Yale University

This study tests whether combining two drugs, luspatercept and darbepoetin alfa, can help people with a certain type of lower-risk myelodysplastic syndromes (MDS) need fewer blood transfusions. The trial enrolls 60 adults who currently rely on red blood cell transfusions. The goa…

This early-phase study tests two drugs, lenvatinib and pembrolizumab, in 20 people with HPV-related recurrent respiratory papillomatosis (RRP), a condition causing non-cancerous growths in the airway. The goal is to see if the combination shrinks lung growths and reduces the need…

This study tests whether a structured nutrition and exercise program can increase the chance of having no cancer left after chemo-immunotherapy in women with triple-negative breast cancer. About 160 women who are not currently active or eating many fruits and vegetables will be r…

This early-stage study tests a new drug called AB821 in about 50 adults with advanced melanoma or other solid tumors that respond to immunotherapy. The main goal is to check the drug's safety and find the right dose. Participants receive AB821 every two weeks, and researchers wil…

This study tests whether a high-flow nasal cannula (a device that delivers warm, moist oxygen through the nose) works better than non-invasive ventilation (a mask that helps push air into the lungs) to prevent the need for re-inserting a breathing tube in people with systolic hea…

This early-phase study tests a new drug (iadademstat) combined with targeted radiation and an immunotherapy (atezolizumab) in people with extensive-stage small-cell lung cancer that didn't fully respond to initial chemotherapy. The main goal is to check safety and find the right …

This study tests two combinations of cancer drugs for people with metastatic triple-negative breast cancer that has spread and not responded to one prior treatment. About 60 adults will receive either sacituzumab govitecan plus nivolumab, or those two plus relatlimab. The goal is…

This study is testing a new program that combines medication (Naltrexone + Bupropion) with behavior therapy to help people lose weight and quit smoking before they have bariatric surgery. The goal is to see if this approach is practical and acceptable for patients. About 20 adult…

This study tests whether precisely targeted radiation (SBRT) can stop or slow the growth of a few new cancer spots in patients with metastatic kidney cancer who are already on immunotherapy. About 30 adults will receive radiation to up to 5 progressing tumors while continuing the…

This study tests a drug called sacituzumab govitecan in people whose cervical cancer has returned or not gone away after at least one prior treatment. The drug works like a guided missile, delivering chemotherapy directly to cancer cells. About 20 participants will be enrolled to…

This study tests whether the medication varenicline can help adults stop using e-cigarettes (vaping). Researchers will compare varenicline to a placebo in 326 people who vape daily and want to quit. The main goal is to see if more participants are able to stay off e-cigarettes fo…

This study tests a new decision-making tool to help women at risk for HIV talk about and start PrEP (a daily pill that prevents HIV) during regular sexual or reproductive health appointments. About 50 women who do not have HIV and are not already on PrEP will take part. The goal …

This study aims to reduce COVID-19 illness and death among people who live or work in prisons. Researchers will test different ways to encourage vaccine uptake in Pennsylvania prisons, involving over 37,000 participants. The goal is to find what works best to increase vaccination…

This study tests whether a smartphone app called Kick-Nic! can help high school students quit vaping. About 306 teens who want to quit will either use the app or visit a standard quit-smoking website for 8 weeks. Researchers will check if they've stopped vaping using saliva tests…

This study tests a special sleep and light routine (called a chronobundle) for 160 critically ill adults in the ICU. The goal is to realign their body clocks, which are often disrupted, to improve sleep quality and metabolism. Participants will receive the bundle or standard care…

This study tests whether a small, home-used device that gently stimulates a nerve in the ear can safely help young adults (ages 18–29) manage irritable bowel syndrome (IBS) pain and other symptoms. About 80 participants will use either the active device or a sham version twice da…

This study tests a daily pill called fezolinetant to see if it can reduce hot flashes in breast cancer survivors who are on hormone therapy. About 92 women with early-stage breast cancer will be randomly assigned to receive either the drug or a placebo. The main goal is to measur…

This study tests whether adding music to guided mindfulness meditation helps reduce stress and anxiety better than meditation alone. It involves 70 adults of African descent who have symptoms of anxiety or depression. Participants will join virtual sessions and report their stres…

This study is for veterans who have ongoing headaches after a head injury. It will test three different strengths of a numbing medicine injected near a nerve in the scalp to see which one works best and feels most comfortable. Each participant will receive all three strengths, on…

This study tests whether a brief training program helps heavy-drinking young adults (ages 18-26) reduce how much they drink. Participants learn techniques to manage alcohol cravings based on cognitive-behavioral or mindfulness methods. The goal is to see if these skills lead to f…

This study tests whether people with overweight or obesity can learn to change their brain's response to food cues using real-time neurofeedback. Fifty participants will undergo brain scans while practicing techniques to reduce craving-related brain activity. The goal is to see i…

This study is testing a new method called mass-based response testing (MRT) to help doctors choose the best chemotherapy drugs for people with advanced appendix or colorectal cancer that has spread to the lining of the abdomen. About 20 participants will have a small sample of th…

This study uses a special brain scan (PET) with a new tracer called [11C]APP311 to measure synaptic density—the connections between brain cells—in people with psychotic disorders or cannabis use disorder, compared to healthy volunteers. Researchers aim to understand how these con…

This study aims to understand why some people are more vulnerable to alcoholism by looking at brain activity. Researchers will give 80 adults with a family history of alcohol problems either a single dose of the drug mavoglurant or a placebo, then use MRI scans to see how their b…

This study is testing a new imaging agent called [18F]GATT-44 to see how well it can show GABA transporters in the brain using PET scans. It involves 32 healthy adults aged 18 to 60. The goal is to understand how the tracer moves through the body and binds to brain targets, not t…

This Yale University study uses special brain scans to see how cannabis use affects brain connections in adults aged 50 and older. Researchers will compare brain scans of cannabis users and non-users to understand how cannabis might change brain structure. The study aims to gathe…

This study is testing a virtual reality (VR) tool called Life at 100.4 to help teens and young adults with cancer, along with their caregivers, learn about their diagnosis and treatment. About 45 participants will try the VR experience and answer questionnaires to see if it is ea…

This study looks at how the brains of people with OCD process fear and safety signals. Researchers will use brain scans and mild electrical stimulation to see if they can improve learning during exposure therapy. The goal is to understand OCD better and find new ways to make trea…

This study uses a special brain scan (PET) to measure the density of connections between brain cells in people with cocaine use disorder compared to healthy volunteers. Researchers want to understand how cocaine changes the brain's wiring. About 80 adults aged 21-60 will particip…

This study looks at how parts of the brain that control arousal help us see things. Researchers will record brain activity from epilepsy patients who already have electrodes implanted. The goal is to understand these circuits better, not to treat or cure epilepsy.

This study looks at how THC, the main active part of cannabis, works in adults aged 65 and older. Researchers want to understand how the body processes THC when taken as a pill or inhaled, and how it affects pain and the risk of misuse. Twenty healthy older adults who have used c…

This study looks at how the brain learns and remembers how to move the mouth and tongue to make speech sounds. Researchers will play with the sound of your voice through headphones to see how your brain adjusts. The goal is to understand the learning process, not to treat any con…