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Tiny yale study probes blood flow cuffs for ACL rehab

NCT ID NCT05012982

Knowledge-focused Sponsor: Yale University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Aug 26, 2026 · Updated 3 times

Summary

This study tests whether using a special cuff to partly block blood flow during exercise can improve recovery after ACL reconstruction. Twenty adults will have two training sessions—one with the cuff inflated and one without—so researchers can compare changes in immune cells and energy use. The goal is to understand the body's response, not to prove a treatment works yet.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
AirBand (blood flow restriction device)
What this could lead to
If successful, this could help design better rehab programs for ACL patients by understanding how blood flow restriction affects recovery.
What could go wrong
This is a very small early study with only 20 participants, so results may not apply to everyone. It focuses on biological markers, not direct recovery outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

18 people

The number who actually took part.

Started

Feb 2023

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Provision of signed and dated informed consent form 2. Stated willingness to comply with all study procedures and availability for two study visits at least 1 week apart 3. All genders, between 18 and 60 years of age 4. In good general health without any underlying medical conditions or prior injury that would place the subject at risk of further injury/illness by participating in the study Exclusion Criteria: 1. Serious medical conditions including cardiovascular, metabolic (diabetes), rheumatologic, pulmonary, or musculoskeletal. 2. Multiple ligament ruptures or trauma 3. Rheumatoid arthritis or other significant comorbidities 4. Lower extremity vascular pathology, including history of deep vein thrombosis 5. Those with a history of sickle cell trait or disease 6. Use of anticoagulant medications 7. Pregnancy 8. Treatment with another investigational drug or other intervention within one month of Study Day 1 9. Current smoker or tobacco use within 3 months of Study Day 1 10. Febrile illness within 2 weeks of Study Day 1

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anterior cruciate ligament reconstruction

Contacts and locations

Locations

  • Gaylord Outpatient Physical Therapy North Haven Clinic

    North Haven, Connecticut, 06473, United States

  • Yale New Haven Hospital

    Milford, Connecticut, 06461, United States

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