up with a regular doctor. Researchers will test whether a telehealth visit soon after diagnosis helps patients get connected to outpatient care. The trial involves 200 adults in New Yor…

This study tests whether a weekly injection of dulaglutide, a GLP-1 drug used for diabetes, can improve early insulin release in adults with cystic fibrosis who have trouble processing sugar. About 30 participants will receive the drug or no drug in a crossover design. The goal i…

This large trial in New Taipei City will test whether a mobile digital health platform with interactive modules helps people better control high blood pressure, high blood sugar, and high cholesterol. It will also compare taking blood pressure medication at night versus in the mo…

This study tests a 16-week behavioral program called T1DAL, designed specifically for teens with type 1 diabetes who have overweight or obesity. About 50 teens will be randomly assigned to either the program or usual care. The program includes virtual group sessions and one-on-on…

This study tests a computer program that alerts doctors and nurses when hospital patients have dangerously high or low blood sugar. The tool suggests care steps to improve glucose control. Researchers will track over 15,000 adults across multiple hospitals to see if the tool redu…

This study is testing whether taking an antibiotic pill for 7 days after surgery to fix a broken leg, ankle, or foot can lower the chance of wound infection in adults with poorly controlled diabetes. About 40 participants will either receive the antibiotic or standard care (no ex…

This study tests whether taking sodium bicarbonate (baking soda) daily can improve muscle energy and physical endurance in people with chronic kidney disease and metabolic acidosis. About 80 adults with moderate-to-severe kidney disease will receive either sodium bicarbonate or a…

This pilot study is testing whether providing free produce boxes and nutrition education can improve health outcomes for Veterans with kidney disease and food insecurity. The study will enroll 20 participants and measure changes in blood pressure and kidney function. Researchers …

This study tests whether continuous glucose monitors (CGMs) can improve blood sugar control in underserved people with type 2 diabetes who are uninsured or on Medicaid. Fifty participants will wear a CGM replaced every 14 days for 6 months. The goal is to see if this technology h…

This early study tests a device that uses radiofrequency energy to create vapor and ablate (remove) a small part of the upper intestine. The idea is that this might improve how the body handles sugar. The study will enroll 20 adults with type 2 diabetes to see if the procedure is…

This study tests a new drug called dorzagliatin in 44 adults with a rare, inherited form of diabetes (GCK-MODY). The drug works by activating a key enzyme to help the body better control blood sugar. Participants will receive both the drug and a placebo at different times to see …

This early-stage study tests how a new medicine, NNC0487-0111, affects insulin sensitivity and pancreas function in adults with type 2 diabetes. About 80 participants will receive either the study drug or a placebo. The goal is to see if the drug can help the body use insulin bet…

This study is testing a new continuous glucose monitoring system called ROME GS in 60 adults with type 1 or type 2 diabetes. The goal is to see if it measures blood sugar accurately and is safe to use. Participants will wear the sensor and have their glucose levels checked agains…

This study is testing a new glucose monitoring system called Eversense Gemini, which includes a flash glucose measurement feature. The goal is to see how accurate and safe it is for adults with type 1 or type 2 diabetes. About 80 participants will wear the device and have their g…

This study is testing whether empagliflozin (Jardiance), a drug used for diabetes and chronic kidney disease, is safe for people who have received a kidney transplant. Researchers will enroll 264 veterans and monitor for side effects like infections and changes in kidney function…

This study looks at how fat cells work differently in normal-weight people with type 2 diabetes compared to those without diabetes. Researchers will test two drugs, pioglitazone and tirzepatide, to see if they improve insulin resistance and fat storage. About 104 adults aged 30-7…

This study tests a single pill containing three diabetes drugs (empagliflozin, linagliptin, and metformin) in 800 adults with type 2 diabetes. The goal is to see if the triple combination improves blood sugar control, weight, quality of life, and treatment satisfaction compared t…

This study tests whether a special exercise program that combines rhythm and multitasking (called RYMA) can reduce falls, fractures, and heart problems in people aged 65 and older with type 1 or type 2 diabetes. Participants will be screened for fall risk, bone health, nerve func…

This study tests whether a single daily dose of long-acting insulin can control blood sugar as well as the usual regimen of long-acting insulin plus mealtime insulin in pregnant women with diabetes. About 176 participants will be randomly assigned to one of the two approaches and…

This study tests whether a supplement called NMN can improve kidney health in people with type 2 diabetes and diabetic kidney disease. About 156 adults will take either NMN or a placebo twice daily for 6 months. The main goal is to see if NMN reduces protein in the urine, a key s…

This study tests whether genetic testing can help veterans at high risk for heart disease start and stick with statin medications. About 410 veterans aged 40-75 with diabetes or heart disease who are not currently taking statins will receive either a genetic report on their stati…

This study is testing whether adding registered dietitian counseling or occupational therapy home safety tips to regular home-delivered meals can reduce fall risk in older adults. Researchers will compare four groups: meals alone, meals plus dietitian, meals plus occupational the…

This study tests whether a low-fat vegan diet and nutrition classes can improve health and lower medical costs for people with type 2 diabetes. Seven hundred Blue Cross Blue Shield subscribers will follow the diet for 16 weeks. Researchers will measure changes in weight, blood su…

This study tests a device called EchoMark/EchoSure that is implanted during fistula surgery for dialysis patients. The device uses automated ultrasound to monitor healing every two weeks. The goal is to see if it helps the fistula mature faster and reduces the need for additional…

This study tests whether dapagliflozin, a diabetes medication, can reduce the amount of time people with diabetes spend in atrial fibrillation (an irregular heart rhythm). About 28 adults with both conditions will wear a heart monitor and complete quality-of-life surveys. The goa…

This study tests whether screening diabetes patients for unmet social needs (like food, housing, or transportation) and connecting them to community resources can improve their health. It will involve 12,000 adults with diabetes in rural Kentucky. The goal is to see if this appro…

This study tests a new type of shoe, called the LEEF-shoe, designed to prevent foot ulcers in people with diabetes and nerve damage. About 30 adults will wear both the LEEF-shoe and standard orthopedic shoes for several weeks to compare how well they relieve pressure on the feet.…

This study tests whether a special adhesive patch (COVER PATCH) can help keep continuous glucose monitors (CGMs) stuck to the skin for their full recommended wear time. About 194 people with type 1 or type 2 diabetes, aged 6 and older, will either use the patch or not for 4 month…

This study tests whether empagliflozin, a diabetes drug, can improve left atrial function in 66 people with paroxysmal atrial fibrillation, high blood pressure, and abnormal glucose metabolism. The goal is to see if it can prevent heart failure. Participants will be randomly assi…

This study tests a digital health program called Corrie Lipids in about 1,000 adults with high LDL cholesterol and heart disease risk. The program includes a smartphone app for tracking cholesterol, medication reminders, and education, plus training for doctors to improve cholest…

This early-phase trial tests transplanting insulin-producing cells into the front chamber of the eye in legally blind people with diabetes. The goal is to see if the cells survive and work safely using only eye drops for immune suppression. Only 2 participants are enrolled, so th…

This study tests whether trained female community health volunteers can help people in Nepal better manage high blood pressure and diabetes. The health workers will lead group meetings, provide health education, and coordinate care with local clinics. About 398 adults with both c…

This study is testing whether a personalized approach to lowering 'bad' cholesterol (LDL-C) works better than standard moderate-dose statins for preventing first heart attacks, strokes, or related events in people aged 70 and older with type 2 diabetes. About 2,186 participants w…

This study is testing whether adding a continuous glucose monitor (CGM) to a text-message diabetes education program helps people with type 2 diabetes better manage their blood sugar. About 140 participants who do not use insulin will receive daily texts about diabetes care and a…

This study compares three approaches to help pregnant women and new mothers maintain a healthy weight. About 795 participants will receive either self-management support via mobile app or mail, community-based help from health workers, or usual care. The goal is to see which meth…

This global study tests whether applying a sunlight-reflecting coating to roofs can lower indoor temperatures and improve health. Researchers will enroll 3,200 households in five hot cities across Africa, Asia, Latin America, and the Pacific. They will measure heart rate, blood s…

This study tests whether a new drug called CIR-0602K can help people with type 1 diabetes keep their blood sugar in a healthy range and reduce their insulin needs. The trial involves 40 adults aged 18-45 who already use an automated insulin pump. Half will get the drug and half a…

This study looks at whether using ultrasound to find fatty lumps (lipohypertrophy) caused by insulin injections can help people with diabetes improve their blood sugar levels. About 50 adults with type 1 or type 2 diabetes who use insulin and a continuous glucose monitor will get…

This early-phase trial is testing a new type of immunotherapy called CAR T-cells for people with a specific kind of stomach and esophageal cancer that has spread to the lining of the abdomen. The treatment involves collecting a patient's own immune cells, modifying them in a lab …

This study tests a program that uses an AI chatbot, health coach, and home monitoring devices to help 300 adults with heart disease, diabetes, or kidney disease manage their conditions. The goal is to see if this approach reduces hospital visits, complications, and deaths over 6 …

This study tests whether adding semaglutide (a drug used for diabetes and weight loss) to a standard topical cream can improve psoriasis symptoms and reduce body-wide inflammation. About 62 adults with plaque psoriasis who are overweight or have type 2 diabetes will receive eithe…

This study tests whether a single infusion of arginine hydrochloride, a natural amino acid, can help people with type 2 diabetes recover faster from diabetic ketoacidosis (DKA), a serious complication. Sixty adults arriving at emergency rooms with DKA will receive either arginine…

This study tests whether using a smart insulin pen (InPen) along with a continuous glucose monitor and telemedicine can improve blood sugar control in veterans with type 2 diabetes who take multiple daily insulin injections. Fifty participants will be randomly assigned to use eit…

This trial tests whether a smart telemonitoring system can help people with type 2 diabetes who use insulin. Participants will use a continuous glucose monitor, insulin pen, and Fitbit at home. One group will also get decision-support algorithms to guide insulin adjustments. The …

This Phase 3 trial is testing a drug called Neovasculgen, given as injections into the leg muscles, to see if it can help heal foot ulcers in people with diabetes. The study will include 144 adults with type 1 or type 2 diabetes who have a non-healing foot ulcer. Participants wil…

This study tests whether formoterol, a drug already used for asthma, can help control diabetic kidney disease. About 120 adults with type 2 diabetes and kidney problems will be randomly assigned to add formoterol to their usual care or continue usual care alone. The main goal is …

This study looks at whether partly replacing animal protein with plant protein can improve blood sugar control in people with type 2 diabetes who are overweight. About 146 adults will follow either a plant-based diet or a standard healthy diet for 24 weeks. The main goal is to se…

This study tests a pharmacy-led program for low-income patients with multiple chronic conditions like diabetes, heart disease, and depression. After leaving the hospital, participants get their medications with no copay, delivery to their bedside and home, and help from a pharmac…

This study compares two triple-drug combinations to see which works better for controlling blood sugar and possibly achieving diabetes remission in people newly diagnosed with type 2 diabetes. About 240 adults aged 18-65 with very high blood sugar (HbA1c ≥9%) will be randomly ass…

This study tests whether a new wound dressing helps diabetic foot ulcers heal faster and safer than standard NHS care. About 100 adults with diabetes and a foot ulcer will be randomly assigned to get either the new dressing or usual care. The main goal is to see if the wound full…

This study looks at whether adding regular exercise (treadmill walking) to vitamin D supplements can improve erectile function in men with type 2 diabetes who also have low vitamin D. Forty men will take vitamin D every two weeks for 12 weeks; half will also walk three times a we…

This pilot study is testing a Norwegian e-health program called DiaMester for adults with type 2 diabetes. The program includes digital education, coaching, and a low-calorie diet to help participants lose weight and potentially achieve diabetes remission. About 99 people will ta…

This phase 1 trial tests N-acetylcysteine (NAC), an antioxidant, in 18 adults with a specific mitochondrial disease caused by the m.3243A>G mutation and low brain glutathione levels. Participants take one of three daily doses (1800, 3600, or 5400 mg) for 3 months to find the safe…

This study tests a diabetes program called Together Overcoming Diabetes (TOD), designed specifically for Lakota and other American Indian/Alaska Native communities. About 140 adults with type 2 diabetes who care for a young person aged 10-25 will take part. The program focuses on…

This study tests whether a mobile app called PortionSize Ed can help recent stroke survivors who also have prediabetes or type 2 diabetes follow a Mediterranean-style diet. Forty adults aged 30 to 65 will be split into two groups: one gets the full app with dietitian support, the…

This study tests whether newer diabetes drugs (SGLT2 inhibitors and DPP-4 inhibitors) can delay or prevent diabetic retinopathy, an eye disease that can lead to vision loss. Researchers will compare these newer drugs to older treatments in 70 people with type 2 diabetes. The goal…

This study tests whether sending text message reminders can help homeless people with uncontrolled type 2 diabetes better manage their condition. One hundred participants will receive SMS prompts for medications and appointments. The goal is to see if this simple approach lowers …

This study tests whether a pharmacist-led care pathway can improve blood sugar control in 600 adults with type 2 diabetes who are not meeting their A1C targets. Participants will receive step-by-step guidance from pharmacists using a web-based tool, compared to usual care from th…

This study looks at whether an automated insulin delivery system (the Medtronic 780G) can help adults with diabetes and advanced kidney disease manage their blood sugar better than their usual insulin injections. Participants will use the system for 8 weeks and then switch to the…

This study tests whether eating quinoa-based foods instead of regular starches can improve blood sugar and fat levels in people with early-stage type 2 diabetes. Sixty adults with diabetes for less than 5 years will eat quinoa noodles, powder, or cookies for 14 weeks. Researchers…

This study tests whether special dressings made from placental membrane can help diabetic foot ulcers heal faster. About 30 adults with diabetes and a chronic foot ulcer will receive the placental dressing. Their healing progress will be compared to similar patients who received …

This study is testing whether whole milk or nonfat milk is better for body composition and health in 200 children aged 9-12 who have a higher BMI. Families receive weekly milk deliveries and monthly check-ins. The goal is to see which milk type helps reduce fat mass and improve m…

This study is testing a mobile app called glUCModel that uses artificial intelligence to predict glucose levels and help people with type 1 diabetes decide how much insulin to take. About 34 adults aged 18 to 65 will use the app for several weeks while wearing a continuous glucos…

This study looks at whether a program that combines digital health coaching for patients and support for clinics can help low-income people with diabetes better manage their condition. Researchers will enroll 600 adults with uncontrolled diabetes or high blood pressure. The goal …

This study tests a program called MINDSET for veterans with chronic conditions like heart disease or diabetes who smoke or drink too much. Participants receive a mailed packet with personalized health information and a brief motivational phone call. The goal is to see if this app…

This study tests whether oral semaglutide (Rybelsus) can safely control high blood sugar in people who recently had a kidney transplant. About 104 participants will receive either the drug or a placebo for 14 weeks, alongside standard care. The goal is to see if it works as well …

This study tests a 24-week community-based lifestyle program called Inspire HER for Black women aged 30-79 with heart, kidney, or metabolic conditions. The program provides health education, physical activity, and social support to improve heart health. Researchers will also comp…

This study looks at 120 people with diabetes who have blocked heart arteries. It compares using a drug-coated balloon together with a drug-eluting stent versus using either device alone. The goal is to see which approach keeps arteries open best after 6 months.

This study compares a standard smartphone app with a more interactive version to see which helps people better follow their care plan after weight-loss surgery. About 200 adults having bariatric surgery will participate. Researchers will measure weight loss, quality of life, and …

This study is testing a special soft cast for people with diabetic foot ulcers. The cast is a multi-layer wrap that cushions the foot and leg to help the wound heal. Researchers want to see if it works well, is comfortable, and safe. About 100 adults with diabetic foot ulcers wil…

This study looks at two ways to help people with type 2 diabetes who have trouble controlling their blood sugar. One group gets care at a day hospital, while the other works closely with a dietitian-nutritionist. The goal is to see which approach lowers HbA1c (a key blood sugar m…

This study tests whether taking myo-inositol (a natural supplement) during pregnancy can improve health outcomes for babies born to mothers with type 2 diabetes. About 182 pregnant women will take either myo-inositol plus folic acid or folic acid alone from early pregnancy until …

This study tests whether an AI-powered smartphone app, called 'Smart family doctor,' can help people who have had heart bypass surgery or stents better control their blood pressure, diabetes, and cholesterol. About 536 adults who already have these conditions will use the app to …

This study compares three types of weight-loss surgery (sleeve gastrectomy, gastric bypass, and duodenal switch) with standard medical care for people with type 2 diabetes and a BMI of 35 or higher. The goal is to see which approach leads to long-term diabetes remission and impro…

This study looks at whether changing the dose or form of aspirin can improve blood clotting control in people with type 2 diabetes who don't respond well to standard enteric-coated aspirin. About 30 participants will try three different aspirin regimens over several weeks. The ma…

This study tests a new insulin drug, GZR4, against another insulin (Insulin Icodec) in 300 adults with type 2 diabetes who already use basal insulin. The goal is to see which one controls blood sugar better and causes fewer side effects like low blood sugar. Participants may also…

This study tests whether giving low-income adults with type 2 diabetes vouchers for fruits and vegetables helps them attend diabetes education classes and improve their diet and blood sugar control. 120 participants will be split into three groups: usual care, vouchers alone, or …

This study tests whether a continuous glucose monitor (CGM) helps pregnant women with type 2 diabetes track their blood sugar better than traditional finger-stick testing. Seventy participants will be randomly assigned to use either a CGM or a glucometer from enrollment until del…

This study tests a program that helps people with high blood pressure, diabetes, or kidney disease manage their health at home. Participants use a blood pressure monitor that sends readings to their care team, and they get support from community health workers and pharmacists. Th…

This study tests whether using a mobile health app helps people with type 2 diabetes and obesity lose weight and control blood sugar better than standard programs. Thirty adults will track their weight daily and blood sugar before and after meals for six months. The goal is to se…

This study tests whether mobile health apps like Weight Watchers and Healthi can help low-income Hispanic adults with type 2 diabetes lose weight and improve blood sugar control. Forty-five participants will use one of the apps or a standard program for six months, tracking their…

This Phase 3 study tests whether a gel called ENERGI-F703 can help close diabetic foot ulcers better than a placebo gel. About 230 adults with diabetes and a foot ulcer that hasn't healed for at least 4 weeks will receive either the active gel or a placebo, along with standard wo…

This study tests whether adding a structured self-management program (DECIDE) to standard community health worker support helps 500 Philadelphia residents aged 35-75 better manage heart disease risks and meet their social needs. Participants will either receive the enhanced progr…

This study tests whether an online training and peer support platform (Support-t) helps teens with type 1 diabetes prepare for the move from pediatric to adult healthcare. About 200 teens aged 14-16 will either use the platform plus usual care or just usual care. The main goal is…

This study provides 400 adults with diabetes or prediabetes who struggle to afford food with free fresh food boxes and nutrition classes twice a month for six months. Researchers will check if this program helps lower blood sugar levels and reduces food insecurity. The goal is to…

This early-stage trial tests a new treatment called RGB-5088 for people with type 1 diabetes. It involves transplanting insulin-making cells under a muscle layer in the abdomen. The goal is to see if it is safe and if it can help patients control blood sugar without insulin shots…

This study tests whether taking spirulina (a microalgae) or seaweed (Gelidium corneum) supplements for 20 weeks can improve markers of heart health and change gut bacteria in people at high risk for heart disease. The trial includes 150 adults aged 50 or older with conditions lik…

This study tests whether giving diabetes doctors specific care recommendations when their patients have eye problems from diabetes can help lower blood sugar. About 336 adults with diabetes and diabetic retinopathy in Bangladesh will take part. Doctors in one group get eye test r…

This study tests whether automated voice messages reminding people with diabetes about their appointments, plus free reading glasses, can increase attendance at diabetes and eye exams. 640 adults recently diagnosed with diabetes in Bangladesh will take part. The goal is to see if…

This study tests whether enavogliflozin, a diabetes drug, can improve heart function and exercise capacity in 30 obese adults with type 2 diabetes. Participants receive either the drug or a placebo for 12 weeks, and doctors measure changes in heart blood flow and fitness. The goa…

This trial tests whether a community-based learning program can help prevent and control type 2 diabetes in rural Pakistan. Over 12,000 adults aged 20 and older will participate in group sessions focused on healthy behaviors. The study will measure changes in blood sugar levels a…

Researchers on Réunion Island are measuring blood sugar levels in 2,000 adults to estimate how many people have diabetes or pre-diabetes. Participants give a fasting blood sample and drink a 75g glucose solution, then give a second blood sample two hours later. The study also che…

This trial tests whether adding an AI analysis of eye photos, an eye pressure check, and a virtual reality visual field test to standard diabetic eye screening can help detect glaucoma. About 2,000 people with diabetes who are already getting AI-based screening for diabetic eye d…

This trial is testing whether an artificial intelligence (AI) model, called MONA DR, can accurately detect diabetic retinopathy—a common eye complication of diabetes that can lead to blindness—from retinal photographs. The study will enroll 100 adults with diabetes and compare th…

This study tests a small, noninvasive device that analyzes breath to detect high and low blood sugar events in children and young adults with diabetes. Participants aged 7–25 who already use a continuous glucose monitor will provide breath samples during normal, high, and low blo…

This study collects blood samples from healthy people, those with benign diseases, and cancer patients to develop a multi-analyte blood test. The test looks for DNA methylation markers that may indicate the presence of various cancers, especially liver cancer. Researchers aim to …

This study is testing a new laser-based blood test that uses nanoparticles to detect pancreatic cancer early. Researchers will enroll 400 people, including those with diabetes, pancreatic cysts, or pancreatic cancer, to see if the test can accurately identify cancer. The goal is …

This study tests whether a device that shines light through the toe (photoplethysmography) can quickly detect peripheral artery disease in people with diabetes. The new method measures how long it takes blood to refill the toe after a heartbeat, and researchers compare it to the …

This study aims to develop a non-invasive breath test to detect pancreatic cancer earlier. Pancreatic cancer is often diagnosed late because early symptoms are vague. The test measures tiny molecules in breath that may signal cancer. Researchers will collect breath and urine samp…

This study tests whether a wearable breath sensor can detect high or low blood sugar in teens with type 1 diabetes. Participants wear the device for 72 hours and provide breath samples while checking blood sugar with a finger prick. The goal is to see if breath chemicals can repl…

This study will enroll nearly 3,000 people with type 2 diabetes to improve how diabetic retinopathy (an eye disease) is diagnosed and managed. Researchers will use eye exams, blood tests, and continuous glucose monitors to build better models for predicting and treating the condi…

This study tests whether an AI software can help doctors spot diabetic retinopathy (an eye disease caused by diabetes) earlier. About 340 adults with type 2 diabetes who have not been diagnosed with eye disease will be randomly assigned to get either standard care or standard car…

This study is testing whether whole genome sequencing (a complete scan of a person's DNA) can help doctors identify the cause of atypical diabetes—unusual cases that don't fit typical type 1 or type 2 diabetes. Researchers will compare this advanced genetic test to the current st…

This study is testing a new blood test called Avantect to see if it can find pancreatic cancer early in people who were diagnosed with type 2 diabetes in the last 6 months. About 15,000 adults aged 50-84 will give blood samples and fill out anxiety questionnaires over a year. The…

This study tests a portable DNA device called MinION that can identify bacteria and fungi in foot wounds of people with diabetes in under 4 hours. Standard lab cultures take longer and may miss some germs. The goal is to see if this faster method gives a more complete picture of …

This study tests whether an artificial intelligence (AI) program can help spot glaucoma, a leading cause of blindness, in people with diabetes. About 1,040 adults with diabetes will have their eye photos checked by either the AI or a human grader to see which method finds glaucom…

This study compares three common blood tests—fasting blood sugar, sugar load test, and HbA1c—to see which one is best at detecting diabetes caused by long-term steroid use. Researchers will enroll 75 non-diabetic adults who need steroids for more than three months. The goal is to…

This study is testing a new device that uses light (Raman spectroscopy) to measure blood sugar without needing a finger prick. Researchers will compare the device's readings to traditional blood tests in 49 people with diabetes. The goal is to see if this painless method is accur…

This study checks if an AI software named DRISTi can accurately detect diabetic retinopathy, a serious eye disease, in people with diabetes. About 900 participants will have their eye images analyzed by both DRISTi and a human reading center. The goal is to see if the AI matches …

This study tests an artificial intelligence system called iPredict-DR that analyzes retinal photos to detect diabetic retinopathy, a leading cause of blindness. Researchers will enroll 922 adults with diabetes at primary care and endocrinology clinics. The AI's accuracy will be c…

This study tests whether regular, personalized health coaching—delivered virtually and during community screenings—can reduce the 10-year risk of heart attack or stroke in adults aged 40-75 who have at least one cardiometabolic risk factor like high blood pressure, high cholester…

This study tests a program called PINPOINT that helps women with obesity or diabetes get screened for cervical cancer. About 20 women who are behind on screening will be offered options like self-collection or a Pap smear. The goal is to see if the program is practical and well-l…

This study tests a family-oriented version of the Diabetes Prevention Program for Black families in Southwest Georgia. Parents with prediabetes and their children aged 8-15 will learn healthy eating and exercise habits together. The goal is to help parents lose weight and lower t…

This study tests if special sensor-equipped insoles can help prevent foot ulcers from coming back in people with diabetes and nerve damage. About 400 high-risk participants will use the insoles alongside standard care or just standard care alone. The goal is to see if the insoles…

This study tests a mobile health app designed to help Hispanic adolescents (ages 12-18) who are overweight improve their diet, physical activity, and sleep. The goal is to see if the app can help prevent type 2 diabetes. The study will enroll 30 participants and last 30 days, foc…

This study is testing whether a home-based screening kit can identify hidden heart risks better than standard doctor visits. 45,000 adults in Sweden aged 50-75 will either receive a home blood pressure monitor, a finger-prick blood test, and a health questionnaire, or continue wi…

This pilot study tests whether a family-centered health and wellness coaching program can help prevent type 2 diabetes in South Asian and Black African/Caribbean families in Ontario, Canada. Each family dyad includes an adult caregiver and a youth aged 14–24. Participants receive…

This study tests whether extra lifestyle coaching plus medically tailored meals can help prevent type 2 diabetes in mothers who had gestational diabetes. Nearly 1,000 pregnant or recently postpartum women from home visiting programs will be randomly assigned to receive either enh…

This study tests whether personalized telehealth coaching from a pharmacist can help people adopt preventive health strategies like better nutrition, exercise, and medication use. Researchers will enroll 360 adults from industries like healthcare and food service in Louisiana. Pa…

This study tests an enhanced version of the National Diabetes Prevention Program (NDPP-NextGen) designed for young women aged 18-39 with overweight or obesity who may become pregnant within two years. Participants will either join online group classes for 12 months or receive sta…

This study tests whether adding reminders to electronic medical records helps doctors better manage pre-diabetes. About 6000 adults with pre-diabetes will take part. Some clinics will use the reminders, others won't. The goal is to see if the prompts lead to more blood tests, ref…

This study tests two lifestyle programs in 400 older African American and non-Hispanic white adults at risk for dementia and diabetes. One group does aerobic exercise three times a week; the other learns to follow the MIND diet, which emphasizes berries, greens, and whole grains.…

This study tests whether giving the COVID-19 vaccine (Comirnaty) to children starting at 6 months old can lower their chance of developing type 1 diabetes. The trial will include 2,252 children who have a high genetic risk for the disease. Half will get the vaccine, half a placeb…

Researchers test whether adding a predictive app to a continuous glucose monitor changes fear of low blood sugar, sleep quality, and diabetes distress in adults with type 1 or insulin-treated type 2 diabetes. Participants use the monitor alone for two weeks, then with the app for…

Researchers are testing SugarVita 2.0, a digital game that lets players make nutrition, activity, and medication decisions while a glucose simulator shows the results. The 12-week pilot enrolls 30 adults with type 2 diabetes and an HbA1c above 55 mmol/mol. The study measures chan…

This pilot study investigates how the design of removable cast walkers—used to offload diabetic foot ulcers—affects how often patients wear them and how well the ulcers heal. Researchers will compare a knee-high walker with an ankle-high version paired with a shoe lift, measuring…

Diabetes patients often suffer from dry mouth, which affects eating, speaking, and quality of life. This study tests whether endocrinologists can deliver simple oral care—like screening, counseling, and saliva substitutes—during routine diabetes visits. Researchers will follow 80…

This study tests a three-session training program to help older adults (65+) who use insulin learn to use a continuous glucose monitor (CGM). Participants will be randomly assigned to the program or standard training. The goal is to see if the program improves how often they wear…

This study tests a program called enCompass Humana, which provides coaching and resources to unpaid caregivers of adults with both cancer and diabetes. The goal is to see if the program is practical and helpful for caregivers, improving their coping skills and reducing loneliness…

This pilot study tests a new flexible bandage called exciflex that delivers mild electrical stimulation to chronic wounds that won't heal normally. The study includes 16 veterans with diabetes or spinal cord injury who have lower leg wounds. The bandage is designed to work for up…

This pilot study tests a care model called Patient Priorities Care (PPC) for older African Americans with heart disease plus other chronic conditions like diabetes or COPD. The approach shifts focus from treating each disease separately to aligning care with what matters most to …

This study explores whether 8 weekly telehealth music therapy sessions can improve quality of life and reduce depression and anxiety in adults with autoimmune endocrine diseases (like Type 1 diabetes or Hashimoto's) who also have depression. Ten participants will meet with a boar…

This pilot study tests a device called CRAD ULCER X-01 that uses pulsating electromagnetic fields (PEMF) to help heal diabetic foot ulcers. 32 people with chronic, non-healing ulcers will be split into groups receiving standard wound care plus either a placebo or 1-3 hours of PEM…

This study investigates whether low-frequency pulsed electromagnetic field (PEMF) therapy can improve vibration perception and protective sensation in people with diabetic foot ulcers. Forty-two participants with type 2 diabetes and Wagner grade 1 ulcers will receive either real …

This study looks at whether the timing of a 9-hour eating window (early, mid, or late in the day) affects blood sugar control in people with obesity who have or are at risk for type 2 diabetes. Over 7 days, 120 participants will follow one of three time-restricted eating schedule…

This study tests whether ear acupuncture, led by village doctors and supported by telemedicine, can improve sleep in adults aged 65 and older who have both diabetes and high blood pressure. Participants will receive either real or sham ear acupuncture for 6 weeks. The goal is to …

This Phase 2 trial tests whether KL1333 can reduce fatigue and improve leg strength in adults with primary mitochondrial disease, a genetic condition that affects energy production. About 180 participants will receive either KL1333 or a placebo twice daily for 48 weeks. The study…

This study looks at whether counseling sessions can help people with type 2 diabetes become more physically active and sit less. Researchers will compare standard care with informational sessions on exercise benefits, with or without practical guidance from a kinesiologist. The g…

This study looks at why people with indigestion and diabetes have stomach issues, possibly due to increased sensitivity in the small intestine. Researchers are testing ondansetron, a drug used for nausea, to see if it can reduce symptoms like fullness, discomfort, and nausea. The…

This study tests whether a whole-food, plant-based diet (no added oils) can reduce painful diabetic neuropathy better than standard medication. Forty adults with type 2 diabetes and nerve pain will be randomly assigned to either the diet or medication optimization. The main goal …

This study tests whether taking 3 mg of melatonin each night for 8 weeks can improve sleep and daily body rhythms in people with diabetic retinopathy. Researchers will track sleep patterns and hormone levels in 42 adults aged 40-65 with type 2 diabetes and moderate eye damage. Th…

This study tests whether an 8-week program of supervised physical and cognitive exercises can improve walking, thinking, strength, and quality of life in 374 adults with Long COVID and conditions like high blood pressure or diabetes. Participants are randomly assigned to either t…

This study tests two walking training programs to help veterans with leg amputation walk more evenly. The goal is to reduce pain, improve mobility, and protect the skin of the remaining limb. About 54 veterans who lost a leg due to diabetes or artery disease will take part.

This study tests whether weight loss drugs like tirzepatide and semaglutide are practical and safe for endometrial cancer patients who are overweight, obese, or have diabetes and are undergoing chemotherapy. About 36 participants will take weekly doses for 24 weeks. Researchers w…

This study tests whether a four-week online self-compassion course can reduce diabetes-related distress, self-criticism, and shame in adults with type 1 or type 2 diabetes. Researchers will enroll 50 participants to see if the program is feasible and acceptable. The course includ…

This study tests a program that gives people with diabetes a continuous glucose monitor (CGM) when they leave the hospital. The goal is to see if it makes patients more satisfied and improves their quality of life. About 37 adults with Type 1 or Type 2 diabetes who use insulin wi…

This study tests a culturally adapted diabetes education program for Arab Americans with type 2 diabetes. Participants will receive peer-led classes in Arabic and text message support for 3 months. The goal is to see if this approach improves diabetes knowledge, self-care, and bl…

This early-phase study tests whether a weight-loss drug called tirzepatide can help overweight or obese men with intermediate-risk prostate cancer lose weight before their prostate removal surgery. The study will enroll 30 participants and focus on safety and how well the program…

This study tests whether a spinal cord stimulator—a device that sends mild electrical pulses to the spine—can reduce pain and improve blood flow in the legs of people with type 2 diabetes who have nerve pain. Researchers will enroll 25 adults with painful diabetic neuropathy and …

This study looks at whether repairing blocked leg blood vessels within 48 hours helps heal foot ulcers in people with type 2 diabetes faster than waiting for a scheduled procedure. About 200 adults with diabetic foot sores will be randomly assigned to early or standard treatment.…

This pilot study tests whether walking on a treadmill with a blood pressure cuff around the legs (blood flow restriction) is safe and helpful for people with type 2 diabetes. Sixty participants will either walk with or without the cuff for 6 weeks. Researchers will measure how ma…

This study tests whether cognitive behavioral therapy for insomnia (CBTi) can improve sleep, blood sugar levels, and quality of life in adults with type 1 diabetes. Fifteen participants will either receive 8 virtual CBTi sessions or health education emails and calls over 12 weeks…

This study looks at whether different exercise programs can improve blood flow in the legs of older adults with poor circulation. About 425 participants will be split into groups doing either mixed exercise, high-intensity rowing, or vibration exercise for 12 weeks. The goal is t…

This pilot study tests whether drinking beetroot juice daily for two weeks can improve memory and brain blood flow in 25 people with small vessel disease and diabetes. The juice is rich in nitrate, which the body can convert to nitric oxide, a molecule that helps blood vessels wi…

This study provides free continuous glucose monitors (CGMs) to 17 adults with poorly controlled type 2 diabetes. Researchers will track changes in blood sugar levels and quality of life over time. The goal is to see if easier access to CGM technology helps patients manage their d…

This study tests whether a special type of talk therapy, delivered via video calls, can reduce anxiety and depression in young adults (ages 18-64) with type 1 diabetes. The therapy also includes reviewing continuous glucose monitor data to help link emotions and blood sugar level…

This study compares two virtual group programs—one focused on emotions, the other on problem-solving—to help adults with type 1 diabetes reduce diabetes distress. Participants who don't improve can get extra one-on-one sessions. The goal is to find better ways to support emotiona…

Researchers want to learn how the body's own remaining insulin production, measured by a marker called C-peptide, affects quality of life and health outcomes in people with insulin-treated diabetes. The study follows about 700 adults, including some from a previous diabetes study…

This study will follow 2,000 adults with metabolic syndrome or prediabetes over time to understand how these conditions progress and lead to complications. Researchers will track health records, nutrition, and physical function to find key factors that affect long-term outcomes. …

This study looks at how your genes and your environment—like what you eat, breathe, and experience—work together to influence common diseases such as diabetes, heart disease, and asthma. Researchers are collecting health questionnaires, genetic data, and other information from 25…

This study looks at how fear of low blood sugar (hypoglycemia) affects how well people with diabetes follow their diet and take their medication. Researchers will measure fear levels, medication adherence, and diet adherence in 100 adults with diabetes who have had at least one l…

This study looks at how obesity and body fat affect heart disease risk in 2,000 healthy African American men and women. Researchers will measure body fat, blood fats, and insulin function to see if risk factors differ by sex. The goal is to understand why heart disease rates are …

Researchers at the University of Miami are studying whether advanced eye imaging devices can reveal useful information about the eye in health and disease. The study has two parts: one observes the eyes of healthy people and people with conditions such as multiple sclerosis, dry …

This study explores whether stem cells from taste buds can be turned into insulin-making cells. Researchers will take tiny tissue samples from the tongues of 250 healthy adults to isolate and grow these stem cells in a lab. The goal is to see if this is possible in humans, which …

This study follows 1,500 pregnant women and their children for up to 18 years to understand how a mother's health, lifestyle, and environment affect her child's growth and risk for obesity, diabetes, and fatty liver. Mothers attend visits during pregnancy and after birth, while c…

This natural history study will look at how metabolism relates to body size and composition in 2,000 people aged 2 and older, including healthy volunteers and those with conditions like diabetes, obesity, or cancer. Participants will stay in the hospital for two days to undergo v…

This study follows 2,800 unpaid caregivers of people with chronic conditions like diabetes or inherited disorders. Researchers will survey and interview caregivers over up to 5 years to track changes in their health, stress, and social support. The goal is to understand how careg…

Researchers are following 10,000 registered nurses in Xiamen, China, to see how genes, lifestyle, and environment relate to common chronic diseases like high blood pressure, heart disease, stroke, diabetes, kidney disease, and some cancers. The study collects health and lifestyle…

This study aims to find biological markers (biomarkers) that can predict whether a diabetic foot ulcer will heal or not. Researchers will collect samples like blood and wound fluid from 5,000 adults with diabetes and open foot ulcers. The goal is to develop a tool that helps doct…

Researchers are building a large, diverse group of adults with varying body sizes, ethnicities, and diabetes risk. They will collect blood, stool, and fat tissue samples to study how obesity relates to diabetes and other health issues. The goal is to create a rich resource for fu…

This study is testing new magnetic resonance imaging (MRI) techniques to get clearer pictures of the heart and blood vessels without using radiation. Researchers will compare these new MRI methods to standard tests like angiography and CT scans. Up to 4,000 adults—including healt…

This early-stage trial is testing a new drug called ACI-19764 in 78 healthy adults to see if it is safe and how the body handles it. The drug targets a protein in the brain linked to inflammation. Participants will receive either the drug or a placebo, and researchers will monito…

This study looks at why people with pre-diabetes or type 2 diabetes tire more quickly during leg exercises. Researchers will test a special low-load resistance training program, sometimes with blood flow restriction, to see if it improves muscle strength, blood flow, and energy u…

This study aims to find out why people with diabetes often have lower vitamin C levels in their blood. Researchers will measure vitamin C in blood, urine, and cells from 5,000 adults with and without diabetes. They will also look at genes that control vitamin C transport. The goa…

This study looks at data from over 6,000 Brazilian patients with heart failure, kidney disease, diabetes, or high blood pressure to understand how common high potassium levels (hyperkalemia) are and how doctors manage it. By analyzing medical records, researchers hope to identify…

This study looks at how hormone levels change after a mixed meal in people with cystic fibrosis. Researchers want to find links to blood sugar problems common in this condition. About 61 adults aged 18-45 with cystic fibrosis will participate. No treatment is given; this is an ob…

This study tests whether spinal cord stimulation (SCS), a treatment for chronic back and leg pain, can also activate brown adipose tissue (BAT) — a type of fat that burns calories. Researchers will place an extra research electrode during a standard SCS implant in about 10 adults…

This study aims to learn more about insulin resistance and diabetes by collecting blood and skin samples from up to 1,200 participants, including patients with severe insulin resistance and their family members. Researchers will study genetics and how insulin works in the body to…

This study tests a digital tool called CGM ASSIST that combines a continuous glucose monitor with easy-to-read displays. The goal is to help people with Alzheimer's or dementia and diabetes, along with their caregivers, better understand blood sugar levels and make informed decis…

This study compares walking patterns between people with diabetic peripheral neuropathy (nerve damage from diabetes) and healthy adults. It also tests whether giving people real-time feedback on their walking form can immediately change how they walk. The goal is to understand th…

This study uses continuous glucose monitors (CGMs) to track blood sugar levels in the days right after a kidney transplant. It compares three groups of recipients: those with diabetes, those with pre-diabetes, and those without diabetes. The goal is to see if glucose patterns dif…

This study looks at whether tiny particles released by fat cells, called adiposomes, carry harmful fats that damage blood vessels in people with obesity and type 2 diabetes. Researchers will test if a 12-week aerobic exercise program or weight-loss surgery can reduce these harmfu…

This pilot study is testing whether a real-time continuous glucose monitor (FreeStyle Libre 3) can reveal differences in blood sugar patterns between people with diabetes who have gastroparesis (delayed stomach emptying) and those without it. About 50 adults with type 1 or type 2…

This study is collecting blood samples and health data from 15,000 symptom-free adults over 40 to understand what healthy aging looks like at the molecular level. By tracking participants over time, researchers hope to establish normal ranges for thousands of blood markers and id…

This study will screen 7,000 adults in China who are at high risk for diabetes but do not yet have it. Researchers will track blood sugar changes, eye health, and bone density over time. The goal is to find better ways to prevent diabetes and create a new model for managing high-…

This study surveys adults taking GLP-1 medications (like semaglutide or tirzepatide) for diabetes or weight loss to understand their resistance training habits before and after starting the drug. The goal is to learn how often people strength train, what their workouts look like,…

This study uses advanced MRI scans to track changes in muscle and fat in the body and heart over 12 months in 50 adults starting semaglutide for type 2 diabetes or weight loss. Participants will undergo MRI scans, physical tests, blood samples, and questionnaires. The goal is to …

This study investigates whether proteins released by muscles, called myokines, can serve as early warning signs or even causes of muscle loss (sarcopenia) in people with metabolic or endocrine conditions like diabetes, obesity, and Cushing syndrome. Researchers will measure myoki…

This study is testing a smartphone app designed to help older adults (55+) with conditions like heart failure, diabetes, and kidney disease manage their health after leaving the hospital. The app provides fall prevention tips, a personalized care plan, and a way to track symptoms…

This study follows 1,000 adults with diabetes to find early signs that predict serious complications like nerve damage, eye disease, kidney problems, and heart issues. Researchers measure blood sugar control and other health markers over time. The goal is to develop better risk a…

This study is looking for biological markers (biomarkers) in blood, saliva, and urine that signal damage to insulin-producing beta cells in the pancreas. Researchers will compare samples from people with type 1 diabetes, type 2 diabetes, prediabetes, and healthy volunteers. The g…

This study tests a program called SPARK-CGM that helps primary care clinics prescribe continuous glucose monitors (CGM) to people with diabetes. CGM devices track blood sugar in real-time, but they are underused in primary care. The program provides training, workflow support, an…

This study looks at whether sulfasalazine, a drug for inflammatory arthritis, makes the standard diabetes blood test (HbA1c) falsely low. That could mean diabetes goes undiagnosed or is undertreated in these patients. Researchers will use continuous glucose monitors and fasting b…

This study from Mayo Clinic looks at how one session of exercise changes breastmilk. Researchers will measure tiny particles called exosomes that carry messages between cells. They want to see if exercise boosts these particles in breastmilk, which might help prevent childhood ob…

This study looks at how a 12-week lifestyle change affects inflammation and stress markers in 60 overweight adults with type 2 diabetes and moderate chronic kidney disease. Participants will follow a modified diet and exercise plan. The goal is to see if these changes can reduce …

This study is collecting health data from 1,500 adults with diabetes in Switzerland to see how well current treatments work in everyday life. Researchers will track complications, quality of life, and survival over time. The goal is to find out what's working and what needs impro…

This study looks at how social factors and health literacy affect the ability of people with diabetes to manage their own care. Researchers will survey 400 adults with type 1 or type 2 diabetes to understand these connections. The goal is to design better support programs that he…

This study looks at why wounds heal slowly or not at all in people with diabetes. Researchers will collect blood and wound fluid from 250 adults with chronic wounds to compare immune cells between diabetic and non-diabetic participants. The goal is to understand the biological re…

This study looks at whether a genetic risk score can predict which people with newly diagnosed diabetes will eventually need insulin. Researchers will follow about 3,000 patients aged 14 to 50 for up to 3 years, tracking their C-peptide levels (a marker of insulin production) and…

This study is looking at whether GLP-1 receptor agonists—drugs used for type 2 diabetes and obesity—can also improve dry eye disease. Researchers will measure changes in tear stability and eye surface health in 100 patients who have not taken these drugs before. The goal is to un…

This early-stage study looks at how the body processes HRS9531 injection in people with mild or moderate liver issues compared to those with healthy livers. Researchers will measure drug levels and check for side effects in 24 participants. The goal is to understand if liver func…

This study is testing whether a smartphone-based program that provides high-fiber foods and continuous glucose monitors can help young adults (ages 18-39) with prediabetes improve their blood sugar control. The main goal is to see if people find the program easy to use and stick …

This study is checking how accurate the Dexcom G7 continuous glucose monitor is for patients in the intensive care unit after major abdominal surgery or organ transplant. Researchers will place two sensors on each patient—one that is calibrated and used to guide insulin dosing, a…

This study surveys 100 general practitioners in Italy to assess their knowledge of how oral health, especially gum disease, relates to systemic conditions like diabetes. Participants complete a 35-question digital questionnaire. The goal is to identify gaps in knowledge and impro…

This study is collecting blood samples from 1,160 people with and without type 1 diabetes to analyze the immune cells that mistakenly attack the pancreas. The goal is to better understand how these cells work, which could lead to improved treatments or prevention strategies in th…

This study follows 500 American Indian adults with early kidney disease to learn how their condition progresses and what factors affect heart health. Researchers will measure kidney function and track heart events like heart attacks and strokes. The goal is to fill knowledge gaps…

This study looks at whether giving older adults (65+) with diabetes or high blood pressure access to their visit notes and audio recordings of their appointments helps them feel better and manage their health. About 1,022 participants will be randomly assigned to receive either w…

This study looks at genetic and chemical markers in fat tissue from 500 people with severe obesity who are having weight-loss surgery. Researchers collect a small amount of belly fat during the operation and take blood samples afterward. The goal is to understand why some patient…

This study aims to see if short videos featuring Latinx patients and doctors can encourage more Latinx people with diabetes to get regular eye exams. Researchers will survey about 1,500 people and hold small group discussions to measure changes in eye health knowledge and trust i…

This study looks at how semaglutide, a drug used for diabetes and weight loss, changes fat tissue around the kidneys, heart, and liver in people with type 2 diabetes and chronic kidney disease. Researchers will compare patients taking semaglutide to those not taking it. The goal …

This study aims to find out how many adults with type 2 diabetes experience severe diabetes-related distress—a feeling of being overwhelmed by the demands of managing the disease. Researchers at a French hospital will ask 246 participants to fill out questionnaires about their em…

This study is not testing a new drug or treatment. Instead, researchers want to make sure their lab tests and equipment give accurate and repeatable results when studying conditions like obesity, diabetes, heart disease, and bone loss. Up to 100 healthy volunteers and people with…

This study tests whether an AI tool called EchoGo can help doctors spot early signs of heart failure in people with type 2 diabetes who have no symptoms. Researchers will send alerts to doctors about patients at risk, and see if this leads to more prescriptions of heart-protectin…

This study is testing a new ultrasound method that uses tiny, safe bubbles to measure blood flow in the pancreas. The goal is to see if changes in blood flow can help detect type 1 diabetes early, before symptoms appear. Researchers will compare 50 healthy adults and people recen…

This study surveys up to 900 adults with type 1 diabetes who use a closed-loop insulin system for at least 4 months. The goal is to understand how satisfied they are with the special 'physical activity mode' designed to prevent low blood sugar during exercise. Participants fill o…

This study looks at whether a structured goal-setting program can help people with chronic conditions like high blood pressure, diabetes, or high cholesterol adopt healthier behaviors. Researchers will compare 600 participants who receive the program to those who get usual care. …

This study tests whether sending automatic WhatsApp reminders helps more women with gestational diabetes attend their postpartum glucose test. It also compares a newer one-hour blood sugar measurement to the standard two-hour test to see which catches prediabetes and diabetes ear…

This study tests whether a machine learning program can detect lipohypertrophy—hidden lumps under the skin caused by insulin injections—using portable ultrasound. About 100 people with diabetes will first have their injection sites scanned. In a second phase, 40 people found to h…

This early-stage trial tests a new insulin formula (U-500) given directly into the belly cavity in 25 adults with type 1 diabetes. Researchers want to see if it's safe, how fast it's absorbed, and how quickly it works compared to standard insulin shots. Participants will have the…

This study looks at how a drug called diazoxide, which activates certain brain centers, can change how much sugar the liver makes. People with type 2 diabetes often have livers that produce too much sugar, leading to high blood sugar. The study will involve 100 participants (both…

This early-stage study tests different doses of an experimental diabetes drug called SHR-3167 in 60 healthy adults aged 18 to 55. The goal is to measure how much of the drug gets into the blood and how safe it is, not to treat any disease. Participants will receive a single injec…

This study is a large registry that will follow 20,000 people with type 1 diabetes across China. It aims to track changes in blood sugar, kidney function, heart health, and emotional well-being over many years. The goal is to better understand how the disease progresses and impro…

This study looks at whether repeated eye injections of bevacizumab, a drug used for diabetic eye disease and other conditions, might affect heart health. Researchers will measure certain enzymes in the blood that are linked to heart disease risk. The study includes 180 adults age…

This study looks at how certain diabetes medications (semaglutide, liraglutide, and tirzepatide) affect blood flow and oxygen use in the eyes of people with diabetes. Researchers will use special cameras to measure eye blood vessels and oxygen levels in 20 adults before and after…

This study follows 1,000 people who are having weight-loss (bariatric) surgery. Researchers will measure changes in weight, body fat, blood sugar, cholesterol, and other health markers before surgery and at several follow-up visits over two years. The goal is to better understand…

This study looks at 3,000 people with type 2 diabetes to see if certain signs of inflammation in the blood are linked to diabetes-related health problems. Researchers hope to find early clues that could help identify patients at higher risk for complications. The study is purely …

This study looks at whether people aged 50+ who are newly diagnosed with diabetes (or whose diabetes gets worse) might have early-stage pancreatic cancer. Researchers will use MRI scans and collect blood samples over time to find cancer or pre-cancerous changes. The goal is to de…

This study explores whether advanced MRI scans can noninvasively diagnose and track diabetic kidney disease (DKD). Researchers will scan 150 people—including DKD patients and healthy volunteers—using multiple MRI techniques. The goal is to see if these scans can predict kidney fu…

People with serious mental illness often have undiagnosed physical conditions like heart disease, diabetes, and cancer. This study tests whether adding routine physical health checks to psychiatric care helps find and treat these hidden illnesses. About 2,800 adults in Denmark wi…

This study follows 800 adults with type 2 diabetes to see how their lifestyle choices relate to long-term complications like heart or kidney problems. Researchers will track participants over time and record any complications that develop. The goal is to find early warning signs …

This study is looking at whether long-term blood sugar levels (HbA1c) affect how fast the stomach empties before surgery. Slow stomach emptying can increase the risk of stomach contents entering the lungs during anesthesia. Researchers will use ultrasound to measure stomach conte…

This observational study will enroll 8,000 adults undergoing routine health checkups. Researchers will measure hormone levels and collect health data to understand how environment, genes, and proteins interact in conditions like high blood pressure and diabetes. The goal is to cr…

This study aims to better predict which kidney transplant patients who develop diabetes will later suffer serious complications like heart disease or kidney failure. Researchers will use machine learning and genetic analysis to find new markers in blood, urine, and kidney tissue.…

This study follows over 500 adults with type 2 diabetes who had a heart CT scan years ago. Researchers will repeat the scan to see how plaque builds up in heart arteries over time and identify factors that increase risk. The goal is to better understand heart disease in diabetes,…

This study looks at how long people with type 2 diabetes need to stop taking GLP-1 medications (like semaglutide) before surgery to make sure their stomach is empty. These drugs slow down digestion, which can increase the risk of food or liquid entering the lungs during anesthesi…

This study tests whether a simple electronic health record alert can help primary care doctors identify patients with fatty liver disease who may have advanced liver scarring. The alert prompts doctors to calculate a risk score and, if needed, order a special ultrasound to check …

This study observes 80 adults with and without diabetes to see how long-term blood sugar control (measured by HbA1c) affects brain oxygen levels during urologic surgery. Researchers use a special light device (NIRS) to measure brain oxygen and track recovery after surgery. The go…

This study looks at how fat buildup in the pancreas (pancreatic steatosis) is connected to type 2 diabetes and metabolic syndrome. Researchers will use a special ultrasound technique to measure the fat and see how it relates to the cells that make insulin. The goal is to better u…

This study looks at how the body controls blood pressure and heart rate in healthy young adults and older adults with high blood pressure. Participants will do tests like standing up and cycling while their heart and blood vessels are monitored. The goal is to better understand t…

This study takes a small sample of skin, blood, or urine from people with diabetes and healthy volunteers. Scientists will turn those cells into stem cells and then into insulin-producing cells in the lab. The goal is to learn more about diabetes and pave the way for future cell-…

This study aims to understand the step-by-step process that causes type 1 diabetes by looking at genetics and environment. Researchers will follow families with a history of the disease, as well as healthy controls, for up to 10 years. Participants provide a blood sample, medical…

This study tests whether real-time visual and audio cues can help people with diabetic peripheral neuropathy walk better. Researchers will measure foot pressure and push-off force as 25 participants walk on a treadmill. The goal is to understand how biofeedback changes walking pa…

This study collects blood, tissue, and other samples from up to 10,000 people to create a biobank for research. The goal is to help scientists study the causes of diseases like cancer, heart disease, and diabetes. Participants provide samples and basic health data, but no treatme…

This study tests whether a simple fetal ECG monitor worn at home can effectively track the health of babies in high-risk pregnancies. Fifty pregnant women who need weekly fetal testing will use the device for 30-minute sessions, three times a week, starting at 32 weeks. The goal …

This study tests whether a nurse-led foot care education program, based on the Health Belief Model, can improve foot care knowledge and behavior in diabetic patients undergoing hemodialysis. Fifty participants will be randomly assigned to receive the training or standard care. Th…

This study will have up to 10,000 adults wear a smartwatch for one year to collect health data like heart rate and activity. Participants will also answer questions through a phone app. The goal is to see if smartwatch data can help doctors spot heart problems earlier. No drugs o…

This study looks at how type 1 diabetes affects the nerves that control the heart in children. Researchers will measure heart rate variability in 100 children with diabetes and compare them to healthy kids of the same age and sex. The goal is to find early signs of cardiac dysaut…

Researchers in Slovenia are testing a new continuous glucose monitor called Syai Tag in 100 intensive care patients. The device uses small sensors on the upper arm to track blood sugar levels without needles. The study will compare its accuracy to standard blood tests to see if i…

This study at Johns Hopkins University will follow 50 people who have had a stroke and have risk factors like high blood pressure, high cholesterol, or diabetes. Researchers will use repeated MRI scans over about 15 months to track changes in the brain's white matter. The goal is…

This study follows 100 men aged 30-75 who had a heart procedure called PCI (stent placement) to open blocked arteries. Researchers want to see how erectile function changes over 6 months, comparing those who had a heart attack to those with stable chest pain. Participants fill ou…

This study partners with community organizations to improve participation in health research among Black, Latino, and Native American communities in Colorado. Researchers will track changes in diet, transportation access, and social support over time. The goal is to build lasting…

This study is collecting kidney tissue, blood, urine, and genetic samples from 400 adults with diabetes who are already scheduled for a kidney biopsy. Researchers will compare people whose kidney function declines quickly versus slowly to find molecular clues. The goal is to bett…

This study is surveying 500 adults with type 2 diabetes to see how much they know about nutrition and how closely they follow the Mediterranean diet. Researchers will also measure blood sugar, cholesterol, and muscle strength. The goal is to understand the link between diet knowl…

This study looks at why people with diabetes have a higher risk of memory problems and dementia. Researchers will use brain scans and thinking tests to see if brain insulin resistance and damaged blood vessels play a role. About 150 adults aged 50-80 with type 1 or type 2 diabete…

This study tests a tele-education program called ECHO Diabetes for primary care providers at 18 federally qualified health centers across the U.S. Providers attend twice-monthly online sessions for 6 months, led by a team at the University of Florida. The goal is to see if this t…

This observational study aims to understand why some adults with diabetes find it hard to take their medicines as prescribed. Researchers will survey 220 patients to examine factors like medication knowledge, family support, communication with doctors, and access to care. The goa…

This study looks at whether a continuous glucose monitor (CGM) can help predict who will develop diabetes after an episode of acute pancreatitis. Researchers will follow 800 people for up to 36 months, using the CGM device to track blood sugar levels. The goal is to see if CGM ca…

This study is building a biobank of DNA samples and health information from 500 adults. Researchers will use this resource to explore how genetic variations relate to heart disease, high blood pressure, diabetes, and obesity. Participants provide samples and data, but no experime…

This study will use a special camera (NIRS-OCT) to look inside the heart arteries of 1,516 people with diabetes. The goal is to find fatty plaques that might rupture and cause heart attacks. Researchers hope to create a new way to identify these dangerous plaques early, so doctor…

This study looks at whether trained community health workers can effectively screen and manage chronic diseases like high blood pressure and diabetes in rural Lesotho. About 17,500 adults will take part, with health workers using simple tools and eHealth apps to monitor and refer…

This study looks at how losing weight and improving diabetes after bariatric surgery changes brain function and thinking skills. Researchers will also test if a non-invasive nerve stimulation device, started 30 days after surgery, can further improve brain health. The study invol…

This study looks at how often people with cystic fibrosis and diabetes develop complications like eye, kidney, and nerve problems. Researchers will also check blood pressure and cholesterol. The goal is to better understand these risks in a diverse group of 200 adolescents and ad…

This early-phase study looks at how alpha cells in the pancreas communicate with beta cells to control blood sugar. Researchers will give healthy volunteers exendin-9 (a GLP-1 blocker) and dexamethasone to see how insulin secretion changes. The goal is to better understand diabet…

This study is creating a large registry and tissue bank for people with mitochondrial disorders. Researchers will collect medical information and samples from up to 1,000 participants, including those diagnosed with or suspected to have a mitochondrial disease. The goal is to gat…

This study is looking for 120 adults with type 2 diabetes to help researchers understand why some people develop high pressure on their feet while walking. High foot pressure can lead to painful ulcers. The goal is to find simple measurements that can predict this risk and create…

This study is following 1,000 people who have had a severe type of heart attack called STEMI. Researchers are collecting detailed medical data to understand how different organs talk to each other during recovery. The goal is to find key signals that could lead to better treatmen…

This study aims to better understand periodontitis and peri-implantitis by analyzing biological samples like plaque, saliva, and gum fluid from 219 participants. Researchers will compare samples from people with severe gum disease to those with healthy gums. The goal is to identi…

This study aims to understand why many people with cystic fibrosis develop diabetes. Researchers will give two gut hormones, GLP-1 and GIP, to 45 adults with cystic fibrosis and measure how their pancreas releases insulin. The goal is to learn more about cystic fibrosis-related d…

This study follows 1,000 adults with diabetic foot ulcers for up to 5 years to learn why some have worse outcomes, including death. Researchers will track health events and build a risk score to identify those most at risk. The goal is to better understand the disease and improve…

This study looks at people with rare genetic changes that affect beta cells, which control blood sugar. Researchers will collect blood samples and optional MRI scans to find biomarkers and understand how these genes change body function. No treatment is given, and participants co…

This study looks at how heart rate affects metabolism in people with heart failure and diabetes. Researchers will take small samples of fat, muscle, and blood during pacemaker surgery to understand the link. The goal is to find new ways to treat heart failure by targeting metabol…

This study aims to create a prediction model using artificial intelligence and statistics to identify which people with diabetes are at risk of developing foot ulcers. Researchers will analyze health records and demographic data from 100,000 adults in Sweden. The goal is to impro…

This study will follow 20,000 adults in rural China for three years to understand how chronic diseases like high blood pressure, diabetes, and frailty develop. Participants will provide health data and samples to build a comprehensive database. The goal is to create better diseas…

This study is testing whether people with diabetes can collect their own blood at home (using a finger prick or a device on the upper arm) to check blood sugar, cholesterol, and thyroid levels. The results will be compared to standard blood draws done by a nurse in the clinic. Th…

This study tests whether a mild, non-invasive electrical stimulation of the vagus nerve through the ear can improve motivation and mood in people with depression. Researchers will compare 60 depressed patients and 60 healthy controls, looking at how insulin sensitivity affects th…

This study tests a new imaging tracer called 11C-Martinostat that lights up a specific enzyme (histone deacetylase) in the heart during a PET-MRI scan. Researchers will compare enzyme activity in people with aortic stenosis or diabetes to healthy volunteers. The goal is to see if…

This study is building a worldwide registry for people with Wolfram syndrome, a rare genetic disorder causing diabetes, vision loss, and hearing problems. Researchers will track how the disease progresses over time and analyze participants' genetic information. The goal is to bet…

This study aims to understand how a person's weight and blood sugar levels influence the activity of genes in tissues that process sugar and fat. Researchers will collect tissue samples from 20,000 adults undergoing abdominal surgery. The goal is to learn more about the link betw…

This study looks at whether the chemicals in your breath change throughout the day and if those changes are different for people with diabetes. Researchers will measure breath samples from 60 adults—some without diabetes, some with type 1, and some with type 2. The goal is to lea…

This study will follow 1000 pregnant women to find what raises the risk of gestational diabetes and create a tool to predict it early. Then, some women will try a personalized health plan (GLOW plan) to see if it improves blood sugar control. The goal is to reduce short- and long…

This study aims to identify subgroups of people with diabetes who share similar patterns between their blood sugar levels and mental health. By using smartphone surveys and continuous glucose monitors, researchers will create 'digital twins'—virtual models that can predict how me…

This study looks at how common memory problems are in older adults (65+) with type 2 diabetes. It then tests a program that combines several lifestyle changes to see if it can prevent or slow down memory loss. About 420 people will take part, and their thinking skills will be com…

This study looks at how a substance called lactate affects blood flow to the brain in people with and without obesity. Researchers will measure brain blood flow and lactate levels during rest and exercise. The goal is to understand if short-term exercise training can improve lact…

This study tests whether a bedside bone biopsy, done in the patient's room, works as well as the usual surgical or radiology-guided biopsy to diagnose bone infection in diabetic foot ulcers. The trial will include 320 adults with diabetes and signs of foot bone infection. If the …

This study is for people with diabetic macular edema, a condition that causes vision loss. Researchers want to see if certain substances in the blood and patterns on eye scans can predict how well a patient will respond to two common treatments: anti-VEGF injections or a dexameth…

This observational study follows 200 adults with chronic kidney disease and a type of heart failure (HFpEF), some taking SGLT2 inhibitors (flozins) and some not. Researchers will measure arterial stiffness, heart function, and kidney decline over time to see if flozins are linked…

This study tests a high-resolution imaging system to see tiny structures in the eye that routine tools cannot detect. Researchers will scan 1,200 people with various eye conditions and healthy volunteers. The goal is to better understand diseases like glaucoma, diabetes, and reti…

This study follows 800 people who recently had acute pancreatitis to see who develops diabetes and why. Participants are observed for 36 months with tests and surveys. No new treatments are tested; the goal is to learn how and why diabetes occurs after pancreatitis.

This study tests whether wearing noise-canceling earplugs can lower stress and reduce heart disease risk in people annoyed by traffic noise. Researchers will use brain and blood vessel scans to measure changes over 6 months in 26 adults with heart risk factors. The goal is to see…

This study uses MRI to measure pancreas size in pregnant women and their babies, since smaller pancreases are linked to diabetes. Researchers will follow 87 women from early pregnancy to one year after birth. The goal is to see how pancreas changes relate to diabetes, which could…

This study collects plucked hair follicles from 100 healthy volunteers to see if cells from them can be grown and turned into stem cells. Researchers will then try to turn those stem cells into pancreatic or blood cells for disease modeling and future cell replacement therapies. …

This study examines whether using advanced automated insulin pumps soon after diagnosis can protect brain growth and thinking skills in children aged 5-7 with type 1 diabetes. Researchers will compare brain scans and cognitive tests over 18 months between children using standard …

This study looks at whether certain proteins in the blood can predict postoperative delirium (sudden confusion after surgery) in elderly patients with diabetes. Researchers will measure levels of TGF-β, ADNP, MAP6, and PGC-1α in 180 participants before surgery and track who devel…

This study looks at how high blood pressure, diabetes, and high cholesterol affect the tiny blood vessels in the back of the eye. Researchers will use a special, non-invasive camera to take detailed images of the retina and track changes over five years. The goal is to see if eye…

This study is collecting information from 200 patients with diabetic foot ulcers admitted to 5 Azar Hospital in 2024. Researchers will analyze blood tests and other data to see how they relate to ulcer severity. The goal is to find patterns that could help doctors prevent and man…

This study looks at how taking multiple medications (polypharmacy) affects the health of elderly people with chronic diseases like heart disease, diabetes, and high blood pressure. Researchers will survey 2000 patients aged 65 and older over two years to understand their medicati…

This study will follow 9,000 people with type 2 diabetes and high blood pressure who are already taking dapagliflozin. Researchers want to see how well the drug controls blood sugar and blood pressure in real-life settings. It is an observational study, meaning no new treatment i…

Researchers at Mayo Clinic are studying 600 Somali-American adults to understand how common obstructive sleep apnea is and how it affects heart health. Participants will have sleep tests, blood pressure monitoring, and glucose testing. The goal is to learn about unique risk facto…

This study is building a registry of genetic and health information from 3,000 people with conditions like diabetes, high cholesterol, cancer, and heart disease. The goal is to help doctors choose the safest and most effective medications based on a person's genetic makeup. Parti…

This study uses ultrasound to measure the size and appearance of leg nerves in people with type 2 diabetes who have nerve damage (diabetic polyneuropathy). Researchers will then test how these nerve measurements relate to balance, walking, and daily life. The goal is to better un…

This pilot study is testing whether wearable devices like smartwatches, blood pressure monitors, and smart scales can help patients recover after a stay in the intensive care unit (ICU). Many ICU survivors face physical and mental challenges, known as Post-Intensive Care Syndrome…

This study follows 4,094 adults in Shanghai who were part of an earlier health survey. Researchers will track them for up to 10 years to see how heart disease, kidney problems, and metabolic conditions like diabetes and obesity develop and interact. The goal is to better understa…

This study aims to understand how fat buildup in the pancreas (pancreatic steatosis) is linked to type 2 diabetes and metabolic syndrome. Researchers will use a special ultrasound technique to measure pancreatic fat and compare it with blood sugar and other metabolic tests. 100 a…

This study investigates how red blood cells influence heart attack risk in people with type 2 diabetes. Researchers will collect blood from 500 participants (patients with heart attacks, type 2 diabetes, and healthy volunteers) and test the cells in the lab to understand their ef…