Can a common salt boost diuretics in stubborn heart failure?
NCT ID NCT06209359
First seen May 24, 2026 · Last updated Jun 23, 2026 · Updated 7 times
Summary
This study looks at why some heart failure patients don't respond well to water pills (diuretics). Researchers will give 50 participants either ammonium chloride or a placebo along with standard diuretics to see if it improves sodium excretion. The goal is to understand the mechanism of diuretic resistance, not to test a new treatment.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Yale University
RECRUITINGNew Haven, Connecticut, 06510, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ammonium chloride
What this could lead to
If successful, this could point toward a way to make standard diuretics work better for heart failure patients who don't respond well to them.
What could go wrong
This is a very early phase 1 study with only 50 participants, so results may not apply broadly. The intervention is a short-term metabolic challenge, not a new treatment.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.