PULMONARY DISEASE

This study tests whether adding a freezing spray (cryospray) to usual treatments can keep narrowed airways open longer in people with benign airway stenosis. About 40 adults will be randomly assigned to get either standard care alone or standard care plus cryospray. The goal is t…

This study tests a new device (Alterra Prestent) used with a replacement heart valve (SAPIEN 3) to fix a leaky pulmonary valve in people born with heart defects. About 86 participants with moderate or severe leakage will get the device through a tube in a blood vessel, avoiding o…

This study tests whether having extra appointments with a heart specialist at a local GP practice helps people get better treatment for heart, kidney, metabolic, and lung conditions. 138 high-risk adults will either receive standard GP care or additional specialist reviews to opt…

This study is testing whether biomarkers found in blood and airway samples can help predict lung cancer in people with suspicious lung nodules. Researchers will collect samples from 85 high-risk smokers and compare them to standard imaging results. The goal is to improve how doct…

This study is gathering health information from 4,600 people in rural areas of Alabama, Kentucky, Louisiana, and Mississippi. Researchers will look for risk factors that lead to heart and lung disease. No treatments or drugs are being tested. The goal is to learn more about what …

This study is looking for early signs of lung cancer in people at high risk, such as older smokers or those with COPD. Researchers will collect blood and airway samples from 665 participants to find biomarkers that could predict lung cancer before symptoms appear. The goal is to …

This study aimed to see if a non-invasive finger cuff monitor could track heart function in people with a pulmonary embolism (a blood clot in the lung). The device measures stroke volume and cardiac output continuously, which might help doctors detect early signs of heart failure…

This study will use advanced heart scans (coronary CT angiography) on 4,000 people with rheumatoid arthritis aged 50-75. The goal is to better understand why people with this condition have higher risks of heart attacks, strokes, and lung problems. Researchers will track particip…

This study was designed to test a new device called a leak-free bronchoscope adapter. The goal was to see if it could reduce air leaking from the ventilator and limit the spread of aerosols into the operating room during bronchoscopy in intubated patients. The trial was withdrawn…