Human papilloma virus

This study is testing how well the 9-valent HPV vaccine (Gardasil9) triggers an immune response in people born male who have used estrogen or androgen blockers, including those living with HIV. Participants receive three doses of the vaccine over six months, and their immune resp…

This study looks at whether giving two doses of the HPV vaccine instead of three can protect women living with HIV just as well. Researchers will compare immune responses in 275 Canadian women aged 18-45 who have not been vaccinated before. If two doses work, it could make HPV va…

This trial tests whether 2LPAPI, an immune regulator used for over 20 years, can help clear high-risk genital HPV infections faster than a placebo. Researchers will enroll 284 women aged 25 to 45 with a current high-risk HPV diagnosis. Participants receive either 2LPAPI or a plac…

This phase III trial compares a new, shorter radiation approach to the standard 7-week chemoradiation for patients with HPV-positive oropharynx cancer. The experimental treatment uses a precise, high-dose radiation boost to the tumor followed by a reduced-dose chemoradiation cour…

This early-phase study tests two cancer drugs—lenvatinib (a daily pill) and pembrolizumab (an IV infusion)—in 20 adults with HPV-related recurrent respiratory papillomatosis (RRP) that has spread to the lungs. The goal is to see if the combination can shrink papillomas and reduce…

This early-stage trial is testing whether injecting the local anesthetic lidocaine into HPV-related throat tumors before robotic surgery is safe and might help destroy more cancer cells. About 30 adults with HPV-positive oropharyngeal cancer will receive the injection during a ro…

This study is testing whether a much lower dose of radiation (30 Gy) combined with standard chemotherapy can control HPV-positive throat cancer as well as the usual high dose (70 Gy). The goal is to reduce side effects from radiation while still keeping the cancer from coming bac…

This study explores whether women can accurately collect their own samples for HPV testing, which could make cervical cancer screening easier and more accessible. The research focuses on minority women who are often under-screened, using community health workers to help with the …

This study aims to make cervical cancer prevention easier for women who often miss out on routine care, such as those experiencing homelessness, substance use, or incarceration. Researchers will offer the HPV vaccine (Gardasil-9) and a self-swab test during regular sexual health …

This study is testing whether an educational video and toolkit can help more people from underserved groups start and finish the HPV vaccine series. The vaccine protects against HPV, a virus that can cause certain cancers. The trial will enroll 1,000 patients and parents at Denve…

This study in Honduras tests a new way to prevent cervical cancer using a self-collected HPV test that gives results in under an hour, combined with AI-powered imaging. 5,000 women will participate to see if this same-day screening-and-treatment approach is accurate, feasible, an…

This study aims to learn more about oropharyngeal carcinoma, a type of throat cancer that can be linked to HPV. Researchers will collect blood samples from 1,000 patients before treatment and at six follow-up visits, and also gather tumor tissue when available. The goal is to bet…