Yale study probes diuretic resistance in heart failure
NCT ID NCT05323487
First seen Jun 10, 2026 · Last updated Jun 23, 2026 · Updated 1 time
Summary
This study aims to understand why some people with heart failure do not respond well to diuretics (water pills). Researchers will give 75 heart failure patients different doses of bumetanide and measure how their kidneys handle sodium. The goal is to identify biological markers of diuretic resistance, which could help tailor treatments in the future.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Yale University
RECRUITINGNew Haven, Connecticut, 06510, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
bumetanide (a loop diuretic)
What this could lead to
If successful, this study could help doctors understand why some heart failure patients are resistant to diuretics, potentially leading to better personalized treatment strategies.
What could go wrong
This is a small, early-phase study (75 participants) focused on measuring biological markers, not on treating disease. It may not lead to immediate clinical changes or benefit participants directly.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.