Yale University

This study tested whether a combination of naltrexone and bupropion can reduce binge-eating episodes and promote weight loss in people with binge-eating disorder and obesity. Participants took either the drug combo or a placebo for 12 weeks. The trial was very small, with only 3 …

This study tested whether quitting cigarettes and e-cigarettes at the same time or one after the other is more effective. Nineteen adults who smoked and vaped received varenicline (a medication to reduce cravings) and counseling. Researchers measured abstinence and health markers…

This study tested a program called the Transitions Clinic Network for people leaving jail who have opioid addiction. About 400 participants were randomly assigned to either the program or standard primary care. The program offered primary care, medication for addiction, and a com…

This study tested the Bright Bodies program, a family-based lifestyle intervention for children aged 7-13 with obesity. The program includes nutrition education, behavior modification, and exercise sessions. Researchers measured changes in BMI and other health outcomes across thr…

This study tested whether the drug lisdexamfetamine (LDX) can help adults with binge-eating disorder and obesity avoid relapse. 61 participants who initially responded to treatment were randomly assigned to receive LDX or a placebo for 12 weeks. The main goal was to see if LDX re…

This study tested whether the drug Taltz can slow scar tissue growth in the throat, reducing the need for repeat surgeries in people with idiopathic subglottic stenosis. Ten adults with the condition received the drug, and researchers measured how long they could go between surge…

This study tested a GLP-1 drug (a type of medication that affects appetite) against a placebo in 96 adults with obesity. The goal was to see if the drug could reduce cravings, hunger, stress, and food intake. Results suggest the drug may help control eating behaviors and support …

This study tested a combination of two targeted drugs, afatinib and cetuximab, in 50 adults with advanced head and neck cancer that had already been treated with chemotherapy or immunotherapy. The goal was to see if the drug pair could shrink tumors. The study measured how many p…

This small pilot study tested whether spironolactone, a medication usually used for heart conditions, could help people with HIV reduce their alcohol use. Twenty-one participants received the drug along with support from a pharmacist and psychiatrist. The study focused on whether…

This study tested whether community health workers (trained members of the community) can help people with type 2 diabetes and food insecurity use a program that provides free fruits and vegetables. 104 Hispanic adults on Medicaid in Connecticut took part. The goal was to see if …

This study tested different ways to help people living with HIV quit smoking. Participants received nicotine replacement therapy (like patches or gum), the medications varenicline or bupropion, and financial rewards for staying smoke-free. The goal was to see if these approaches …

This study tested two different approaches to help people recently released from jail or prison get connected to care for HIV, hepatitis C, STIs, and opioid use disorder. Over 600 adults took part. The goal was to see which method worked better for starting and staying on treatme…

This study tested whether adding reminders to electronic health records helps doctors follow guidelines for managing overweight and obesity in children. Over 58,000 children and their doctors took part across multiple primary care practices. The goal was to improve care and help …

This study tested a telehealth platform designed to help people with opioid use disorder start medication treatment and reduce overdose events. 33 adults with a history of opioid overdose and moderate to severe opioid use disorder participated. The platform aimed to connect them …

This early-phase study tested a new drug (APX005M) added to two existing immunotherapy drugs (nivolumab and ipilimumab) in 26 people with advanced melanoma or kidney cancer who had not received prior immunotherapy. The main goals were to check safety and find the best dose. The s…

This study tested a combination of chemotherapy drugs given both before and after surgery for people with early-stage pancreatic cancer. The goal was to shrink the tumor before surgery and kill any remaining cancer cells afterward. 46 participants were enrolled to see if this app…

This study tested a program that gave low-income pregnant Latina women money each month to buy fruits and vegetables, along with nutrition education and text reminders. Over 10 months, the goal was to see if women bought and ate more produce and felt less food insecurity. The pro…

Researchers at Yale University developed a virtual reality game called Invite Only VR to help middle school students learn about the risks of vaping nicotine and cannabis. In the game, players practice refusing offers to vape in realistic social situations. The study tested the g…

This study tested whether a 12-session parent-based treatment (Supportive Parenting for Anxious Childhood Emotions) can reduce anxiety in children by changing how their brains respond. 214 children with anxiety disorders participated. The goal was to see if parent training alone …

This study tested a mobile app designed to help middle-aged adults with type 1 diabetes exercise more often and with greater confidence. The app uses data from blood sugar monitors, activity trackers, and sleep patterns to provide personalized encouragement and insights. Twenty-f…

This study tested whether a digital mindfulness app is practical and acceptable for people in early recovery from substance use disorders. 36 participants were randomly assigned to standard group therapy alone or standard therapy plus the app for 8 weeks. The main goal was to see…

This study tested a web-based program that combines cognitive behavioral therapy and pain self-management for people being treated for opioid use disorder who also have chronic pain. The program includes online lessons and daily text surveys to track pain and activity. Researcher…

This study looked at whether a shorter (3-week) or longer (6-week) period of activity restriction after midurethral sling surgery leads to better recovery and satisfaction. 206 women who had the surgery were followed. The goal was to find the best balance between healing and gett…

This study tested whether combining two medications, varenicline and guanfacine, helps people quit smoking better than standard treatments. 167 adult smokers who smoked at least 10 cigarettes daily took part. Researchers measured how long participants could delay their first ciga…

This study tested whether a web-based social support program is practical and helpful for people who drink heavily and want to cut down or quit. 30 adults in Connecticut used the tool for 28 days. The goal was to see if people would use it and find it acceptable, not to measure l…

This study tested an online version of a proven psychological treatment for children with serious behavior problems like aggression and defiance. 86 children and their parents took part from home. The goal was to see if online therapy could improve child behavior and reach famili…

This early-stage study tested whether cannabidiol (CBD) could safely help people with both opioid addiction and chronic pain. Seven adults on methadone or buprenorphine received different doses of CBD or a placebo in a controlled setting. Researchers measured sedation, cognitive …

This study tested a new program called COPES against standard cognitive behavioral therapy (CBT-CP) for veterans with chronic pain. Over 700 veterans participated to see which approach better reduces pain's impact on daily life. Both programs teach skills to manage pain without m…

This study tested a short, self-guided online program designed to increase hope in women experiencing intimate partner violence. 97 women completed the program, which included facts about the brain, survivor stories, and writing exercises. Researchers measured whether the program…

This study tested a phone-based counseling program called SBIRT-PM for veterans with chronic pain who were also at risk for substance misuse. Over 1,100 veterans participated, receiving up to four phone calls over 12 weeks to help them engage in non-drug pain treatments and reduc…

This pilot study tested an online guided self-help program for teens aged 12–17 who binge eat and have a higher weight. Eight teens completed weekly online sessions over four months. The main goal was to see if the program was practical and acceptable, not to measure effectivenes…

This study tested whether giving women a single dose of olanzapine before outpatient surgery improves how they feel the day after. 384 women aged 18-50 took either the drug or a placebo. The goal was to see if it helps with nausea, pain, and overall recovery quality.

This study tested two online treatments for teenagers who have bulimia nervosa (binge eating and purging) and are overweight. The goal was to see if these therapies are practical and helpful for reducing binge eating and purging. Twenty-five teens participated, and the study meas…

This study tested a digital neurotherapy (a brain training program) in 36 adults who were either cancer survivors or on dialysis for kidney failure. The goal was to see if it could help with depression, thinking skills, and quality of life. Participants used the program and compl…

This study tested a new behavior therapy for teens with autism who struggle with irritability and aggression. The therapy teaches emotion regulation and coping skills for the challenges of growing up. 65 adolescents participated, and researchers measured changes in aggressive beh…

This study tested a therapy called BE-SMART-DR in 65 teens and young adults with bipolar disorder or major depression who had suicidal thoughts or past attempts. The therapy teaches self-directed strategies to regularize sleep and daily routines, aiming to reduce suicide risk. Re…

This study tested a new way to help people with temporal lobe epilepsy who still have seizures despite medications or other treatments. Instead of trying to stop the seizures, researchers used electrical stimulation in the thalamus (a deep brain area) to try to keep people consci…

This study tested whether repeated doses of ketamine, given through an IV, can safely and effectively reduce depression in people with Parkinson's disease. 51 adults aged 40-80 with both conditions took part. Researchers compared ketamine to a placebo and used brain scans to expl…

This study tested two bowel-cleansing drinks in 520 hospitalized adults needing a colonoscopy. One drink (MoviPrep) uses a smaller volume than the standard (GoLYTELY). The goal was to see if the lower-volume option works just as well and is easier to tolerate. Results could help …

This study tested a new device called Miraπ that physically moves a stroke patient's affected hand during mirror therapy. It compared this device to standard mirror therapy in 24 stroke patients with one-sided hand paralysis and pain. The goal was to see if the device could impro…

This study tested whether a numbing injection (nerve block) given before thyroid surgery helps people feel better the day after. 160 adults having thyroid surgery were randomly assigned to get either the numbing medicine or a saltwater placebo. They filled out surveys about their…

This study tested a portable device that gently moves the hand to reduce muscle tightness (spasticity). Ten adults with hand paralysis or motor problems used the device for one 20-minute session. Researchers measured changes in muscle tone and asked participants about the device'…

This completed early-phase study at Yale tested how the dose and speed of nicotine delivery affect its addictive potential and its ability to reduce smoking urges. Twenty daily smokers received IV nicotine pulses at different doses and rates to mimic cigarette smoking. The goal w…

This completed Phase 2 trial tested whether a drug called CVL-562 can change brain activity related to working memory in people with early schizophrenia. 112 participants received different doses or a placebo while undergoing brain scans. The goal was to find brain imaging marker…

This study from Yale University looked at how menthol flavor in e-cigarettes affects smoking behavior and nicotine levels in people who smoke menthol cigarettes. Fourteen adult smokers participated in lab sessions where they used e-cigarettes with menthol or non-menthol flavor. R…

This small study looked at how vitamin D (calcitriol) affects dopamine receptors in the brains of people with opioid use disorder. Five participants received either vitamin D or a placebo, then had PET scans to measure brain activity. The goal was to understand if vitamin D could…

This pilot study tested whether a patient navigator—a person who helps coordinate medical care—could increase eye exam rates in 35 adults with diabetes who were at high risk for blindness. Participants met with a navigator quarterly to overcome barriers to care. The study measure…

This study tested whether a portable MRI machine can start scans faster than a conventional MRI in the emergency department. About 100 adults with brain scan orders were randomly assigned to get either a portable MRI plus usual care or usual care alone. Researchers measured how q…

This study tested a special imaging method (SPECT/CT) to measure blood flow in the leg muscles of people with peripheral arterial disease (PAD) and diabetes. Researchers compared these images to those from healthy volunteers to see how treatment affects muscle blood flow. The goa…

This study tested whether instant computer feedback helps community health workers in Nigerian clinics make better care decisions. Researchers compared patient notes written before and after the computer gave advice, with a doctor reviewing the notes. The goal was to see if the t…

This study looked at whether letting children start preschool at age 3, instead of the usual age 4, improves their learning and helps their mothers find work. Researchers worked with over 2,000 families in rural Kenya. They measured children's thinking and language skills, and tr…

This early-phase study looked at how a single dose of cannabidiol (CBD) affects brain inflammation and pain sensitivity in 28 healthy adults. Researchers used brain scans to measure inflammation and a skin cream test to check pain response. The goal was to understand CBD's potent…

This pilot study tested a suicide prevention package (SuPP) in rural Pakistan, involving 50 women at risk. The package includes safety planning and brief follow-up contacts delivered by trained peers. The goal was to see if this approach is feasible and acceptable in low-resource…

This completed study enrolled 311 people with myasthenia gravis, a condition that causes muscle weakness. Researchers collected clinical information and blood samples to build a repository for future studies. The goal is to help scientists better understand the disease and potent…

This study looked at how men and women differ in their sensory experience and liking of e-cigarette flavors. 66 adult smokers who also used e-cigarettes tried sweet, cooling, and unflavored e-liquids with nicotine. Researchers measured how much they liked each flavor, how sweet o…

This completed study at Yale University enrolled 600 men with prostate cancer to test a new biopsy method that combines MRI and ultrasound images. The goal was to collect extra tissue samples for detailed single-cell analysis, looking at proteins and other markers to better predi…

This study tested whether a bacterial toxin called endotoxin can increase alcohol consumption in people with alcohol use disorder. 27 participants received either endotoxin or a placebo, and their alcohol intake was measured during a 2-hour session. The goal was to gather early d…

This study looked at how a short stressful experience changes the way the brain learns and remembers. Healthy adults aged 18-45 underwent a cold water stress test or a control version while their brain activity was measured with fMRI. The goal was to understand the neural mechani…

This study tested a special MRI contrast agent called ferumoxytol to see if it can detect inflammation in the walls of brain arteries in people who recently had a stroke. The researchers compared it to a standard MRI contrast to see which one better shows artery inflammation. The…

This study, completed by Yale University, tested whether a standardized field test can measure marijuana impairment in drivers. 41 participants who use marijuana regularly completed cognitive tasks and simulated driving after smoking either medium-THC or placebo marijuana. The go…

This study looked at how cannabis use affects brain receptors and electrical activity, and how these change when people stop using. Researchers used brain scans and EEGs in 162 people, including cannabis users and healthy controls. The goal was to understand the brain's recovery …

This completed Phase 4 study at Yale University looked at how the heart failure drug Entresto (LCZ696) lowers blood pressure and affects sodium excretion. 46 stable heart failure patients with reduced ejection fraction participated. The goal was to understand the body's response …

This study used PET scans to compare the density of synapses—connections between brain cells—in 40 people: experienced meditators and non-meditators. Researchers gave participants a radioactive tracer that binds to a protein on synapses, then scanned their brains. The goal was to…

This study tested a new way to find people exposed to tuberculosis (TB) in Cali, Colombia. Instead of relying only on in-person visits, researchers used a mobile phone chatbot and a simple oral (mouth) test that people could do at home. The goal was to see if this approach was pr…

This study aimed to understand what helps or hinders breast cancer screening using a simple physical exam in primary health centers in Abuja, Nigeria. Researchers interviewed and observed 62 healthcare workers and community members to identify barriers and develop practical strat…

This study looked at how different cooling ingredients in e-cigarettes, like WS-3 and menthol, change the feeling of coolness for users. 31 adults who vape nicotine took part. They tried 16 different e-cigarette mixes and rated the coolness, flavor, sweetness, and harshness using…

This study looked at 165 emergency room patients with persistently high blood pressure to see how many had undiagnosed left ventricular hypertrophy (thickened heart muscle) using a bedside ultrasound. Researchers also tested whether telling patients about the finding and giving t…

This study looked at how giving extra chloride (without sodium) affects fluid balance in people with stable heart failure. Twenty participants were closely monitored over a week. The goal was to learn more about how chloride impacts the body's handling of fluids and salt, which c…

This study tested a computer tool designed to help emergency room doctors follow best practices for treating opioid use disorder. Researchers looked at whether the tool increased the use of standard assessments and buprenorphine treatment. The study involved 267 adults with moder…

This study aims to confirm that certain brain and eye measurements can serve as reliable biomarkers for autism. Researchers will compare 200 children with autism and 200 typically developing children, ages 6 to 11. The goal is to provide better tools for future clinical trials, n…

This study tested whether a virtual reality program (DeepDream) can produce experiences similar to psychedelic drugs. Ten healthy volunteers took part at Yale University. Researchers measured changes in consciousness, mystical feelings, and sense of self. The goal was to see if V…

This study tested a digital program called Be There Certificate among 102 college students living in dorms. The goal was to see if students would use the program and if it improved their mental health knowledge and ability to support peers. Researchers measured completion rates, …

This study tested whether using a special computer model to send kidney injury alerts only to patients who would benefit most could reduce worsening kidney damage, need for dialysis, or death. Over 2,000 hospitalized adults with acute kidney injury took part. The goal was to see …

This study looked at whether telling older women about overdiagnosis (finding cancers that would never cause harm) changes their desire to get mammograms. Over 300 women aged 70 and older watched a video explaining overdiagnosis and answered surveys about their screening intentio…

This study looked at how to best prevent tuberculosis (TB) in Malaysian prisons. Researchers compared a standard 40-week daily TB prevention treatment to a shorter 12-week weekly treatment in 316 inmates, some with HIV or opioid dependence. The goal was to see which approach work…

This study tested a computer tool that helps emergency doctors start buprenorphine treatment for people with opioid use disorder. The tool guides doctors through diagnosis, withdrawal assessment, and treatment steps. Over 1,100 patients took part, and the study measured how often…

This study looked at whether doctors trust and find useful an artificial intelligence (AI) tool that predicts the risk of serious stomach bleeding. 108 medical residents used the tool in simulated emergency scenarios. The goal was to see if adding a chat-like AI interface made th…

This study looked at how flavors in e-cigarettes affect how much adult smokers like and want them. It included 130 smokers aged 21-50 who used only e-cigarettes for two weeks. The goal was to measure their reactions, not to treat or cure any condition.

This study tested a new, portable low-field MRI to measure white matter hyperintensities (WMH)—tiny brain changes linked to aging and vascular risk. Researchers enrolled 100 adults with at least one risk factor like high blood pressure or diabetes. They developed a simple grading…

This study looked at whether a blood test called DiviTum-TKa can help doctors check if patients with metastatic breast cancer are taking their CDK4/6 inhibitor medication correctly and if other drugs are interfering. The test measures a marker of cell growth to see if the treatme…

This study explored how a very low carbohydrate diet impacts blood sugar levels and brain function in 19 adolescents with type 1 diabetes. Researchers measured time spent in the optimal glucose range and episodes of low blood sugar over two weeks. The goal is to understand the sa…

This study looked at how a single dose of THC (the active ingredient in cannabis) changes immune-related genes and proteins in the blood. Researchers compared 56 adults with and without HIV to see if the effects differ. The goal was to understand THC's impact on the immune system…

This study looked at how gut bacteria might influence fat metabolism in young people aged 15 to 21. Researchers gave a special sugar drink to 38 healthy and obese participants to measure changes in fat production in the liver. The goal was to understand the role of gut bacteria i…

This study worked with healthcare workers and community members in Soweto, South Africa, to find the best ways to offer breast cancer screening using simple physical exams in local clinics. Researchers observed clinic workflows and held group discussions with 80 participants to u…

This study looked at how people with autoimmune diseases like multiple sclerosis or blistering skin conditions respond to COVID-19 vaccines while on B-cell depleting therapies. Researchers measured antibody levels and T-cell activity over time to understand vaccine effectiveness …

This study looked at how the strength and form of nicotine in e-cigarettes affect how fast and how much nicotine gets into the blood. Thirty-six adults who vape regularly took puffs from different e-cigarette setups while their blood was sampled through a small tube in their arm.…

This study used MRI and PET scans to examine the glutamate system in people with major depression, PTSD, or bipolar disorder. Researchers aimed to understand how a specific glutamate receptor (mGluR5) relates to these conditions. 180 participants aged 18-70 completed cognitive te…