Radiation may stop Dupuytren's hand disease in its tracks
NCT ID NCT07661342
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 3 trial tests whether radiation therapy can prevent Dupuytren's contracture—a condition where fingers bend toward the palm—from progressing or coming back after treatment. About 158 adults will receive radiation to the hand, and researchers will measure changes in finger straightness over time. The goal is to find a non-surgical way to control the disease.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- radiation therapy
- What this could lead to
- If it works, this could offer a way to slow or stop Dupuytren's contracture from getting worse, reducing the need for surgery.
- What could go wrong
- This is an early-stage trial with only 158 participants, and radiation therapy carries risks like skin irritation or long-term side effects. It may not prevent progression for everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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About 158 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Aug 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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30 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * English-speaking * Patient consent * No previous radiotherapy to the affected hand * No history of radiation sensitivity diseases (e.g. Scleroderma, Ataxia Telangiectasia, Li Fraumeni) * Age\>30 * Life expectancy \>5 years * Available and willing to participate in at least 5 years of follow-up * Female patients capable of child-bearing that are not pregnant Exclusion Criteria: * Pregnancy or lactation * Known genetic disease that would make them extremely sensitive to radiation therapy, e.g. Scleroderma, Ataxia Telangiectasia, Li Fraumeni
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Greenwich Hospital
Greenwich, Connecticut, 06830, United States