New study tracks organ health after sickle cell 'Cures'

NCT ID NCT05153967

Recruiting now Knowledge-focused Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 28, 2026 · Updated 2 times

Summary

This study follows 750 people with sickle cell disease to see how curative therapies affect the heart, lungs, and kidneys over time. Researchers will compare those who received a stem cell transplant with those on standard treatment. The goal is to understand whether curative therapies improve or worsen organ damage, helping patients make better treatment choices.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could help doctors and patients decide whether curative therapy or standard care is better for long-term heart, lung, and kidney health.
What could go wrong: This is an observational study, not a treatment trial. It will not test a new drug or cure, and results may take years to influence care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

heart disorder kidney disorder lung disorder sickle cell disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART DISEASE PULMONARY DISEASE RENAL DISEASE SICKLE CELL DISEASE

Contacts and locations

Locations

Children's National Medical Center
NOT_YET_RECRUITING

Washington D.C., District of Columbia, 20010, United States
Emory University School of Medicine
NOT_YET_RECRUITING

Atlanta, Georgia, 30322, United States
Johns Hopkins Hospital
NOT_YET_RECRUITING

Baltimore, Maryland, 21287, United States
National Institutes of Health Clinical Center
NOT_YET_RECRUITING

Bethesda, Maryland, 20814, United States
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232-9000, United States

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