PULMONARY DISEASE

This early-phase study tests two drugs, lenvatinib and pembrolizumab, in 20 people with HPV-related recurrent respiratory papillomatosis (RRP), a condition causing non-cancerous growths in the airway. The goal is to see if the combination shrinks lung growths and reduces the need…

This study looks at three different breathing treatments (IPPB, EzPAP, and Metaneb) to see which one helps the lungs expand and recover best after heart surgery. About 324 adults who had certain types of heart surgery will take part. The goal is to find out which therapy improves…

This study tests a new way to plan radiation therapy for advanced lung cancer. Doctors will use a special scan (SPECT/CT) to see which parts of the lung work best, then aim radiation away from those areas to reduce side effects like coughing and shortness of breath. About 90 peop…

This study looks at whether a special exercise program (pulmonary rehabilitation) can help people who need high flow oxygen therapy. Researchers will measure muscle strength, breathing, and daily living skills in 70 adults. The goal is to see if rehab can make it easier for patie…

This study looks at proteins in lung fluid from people with pneumonia to find out what is causing their lung inflammation. Researchers hope to discover protein patterns that can help doctors diagnose different types of pneumonia more accurately. About 750 patients already schedul…

This study follows 750 people with sickle cell disease to see if curative treatments like stem cell transplants improve or harm the heart, lungs, and kidneys over time. Researchers will compare those who received curative therapy with those on standard care. The goal is to help p…

This study creates a registry and biorepository of lung images and biological samples from 100 people with pulmonary disease. Researchers will use this data to improve imaging techniques and understand what the images mean for patient health. Participants must already be enrolled…

This study follows people with pulmonary arterial hypertension (PAH) and healthy volunteers to see how the disease progresses. Researchers will use blood tests, heart and lung imaging, and walking tests to find new markers that could lead to better treatments. About 270 adults ag…

This study is creating a massive collection of medical images (CT and MRI scans) and health information from 50,000 adults. Researchers will use this data to find hidden patterns in images that could help predict, diagnose, and treat diseases like cancer, heart disease, and brain…

This study surveys 384 adults who have completed a pulmonary rehabilitation program for lung conditions like COPD or asthma. Researchers want to understand how happy patients were with their care and how the rehab team's structure affects satisfaction. No new treatments are teste…

This study follows 500 adults in Taiwan with severe asthma who are taking biologic medications. Researchers want to see how well these drugs control asthma in everyday life, what happens when patients switch biologics, and which factors predict the best treatment. The goal is to …