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Can a computer game lift depression? new study tests digital therapy for cancer and kidney patients

NCT ID NCT04961047

Symptom relief Sponsor: Yale University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tested whether a home-based digital brain training program could help with depression, thinking skills, and quality of life in 36 people with cancer or end-stage kidney disease. Participants used a computer program called Rejuvenate for 30 minutes, four times a week, for eight weeks. The goal was to see if this approach is practical and helpful for managing mood and mental function alongside major medical illnesses.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
digital neurotherapy (brain training program)
What this could lead to
If it works, this could offer a non-drug, home-based option to ease depression and improve thinking skills in people with serious illnesses.
What could go wrong
This is a small, early feasibility study with only 36 participants, so results may not apply widely. The digital program may not work for everyone or may be hard to stick with.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

36 people

The number who actually took part.

Started

Dec 2021

Finished

May 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Cancer Survivor Group Inclusion Criteria: 1. Provision of signed and date informed consent form. 2. Stated willingness to comply with all study procedures and availability for the durationof the study. 3. Associated with Smilow Cancer Hospital with a diagnosis for cancer 4. Have received chemotherapy, and/or radiation treatment, and/or immuno therapy treatment for cancer 5. Able to understand and read English Exclusion Criteria: 1. Stage 4 cancer 2. Brain cancer 3. Diagnosis of serious mental illness (ie, psychosis) 4. Cognitive impairment (ie, diagnosed dementia, intellectual development disorder) 5. Hearing or vision insufficient to do the computer exercises. ESKD Group Inclusion Criteria: 1. Associated with Yale Nephrology practice and receiving in-center hemodialysis treatment 2. Have received hemodialysis for at least one month from start of outpatient dialysis and attended 10 of first 12 visits. Exclusion Criteria: 1. Diagnosis of serious mental illness (ie, psychosis) 2. Cognitive Impairment (ie, diagnosed dementia, intellectual development disorder) 3. Hearing or vision insufficient to do the computer exercises

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Conditions

The condition(s) this trial relates to.

cancer cognitive disorder Depression depressive disorder end stage renal failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cognition Depression Quality of life

Contacts and locations

Locations

  • Yale New Haven Hospital

    New Haven, Connecticut, 06512, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.