POSTOPERATIVE PAIN

This study tests a dental surgery method for people with a narrow jawbone who need dental implants. The procedure involves splitting the bone and placing the implant at the same time, covering it with a special growth factor membrane to help healing. Ten adults aged 20 to 50 will…

This early-stage study tests a new medicine called SYH9089 for pain after abdominal surgery. About 60 adults will receive either the new drug, an active painkiller, or a placebo to see how safe and effective it is. The goal is to find the best dose and understand how well it cont…

This study compares two types of nerve blocks (SAPB and SPSIPB) to see which provides better pain relief after breast surgery (mammoplasty). Sixty women aged 18-85 will receive one of the two blocks before surgery. Researchers will measure pain levels, opioid use, and patient sat…

This study compares two methods for controlling pain after total hip replacement: a nerve block (PENG block) versus morphine given through a spinal injection. The goal is to see which approach reduces pain, lowers the need for additional opioids, and improves patient satisfaction…

This study tests if a surgeon can numb the knee during replacement surgery as effectively as an anesthesiologist using ultrasound. 48 adults having both knees replaced will get one method on each knee. The goal is to see if the surgeon's technique provides equal pain relief and r…

This study looks at whether adding a nerve block to the back of the hip to two standard front-hip blocks can improve pain relief after hip surgery. About 50 adults having hip surgery will be split into two groups to compare pain scores and the need for extra pain medicine in the …

This study compares two common pain relief methods for people having gallbladder removal surgery. The goal is to see which method better reduces pain and the need for strong painkillers. Sixty adults will be randomly assigned to receive either local anesthetic infiltration or an …

This study tests whether a special numbing medicine injected near the hip before surgery can provide better pain relief for up to 3 days after hip fracture surgery in older adults. The medicine is designed to release slowly, aiming to reduce pain and the need for strong painkille…

This study looks at women having planned C-sections to see if using a larger volume of the same amount of painkiller (bupivacaine) in a nerve block helps reduce pain and the need for extra morphine. 50 participants will receive one of two volumes, and their pain and morphine use …

This study tests whether spraying a numbing medicine (bupivacaine with epinephrine) over the diaphragm can reduce shoulder pain after laparoscopic gynecologic surgery. About 100 adults having benign gynecologic laparoscopy will be randomly assigned to receive the spray or a place…

This study compares two types of nerve blocks (SPSIP and Rhomboid Intercostal Block) to see which provides better pain relief after breast cancer surgery that also removes lymph nodes under the arm. About 60 women aged 18-65 will take part. The goal is to find a more effective wa…

This study tests a new pain medicine called suzetrigine for women recovering from pelvic surgery. The goal is to see if it controls pain as well as standard opioids but without the risk of addiction or side effects like drowsiness. About 120 women will take either suzetrigine or …

This study looks at two ways to manage pain after hip replacement surgery. One method numbs the front of the hip joint, and the other adds numbing to the back. The goal is to see if using both together provides better pain relief. About 40 adults having hip replacement will take …

This study compares two types of nerve blocks to manage pain after video-assisted lung surgery. Sixty adults will receive one of the two blocks, and researchers will measure pain levels, opioid use, and side effects over 24 hours. The goal is to find which block provides better p…

This early-stage study tests a new tablet called KHN702 for people with moderate to severe pain after surgery. About 24 adults will receive either the drug or a placebo to see if it safely reduces pain. The goal is to gather initial data on how well it works and how safe it is.

This study tests whether rinsing with hydrogen water can reduce pain, mouth sores, and inflammation in people recovering from oral cancer surgery. About 36 adults who had a free flap reconstruction will use hydrogen water mouth care for 7 days. Researchers will measure changes in…

This study compares two ways to manage pain after ear tube surgery in 300 children aged 6 months to 6 years. One group gets standard pain medicine (fentanyl and ketorolac shots), and the other gets a nerve block (an injection near the ear). The goal is to see if the nerve block w…

This study looks at 50 adults having knee replacement surgery to find out which type of anesthesia works best for controlling pain and reducing the need for painkillers after the operation. Patients will receive either general anesthesia or spinal anesthesia, both combined with a…

This study looks at whether a special nerve block given during minimally invasive left-sided colon surgery can better control pain and reduce the need for opioids. Researchers will track pain, nausea, and recovery in 400 adults. The goal is to improve standard pain management and…

This study compares two types of nerve blocks to see which one better controls pain after open ventral hernia repair. Fifty adults scheduled for this surgery will receive one of the two blocks. The goal is to reduce the need for painkillers and lessen nausea and vomiting after th…

This study tests if a magnesium drip given after a C-section can lower pain and help new mothers recover faster. About 150 women having planned or non-urgent C-sections will be randomly assigned to receive either magnesium or a saltwater placebo. Neither the patient nor the care …

This study compares two types of nerve blocks used to manage pain after breast surgery (mastectomy). The goal is to see which block is easier for doctors to perform and which provides better comfort for patients. Researchers will enroll 64 adults aged 25-65 who are scheduled for …

This study looks at the best time to give a new pain drug called Anrikefon to adults having gallbladder surgery. About 274 people will either get the drug before anesthesia or right after the gallbladder is removed. The goal is to see which timing reduces pain better and helps pa…

This study tests if adding a common anti-inflammatory drug (dexamethasone) to a long-lasting numbing medicine (liposomal bupivacaine) can make pain relief last longer after shoulder surgery. About 80 adults having shoulder surgery with a nerve block will be randomly assigned to g…

This study compares two types of nerve blocks (iPACK and BiFeS) to see which one works better for pain after total knee replacement. About 100 adults having knee surgery will receive one of the two blocks. Researchers will measure pain scores, how much pain medicine is needed, an…

This study tests whether a combination of two drugs (dexmedetomidine and ketamine) can replace opioids during kidney stone surgery. Sixty adults will receive either this opioid-free approach or standard opioid-based anesthesia. The goal is to see if the opioid-free method reduces…

This study compares two numbing techniques—RIB and PVB—to control pain after video-assisted chest surgery. Sixty adults will be randomly assigned to receive one of the two blocks after surgery. Researchers will measure pain levels and side effects over 24 hours to find which meth…

This study will compare two types of nerve blocks to control pain after laparoscopic sleeve gastrectomy (weight-loss surgery). Sixty adults will be randomly assigned to receive either an intertransverse process block or a subcostal transversus abdominis plane block. The goal is t…

This study compares two types of nerve blocks to control pain after laparoscopic hysterectomy. Sixty women aged 18-65 will receive either an Intertransverse Process Block or an M-TAPA block. The main goal is to see which block provides better pain relief in the first 24 hours aft…

This study tests whether placing a loxoprofen sodium patch on the skin before video-assisted lung surgery can reduce pain and the need for strong painkillers afterward. About 156 adults aged 18 to 64 having lung surgery will be randomly assigned to get the patch or a placebo. The…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can reduce pain and the need for strong painkillers after complex spinal surgery. About 98 adults having major back surgery will be randomly assigned to receive either the real stimulati…

This study aims to find out whether taking acetaminophen (Tylenol) by mouth or through an IV works better for pain control after lumbar spine fusion surgery. About 180 adults will be randomly assigned to receive either oral or IV acetaminophen for 48 hours after surgery. Research…

This study tests an experimental pain medicine called CPL-01 in 112 adults who are having bunion surgery. Half will get the drug, half a placebo. Researchers will measure how much pain people feel and how much extra pain medicine they need. The goal is to see if CPL-01 provides b…

This study tests a new type of nerve block (r-PVB) to reduce pain and improve recovery after stoma closure surgery. 250 adults will receive either the new block or standard care. The goal is to see if the new method lowers pain scores and helps patients feel better faster.

This study compares two natural medicines—propolis and green tea extract—against the standard calcium hydroxide paste for reducing pain and sudden flare-ups after root canal retreatment. Forty adults with a failed root canal in a single-rooted tooth will receive one of the three …

This study tests whether a new type of nerve block, called SPSIPB, can reduce pain and the need for strong painkillers after heart surgery. About 120 adults having elective heart surgery will either receive this block or standard care. The goal is to see if the block leads to les…

This study compares a new under-the-tongue painkiller (sublingual sufentanil) to standard oral morphine for managing pain after surgery. Researchers want to see if the new drug helps patients recover their health faster and better. About 1,150 adults having surgery will take part…

This study looks at whether using a pillow placed behind the shoulder after rotator cuff repair surgery can help reduce pain and improve sleep. About 126 adults aged 40 to 70 who are having this surgery will be invited to use the pillow or not, based on their choice. Their pain, …

This study compares two types of nerve blocks (ITPB and M-TAPA) to see which provides better pain relief after laparoscopic gallbladder removal. Sixty adults having elective surgery will be randomly assigned to receive one of the two blocks. Researchers will measure pain scores, …

This study tests whether injecting tramadol, with or without dexamethasone, into the knee after arthroscopy can reduce pain and the need for extra painkillers. About 135 adults having minor knee surgery will be randomly assigned to receive one of two drug combinations or a placeb…

This study tests two methods to reduce pain after keyhole stomach surgery for cancer. One method uses a standard ultrasound-guided nerve block, while the other applies a special temperature-sensitive gel mixed with numbing medicine directly to the surgical site. The goal is to se…

This study tests if using scalp nerve blocks and a drug called dexmedetomidine can reduce the need for strong opioid painkillers and prevent confusion after brain tumor surgery. About 2000 adults having brain surgery will be randomly assigned to receive one or both treatments, or…

This study compares two common root canal cleaning solutions—chlorhexidine and sodium hypochlorite (bleach)—to see which one leads to less pain the day after the procedure. About 90 adults needing a root canal will be randomly assigned to one of the two solutions. Participants wi…

This study tests a new type of nerve block (called r-PVB) to see if it can reduce pain and help people recover faster after gallbladder removal surgery. About 250 adults having this surgery will be randomly assigned to get the nerve block or standard care. The goal is to measure …

This study tests two different nerve blocks to control pain after laparoscopic sleeve gastrectomy, a weight loss surgery. Sixty adults will be randomly assigned to receive one of the two blocks. The goal is to see which block provides better pain relief, reduces the need for stro…

This study tests two different numbing injections (TLIP block vs. retrolaminar block) to see which helps people recover better after lower back fusion surgery. About 70 adults having one- or two-level spine fusion will be randomly assigned to one of the two blocks. The main goal …

This study compares two types of nerve blocks to control pain after open gallbladder removal. Sixty-six adults having surgery will receive one of the two blocks along with standard anesthesia. The goal is to see which block provides better pain relief and reduces the need for ext…

This study looks at whether adding a steroid called dexamethasone to standard pain medicine helps people feel less pain after shoulder surgery. About 70 adults having shoulder arthroscopy will get either the steroid or a placebo, and researchers will measure how long it takes bef…

This study compares a new, simpler nerve block method to the traditional one for people having lung surgery with a camera (VATS). The goal is to see if the new method works just as well for pain control and helps patients recover faster. About 200 adults will be randomly assigned…

This early-phase trial will test whether a single dose of psilocybin is safe and practical for adults with opioid use disorder who are recovering from trauma surgery. About 70 participants will receive psilocybin during their hospital stay and be monitored for pain, mood, and opi…

This study compares two types of nerve blocks given during gallbladder removal surgery to see which one helps patients recover better. About 76 adults having planned laparoscopic gallbladder surgery will be randomly assigned to one of two block techniques. The main goal is to mea…

This study looks at 100 children aged 3-10 who are having their tonsils removed. Researchers want to find out if giving the anxiety medicine midazolam before surgery or during anesthesia works better to reduce stress and pain. The goal is to improve recovery and comfort for child…

This study looks at whether a hot water foot bath can reduce pain and help people pass gas sooner after laparoscopic gallbladder removal. About 62 adults will be randomly assigned to receive the foot bath or standard care. The goal is to find a simple, drug-free way to improve re…

This study tests whether a special nerve block (M-TAPA) can reduce pain and the need for strong painkillers after open-heart surgery. About 80 adults having elective open-heart surgery will receive either the block plus standard care or standard care alone. The goal is to see if …

This study tests a combination of pain medicines and local numbing to improve pain control after brain tumor surgery. The goal is to reduce the need for strong opioids, which can have side effects. 2000 adults having planned brain surgery will take part. The main measure is how m…

This study tests whether using a special vibration tool after wrist fracture surgery can improve pain control and reduce the need for opioid painkillers. About 100 adults who have had surgery for a broken wrist will use the vibration device and report their pain levels and medica…

This study tests a technique called cryoablation, where doctors temporarily freeze nerves in the chest during open-heart surgery. The goal is to see if this reduces pain, helps patients breathe deeper and cough better after surgery, and lowers the need for strong painkillers like…

This study looks at whether listening to music and using Emotional Freedom Techniques (a type of tapping therapy) can help people recover after knee arthroscopy. About 85 adults having knee surgery will try these simple, drug-free methods to see if they reduce pain, fear of movem…

This study will compare two types of nerve blocks (ITP and ESP) to see which one provides better pain relief after robotic colorectal surgery. Fifty adults having this surgery will be randomly assigned to receive one of the two blocks. The main goal is to measure pain levels and …

This study looks at whether adding two types of nerve blocks (parasternal and adductor canal blocks) to standard pain medicine can better control pain and reduce the need for strong painkillers after coronary artery bypass surgery. About 120 adults having planned bypass surgery w…

This study looks at whether adding electroacupuncture to standard numbing medicine can lower pain and stress during impacted wisdom tooth extraction. Sixty adults aged 25-35 will be split into three groups: real electroacupuncture, fake acupuncture, or no extra treatment. Researc…

This study tests whether giving a single dose of methadone at the start of surgery can provide better pain relief and faster recovery compared to standard short-acting opioids. About 400 adults having intermediate-risk noncardiac surgery will take part. The main goal is to see if…

This study compares two common nerve block techniques for shoulder surgery pain. Sixty adults having arthroscopic shoulder surgery will receive either an interscalene block alone or a combined interscalene and suprascapular block. Researchers will measure pain scores, painkiller …

This study tests a special numbing injection called M-TAPA to see if it reduces pain and the need for strong painkillers after laparoscopic hysterectomy. About 60 adults having this surgery will be randomly assigned to get either the nerve block or standard pain care. Researchers…

This study compares two types of nerve blocks—Quadroiliac Plane Block and Suprainguinal Fascia Iliaca Compartment Block—for pain after hip surgery. About 60 adults will rate their pain on a 0-10 scale and track how much extra painkiller they need. The goal is to see which block p…

This study tests whether a single injection of dexamethasone given before removing an impacted lower wisdom tooth can lessen pain and difficulty opening the mouth afterward. 268 adults aged 18 to 55 will be randomly assigned to receive either the steroid or no extra medication. P…

This study tests whether two types of breathing exercises—pranayama and pursed-lip breathing—can help reduce pain and anxiety after breast surgery. About 126 adults having their first mastectomy will be randomly assigned to one of three groups: pranayama, pursed-lip breathing, or…

This study tests whether a cold anti-inflammatory rinse (ketorolac tromethamine at 2-5°C) placed inside the tooth after root canal can lower post-treatment pain compared to the same rinse at room temperature. Sixty adults with painful tooth infections will rate their pain and hav…

This study compares two ultrasound-guided nerve blocks (TFP and ESP) to control pain after cesarean section. The goal is to see which block provides better pain relief and reduces the need for opioid painkillers. Sixty women having a planned C-section will participate, and their …

This study compares two types of nerve blocks to manage pain after open-heart surgery. 80 adults having planned heart surgery will receive one of two ultrasound-guided injections along with standard anesthesia. The goal is to see which method reduces the need for strong painkille…

This study compares two types of nerve blocks (TFPB and M-TAPA) to see which provides better pain relief after laparoscopic inguinal hernia repair. Sixty adults aged 18-65 will be randomly assigned to receive one of the blocks before surgery. Researchers will track pain scores, o…

This study tests if a special nerve block (ESP block) can better control pain and reduce the need for strong painkillers after spinal fusion surgery. About 75 adults having back or neck fusion will receive either a standard painkiller or the nerve block. Researchers will measure …

This study will compare two types of nerve blocks (SPSIP and ESP) to see which one works better for pain after rib fracture surgery. About 60 adults will take part, and researchers will measure pain levels, opioid use, and side effects. The goal is to find a safer, more effective…

This study compares two types of nerve blocks (M-TAPA and ESPB) to see which provides better pain relief after laparoscopic gallbladder removal. About 124 adults having elective surgery will receive one of the two blocks, and researchers will measure pain scores, opioid use, and …

This study looks at whether using a vibrating device or doing breathing exercises just before a chest tube is removed can help lower pain and anxiety. About 70 adults who have a chest tube after surgery will be split into three groups: vibration, breathing exercises, or standard …

This study looks at whether a device called TENS, which sends mild electrical pulses through the skin, can help reduce pain and improve sleep after inguinal hernia surgery. About 80 adults having this surgery will either receive TENS or standard care. Researchers will measure pai…

This study tests two different medicines (dexmedetomidine and low-dose ketamine) to see which works better for pain control after weight-loss surgery. About 90 adults will be randomly assigned to receive one of these medicines or a placebo during and after surgery. The goal is to…

This study looks at whether a simple breathing technique called box breathing can help older adults (65+) recover from total knee replacement surgery. The goal is to see if it's possible to add this breathing exercise to standard care and whether it might reduce stress, pain, anx…

This study reviews past medical records of 66 women who had a mastectomy to compare three pain relief methods: standard painkillers, a nerve block called rhomboid intercostal block, and that block combined with another nerve block. Researchers will look at pain scores, opioid use…

This study watches anesthesia residents as they place epidural catheters using one of two methods: loss of resistance or hanging drop. The goal is to see which method leads to more successful first attempts and fewer complications. About 440 adults having planned surgery will tak…

This study tests three different ways to numb the abdomen in healthy volunteers to see which works best. Each volunteer gets all three blocks on separate days, and researchers map the numb areas and check leg strength. The goal is to improve pain relief after surgery without usin…

This study watches 250 children aged 2 to 8 who are having urogenital surgery. Researchers want to see if the time they fast (no food or drink) before the operation changes how much pain or confusion they feel afterward. The goal is to learn if shorter fasting times could help ki…

This study looks at whether the position you are in when you get a nerve block for lung surgery changes how well it works. 90 adults having video-assisted lung surgery will be randomly placed in either a sitting or lying-on-the-side position for the block. Researchers will measur…

This study looks at how a drug called Anrikefon works in people aged 65 and older after laparoscopic abdominal surgery. Thirty participants will receive the drug at set times, and researchers will measure its levels in the blood and how well it controls pain. The goal is to under…

This study will check if the pain you feel when getting an IV and your anxiety before surgery can predict how much pain you'll have after gallbladder removal. About 100 adults having planned laparoscopic gallbladder surgery will rate their IV pain and anxiety beforehand. Research…

This study looks at whether negative pressure wound therapy (a machine that helps heal wounds) is linked to ongoing pain six months after a war injury. Researchers will follow 150 adults with severe soft tissue injuries from blasts, bullets, or burns. The goal is to find early si…

This study will check if measuring belly muscle thickness with ultrasound before surgery can help predict how much opioid pain medicine older patients need after abdominal surgery. Researchers will follow 62 patients aged 65 and older for 24 hours after surgery, recording pain sc…

This study looks at whether measuring skin conductance can provide a continuous, objective way to assess pain in newborns after surgery. Pain assessment in babies is hard because they can't talk, and current methods rely on periodic observation. The study will compare skin conduc…

This study looks at 100 adults having their thyroid gland removed to see how different pain treatments after surgery affect their recovery and swallowing pain. Researchers will observe patients under normal care without changing their treatment. The goal is to find which pain man…