Could an asthma drug slow kidney damage in diabetes?
NCT ID NCT07022418
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether formoterol, a drug already used for asthma, can help control diabetic kidney disease. About 120 adults with type 2 diabetes and kidney problems will be randomly assigned to add formoterol to their usual care or continue usual care alone. The main goal is to see if the drug is safe and worth testing in a larger trial.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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About 120 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Dec 2025
- Expected to finish
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Nov 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adults aged 18-75 * Diagnosis of type 2 diabetes according to American Diabetes Association (ADA) criteria * On stable medical therapy for at least 3 months * Stage CKD G2 to G3b; A2-A3 as defined by eGFR with no requirement for renal biopsy for diagnosis * Diabetic kidney disease as per Nephrologist * Urinary albumin to creatinine excretion rate (UACR) 200-5000 mg/g/24hrs on at least two occasions (one of these can be a spot UACR) * HbA1c \<8% * Receiving stable doses of ACE inhibitor or ARB therapy prior to screening (at least 3 months, unless contraindicated) and/or a stable dose of an SGLT inhibitor (at least 3 months preceding enrollment) * Receiving stable doses of all additional anti-HTN medications, insulin, oral and injectable non-insulin agents and cholesterol lowering medications at least 3 months prior (unless contraindicated) to randomization and agree to maintain until the study's conclusion. * Willing and able to comply with schedule of events and protocol requirements, including written informed consent. Exclusion Criteria: * Female subjects who are pregnant or breast feeding or who plan on becoming pregnant * Currently take beta-agonists * Organ transplant recipients * Any history of New York Heart Association (NYHA) class III/IV heart failure or recent history of serious heart problem (CABG, stroke, MI) in the past 12 months * Any history of asthma * Patients with serum potassium levels \<3.5 mEQ/L * Patients with uncontrolled HTN SBP \>150mmHg, DBP \>95mmHg * EKG showing QTc elongation or tachyarrhythmia; including sinus tachycardia \>100bpm * Contraindications to formoterol fumarate (hypersensitivity, including patients with known hypersensitivity to ACE inhibitors or ARBs) * Advanced organ failure * Untreated/uncontrolled cardiovascular, pulmonary, or gastrointestinal disease * Patients with BMI \>50 * Active untreated cancer * Alcohol or drug abuse in the past 6 months * Being involuntarily incarcerated * Participating in another interventional study * Unable or unwilling to do the 36-week intervention
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Medical University of South Carolina
RECRUITINGCharleston, South Carolina, 29425, United States
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Other studies related to the condition(s) this trial covers.
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- Can we predict kidney damage in young diabetics before it starts?