PULMONARY DISEASE

This early-phase study tests two cancer drugs—lenvatinib (a daily pill) and pembrolizumab (an IV infusion)—in 20 adults with HPV-related recurrent respiratory papillomatosis (RRP) that has spread to the lungs. The goal is to see if the combination can shrink papillomas and reduce…

This study tests whether using a SPECT scan to map healthy, working lung tissue can help doctors aim radiation away from those areas during treatment for advanced lung cancer. The goal is to reduce lung damage and side effects like breathing problems. About 90 people with lung ca…

This study compares three breathing therapy devices (EzPAP, Metaneb, and IPPB) to see which one best helps lung recovery after heart surgery. 324 adults who had open-heart surgery will use one of the devices for 10 minutes, four times a day. The goal is to find which therapy impr…

This study looks at whether a pulmonary rehabilitation program—including exercise training, education, and behavior changes—can help patients who need high flow oxygen therapy. Researchers will measure muscle strength, breathing, and daily living skills in 70 participants. The go…

This study looks at proteins in lung fluid from 750 people with pneumonia to find biomarkers that could reveal what's causing the lung inflammation. Participants undergo a standard bronchoscopy with lung washings, plus a blood draw. The goal is to better understand different type…

This natural history study follows 270 adults with pulmonary arterial hypertension (PAH) and healthy volunteers to track how the disease changes over time. Researchers will use blood tests, heart and lung imaging, and a six-minute walk test to find new markers of disease severity…

This observational study will follow 500 adults in Taiwan who are receiving biologic treatments (such as omalizumab, mepolizumab, or dupilumab) for severe asthma. Researchers aim to see how well these drugs work in everyday practice, what factors predict better control, and how o…

This study creates a registry and biorepository of lung images and biological samples from 100 people with pulmonary disease. Researchers will use this information to better understand imaging biomarkers and develop new analysis methods for CT and MRI scans. Participants must alr…

This study follows 750 people with sickle cell disease to see how curative therapies affect the heart, lungs, and kidneys over time. Researchers will compare those who received a stem cell transplant with those on standard treatment. The goal is to understand whether curative the…

This study is creating a huge collection of medical images and health information from 50,000 adults. Researchers will use advanced CT and MRI scans to find hidden patterns that could help predict, diagnose, and treat diseases like cancer, heart disease, and brain disorders. Part…

This pilot study is testing a new ultrasound tool that measures how much the lungs stretch (strain) in patients on breathing machines in the ICU. The goal is to collect initial data from 10 adults with lung disease to see if this technique can help doctors better monitor and prev…

This study surveys 384 adults in Türkiye who have completed a pulmonary rehabilitation program for lung conditions like COPD or asthma. Researchers want to learn how satisfied patients are and how the rehab team's structure affects their experience. No new treatment is being test…