Yale University

This study tests a program called T1CARE, where a community health navigator helps young adults with type 1 diabetes address social needs like housing, food, and healthcare access. 100 participants will be randomly assigned to get the navigator right away or after a wait. The goa…

This Phase 2 trial tests whether guanfacine, a drug used for high blood pressure and ADHD, can help people with alcohol use disorder drink less. Researchers will compare guanfacine to a placebo in 160 men and women, measuring alcohol consumption in lab sessions and during a treat…

This study tests whether a low dose of digoxin, a drug currently used for heart conditions, can help people with a severe form of fatty liver disease called NASH (also known as MASH). The trial will enroll 144 adults with biopsy-confirmed NASH and liver scarring. Participants wil…

This early study tests whether delivering focused ultrasound pulses to the liver and a nearby nerve bundle can improve blood sugar control in people with type 2 diabetes. Thirty adults on stable oral diabetes medications will receive the ultrasound treatment. The main goal is to …

This Phase 2 trial tests whether the hormone pregnenolone can help people with alcohol use disorder drink less heavily. 150 adults aged 18-70 will take either 300 mg of pregnenolone or a placebo daily for 12 weeks. The main goal is to see if more people in the pregnenolone group …

This phase II trial tests whether combining luspatercept and darbepoetin alfa can help people with a certain type of lower-risk myelodysplastic syndrome (MDS) go longer without needing red blood cell transfusions. The study will enroll 60 adults who currently depend on transfusio…

This phase 2 trial tests the drug afatinib in 50 women with a rare, aggressive uterine cancer that has come back or not responded to treatment. The cancer must have a specific marker called HER2. Afatinib is a pill taken daily that targets HER2 to try to stop the cancer from grow…

This study compares two blood thinners—apixaban (Eliquis) and aspirin—in 700 people who have had a brain bleed and also have atrial fibrillation, an irregular heartbeat that raises stroke risk. The goal is to see which drug better prevents future strokes or death. Participants ar…

This study tests a stent graft that doctors modify to fit each patient's unique aneurysm in the chest and abdomen. The goal is to see if this less invasive approach is as safe and effective as traditional open surgery. About 80 people aged 50 and older with large aneurysms will t…

This study tests whether taking vitamin D daily for 6 months can improve menstrual regularity and mood in teenage girls with PCOS who also have low vitamin D levels. Sixty participants will be randomly assigned to receive either vitamin D or a placebo, and neither they nor their …

This study tests whether a structured nutrition and exercise program can improve the chance of a complete response to pre-surgery chemo-immunotherapy in women with triple-negative breast cancer. About 160 women who are not currently exercising or eating many fruits and vegetables…

This study compares two breathing support methods—high-flow nasal cannula (HFNC) and non-invasive ventilation (NIV)—in heart failure patients after their breathing tube is removed. The goal is to see which method better prevents the need for re-insertion of the breathing tube or …

This study is testing a device that uses sound waves to break up calcium buildup in the leg arteries of people with peripheral artery disease. The goal is to improve blood flow, reduce pain, and help people walk better. About 50 participants will be followed for one year to see i…

This study tests a drug called sacituzumab govitecan in 20 people whose cervical cancer has returned or persisted after at least one prior chemotherapy. The drug is an antibody-drug conjugate designed to deliver chemotherapy directly to cancer cells. The main goal is to see how m…

This study tests whether adding an SGLT2 inhibitor (a type of diabetes medicine) to standard hospital care helps people with heart failure who also develop acute kidney injury. Researchers will compare outcomes like survival, need for dialysis, and symptom relief between those wh…

This study tests if guselkumab can help people with Hailey-Hailey disease, a genetic condition causing painful blisters and sores in skin folds. Ten adults with moderate to severe disease will receive the drug and be monitored for changes in skin severity and quality of life. The…

This study tests a program called Fathers for Change (F4C) for fathers who have been violent with their partner. The goal is to see if F4C works better than standard anger management classes at stopping violence and improving children's mental health. About 1,080 fathers with a h…

This pilot study is testing whether semaglutide, a drug used for diabetes and weight loss, can help people with HIV reduce their alcohol use. Thirty participants will receive the drug along with support from a pharmacist and psychiatrist. The goal is to see if the approach is pra…

This study tests a new stepped care program called PCT+2HOPE for women with opioid use disorder who have also experienced intimate partner violence and have PTSD symptoms. The program combines group therapy with optional individual sessions to address trauma and improve recovery.…

This Phase 2 trial tests whether adding a short 30-day course of the oral hormone drug Relugolix to standard targeted radiation (SBRT) can better lower PSA levels in men with unfavorable intermediate-risk prostate cancer, compared to radiation alone. The study enrolls 60 men and …

This study tests whether trained community health workers can help people in Nepal prevent and control high blood pressure. Over 3,500 participants with high blood pressure will receive home visits and group counseling from health workers. The goal is to see if this approach lowe…

This early-phase trial is testing a new drug called iadademstat, taken as a liquid by mouth, together with the immunotherapy atezolizumab and targeted radiation (SBRT) in people with extensive-stage small-cell lung cancer that has persisted, come back, or gotten worse after initi…

This study tests a new way to give radiation before T-cell therapies (CAR T or bispecific antibodies) for people with relapsed or refractory diffuse large B-cell lymphoma. Each participant's tumor is split in half: one side gets once-daily radiation, the other gets twice-daily ra…

This early-stage study tests a new drug called AB821 in people with advanced melanoma or other solid tumors that have spread. The main goal is to check safety and find the right dose. About 50 adults will take part at Yale University.

This early-stage study tests whether the psychedelic DMT, combined with talk therapy, can help people with alcohol use disorder drink less. About 63 adults with the condition will receive either DMT or a placebo in a controlled setting. The main goals are to check safety and see …

This study tests whether adding bipolar androgen therapy (BAT) to the standard Sipuleucel-T vaccine can strengthen the immune system's response against advanced prostate cancer that no longer responds to hormone therapy. About 26 men with this type of cancer will receive both tre…

This study is for people with metastatic triple-negative breast cancer that has not responded to one prior treatment. It tests two combinations of drugs: one with sacituzumab govitecan and nivolumab, and another that adds a third drug, relatlimab. The goal is to see which combina…

This study tests whether the drug apremilast can help people with alcohol use disorder drink less. About 80 adults aged 21-65 will receive either apremilast or a placebo, and researchers will measure how much alcohol they consume during a lab drinking session. The goal is to see …

This study is for people with a common type of breast cancer (ER-positive, HER2-negative) that has a moderate to high risk of coming back based on tumor size and lymph node involvement, but a low genetic risk score. Instead of chemotherapy after surgery, participants can choose t…

This study aims to find the best way to help people control their blood pressure. It compares two approaches: remote blood pressure monitoring alone, or remote monitoring plus support from a community health worker. About 1440 adults with high blood pressure will take part. The g…

This study looks at whether starting HIV treatment soon after diagnosis can reduce stigma and improve health in people who inject drugs. Researchers will test a new approach that speeds up when doctors prescribe medication. The goal is to lower HIV-related stigma and help more pe…

This study tests if empagliflozin, a diabetes drug, can reduce sugar absorption during peritoneal dialysis in 30 adults with end-stage kidney disease. Participants will receive either the drug or a placebo in a crossover design, followed by an 8-week open-label phase where everyo…

This study tests adding the drug mogamulizumab to standard chemotherapy for people with aggressive T-cell lymphoma, a type of blood cancer. About 22 adults with newly diagnosed or returning lymphoma will receive the combination treatment. The goal is to see if more patients achie…

This study looks at whether e-cigarettes or nicotine pouches can help adults who smoke cigarettes reduce how much they smoke. About 256 people will try one of these products for 4 weeks, with different flavors and nicotine levels. Researchers will track how many cigarettes they s…

This study tests a new drug called CUE-101, alone or with another drug (pembrolizumab), in 30 people with newly diagnosed HPV-16 positive head and neck cancer that cannot be easily removed with surgery. The goal is to see if these drugs can boost the immune system to fight the ca…

This small pilot study at Yale tests whether semaglutide (a drug used for diabetes and weight loss) can help people who have had bariatric surgery and now struggle with alcohol use disorder. Ten adults will take the drug for three months and be followed for three more months to s…

This study tests whether precisely targeted radiation can control kidney cancer that has started growing in a few spots while a patient is on immunotherapy. About 30 adults with metastatic renal cell carcinoma will receive radiation to up to 5 progressing tumors and continue thei…

This study tests a program called Fathers for Change (F4C) for 280 fathers who struggle with substance misuse and have been violent toward family. The program aims to help them control emotions, stop substance use, and prevent violence. Researchers compare F4C to standard drug co…

This study tests whether the medication varenicline can help adults quit using e-cigarettes. Researchers will compare varenicline to a placebo in 326 people who vape daily. The main goal is to see if more participants can stop vaping for at least a week by the 12-week mark, with …

This study tests whether prazosin, a blood pressure medicine, can help people with alcohol use disorder who also have withdrawal symptoms drink less heavily. About 150 adults will receive either prazosin or a placebo for 12 weeks, along with weekly counseling. The main goal is to…

This study tests whether using a PAP machine (a device that helps keep your airway open during sleep) can improve recovery after a stroke. Researchers will enroll 360 people who have had an ischemic stroke and also have moderate to severe obstructive sleep apnea. Half will receiv…

This study tests a drug called elacestrant in 50 adults with ER+ breast cancer who have a high risk of the cancer coming back years later. Participants must have cancer DNA in their blood but no signs of spread on scans. The goal is to see if elacestrant can clear that DNA and im…

This study compares two medications—methadone and buprenorphine—given in a doctor's office to treat opioid use disorder. Researchers want to see which one helps people stay in treatment longer over 168 days. About 600 adults starting a new treatment episode will take part. The go…

This study tests whether a higher starting dose of buprenorphine in the emergency room helps more people with opioid use disorder engage in treatment within 10 days. It also looks at whether the higher dose reduces cravings, withdrawal symptoms, and use of illicit opioids. The tr…

This early-phase study tests two drugs, lenvatinib and pembrolizumab, in 20 adults with HPV-related recurrent respiratory papillomatosis (RRP) that has spread to the lungs. The goal is to see if the combination can shrink growths and reduce the need for repeated surgeries. Partic…

This study looks at whether surgery to remove remaining cancer spots can help people with advanced bladder cancer that has been controlled by drug therapy. About 32 adults whose cancer has not spread widely will receive surgery on the main tumor and any other treatable spots. The…

This study is testing a program that combines medication (Naltrexone + Bupropion) with behavior therapy to help adults who are planning to have bariatric surgery lose weight and quit smoking. The goal is to see if this approach is practical and acceptable for patients. About 20 p…

This study tests a drug called trastuzumab deruxtecan (T-DXd) in 40 adults with metastatic breast cancer that is HER2-negative (IHC 0). The goal is to see how well the drug shrinks tumors and which patients benefit most. Participants receive the drug and are monitored for respons…

This study tests whether empagliflozin, a diabetes drug, can help people with cirrhosis and ascites (fluid buildup in the belly) get rid of excess salt and water. About 20 adults on stable diuretics will take the drug or a placebo for 14 days. Researchers will measure changes in …

This study is testing whether placing a contraceptive implant in the shoulder blade area works as well as the usual arm placement. Researchers will check hormone levels and side effects in 62 women over two years. The goal is to see if this new spot is a good option for long-term…

This study tests whether adding ertugliflozin (a diabetes drug) or metolazone to standard diuretics helps control fluid buildup and heart failure symptoms better than placebo. About 60 adults with chronic heart failure who already take daily diuretics will participate. Researcher…

This study tests whether adding surgery or radiation to standard chemotherapy helps people with metastatic upper GI cancer live longer without the disease getting worse. It includes 54 adults whose cancer has spread but whose blood shows no detectable tumor DNA after three months…

This study tests whether the diabetes drug metformin can protect kidney cells in people with a rare kidney disease called FSGS. About 30 adults will receive either metformin or a placebo for 6 months, alongside their usual treatments. The goal is to see if metformin reduces kidne…

This study tests whether a self-administered fingerstick glucose tolerance test done at home can accurately measure blood sugar levels compared to the standard clinic-based test. Researchers will enroll 60 people at risk for or recently diagnosed with type 1 diabetes. If accurate…

This study looks at whether enoxaparin, a blood thinner, can prevent blood clots caused by central catheters in critically ill children. Researchers will enroll 258 children from newborns to age 17 who have a new catheter in a neck or leg vein. The goal is to see if age affects h…

This study tests a decision aid that helps women in sexual and reproductive health clinics decide whether to take PrEP, a daily pill that prevents HIV. Fifty women who are HIV-negative, not on PrEP, and have a uterus will use the aid during a counseling visit. Researchers will me…

This study tests whether providing housing support to recently incarcerated people and their families, along with mental wellness training for community members, can reduce gun violence in New Haven's highest-risk neighborhoods. Researchers will track neighborhood-level gun viole…

This study looks at two different support programs to help people recently involved with the justice system start or restart HIV prevention (PrEP) or HIV treatment (ART), as well as treatment for substance use. About 400 participants will be randomly assigned to either a standard…

This study tests a digital health program to help women involved in the criminal justice system start PrEP (a daily pill to prevent HIV) and get treatment for opioid use disorder. Researchers will compare the program to a simpler decision aid alone. The goal is to reduce stigma a…

This study aims to reduce COVID-19 illness and death among people who live or work in prisons. Researchers will test different ways to encourage COVID-19 vaccination in Pennsylvania prisons, involving over 37,000 participants. The goal is to find what works best to increase vacci…

This phase 2 study at Yale is testing whether a combination of THC and CBD can reduce both pain and opioid cravings in people who have opioid use disorder and chronic pain. The 147 participants are all on methadone therapy. Researchers will measure pain sensitivity and craving re…

This study looks at whether giving cancer patients in Maine free, healthy groceries and nutrition advice can improve their diet and well-being. One hundred adults with any stage of cancer will be split into three groups: some get groceries plus counseling, some get groceries only…

This study explores whether group drumming or music-listening sessions can help reduce pain and improve well-being in people with early Alzheimer's disease, mild dementia, or mild cognitive impairment, as well as their caregivers. Over 8 weeks, 60 participants will take part in g…

This study tests whether brief training in mindfulness or cognitive-behavioral techniques can help young adults ages 18-26 who drink heavily reduce their alcohol use. Participants will complete 1-4 training sessions and report their drinking via smartphone. The goal is to see if …

This study tests whether real-time fMRI neurofeedback can help teens aged 10-16 with Tourette Syndrome reduce their tics. Participants learn to control activity in a brain region linked to tics by watching their own brain activity on a screen. The trial compares this to a control…

This early-stage study at Yale University is testing whether a single 25 mg dose of psilocybin is safe and tolerable for people whose daily life is impaired by mood, anxiety, trauma, or addiction symptoms. Fifty adults will receive the drug in an open-label design (everyone knows…

This study tests whether a mobile app can help patients do simple in-bed exercises after hip, knee, or spine surgery. About 100 adults will use the app or receive usual care. The goal is to see if the app improves physical function and patient satisfaction during recovery.

This study is testing whether a remote, video-based pelvic floor muscle therapy program is easy to use and practical for patients with pelvic floor disorders like prolapse, incontinence, or bowel issues. Twenty participants will follow an 8-week online course at home. The main go…

This study tests whether using RECELL® — a device that creates a spray from a patient's own skin cells — can improve skin color matching after head and neck reconstructive surgery. Twenty adults who need this surgery will receive the treatment, and their color match, healing, and…

Researchers at Yale University are testing whether a smartphone app called Caravan Wellness can improve quality of life, reduce stress, and ease symptoms of anxiety and depression. The app offers short mindfulness and light exercise modules like yoga and meditation. The study wil…

This study looks at whether improving sleep can help people stop smoking. Researchers will test behavioral treatments in 114 adult smokers to see if better sleep reduces cravings and improves self-control. The goal is to find brain markers that show why this approach works.

This study tests whether a daily medication called valbenazine can reduce hair-pulling in adults with trichotillomania. About 20 people will receive either the drug or a placebo for 12 weeks, then everyone gets the drug for another 12 weeks. The goal is to see if the drug safely …

This study tests whether the Thrive AI Health app can help adults with type 2 diabetes or overweight improve their daily habits like diet, exercise, and sleep. About 20 participants will either use the app or not, and researchers will compare changes over time. The app uses artif…

This study is for veterans with long-term headaches after a head injury. It compares three different doses of a numbing medicine injected near a nerve in the scalp. Each participant will try all three doses, one week apart, to see which works best and feels most comfortable. The …

This study tests a mobile app that gives personalized tips and insights based on your blood sugar, exercise, mood, and sleep patterns. The goal is to help 60 adults aged 30-65 with type 1 diabetes or similar conditions exercise more often and with confidence. All participation is…

This study tests a 10-session online therapy designed for sexual minority women who drink heavily and have anxiety or depression. The therapy is LGBTQ-affirmative, meaning it addresses unique stressors faced by this group. Researchers will compare it to standard care to see if it…

This study provides free continuous glucose monitors (CGMs) to 17 adults with poorly controlled type 2 diabetes. Researchers will track changes in blood sugar levels and quality of life over time. The goal is to see if easier access to CGM technology helps patients manage their d…

This study looks at whether a sleep medication (eszopiclone) can help people with obstructive sleep apnea use their CPAP machine more consistently and improve their thinking skills. Researchers will study 250 adults with a new sleep apnea diagnosis. The goal is to see if raising …

This early study tests whether a non-invasive brain stimulation technique called tDCS can improve voice quality in people with laryngeal dystonia (spasmodic dysphonia). Ten participants will receive active, sham, and no stimulation to compare effects. The goal is to see if target…

This study compares nipple stimulation to standard oxytocin medication for inducing labor in first-time mothers. About 988 women will be randomly assigned to one of the two methods. The goal is to see if nipple stimulation leads to more spontaneous vaginal deliveries, better birt…

This small study at Yale is testing whether a single dose of MDMA can improve how adults with borderline personality disorder understand and interact with others. Ten participants will take the drug and complete tasks measuring social thinking and emotion recognition. The goal is…

This study tests whether a parent-only therapy (SPACE) can reduce anxiety in teens, compared to a parent education support group. About 108 adolescents with anxiety disorders will participate. Parents attend 12 weekly sessions, and researchers measure teen anxiety symptoms before…

This study tests whether a smartphone app called Kick-Nic! can help high school students stop vaping. About 306 teens who want to quit will be randomly assigned to use the app or a standard quitting website. Their progress will be tracked for 6 months, including saliva tests to c…

This early-phase study tests whether the drug mavoglurant can help heavy drinkers with Alcohol Use Disorder reduce their cravings and alcohol consumption. Researchers will measure changes in the number of drinks consumed and craving levels using a simple questionnaire. The study …

This study tests a drug called fezolinetant to see if it can reduce hot flashes in women who have had breast cancer and are taking hormone therapy. About 92 women will be randomly assigned to receive either fezolinetant or a placebo daily for 12 weeks. The main goal is to measure…

This study compares two FDA-cleared devices used to soften and open the cervix before a dilation and evacuation (D&E) procedure in the second trimester. One device is a balloon catheter, the other is a set of absorbent rods (osmotic dilators). The goal is to see which method work…

This study tests whether a gentle, non-invasive ultrasound treatment can reduce or stop seizure activity in people with a severe type of ongoing seizure called status epilepticus that hasn't improved with standard medications. Ten participants in the ICU will receive a 10-minute …

This study tests whether a mindfulness-based sleep program can improve sleep and reduce stress in Black women with insomnia. Researchers will enroll 340 Black women who have trouble sleeping. The goal is to see if better sleep can lower the risk of heart disease and other health …

This study follows 200 people with chronic low back pain who are scheduled for a procedure called basivertebral nerve ablation. The goal is to see how much pain and function improve over two years and to figure out which patients benefit the most. Participants will answer weekly …

This study tests whether bexagliflozin, a drug typically used for diabetes, can reduce the severity of sleep apnea in overweight or obese adults. About 164 participants will receive either the drug or a placebo for 6 months, along with routine care. Researchers will measure chang…

This study tests a portable device called PoRI that helps stroke survivors regain hand movement. About 12 people who had a stroke within the past 2 days to 2 months will use the device or receive standard hand therapy. The goal is to see if the device improves hand function and r…

This study tests whether a special brain training technique, called mindfulness-based neurofeedback, can help adults with borderline personality disorder (BPD) get more out of their regular talk therapy. Researchers will use real-time brain scans to help participants learn to con…

This study tests whether extra support for case managers helps veterans leaving the military better manage pain and reduce risky substance use. About 1800 veterans will take part. The program focuses on non-drug pain treatments and counseling.

This study tests a mindfulness app called Calm Health in 10 young adults (ages 18-30) with type 1 diabetes or similar conditions. Participants use the app to track mindfulness, blood sugar, stress, and sleep, and get personalized feedback. The goal is to see if the app is easy to…

This study compares two forms of ketamine for people with depression that hasn't improved with other treatments. One is given through an IV drip, the other as a nasal spray. Researchers want to see which works better, is more acceptable to patients, and has fewer side effects. Ab…

This study tests a gentle exercise program combining Baduanjin (a traditional Chinese mind-body practice) with resistance training for older adults with osteoporosis and a slipped disc in the lower back. Researchers want to see if it can reduce pain, improve muscle strength, and …

This study tests whether a small, home-use device that gently stimulates a nerve in the ear can help young adults (ages 18-29) manage pain and other symptoms of irritable bowel syndrome (IBS). Eighty participants will use either the active device or a sham (inactive) version twic…

This study tests whether a smartphone app called Change4Better (C4B) can help reduce problem gambling compared to standard treatment alone. About 128 adults who gamble and want help will use the app for 6 months. Researchers will track changes in gambling symptoms and how often p…

This study compares two common types of heart medications (beta-blockers and calcium channel blockers) in adults aged 65 and older who have stable angina and at least two other chronic health conditions. The goal is to see which medication improves quality of life more and is eas…

This study looks at whether cannabidiol (CBD) is safe and can help with pain and opioid cravings in people already receiving methadone or buprenorphine for opioid use disorder. About 34 adults with chronic pain will take part in a short, four-week trial where they receive CBD or …

This study tests two types of therapy for LGBTQ+ adults (age 20+) who have parents that are not accepting of their identity. The therapies, delivered online, aim to reduce symptoms of depression and anxiety. About 124 participants from the US and Israel will take part.

This study compares music-backed mindfulness meditation to meditation alone for reducing stress and anxiety in people of African descent. 70 participants with anxiety or depression will join virtual sessions. The goal is to see if adding music makes stress management more effecti…

This study tests a combination of sleep-promoting and circadian-aligning treatments (a "sleep chronobundle") in 160 critically ill ICU patients. The goal is to see if realigning the body's internal clock can improve sleep quality and metabolism. Participants will receive the bund…

This study looks at whether taking sitz baths (sitting in warm water) after surgery for pelvic organ prolapse can help reduce pain and improve recovery. About 112 women will be randomly assigned to either use sitz baths or follow standard care. The main goal is to measure pain le…

This early study tests whether patients recovering from shoulder surgery can safely and effectively give themselves liquid acetaminophen (like Tylenol) instead of waiting for a nurse to bring pills. About 24 adults will be enrolled to see if this approach is practical and accepta…

This study tests whether a virtual, community-based program combining music and mindfulness can help manage stress, anxiety, and depression in people of African descent during COVID-19. About 48 participants aged 16 and older will join online sessions and have their brain activit…

This study looks at whether dronabinol, a drug similar to THC in cannabis, can reduce pain sensitivity and improve thinking and mood in people being treated for opioid use disorder. About 36 adults aged 18-70 who are stable on methadone or buprenorphine will receive either dronab…

This study tests whether a noninvasive brain stimulation technique called rTMS can improve social abilities in adults with autism. Researchers will measure brain responses and eye gaze patterns before and after treatment. The goal is to see if this approach can ease core social c…

This study tests whether people with overweight or obesity and high food cravings can learn to change their brain's response to food cues using neurofeedback. Participants will undergo brain scans while receiving real-time feedback to help reduce cravings. The goal is to see if t…

This study follows 350 older adults (65+) who return home after an ICU stay to see what help they still need with daily activities. Researchers will track disabilities, hospital readmissions, and deaths over six months. The goal is to identify gaps in care so better programs can …

This study at Yale University is testing whether blocking a specific brain receptor (AMPA) stops ketamine from reducing suicidal thoughts. Thirty adults with depression, bipolar disorder, or PTSD who have current suicidal thoughts will receive either perampanel (an AMPA blocker) …

This study looks at how the brain's arousal systems work when we see, hear, or feel things. Researchers will use brain scans, eye tracking, and electrical recordings in healthy volunteers and epilepsy patients. The goal is to understand shared brain pathways that help us stay ale…

This study looks at how the gut's natural fermentation process affects metabolism in young people aged 15 to 22 with obesity. Researchers will give lactulose to trigger fermentation and measure changes in fat breakdown and sugar production. The goal is to understand why some deve…

This study looks at why some heart failure patients don't respond well to water pills (diuretics). Researchers will give 50 participants either ammonium chloride or a placebo along with standard diuretics to see if it improves sodium excretion. The goal is to understand the mecha…

This study aims to understand why some people with heart failure do not respond well to diuretics (water pills). Researchers will give 75 heart failure patients different doses of bumetanide and measure how their kidneys handle sodium. The goal is to identify biological markers o…

This study tests whether a culturally responsive, peer-delivered motivational interviewing program can help Latinos with serious mental illness engage in mental health treatment. Thirty participants who are not currently in treatment will receive six weekly one-hour sessions. The…

This study looks at how to increase access to medication-assisted treatment for opioid addiction in Kazakhstan, Kyrgyzstan, and Tajikistan. Researchers will train local health officials and track how many people start and stay on treatment. The goal is to reduce HIV infections, w…

This study looks at how ketamine works in the brain to relieve depression. Researchers are giving people with hard-to-treat depression either a placebo or a drug called perampanel before a dose of ketamine. They will use brain scans to see if blocking certain brain receptors chan…

This study looks at why some people with heart failure don't get rid of excess fluid with standard water pills (diuretics). Researchers will test adding two other types of diuretics—bendroflumethiazide and amiloride—to see if they improve the body's response. Fifty adults with he…

This study at Yale investigates how people with OCD process fear and safety signals in the brain. Researchers will use mild electrical stimulation (tDCS) to see if it can improve fear extinction learning, which is key to exposure therapy. 180 adults with OCD will undergo brain sc…

This study explores how the brain learns and remembers speech movements. Researchers will have 330 healthy adults say words while hearing their own voice slightly altered through headphones. The goal is to understand which brain areas help us adapt and retain new speech patterns,…

This study uses a special brain scan (PET) to measure the density of connections between brain cells in people with psychotic disorders (like schizophrenia) or cannabis use disorder, compared to healthy volunteers. The goal is to understand how brain connection changes relate to …

This study looks at whether the body can store sodium without holding onto extra water, and how much sodium is stored this way. Researchers will study 10 adults on peritoneal dialysis who also have heart failure. The goal is to better understand sodium balance, which could help i…

This study uses a special brain scan (PET) to compare the number of connections between brain cells in people with cocaine use disorder versus healthy volunteers. Researchers want to see if these connections change after three weeks of staying off cocaine. The study does not test…

This early-phase study looks at whether adding dapagliflozin, a diabetes drug, to standard chemotherapy changes insulin-related markers in the blood. It involves 20 women with early-stage HER2-negative breast cancer who also have high insulin levels. The goal is to gather safety …

This study looks at women born with an irregularly shaped uterus (congenital uterine anomaly) to see if they have higher chances of certain cancers, like breast or ovarian cancer. Researchers will also try to find genetic or environmental reasons for the condition. About 300 wome…

This study is testing a virtual reality (VR) program called Life at 100.4 to help teens and young adults with cancer, along with their caregivers, learn about their diagnosis and treatment in an immersive way. About 45 participants will use the VR tool, and researchers will measu…

This study looks at whether measuring copper in urine after a short break from Wilson Disease medication can reliably show how well the disease is controlled. About 30 stable patients will temporarily stop their usual treatment under close watch and provide daily urine and blood …

This study aims to find the brain areas responsible for depression in people with Parkinson's disease. Researchers will use brain scans to compare 120 participants aged 40-80 who have both conditions. The goal is to identify targets for future treatments, not to test a new therap…

This study tests a new program to help liver doctors provide medications and counseling for alcohol use disorder. The program includes education for doctors and patients, plus tools to support decision-making. Researchers will enroll 30 clinicians to see if the program is feasibl…

This study is a large registry that collects information from hospitals across the U.S. on pregnant women who receive general anesthesia during a cesarean delivery. Researchers aim to understand why general anesthesia is used, how it is managed, and what outcomes occur for both m…

This study tests a nutrition education program for first-time pregnant women in northern Ghana. The program teaches women how to eat a wider variety of local foods, get more protein and iron, and gain a healthy amount of weight during pregnancy. Researchers will measure changes i…

This pilot study tests a suicide prevention package (PSuPP) for primary care providers in rural Nepal. The package includes training, screening tools, safety planning, and follow-up care coordination. Researchers will enroll 147 providers and patients to see if the approach is fe…

This study is building a large registry and biorepository of 5,000 adults with various rheumatic diseases like rheumatoid arthritis, lupus, and scleroderma. Researchers at Yale University will collect medical data and biological samples over time to better understand these condit…

This study uses a special PET scan tracer called [11-C]OMAR to measure cannabinoid receptors in the brain. Researchers will compare healthy volunteers to people with schizophrenia, cannabis dependence, PTSD, opioid use disorder, and other conditions. The goal is to understand how…

This study is building a registry of 800 adults with myasthenia gravis at Yale University. Participants will donate blood and stool samples, which will be used for future research. No new treatments are being tested—the goal is to collect data to help scientists better understand…

This study at Yale uses brain stimulation (TMS and tDCS) along with EEG and eye tracking to understand how two people's brains synchronize during live face-to-face interactions. Fifty healthy adults will have their brain activity and gaze measured before and after stimulation. Th…

This observational study at Yale University is recruiting 200 people who are already taking part in another trial where they may receive a serotonergic psychedelic (like psilocybin or LSD) or a placebo. Researchers want to understand how these substances change the brain's inform…

This study tests a new device that measures blood pressure in a neck vein to estimate pressure in the heart's central veins, without needing a catheter. About 40 adults in the cardiac ICU will have both the non-invasive test and the standard invasive measurement to see if the new…

This study looks at how alcohol, cannabis, and certain medications may increase the risk of falls and memory or thinking problems in people with HIV. Researchers will enroll 100 participants from VA clinics who currently drink alcohol and take five or more medications. The goal i…

This study looks at how cooling ingredients like menthol and WS-23 affect how much adults like e-cigarettes and how addictive they find them. About 66 adults who currently vape will try different e-liquid flavors and report their feelings. The goal is to understand if these addit…

This study looks at how THC, the active ingredient in cannabis, temporarily affects memory, learning, and balance in adults aged 21 to 55 who have used cannabis before. Ten participants will complete memory tasks and balance tests inside an fMRI scanner after taking either THC or…

This study looks at how cannabis use changes brain cell connections in adults aged 50 and older. Researchers will use special brain scans to measure synaptic density in the hippocampus, a key memory area. The goal is to understand cannabis's impact on the aging brain, not to trea…

This study looks at whether a short, low-intensity exercise test called SHAPE-HF can be used before surgery to measure aerobic fitness in adults over 60. The goal is to see if it's practical and if results relate to recovery and complications after surgery. Participants attend on…

This study watches 150 people who had a stroke to see if ups and downs in blood pressure affect their recovery. Researchers will track brain scans and thinking skills to understand why this happens. The goal is to find new ways to treat blood pressure after a stroke.

This study is testing a new radioactive tracer called [18F]GATT-44 to see how well it can image GABA transporters in the brain using PET scans. The goal is to understand how the tracer moves through the body and binds to brain cells, and to measure the radiation exposure. About 3…

This study looks for early clues that someone might develop multiple sclerosis (MS) before they have any symptoms. Researchers will collect health data and samples from 1,000 adults who have risk factors like a family history of MS or past Epstein-Barr virus infection. The goal i…

This study looks at how a drug called dichloroacetate affects brain function when blood sugar drops too low in people with type 1 diabetes. It involves 16 adults who have had severe low blood sugar or don't notice symptoms of low blood sugar. Participants will receive the drug or…

This study looks at how HIV affects the brain even when the virus is controlled by medication. Researchers will use special PET and MRI scans to measure brain cell connections in 70 people with HIV and healthy volunteers. The goal is to understand why some people with HIV still h…

This study is testing whether an AI-powered chatbot on a smartphone can encourage more men in Malaysia to get tested for HIV. The study will enroll 296 men who have sex with men and have not been tested recently. Participants will use the chatbot and report every 30 days whether …

This study creates a live registry using electronic health records to track heart failure patients across the Yale New Haven Health System. It aims to monitor hospitalizations and use of recommended treatments in up to 40,000 participants. No new treatments are tested; instead, r…

This study looks at immune cells in the gut to understand how they might be involved in brain diseases like multiple sclerosis and Parkinson's. Researchers will collect tissue samples from 100 adults during colonoscopies. The goal is to learn more about the gut's role in these co…

This study looks at the immune cells in the lymph nodes near kidney tumors to learn how the body fights the cancer. Researchers will analyze tissue samples from 10 adult kidney cancer patients to find clues about why some treatments work and others don't. The goal is to discover …

This study aims to find the smallest amount of nicotine that smokers find rewarding or addictive. Researchers will test different nicotine doses in 45 adult smokers to see which dose they can identify and prefer. The goal is to better understand how addiction develops, which coul…

This study looks at whether a 12-session parenting program can change brain activity in mothers recovering from opioid use disorder. Researchers will use EEG to measure brain responses to baby faces and cries before and after the program. The goal is to see if supporting the moth…

This study looks at why standard heart failure medications may not fully block a hormone called aldosterone. Researchers will give 20 adults with stable heart failure either a placebo or the drug spironolactone, then measure how the body handles salt and water. The goal is to und…

This study is testing a new lab test that helps doctors choose the most effective chemotherapy drugs for each patient. It involves 20 people with advanced appendix or colorectal cancer that has spread to the lining of the abdomen. The test analyzes a small tissue sample to see wh…

This study looks at the best way to help parents get online access to their child's medical records. About 5,200 parents will either get a text, a message through their own patient portal, or no message at all. Researchers will then compare which group had more parents successful…

This study tests whether a video or a written guide helps women aged 75 and older make better decisions about breast cancer screening. About 300 women who have had screening before but never had breast cancer will take an online survey. The goal is to see which format reduces con…

This study aims to develop a better way to measure calcium deposits under the skin in people with scleroderma. Researchers will use CT scans and special software to see if these measurements match how patients report their symptoms. About 56 adults with scleroderma and calcium de…

This study looks at whether a non-invasive brain stimulation technique called TMS can change brain activity related to understanding others' thoughts (mentalizing) in young adults with autism. Researchers will compare brain scans before and after stimulation in 80 participants, i…

This study looks at whether sudden stress can cause a worsening of congestive heart failure. Researchers will monitor heart pressure in 112 adults with heart failure who have an implanted monitor, comparing times of stress and calm. The goal is to understand the link between stre…

This study looks at how long-term phosphate therapy affects the kidneys, blood vessels, and heart in people with two rare bone disorders: X-linked hypophosphatemia (XLH) and hereditary hypophosphatemic rickets with hypercalciuria (HHRH). Researchers will measure hormone levels an…

This study aims to create a lab-based test to help screen medications for Alcohol Use Disorder (AUD). Researchers will observe how 90 adults with AUD resist drinking in a controlled setting. The goal is to develop a reliable method to test new treatments, not to provide direct th…

This study uses a special PET scan tracer to measure a brain protein called PDE4B in people with PTSD or alcohol use disorder. Researchers want to see if levels of this protein differ from healthy individuals. The study involves 160 adults aged 18 to 70 and does not offer treatme…

This study aims to understand which parts of the brain help us learn and remember new ways of speaking. Researchers will use brain scans (fMRI) and magnetic pulses (TMS) to map brain activity in 160 healthy adults. Participants will speak words while hearing altered feedback, and…

This study looks at how blood flow changes in healthy volunteers when they lose a small amount of blood. Researchers use a special device to safely reduce blood flow and test different monitors. The goal is to find the most reliable spot on the body to detect early signs of blood…

This study is developing and testing two short online writing exercises to help parents in the Southeast US become more accepting of their sexual and gender minority children (ages 15-29). About 129 parents who identify as heterosexual and cisgender and who report some non-accept…

This study looks at how stress impacts pain, hormone levels, and mood in 120 people with and without HIV, cannabis use disorder, and depression. Participants will complete two sessions of a pain stress task and provide blood samples to measure cortisol and other stress hormones. …

This study will take repeated brain scans of 10 people receiving medication for opioid use disorder to track how their brain activity changes during recovery. The goal is to identify key moments when the brain is more receptive to additional treatments like therapy or stimulation…

This study aims to understand which parts of the brain help us learn and remember new ways of speaking. Researchers will use brain scans and magnetic pulses to observe brain activity in 120 healthy adults. The goal is to learn more about how speech motor learning works, not to te…

This study looks at how feeling disconnected from others affects the brain in people aged 55 and older. Researchers will use brain scans like MRI and PET to measure brain activity and connections. The goal is to understand the link between social isolation and suicide risk in lat…

This study uses brain scans to compare a specific receptor (CB1) in people with opioid use disorder who are on methadone treatment versus healthy volunteers. The goal is to understand how the endocannabinoid system works differently in addiction. No new treatment is tested; it is…

This study tests a portable MRI machine to look for brain injury in patients who have had a cardiac arrest. Researchers will scan the brain multiple times over several days to see how injuries change. The goal is to make brain imaging available at hospitals without specialized sc…

This study looks at how the active ingredient in cannabis, THC, affects men and women differently. Researchers will give THC to 100 healthy adults who have used cannabis before and measure their feelings of being 'high' and memory performance. The goal is to understand why men an…

This study is creating a registry for children with PTEN Hamartoma Tumor Syndrome (PHTS), a rare genetic condition that increases cancer risk. Researchers will follow 100 participants for 3 years to link genetic changes with health outcomes. The goal is to develop better monitori…

This study looks at how THC, the main active part of cannabis, affects older adults aged 65 and up. Researchers want to understand how the body processes THC when taken as a pill or inhaled, and how it impacts pain and the risk of misuse. Twenty healthy volunteers with past canna…

This study aims to discover the genetic reasons behind recurrent pregnancy loss (RPL) by analyzing DNA from parents and pregnancy tissue. Researchers at Yale University will enroll 500 women who have had multiple pregnancy losses. The goal is to identify genetic markers that pred…

This study in Uganda tests whether trained peer counselors can help people with tuberculosis (TB) and HIV stay on track with their medications. About 1,920 adults will take part, and researchers will compare treatment success rates between clinics using peer-led education and tho…

This study looks at how different types of insulin resistance (in fat or muscle) affect the liver's production of fats called triglycerides. Researchers will measure fat production after a meal, with and without exercise beforehand. The goal is to understand why some people have …

This study aims to understand how the brain learns and remembers new ways of speaking. Researchers will use brain scans (fMRI) and magnetic pulses (TMS) to see which brain areas are involved. 50 healthy, right-handed, fluent English speakers with normal hearing will participate. …

This study looks at how using a cuff to limit blood flow during exercise affects immune cells and energy use in people recovering from ACL surgery. Researchers will measure changes in genes, sugars, fats, and stress hormones in 20 adults aged 18-60. The goal is to understand the …

This study looks at brain changes in people who use cannabis heavily and want to quit. Researchers will use brain scans to measure a protein linked to brain cell connections, both before and after at least 4 weeks of not using cannabis. They will also test memory to see if brain …

This study will follow 10,000 people who need hip surgery to compare two approaches: hip preservation surgery (which tries to keep the natural hip joint) and total hip replacement (which replaces the joint). The goal is to see which surgery leads to better pain relief, function, …

This study follows 380 children in Uganda for two years to understand how malaria and HIV treatments interact. Half the children have HIV and half do not. Researchers will measure changes in body weight, blood sugar, and drug levels to find the best ways to treat both infections …

This study aims to understand why some people are more vulnerable to alcoholism by looking at brain activity. Researchers will give 80 adults either a single dose of the drug mavoglurant or a placebo, then use MRI scans to see how their brains respond to rewards and alcohol-relat…

This study is testing whether a short exercise test done before surgery can help predict complications in adults over 45 having moderate- to high-risk operations. Researchers will collect data from routine care and exercise tests to see if results link to heart, lung, or other pr…

This study uses brain scans to understand why some people relapse to opioid use during treatment. Researchers at Yale will follow 240 adults recently started on methadone or buprenorphine, tracking their brain connectivity and drug use for six months. The goal is to identify patt…