New study tests which breathing aid works best for heart failure patients coming off ventilators
NCT ID NCT06671015
First seen Nov 01, 2025 · Last updated Jun 22, 2026 · Updated 36 times
Summary
This study compares two breathing support methods—high-flow nasal cannula (HFNC) and non-invasive ventilation (NIV)—in heart failure patients after their breathing tube is removed. The goal is to see which method better prevents the need for re-insertion of the breathing tube or respiratory failure within 72 hours. The trial will enroll 50 high-risk patients with systolic heart failure at Yale New Haven Hospital.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Yale New Haven Hospital (CICU or MICU)
RECRUITINGNew Haven, Connecticut, 06520, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
High-flow nasal cannula (HFNC) and non-invasive ventilation (NIV) devices
What this could lead to
If it works, this could show that high-flow nasal cannula is a better or equally effective way to prevent reintubation in heart failure patients, potentially improving recovery and reducing complications.
What could go wrong
This is a small pilot study with only 50 participants, so results may not apply to all patients. The open-label design means both doctors and patients know which treatment is given, which could bias outcomes.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.