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New drug combo aims to shrink HPV-Caused growths in lungs and throat

NCT ID NCT04645602

First seen Nov 15, 2025 · Last updated Jun 08, 2026 · Updated 21 times

Summary

This early-phase study tests two drugs, lenvatinib and pembrolizumab, in 20 adults with HPV-related recurrent respiratory papillomatosis (RRP) that has spread to the lungs. The goal is to see if the combination can shrink growths and reduce the need for repeated surgeries. Participants will be monitored for side effects and changes in disease burden.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Yale University

    RECRUITING

    New Haven, Connecticut, 06510, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

Conditions

The condition(s) this trial relates to.

human papilloma virus infection lung disorder recurrent respiratory papillomatosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.