Yale University

This study tests whether combining two approved drugs, belantamab mafodotin and elotuzumab, is safe and works better than either alone for multiple myeloma. About 24 adults whose cancer has returned or not responded to at least three prior treatments will receive the combination.…

This Phase 3 trial tests whether taking Elagolix, a hormone-blocking drug, before IVF can increase live birth rates in women with endometriosis. About 97 women will receive either Elagolix or a placebo before their IVF cycle. The goal is to see if this pre-treatment improves the …

This study tests whether the medication lisdexamfetamine (Vyvanse) can reduce loss-of-control eating and help with weight management in people who had bariatric surgery but still struggle with eating issues. About 60 adults who did not respond to earlier treatments will receive e…

This pilot study tests a community-academic partnership to help children with asthma in New Haven. It offers home visits from trained community health workers (Promotoras) and an online tool for doctors to guide asthma care. The goal is to see if this approach is feasible and can…

This study tests whether a combination of medication (naltrexone/bupropion, also known as Contrave) and behavioral weight-loss counseling can help people who experience loss-of-control eating after bariatric surgery. About 160 adults who had gastric bypass or sleeve gastrectomy a…

This study tests whether adding spironolactone to standard blood pressure treatment helps lower blood pressure more effectively in people who have had a stroke. About 160 adults who had a bleeding or clot-caused stroke are taking spironolactone or continuing their usual care. Res…

This pilot study tests a web-based program called LDART for adults with stimulant use disorder (cocaine or methamphetamine). The program includes daily goal setting, motivational messages from people in recovery, and links to support groups. Researchers want to see if it's feasib…

This study tests whether starting alcohol use disorder treatment while still in the hospital helps people stay in treatment and drink less after they go home. 450 adults with moderate to severe alcohol problems will receive either a brief counseling session alone, or that session…

This early-stage study tests whether briefly raising blood pressure in stroke patients undergoing a clot-removal procedure can slow brain damage. About 40 adults with large-vessel blockage strokes will be enrolled within 24 hours of symptom onset. The main goals are to see if the…

This study tests whether a low-caffeine green tea extract (EGCG) can shrink uterine fibroids and improve pregnancy and live birth rates in women aged 18-40 who have been trying to conceive for at least six months. Participants take the extract and are monitored for changes in fib…

This study tests a two-step treatment for people with pancreatic cancer that hasn't spread but can't be removed by surgery. First, patients receive a stronger chemotherapy cocktail (modified FOLFIRINOX), followed by precise, high-dose radiation (SBRT). The goal is to see if this …

This study tests a new way to help people with heart failure in Uganda manage their condition. It combines a standard care program with a mobile app that tracks symptoms and gives advice. The goal is to see if this approach improves self-care and reduces deaths or hospital stays.…

This study was designed to test whether the drug etrasimod (VELSIPITY) could help reduce the need for steroids in cancer patients who develop diarrhea and colon inflammation from immune checkpoint inhibitors. It planned to enroll about 0 participants with advanced cancer who had …

This pilot study tests a web-based program called Let's Do Addiction Recovery Together! (LDART) for adults with alcohol use disorder. Participants use the website daily for a month to set recovery goals, watch motivational messages from people in recovery, and learn about local s…

This study tests a pharmacist-led program to help women with HIV who also face social challenges like housing or food insecurity. The program supports switching from daily pills to a long-acting injectable medication (cabotegravir/rilpivirine) given every two months. The goal is …

This study tests whether semaglutide (Wegovy), a once-weekly injection, can preserve the pancreas's ability to produce insulin and reduce liver fat in 60 obese youth with prediabetes or early type 2 diabetes and fatty liver disease. Participants receive either semaglutide or a pl…

This study looks at whether adding a combination of two drugs (naltrexone and bupropion) or a behavioral weight-loss program can help people who didn't lose enough weight after bariatric surgery. About 84 participants will receive either the drugs, behavioral therapy, both, or a …

This study looks at ways to help people of color living in areas with high overdose rates start and continue medication-assisted treatment (MAT) for opioid or alcohol use. Researchers will track how many treatment sessions people attend and whether they stick with their medicatio…

This early-stage study tests whether a drug called apremilast can help people with Alcohol Use Disorder drink less alcohol. Ten adults will take the medicine and then have their drinking measured in a lab setting. The goal is to see if the drug reduces alcohol consumption, especi…

This study tests whether a medication normally used for other conditions can help people with HIV reduce their alcohol use. Thirty participants who have HIV, smoke, and drink heavily will receive the medication along with counseling. The goal is to see if this approach is practic…

This study looks at whether surgically removing the prostate, along with hormone therapy and possibly chemotherapy, can help men whose prostate cancer has already spread. About 190 men with newly diagnosed stage IV prostate cancer will be randomly assigned to get either standard …

This early-phase study tests a combination of two immunotherapy drugs (domvanalimab and zimberelimab) in people whose glioblastoma has come back after initial treatment. The goal is to check if the drugs are safe and to see how they affect the tumor and immune system. About 46 pa…

This study tests whether a combination medication (naltrexone/bupropion) can help people who had weight-loss surgery avoid a return of binge eating and weight gain. About 100 adults who responded well to an earlier treatment will receive either the medication or a placebo for mai…

This study looks at three types of weight loss surgery—gastric band, sleeve gastrectomy, and gastric bypass—in severely obese teenagers aged 14 to 19. It tracks changes in weight, blood sugar, and nutrition over time to find out which surgery is safest and most effective. The goa…

This study tests two telemedicine programs for adults with chronic pain and opioid use disorder. One program uses standard collaborative care, while the other adds a self-management tool. The goal is to see which approach better reduces pain interference and opioid misuse. About …

This study tests a drug called sacituzumab govitecan in 20 people with ovarian, fallopian tube, or primary peritoneal cancer that has stopped responding to platinum-based chemotherapy. The drug works like a guided missile, delivering chemotherapy directly to cancer cells. The mai…

This early-phase study tested a new drug called BHV-7000 in 5 people with epilepsy who have a brain implant (RNS) that records brain activity. The goal was to see if the drug reduces abnormal electrical activity linked to seizures. Participants took the drug for 4 weeks, and thei…

This study tests a drug called sacituzumab govitecan in 50 people with endometrial cancer that has returned or not responded to platinum chemotherapy. The drug works by delivering chemotherapy directly to cancer cells. The main goal is to see how many patients' tumors shrink or d…

This study aimed to see if a computer program could correctly identify patients with ATTR amyloidosis, a rare disease that affects the heart and nerves, by looking at their medical records. The program was designed to flag people who might have the condition but were not yet diag…

This study tests whether artificial intelligence (AI) can spot a serious heart valve condition called aortic stenosis using portable, non-invasive devices. Researchers will enroll 410 adults aged 70 and older during routine primary care visits. The goal is to see if AI-powered an…

This study tests a virtual reality (VR) program designed to prevent e-cigarette use in 8th graders. Researchers will work with about 40 students and school staff to see if the VR game is acceptable, easy to use, and practical for classrooms. The goal is to help teens build emotio…

This study tests a 24-week program that uses rewards and support services to help people with opioid use disorder who inject drugs stay on PrEP, a daily pill that prevents HIV. About 526 participants will be followed for a year to see if the program improves medication adherence …

This study is testing a new augmented reality video game called 'No Time Wasted' to help teens aged 16-18 learn about alcohol risks and reduce dangerous drinking. About 20 high school students will play the game and answer surveys to see if it improves their knowledge and encoura…

This pilot study tests a tool called ED-TREAT that helps emergency room staff spot and treat agitation early. The goal is to see if the tool is easy to use and can reduce the need for physical restraints. The study involves 26 adults at Yale New Haven Hospital, but enrollment is …

This early study is testing whether repeated doses of psilocybin, the active ingredient in magic mushrooms, can reduce symptoms of obsessive-compulsive disorder (OCD). About 28 adults with OCD who haven't gotten better with standard treatments will receive two doses of psilocybin…

This study from Yale University will test whether listening to live music can reduce anxiety and improve brain activity in people with early Alzheimer's disease, dementia, or mild cognitive impairment, along with their caregivers. Sixty pairs (patient and caregiver) will attend b…

This small pilot study tests whether psilocybin, the active ingredient in magic mushrooms, can change brain connections to improve depression. 18 adults with major depression who didn't get better with standard treatments will receive psilocybin. Researchers will measure brain ac…

This study looks at whether applying a silicone ointment to the skin before head and neck surgery helps wounds heal with less scarring. About 60 adults having non-emergency surgery will take part. Researchers will compare scars using standard rating scales and also track hospital…

This study looks at a temporary nerve stimulation device placed near the back of the head to treat stubborn headaches. About 300 adults who are already scheduled for this treatment as part of their regular care will be followed for a year. Researchers will measure changes in head…

This small pilot study at Yale University is testing a modified form of cognitive-behavioral therapy (CBT) for children with autism and intellectual disability who struggle with irritability, tantrums, and aggression. Up to 6 children aged with an IQ between 55 and 85 will receiv…

This study planned to see if using virtual reality (VR) before a brain stimulation treatment called TMS could help people with OCD feel more comfortable. It was designed for adults already approved for TMS. However, the study was withdrawn before any participants were enrolled, s…

This early study tests whether a drug called brexanolone is safe and feasible for people who have both PTSD and alcohol use disorder. The goal is to see if it can reduce stress-induced drinking. The study involves 25 adults aged 21-55 and focuses on safety and side effects.

This study tests whether a virtual, community-based program combining music and mindfulness can help reduce stress, anxiety, and depression in people of African descent. About 300 participants aged 16 and older will take part. The goal is to see if these culturally relevant activ…

This pilot study tested whether propranolol, a beta-blocker, reduces alcohol drinking in stressed adults with alcohol use disorder. Twenty participants took either propranolol or a placebo for two weeks, then completed two lab sessions where they were exposed to stress or relaxat…

This study aimed to see if Botulinum Toxin-A (Botox) could help people with hidradenitis suppurativa, a painful skin condition. It planned to enroll adults with active armpit lesions of similar severity on both sides. However, the study was withdrawn before any participants were …

This study looks at whether joining community drum circles and mindfulness programs can help reduce anxiety and depression in Black and other marginalized groups who faced extra stress during COVID-19. About 90 people aged 16 and older will take part. Researchers will measure how…

This study tests whether a wearable device called UpRight Go can reduce pain, numbness, and weakness in people with cubital tunnel syndrome who haven't had surgery. About 40 adults will use the posture trainer and report their symptoms. The goal is to see if improving posture can…

This study tests a digital mindfulness app called Calm Health in 26 adults with chronic kidney disease. Participants use the app for 6 weeks while wearing a wrist sensor to track sleep, activity, and heart rate. The goal is to see if the app is easy to use and if it helps reduce …

This study planned to test whether a small electrical device (TENS) could reduce pain when placing an IUD. It was designed for adults getting a new or replacement IUD. The study was withdrawn before enrolling anyone, so no results are available.

This study tests a 24-week program called SC-POWR for 204 adults with opioid use disorder and chronic pain. Participants get medication, therapy, exercise (like Wii Fit and Tai Chi), and stress reduction (relaxation training and acupuncture). The goal is to reduce pain interferen…

This study tests whether a non-invasive brain stimulation technique called repetitive Transcranial Magnetic Stimulation (rTMS) can change how adults with autism process social information. Researchers will measure brain responses with EEG and eye-tracking before and after stimula…

This study tests whether listening to recordings of communal drumming, combined with mindfulness, can help reduce stress and improve feelings of connection in People of African Descent (PADs) who have anxiety and depression. Researchers will compare how participants rate their se…

This observational study uses PET brain scans to measure CB1 receptor availability in 15 people who currently use synthetic cannabinoids. Researchers want to see if these drugs change the brain's cannabinoid receptors and how that relates to thinking and brain rhythms. No treatme…

This study is collecting information from 458 people with critical limb-threatening ischemia, a severe form of peripheral artery disease that can lead to amputation. The goal is to learn how different treatments affect patients' daily lives and health outcomes. Researchers hope t…

This study looks back at the medical records of 150 children with biliary atresia, a rare liver condition, treated between 2012 and 2021. Researchers want to find out which treatments and factors lead to better survival and fewer liver transplants. The goal is to use this informa…

This study looks at whether a program called SBIRT (Screening, Brief Intervention, and Referral to Treatment) can help adult education students with behavioral health issues like depression, anxiety, and substance use. About 340 students and staff from New Haven Adult Education w…

This study looks at how alcohol and cannabis, alone or together, affect driving ability and thinking. About 40 adults aged 21–55 who have used both substances before will take part. They will complete simulated driving tests and questionnaires after receiving the substances. The …

This study looks at brain changes in people with major depression or PTSD using special PET scans. Researchers want to see if a single dose of ketamine can reverse loss of brain connections. About 130 adults aged 18-70 will have MRI and PET scans, with some receiving ketamine dur…

This study at Yale University looks at how THC, the active ingredient in cannabis, affects short-term and long-term memory. Researchers will give 80 adults who have used cannabis before either a low dose of THC or a placebo and then test their memory. The goal is to better unders…

This study from Yale University is testing how a ban on menthol in cigarettes and e-cigarettes might affect people who currently smoke menthol cigarettes. Researchers will give 150 adult smokers either a ban on menthol cigarettes only or a total ban on menthol in both cigarettes …

This study looks at how alcohol and cannabis, alone or together, affect simulated driving and thinking. About 40 adults aged 21 to 55 who have used both substances before will take part. Researchers measure driving errors and self-reported feelings to understand the risks.

This study looks at how alcohol and cannabis, alone or together, affect driving ability and thinking in a safe, simulated environment. About 40 occasional users aged 21 to 55 will take part. The goal is to better understand the risks of driving under the influence of these substa…

This study follows 350 men with prostate cancer who are getting a new type of PET scan (PSMA PET) for the first time. Researchers want to learn how the scan affects patients' anxiety, decision-making, and quality of life. Participants fill out surveys over a year. No new treatmen…

This study looks at 500 women with chest pain to compare two tests used during heart catheterization—FFR and iFR—to see which better predicts future heart problems like heart attacks or strokes. Participants will be followed for 5 years. The goal is to improve how doctors decide …

This study looks at whether a family-centered approach helps caregivers affected by intimate partner violence (IPV) engage more with support services compared to a child-centered approach. About 95 caregivers with children under 5 who were reported to child protective services fo…

This study looks at whether adding an SGLT2 inhibitor (a type of diabetes medicine) to standard care can help people with acute heart failure and kidney injury recover faster. It involves 30 adults aged 18-85 with heart failure and high NT-proBNP levels. The main goal is to see i…

This study aims to find the genes that cause aortic aneurysms (bulges in the main artery) and heart valve problems. Researchers will collect blood and tissue samples from 3000 people with these conditions and their family members. The goal is to better understand why these diseas…

This study looks at whether giving doctors feedback about their prescribing habits can reduce the number of potentially harmful medications given to older adults when they leave the emergency department. About 200 clinicians from Yale New Haven Health System are taking part. The …

This study looks at how alcohol and cannabis, alone or together, affect driving ability and thinking in a safe, simulated setting. About 40 occasional users aged 21 to 55 will take part. The goal is to better understand the risks of driving under the influence.

This study aimed to see if a structured reflective writing program could reduce burnout in physician assistant students at Yale. It was designed to track changes in burnout scores over time using a questionnaire. However, the study was withdrawn before enrolling any participants,…

This study aimed to see if a simple blood test could find blockages in the tiny blood vessels of the heart in people who had a heart transplant. Researchers planned to take blood samples every three months for a year and check medical records for three years. However, the study w…

This study aimed to see how MDMA changes brain activity in people with PTSD, especially in areas that handle emotions. Researchers planned to give MDMA to a small group and measure brain scans and PTSD symptoms. However, the study was withdrawn before any participants were enroll…

This study looks at how cannabis (specifically the drug Dronabinol) changes the immune system and genes in people with HIV. Researchers will take blood samples before and after giving Dronabinol to 160 participants. The goal is to understand these changes better, which could help…

This study gathers information from 8,000 stroke patients worldwide to learn more about seizures that happen after a stroke. Researchers will analyze the data to see how well patients recover and to create a tool that can predict who might develop epilepsy. The goal is to improve…

This study involves 500 people who have chest pain or other signs of heart trouble, but whose main heart arteries are not blocked. Researchers use special tools during a heart catheterization to measure tiny blood vessel function and look for hidden causes like microvascular dise…

This study tests a digital score to monitor aortic stenosis, a heart valve condition, in 210 adults aged 65 and older with early signs of the disease. Researchers will track changes in heart function over time using data from routine tests. The goal is to improve risk prediction,…