POSTOPERATIVE PAIN

This study tests a program to help people with chronic pain who take opioids before surgery reduce or stop their opioid use afterward. The program includes pain education, counseling, and a mobile app. About 210 adults will take part to see if the program improves pain management…

This study tests whether a nerve block called the external oblique intercostal plane block can reduce pain after liver transplant surgery. Sixty adults receiving a liver transplant will be split into two groups: one gets the nerve block plus standard care, the other gets standard…

This study looks at whether a special ultrasound-guided nerve block (called Quadro-Iliac Plane Block) can help control pain after lumbar spine surgery. Researchers will follow 60 adults who are having elective back surgery and compare pain scores, opioid use, and side effects in …

This study compares two pain control methods after hip surgery: a fascia iliaca block (an injection near the hip) and intrathecal nalbuphine (a painkiller given in the spine). The goal is to see which one delays the need for extra pain medicine. The trial will include 120 adults …

This study looks at whether having patients keep a pain diary after gallbladder surgery helps them report their pain more accurately than standard check-ins. About 142 adults having their first laparoscopic gallbladder removal will either use a diary or get usual care. The goal i…

This study tests a newer nerve block (EOIB) against a standard one (ESPB) for pain after laparoscopic stomach removal. About 184 adults having this surgery will be randomly assigned to receive one of the two blocks. The goal is to see if the newer block provides similar pain reli…

This study tests two types of nerve blocks to see which one works better for pain after breast cancer surgery. 50 women having a mastectomy will get either a newer or a standard block. The goal is to find a way to reduce the need for strong painkillers like morphine and help pati…

This study tests an experimental pain-relief injection called TLC590 for people recovering from bunionectomy (foot bone surgery). About 300 adults will receive either TLC590, a standard painkiller, or a placebo right after surgery. The main goal is to see if TLC590 reduces pain i…

This study tests whether a robotic seal called PARO can help reduce agitation, anxiety, and pain in adults after visceral surgery. About 300 participants will either use PARO or receive standard care. The goal is to see if interacting with the robot improves recovery and reduces …

This study tests whether a combination of two medicines given as a nose spray can reduce pain in children after tonsil and adenoid surgery. About 160 children aged 3 to 7 will take part. The goal is to find a safe and effective way to manage pain without strong side effects.

This study tests a new pain-blocking injection called the External Oblique Intercostal Plane Block for people having major upper abdominal surgery (like stomach, liver, or pancreas surgery). The goal is to see if it reduces the need for strong painkillers (opioids) and improves r…

This study tests if a nerve block done during laparoscopic hernia repair can lower pain and help people recover faster. One hundred adults having elective hernia surgery will be randomly assigned to get the block or not. The block uses a numbing medicine injected under direct vis…

This study tests whether giving oxytocin through an IV during surgery can lower pain and the need for strong painkillers after a minimally invasive hysterectomy. Researchers will compare oxytocin to a placebo in 152 adults aged 18-65. The goal is to find a safer way to manage pos…

This study compares two common pain medicines, fentanyl and remifentanil, given during gallbladder surgery to see which one helps the bowel start working again sooner and controls pain better. About 106 adults having planned laparoscopic gallbladder removal will take part. The go…

This study tests whether using virtual reality (VR) can help people recover better and leave the hospital sooner after major abdominal surgery. Sixty adults will either use VR for guided relaxation before and after surgery or receive standard care. The goal is to see if VR can re…

This study looks at pain after root canal retreatment and compares two medications placed inside the tooth between visits: a standard one (calcium hydroxide) and a newer one (Bio-C Temp). Sixty adults needing retreatment on a single-rooted tooth will rate their pain and report ho…

This study tests if a special nerve block (external oblique intercostal block) can reduce pain and the need for strong painkillers after gallbladder removal surgery. About 56 adults having planned laparoscopic gallbladder surgery will either get the nerve block or not. The main g…

This study tests whether combining virtual reality with pleasant smells can lower pain and anxiety in people recovering from heart or lung surgery. About 80 adults scheduled for cardiothoracic surgery will either receive the VR-and-scent therapy or standard care. The goal is to s…

This study tests whether giving ketamine during surgery can reduce pain, lower the need for opioids, and improve depression and PTSD symptoms in adults with serious orthopedic injuries. About 90 participants will be randomly assigned to receive either ketamine or standard anesthe…

This study compares an herbal extract called Aescin (Reparil) to ibuprofen for managing pain, facial swelling, and jaw stiffness after wisdom tooth removal. About 100 adults aged 18-40 will take either Aescin or ibuprofen for five days after surgery. Researchers will measure pain…

This study looks at two different ways to numb the belly area in children aged 1 to 7 who are having surgery for an undescended testicle. The goal is to see which method reduces pain and the need for extra pain medicine after the operation. About 70 children will take part, and n…

This study compares two types of nerve blocks (meta-PENG and fascia iliaca) to see which one better reduces pain during hip fracture surgery. About 80 adults having hip fracture surgery will receive one of the blocks as part of their routine care. The goal is to find which block …

This study tests whether a numbing medicine injected into the cervix area can lower pain after a type of keyhole surgery (vNOTES) for pelvic organ prolapse. About 58 women having this surgery will be randomly assigned to get either the numbing drug or a placebo. Researchers will …

This study tests two different ultrasound-guided nerve blocks to see which one works better for pain after mastectomy surgery. About 66 women having a mastectomy will receive one of the two blocks before surgery. The goal is to find a method that reduces pain, delays the need for…

This study looks at two different methods to control pain after elective lower back surgery. One method uses an ultrasound-guided nerve block, while the other uses standard pain medications given through a vein. Researchers will use a special monitor that tracks heart rate to see…

This study compares two types of nerve blocks—sacral erector spinae plane block and pericapsular nerve group block—for pain relief after hip replacement surgery. Researchers will enroll 80 adults aged 50 to 90 with a broken hip. The goal is to see which block provides better pain…

This study tests whether a special nerve block given before surgery can lower pain and the need for strong painkillers after minimally invasive heart valve surgery. About 90 adults will receive either the nerve block or a placebo. The goal is to see if this approach leads to bett…

This study tests whether a gel called RADA-16 can reduce bleeding and pain after tonsil removal in adults. About 134 participants will either receive the gel or standard care. They will track symptoms through online surveys every two days for 15 days after surgery.

This study compares 4 mg and 8 mg of dexamethasone (a steroid) given at the surgical site to reduce pain after dental implant surgery. About 138 adults will be randomly assigned to receive one of the two doses or a placebo. Pain levels and the number of painkiller tablets needed …

This study compares two pain-relief medicines given as a nerve block during gallbladder removal surgery. About 86 adults will receive either liposomal bupivacaine or ropivacaine to see which provides better pain control and recovery. Participants are followed for 3 months to chec…

This study looks at whether giving morphine during coronary artery bypass surgery can lower pain after the operation. About 60 adults having elective bypass surgery will be randomly assigned to receive either morphine or standard care. Researchers will measure pain levels and sid…

This study is testing whether adding a low dose of morphine to the standard spinal anesthesia can better control pain after a planned C-section, without causing serious side effects for mothers or babies. About 1,300 women having planned C-sections will be randomly assigned to re…

This study looks at whether adding an ultrasound-guided nerve block to standard pain medicine can lower the amount of strong painkillers (opioids) needed after lower back surgery. Fifty adults having elective lumbar spine surgery will be randomly assigned to get either the nerve …

This study compares two types of pain blocks—sacral erector spinae plane block and dorsal penile nerve block—in 70 boys aged 1-7 years having hypospadias surgery. The goal is to see which block provides better pain control after the operation. Researchers will measure pain scores…

This study tests three different agents (sodium hypochlorite, chlorhexidine, and cold saline) to control bleeding during a partial pulpotomy, a procedure that removes only the top part of the tooth's nerve to save the tooth. Researchers will measure pain levels and how well the n…

This study tests whether a special oral wound dressing (Ora-Aid) works better than a standard plastic guard (palatal stent) for reducing pain after a gum graft procedure. Twenty healthy adults will be randomly assigned to one of the two treatments. Pain levels, painkiller use, wo…

This study looks at whether a special nerve block called FRONT can help people recover better after hip replacement surgery. About 80 adults having hip replacement will either get this nerve block or standard care. The main goal is to see if it improves their overall recovery and…

This study compares two types of ultrasound-guided nerve blocks to control pain after laparoscopic gallbladder removal. 70 adults having elective surgery will receive one of the two blocks, and researchers will measure how much pain medication they need in the first 24 hours. The…

This study tests two types of ultrasound-guided nerve blocks to see which better controls pain after open kidney cancer surgery. 56 adults scheduled for nephrectomy will receive either an external oblique intercostal plane block or a posterior transversus abdominis plane block. T…

This study compares two types of nerve blocks to control pain after open-heart surgery through the breastbone. Fifty adults having planned heart surgery will receive either a combination of two blocks or a single block, along with standard pain medicines. The goal is to see which…

This study tests whether a 15-20 minute hypnosis session before abdominal surgery can lower anxiety and pain. About 48 adults will be randomly assigned to receive either hypnosis or standard psychological preparation. The goal is to see if hypnosis leads to less worry before surg…

This study tests three different nerve block techniques to manage pain after shoulder surgery. The goal is to find a method that works well but avoids the breathing problems that can happen with the standard block. About 120 adults having shoulder arthroscopy will take part, and …

This study tests two different ointments—lignocaine and glyceryl trinitrate (GTN)—to see which one works better for pain relief after hemorrhoid surgery. About 64 adults with severe hemorrhoids will be randomly assigned to receive one of the ointments. Researchers will measure pa…

This study tests two different numbing techniques—one that injects medicine around the spine and another that targets a specific back muscle—to see which better reduces bleeding and pain during lower back fusion surgery. About 62 adults will take part. The goal is to improve reco…

This study looks at whether a special nerve block, called a transversalis fascia plane block, can help control pain and reduce the need for strong painkillers after laparoscopic kidney donation surgery. About 50 living kidney donors will take part. Half will get the nerve block p…

This study tests whether a special nerve block (paravertebral block) can better control pain after a mastectomy with immediate breast reconstruction compared to usual pain medicine. The goal is to see if this approach lowers pain scores in the first few days after surgery and may…

This study tests whether a numbing injection around the cervix during vaginal hysterectomy for pelvic organ prolapse can lower pain and reduce the need for opioid painkillers after surgery. About 56 adults having this surgery will receive either the numbing medicine or a placebo …

This study looks at two ways to control pain after laparoscopic kidney donation surgery: a nerve block injected into the belly muscles before surgery, or numbing medicine injected into the surgical cuts at the end. Pain can make people take shallow breaths, which may harm lung fu…

This study looks at whether a non-invasive device called TENS, which sends mild electrical pulses through the skin, can help people who are having their gallbladder removed. The goal is to see if it lowers anxiety before surgery, reduces pain afterward, and makes patients more sa…

This study tests whether giving a combination of two drugs (lidocaine and dexmedetomidine) during weight-loss surgery can lower pain, inflammation, and cell stress afterward. About 104 adults having laparoscopic bariatric surgery will be randomly assigned to receive the combo, on…

This study compares two ways to manage pain after heart surgery through the breastbone. One method uses a single nerve block, while the other combines two different blocks. The goal is to find which approach provides better pain relief and reduces the need for strong painkillers.…

This study compares two types of pain blocks—sacral erector spinae plane block and caudal epidural block—in 60 children aged 6 months to 7 years undergoing hypospadias repair. The goal is to see which method provides better pain relief in the first 24 hours after surgery. Researc…

This study tests whether a special ultrasound-guided nerve block (ESP block) can reduce pain and the need for strong painkillers after kidney removal surgery. About 66 adults having open nephrectomy will be randomly assigned to receive either the nerve block plus standard care or…

This study tests whether a computer-controlled way of giving anesthesia (target-controlled infusion) works better than the standard manual method during brain surgery. About 70 adults having planned brain surgery will take part. The goal is to see if the computer method lowers th…

This study compares three different intravenous pain medicines (Fentanyl, Tramadol, and Ibuprofen) given after chest surgery to see which one controls pain and helps breathing best. It includes 135 adults having video-assisted chest surgery. The goal is to find the most effective…

This study tests whether a special nerve block (quadro-iliac plane block) can reduce pain and the need for painkillers after kidney stone surgery. About 60 adults having this surgery will be randomly assigned to get the block or not. The main goal is to see if the block lowers pa…

This study compares two pain relief methods for adults having video-assisted chest surgery. One method is a nerve block injection near the ribs, and the other is a spinal injection of morphine. The goal is to see which approach reduces pain and the need for opioid painkillers aft…

This study compares two types of nerve blocks (paravertebral block and external oblique intercostal block) to standard pain medicine for people having gallbladder removal surgery. The goal is to see which method reduces pain and the need for opioids like tramadol. About 147 adult…

This study compares two types of nerve blocks—paravertebral block and erector spinae plane block—for controlling pain during thoracotomy (chest surgery). The goal is to see which method reduces the need for opioid painkillers during and after surgery, using a special pain monitor…

This study aims to find the most effective dose of morphine given into the spinal fluid to control pain after a C-section. Researchers will test different doses in 100 healthy women having planned C-sections, adjusting the dose based on how well the previous participant's pain wa…

This study tests a single dose of tegileridine fumarate, a new pain medicine, given during orthopedic surgery (like hip or knee replacement). The goal is to find the dose that works for 90% of patients to control pain right after surgery without needing extra pain relief. About 1…

This study compares a new nerve block technique (EOIB) to a standard combination of blocks for pain after laparoscopic stomach removal. The goal is to see if the new method works just as well or better, reducing the need for strong painkillers. One hundred adults scheduled for th…

This study looks at whether adding a TAP block (a numbing injection in the belly wall) to standard pain care helps women feel less pain after a C-section. About 70 women having a planned C-section under spinal anesthesia will be randomly assigned to get either the TAP block or us…

This study tests whether a special nerve block, given during surgery, can reduce pain and the need for morphine in people who donate part of their liver. 64 donors will be randomly assigned to receive either the nerve block plus standard pain medicine, or standard pain medicine a…

This study compares two ways to manage pain after minimally invasive surgery for pectus excavatum (a sunken chest). One method freezes the nerves between the ribs (cryoanalgesia), and the other uses an epidural block. The goal is to see which approach leads to a shorter hospital …

This study tests whether a nerve block called a rectus sheath block can reduce pain and the need for strong painkillers after heart surgery. About 75 adults having heart surgery with chest tubes will be randomly assigned to receive the block or not. Researchers will measure pain …

This study tests whether a compressive cold therapy device (Game Ready®) can help people use fewer opioid pain pills after knee replacement surgery. About 74 adults aged 60-80 will either use the device or standard ice packs four times daily for a week. Researchers will track pai…

This study tests two different nerve-block techniques to control pain after total knee replacement. About 78 adults having knee surgery will receive one of two ultrasound-guided injections targeting the back of the knee. The goal is to see which method provides better pain relief…

This study tests a new type of nerve block (deep rectus sheath block) to reduce pain after laparoscopic gallbladder removal. About 60 adults will receive either this block or standard care, and researchers will measure how much morphine they need in the first 24 hours. The goal i…

This study tests whether a numbing injection near the breastbone can lower the amount of strong painkillers (opioids) needed during heart surgery. About 80 adults having planned heart surgery will either get the injection plus standard anesthesia or standard anesthesia alone. The…

This study looks at whether using lidocaine (a numbing medicine) as a spray inside the belly plus an IV drip can reduce pain after laparoscopic fibroid removal. About 100 adults having this surgery will take part. The goal is to see if this approach lowers the chance of moderate …

This study tests whether a special nerve block (rhomboid intercostal block) can reduce pain and the need for opioid painkillers after breast implant surgery. About 40 women will be randomly assigned to receive either the nerve block plus standard anesthesia or standard anesthesia…

This study tests two types of nerve blocks (EXORA and ESP) to see which one works better for pain after gallbladder removal. About 114 adults having laparoscopic gallbladder surgery will receive one of the blocks before surgery. The goal is to find which block reduces the need fo…

This study tests whether simple breathing exercises (pranayama) can reduce pain and improve comfort for women after a cesarean section. About 100 women who had a planned C-section and feel at least moderate pain will be asked to do these exercises. The goal is to see if this drug…

This study tests if a special nerve block, called SPSIPB, can improve recovery and reduce pain after minimally invasive heart bypass surgery. Sixty adults will be randomly assigned to receive either the nerve block plus standard care, or standard care alone. The goal is to see if…

This study tests if giving ketamine before laparoscopic sleeve gastrectomy (a type of weight-loss surgery) can reduce pain after the operation. Researchers will compare how long it takes for patients to need extra pain medicine. The study involves 90 adults with a BMI between 35 …

This study is for children under 6 years old who need heart surgery. It tests a pain medicine called EXPAREL to see if it works well and is safe compared to a standard painkiller. The medicine is given near the surgery area to help with pain after the operation. About 48 children…

This study looks at whether giving a numbing injection to the belly muscles before or after gallbladder surgery helps reduce pain and the need for strong painkillers. About 96 adults having their gallbladder removed will be randomly assigned to get the injection either before the…

This study compares two types of nerve blocks (RIPB and EOIPB) to see which one provides better pain relief after gallbladder removal surgery. About 60 adults having laparoscopic cholecystectomy will receive one of the two blocks. The main goal is to measure how much pain medicat…

This study tests whether melatonin (a natural sleep hormone) works as well as pregabalin (a nerve pain drug) for managing pain and anxiety after spine surgery. About 105 adults aged 21-60 having elective spine surgery will receive one of the two medicines right after surgery. Res…

This study looks at whether a new ultrasound-guided nerve block called the Quadro-Iliac Plane Block can help control pain after lower back surgery. Researchers will measure how much pain medicine patients need and how well they recover in the first two days. The study involves 80…

This study tests whether a special nerve block (Quadro-Iliac plane block) helps people recover better after laparoscopic inguinal hernia surgery. About 70 adults aged 18-65 having planned surgery will be randomly assigned to get the nerve block or a placebo, along with standard a…

This study tests whether injecting botulinum toxin (Botox) into the anal muscle one week before hemorrhoid removal surgery can lower pain after the operation. About 292 adults with severe hemorrhoids will get either Botox or a placebo injection before surgery. Researchers will tr…

This study tests whether giving a combination of nerve blocks right after heart bypass surgery can reduce pain and the need for strong painkillers like opioids. About 56 adults having planned bypass surgery will be randomly assigned to get either the nerve blocks plus standard pa…

This study is testing whether a low dose of ketamine can reduce the amount of strong painkillers (opioids) needed and improve pain control in people recovering from thoracic endovascular aortic repair (TEVAR). About 30 adults scheduled for this surgery will receive either ketamin…

This study looks at whether giving a nerve block (called an erector spinae plane block) before or during lumbar disc surgery can lower the amount of painkillers and anesthesia needed. The goal is to reduce side effects like nausea and help patients recover faster. About 60 adults…

This study tests whether using a free mindfulness app for 4 weeks can lower anxiety in adults waiting for planned surgery. Forty participants will either use the app plus standard care or receive standard care alone. Researchers will measure anxiety on the day of surgery, as well…

This study tests whether injecting a local anesthetic (bupivacaine) at the small incision sites and the vaginal cuff can lower pain after total laparoscopic hysterectomy. About 120 women having the surgery for non-cancer reasons will be randomly assigned to receive the injection …

This study looks at whether getting women up and moving early after a C-section, along with drinking coffee, can help their bowels work better, reduce pain, and improve mood. About 60 women who had a planned C-section will take part. Researchers will check pain, bowel function, a…

This study compares two types of nerve blocks (DIPB and SIFIB) to see which provides better pain relief after hip replacement surgery. Seventy adults having hip surgery will be randomly assigned to receive one of the blocks. The goal is to find which block reduces pain and the ne…

This study tests whether rinsing the belly with saltwater during a scarless hysterectomy (vNOTES) can lower pain and the need for painkillers after surgery. About 94 women having the procedure will be randomly assigned to get the rinse or not. The goal is to see if this simple st…

This study tests whether combining two ultrasound-guided pain blocks (M-TAPA and EXOP) works better than M-TAPA alone for controlling pain after laparoscopic gynecologic surgery. About 86 women will have their pain scores, need for extra pain medicine, and recovery quality measur…

This study tests whether a gel called RADA16 can reduce pain and bleeding after children have their tonsils removed. About 134 children aged 3 to 17 will either get the gel or standard care. Families will track symptoms through online surveys for 30 days after surgery.

This study tests whether using a special brain-wave monitor (Conox) during anesthesia can reduce the amount of pain medicine children need during tonsil and adenoid surgery. About 128 children aged 3 to 12 will be randomly assigned to either standard monitoring or Conox-guided ca…

This study tests whether tea tree oil mouthwash works as well as chlorhexidine mouthwash for reducing pain, swelling, and jaw stiffness after having a wisdom tooth removed. About 54 adults will use one of the two mouthwashes three times a day for a week. Researchers will measure …

This study watches 254 adults after elective surgery to see what factors—like age, type of surgery, or anesthesia—affect how much pain medicine they need in the recovery room. No new treatments are given; researchers just collect data from normal care. The goal is to help doctors…

This study looks at how a person's genes and other factors influence pain after surgery. Researchers will follow 5,000 adults having planned operations to see if certain genetic variants are linked to pain levels and painkiller use. The goal is to better understand and potentiall…

This study looks at whether a person's genetic makeup influences how well the painkiller nalbuphine works after abdominal or pelvic surgery. Researchers will collect blood samples from 263 adults before and after surgery to analyze genes linked to pain relief. The goal is to impr…

This study tests a new device that measures pain by looking at changes in pupil size after a gentle electrical stimulation. Researchers will enroll 100 children and teens ages 6 to 21 who are having surgery or bone marrow transplant. The device is non-invasive and does not change…

This study looks at whether the quality of a woman's sleep before breast cancer surgery affects her pain and inflammation after the operation. Researchers will track 150 women, measuring their sleep quality with a questionnaire and then monitoring their pain levels and immune res…

This study looks at whether the intense pain people feel right before emergency surgery can turn into chronic pain that lasts for months. Researchers will follow 693 adults having emergency orthopedic or abdominal surgery. They want to see if the level of pain before surgery pred…

This study looks at why some people have more pain than others after gum graft surgery. About 93 adults will answer surveys and track their pain for two weeks. The goal is to find out which factors—like anxiety or gum thickness—affect recovery, so doctors can better manage pain i…