PULMONARY DISEASE

This early-phase study tests two drugs, lenvatinib and pembrolizumab, in 20 people with HPV-related recurrent respiratory papillomatosis (RRP) that has spread to the lungs. The goal is to see if the combination can shrink growths and reduce the need for repeated surgeries. The st…

This study tests whether using a SPECT scan to guide radiation therapy can reduce lung damage in people with advanced lung cancer. About 90 patients receiving chemo-radiation will be randomly assigned to standard or SPECT-guided planning. The goal is to see if avoiding highly fun…

This study looks at whether a special exercise program (pulmonary rehabilitation) can help people who need high flow oxygen therapy. About 70 adults with stable vital signs will take part. The goal is to see if the program improves breathing, muscle strength, and daily living act…

This study looks at whether an 8-week Pilates exercise program can improve breathing in overweight and obese women. About 48 women will be split into an exercise group and a control group. Researchers will measure lung function, breathing rate, and quality of life before and afte…

This study looks at three different breathing treatments (IPPB, EzPAP, and Metaneb) to see which one helps the lungs expand and recover best after heart surgery. About 324 adults who had certain types of heart surgery will take part. The goal is to find out which therapy improves…

This study creates a registry of lung images and biological samples from 100 people with lung disease. Researchers will use this information to better understand new imaging techniques and develop tools for future diagnosis. Participants must already be enrolled in a lung MRI or …

This study asks people with lung conditions who have completed a pulmonary rehabilitation program about their satisfaction. Researchers will also look at how rehab teams are organized across Turkey. The goal is to learn what works well and how to make care more patient-friendly. …

This study follows 750 people with sickle cell disease who have received curative therapies (like stem cell transplants) to see how their heart, lung, and kidney health changes over time compared to those on standard treatment. The goal is to understand if these therapies improve…

This study looks at proteins in lung fluid from people with pneumonia to find clues about what causes the disease. Researchers hope to identify biomarkers that could help doctors choose the right treatment. Up to 750 patients already scheduled for a lung exam will provide a small…

This study is creating a massive database of medical images and health information from 50,000 adults. Researchers will use advanced CT and MRI scans to find hidden patterns, or 'signatures,' that could help predict, diagnose, and treat diseases like cancer, heart conditions, and…

This study follows people with pulmonary arterial hypertension (PAH) over several years to learn how the disease changes and to find new markers that could lead to better treatments. About 270 adults with PAH and healthy volunteers will have regular tests like blood draws, heart …