Yale University

This phase 3 trial tests whether radiation therapy can prevent Dupuytren's contracture—a condition where fingers bend toward the palm—from progressing or coming back after treatment. About 158 adults will receive radiation to the hand, and researchers will measure changes in fing…

This study looks at whether eating six olives every day for five weeks can improve cholesterol and other health markers in healthy young adults. Researchers will compare blood tests from 226 Yale college students before and after the olive-eating period. The goal is to see if thi…

This study tests a drug called sacituzumab tirumotecan in 20 people with triple-negative breast cancer that has spread to the brain. The drug is given through a vein twice a month. The main goal is to see if it can shrink brain tumors. This is an early-phase trial, so it focuses …

This study tests a digital pill system that tracks when people with alcohol-related liver disease take their medication (acamprosate) and provides personalized support to help them stay on track. The system includes a sensor in the pill, a wearable patch, and a smartphone app wit…

This pilot study will test whether giving monthly extended-release buprenorphine injections from a mobile pharmacy is acceptable and practical for people with opioid use disorder. Sixty participants will receive the shots for 6 months, and researchers will track how many stay in …

This study tests a program that combines medication (Naltrexone + Bupropion) with behavior therapy to help adults lose weight and quit smoking before bariatric surgery. Researchers will compare this approach to standard care in 64 participants aged 18-65 who smoke and have obesit…

This study tests whether adding hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) to a standard hip procedure (core decompression with bone marrow cells) can reduce pain in people with early-stage avascular necrosis of the hip. The trial will enroll 400 p…

This study tests whether a comprehensive telehealth platform called RecoveryPad helps adults with moderate to severe opioid use disorder start and stay in medication treatment. Researchers will enroll 470 participants and track attendance at treatment appointments within 30 and 9…

This study will develop and test a culturally adapted version of contingency management—a program that gives rewards for staying drug-free—for Black adults with stimulant use disorder. About 70 participants will provide urine samples twice weekly to measure abstinence. The goal i…

This study tests whether two existing medications, anakinra and tocilizumab, can improve outcomes for people with a rare brain condition called NORSE, which causes continuous seizures that don't respond to standard treatments. About 438 children and adults across 33 hospitals wil…

This pilot study will test whether an AI tool called FibroX can help primary care providers diagnose advanced liver fibrosis in people with MASLD, a common liver condition. Forty doctors will review simulated patient cases, using either standard methods or the AI tool, to see if …

This study will test if artificial intelligence (AI) can spot a rare heart condition called ATTR-CM in people with heart failure. Researchers will use AI to analyze electrocardiograms (ECGs) and echocardiograms (Echo) from 150 adults. The AI's findings will be checked against a s…

This study tests a virtual platform called LEARN 2 that provides tailored education to help men living with HIV prevent related health problems like heart disease and metabolic issues. Participants will use the platform weekly, attend live health educator sessions, and track thei…

This study tests whether adalimumab, an anti-inflammatory drug, can prevent brain changes linked to Parkinson's disease in 108 people with REM sleep behavior disorder (RBD). RBD often precedes Parkinson's. Participants will receive adalimumab or a placebo every two weeks for two …

This study will test a chatbot designed to increase awareness and use of PrEP, a daily pill that prevents HIV, among Black men who have sex with men (MSM) in the Southern United States. About 145 participants will interact with the chatbot over 90 days, answering questions and re…

This study tests a virtual reality (VR) program for 8th graders to prevent them from starting to use e-cigarettes. About 1,250 students from schools in Connecticut and Massachusetts will play a VR game that teaches skills to handle emotions and resist vaping. The goal is to see i…

This study tests different methods to help people get screened for colorectal cancer. About 2000 adults from community health clinics will receive reminders or extra support to schedule a colonoscopy or stool test. The goal is to see which approach works best to increase screenin…

This study tests a counseling program called Healthy Families-PrEP that helps women in rural Uganda use HIV prevention medicine (PrEP) when trying to get pregnant, during pregnancy, and after giving birth. About 660 women who are HIV-negative but at risk will take part. The goal …

This study will adapt two proven prevention programs (SISTA/SIHLE) to help Black adolescent girls in Paterson, New Jersey avoid HIV/AIDS and substance abuse. Researchers will use focus groups with 10 girls aged 13-18 to understand their needs and then measure changes in drug use,…

This study looks at two programs designed to help Black men who have sex with men take PrEP regularly to prevent HIV. About 500 participants will receive either a care coordination program or that program plus extra behavioral support. Researchers will track adherence through blo…

This early-phase study at Yale will test whether a single 25 mg dose of psilocybin, the active ingredient in magic mushrooms, is safe and well-tolerated in 10 veterans who smoke and have chronic pain. Researchers will also look for signs that it might improve pain and boost motiv…

This phase 2 trial tests whether a single dose of psilocybin, the active ingredient in magic mushrooms, can improve depression in people with Parkinson's disease. Forty participants will receive a low to high dose with psychological support. The study measures changes in depressi…

This pilot study from Yale University will test whether listening to calming, instrumental music can reduce pain and stress in people with irritable bowel syndrome (IBS). Thirty adults with moderate IBS pain will listen to pre-recorded playlists for 20 minutes twice a day, five d…

This study tests whether adding peer support specialists to emergency department teams can reduce the use of physical and chemical restraints for agitated patients. Researchers will compare restraint rates before and after the peer support program is introduced across several hos…

This study will follow 80 people with chronic pain who are receiving cryoneurolysis, a procedure that uses cold to temporarily freeze nerves and block pain signals. Researchers will track pain levels, disability, and healthcare use for 12 months after treatment. The goal is to se…

This study looks at whether emergency medical services (EMS) can safely start buprenorphine treatment for people with opioid use disorder right at the scene of an emergency. Researchers will first test how practical and acceptable this approach is, then track whether patients sta…

This early study will test whether nimodipine, a drug usually used for blood pressure, can reduce alcohol drinking and cravings in heavy drinkers. Five adults with Alcohol Use Disorder will stay overnight at a hospital, take nimodipine, and then have the option to drink alcohol o…

This study looks at whether a single session of moderate exercise (like a brisk walk) can help adults with OCD feel less distressed and think more flexibly. Fifty adults with OCD will be randomly assigned to either moderate or light exercise. Researchers will measure changes in s…

This study tests whether inulin, a natural dietary fiber, can reduce inflammation and knee pain in older adults with osteoarthritis. About 84 participants will take either inulin or a placebo daily for 8 weeks. Researchers will measure changes in blood markers of inflammation and…

This study tests whether a single dose of psilocybin can help people with chronic low back pain become more aware of their body, which may lead to better pain relief and improved results from physical therapy. About 45 adults aged 18-65 with long-lasting back pain will receive ps…

This study tests whether a mobile app called Tools for Coping with Cancer can help people with a history of cancer reduce distress and improve mood and quality of life. About 50 adults who have had cancer will use the app at home for 8 weeks and fill out questionnaires about thei…

This study will test whether an artificial intelligence chatbot can encourage men who have sex with men in Kuala Lumpur, Malaysia to get tested for HIV. 80 participants will be randomly assigned to receive either automated chatbot messages with HIV testing information or standard…

This study tests whether a computer alert that pops up when doctors open a patient's chart can increase prescriptions of recommended medications for chronic kidney disease. About 1000 patients will take part. The alert shows the patient's lab results and suggests medications they…

This early study tests a new radioactive tracer called 18F-TPP to see if it can map the energy levels inside cells using PET scans. Researchers will study 24 healthy adults to understand how the tracer moves through the body and develop methods to measure cell membrane potential.…

This study tests two new types of nicotine labels for e-cigarettes: one showing nicotine concentration and another showing nicotine emissions (flux). Researchers will survey 2500 youth and adults in the US to see if these labels help people better understand nicotine strength com…

This study aims to improve a short motivational conversation to help young adults (ages 18-25) who were injured in an assault and also misuse alcohol or cannabis. Researchers will interview and survey 50 participants from a hospital violence intervention program to understand how…

This study looks at whether a future large trial of a breathing support method called bubble CPAP is possible for children with severe pneumonia. About 95 children will take part, and researchers will check if the approach works well and is accepted by doctors and families. The g…

This study tests a computer tool that helps emergency doctors decide when to start medication for opioid addiction. About 300 adults with moderate to severe opioid use disorder will take part. The goal is to see if the tool increases the number of patients who get a counselor con…

This pilot study from Yale University will test whether very low, non-hallucinogenic doses of psilocybin (the active compound in magic mushrooms) can improve mood, thinking, and quality of life. Twenty healthy adults with no prior psychedelic use will take either psilocybin or a …

This study will test a new ultrasound device called Accuro 3S that helps doctors see inside the back in real time while placing epidural or spinal needles. The goal is to see if it reduces the number of needle sticks and improves accuracy. About 50 patients needing these procedur…

This small study tests whether a brain imaging technique called fMRI neurofeedback can help people with glioma shift language activity away from tumor-affected areas before surgery. Four participants will practice controlling their brain activity using real-time feedback. The goa…

This study is developing and testing a text-messaging program for caregivers of people with dementia after an emergency room visit. About 80 caregivers will receive text messages for 30 days to see if the program is easy to use and helpful. The goal is to learn if this approach c…

This study tests two different ultrasound machines to see which one helps less-experienced doctors place labor epidurals more accurately. About 200 women getting epidurals during childbirth will take part. The main goal is to see which device leads to fewer needle movements, maki…

This study tests a mobile health program called SAMU to help adults in Uganda who have HIV, high blood pressure, and mental health issues like depression or anxiety. About 1,500 participants will use their phones for mental health screening and get connected to care. The goal is …

This study tests a short digital program delivered via messaging apps like Telegram or WhatsApp to help people who use drugs in Kazakhstan overcome stigma and learn about PrEP, a medication that prevents HIV. About 40 participants will receive informational messages over 2-3 week…

This study looks at how men and women differ in their attraction to and addiction risk from menthol-flavored e-cigarettes, both with and without nicotine. Researchers will measure choices and effort to get the product in 60 adult smokers who already use e-cigarettes. The goal is …

This study will test whether a new smartphone app helps people recently released from prison manage their health information. Researchers will enroll 100 adults with at least one chronic condition who have been out of jail for less than a year. The goal is to see if the app is ea…

This study looks at whether making it easier for teens to have private, confidential talks with their doctor can increase HIV testing. Researchers will work with 4 pediatric clinics to see if this approach is practical and well-liked by staff. The goal is to learn how to make HIV…

This study tests a computer tool that helps doctors decide when to refer heart failure patients to palliative care, which focuses on comfort and quality of life. About 2,260 patients and their healthcare providers will take part. The goal is to see if the tool is easy to use and …