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Can a stimulant drug stop Binge-Eating relapse? new study tests LDX

NCT ID NCT03926052

First seen Jan 06, 2026 · Last updated Jun 22, 2026 · Updated 21 times

Summary

This study tested whether the drug lisdexamfetamine (LDX) can help adults with binge-eating disorder and obesity avoid relapse. 61 participants who initially responded to treatment were randomly assigned to receive LDX or a placebo for 12 weeks. The main goal was to see if LDX reduced the number of binge-eating episodes compared to placebo.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Yale Department of Psychiatry

    New Haven, Connecticut, 06510, United States

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

lisdexamfetamine (LDX)

What this could lead to

If it works, this could provide a medication option to help people with binge-eating disorder maintain control and avoid relapse after initial treatment.

What could go wrong

This is a small, completed Phase 3 trial with only 61 participants, so results may not apply to everyone. LDX is a stimulant and can have side effects like increased heart rate or risk of misuse.

Conditions

The condition(s) this trial relates to.

binge eating disorder Binge-Eating Disorder Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.