Nidovirales infectious disease

Researchers are testing an experimental coronavirus vaccine called OVX033 in healthy adults aged 18 to 49 who have already received 2 to 4 doses of a licensed COVID-19 vaccine. The trial randomly assigns participants to receive one of three dose levels of OVX033 or a placebo, giv…

Researchers are testing an experimental vaccine called RBM-001 in healthy adults aged 18 to 55. The study aims to see if the vaccine is safe and triggers an immune response against COVID-19. Participants receive two doses, and researchers monitor for side effects and measure anti…

This study tests whether a booster dose of the Janssen COVID-19 vaccine lowers the risk of severe COVID-19, hospitalizations, and deaths in adults who received a single Janssen shot at least six months earlier. Researchers will compare boosted participants with those who were not…

This trial tests two experimental COVID-19 vaccines, AZD9838 and AZD6563, in adults to see if they are safe and trigger a strong immune response. Participants receive a single injection of one of the vaccines or a licensed mRNA vaccine for comparison. The study measures side effe…

This first-in-human trial is testing an experimental vaccine that uses self-amplifying mRNA technology to target the SARS-CoV-2 spike protein. The study involves healthy adults aged 18 to 50 who receive two doses a month apart. The main goals are to assess the vaccine's safety, s…

This trial is testing whether a single vaccine can protect against both influenza and COVID-19. Healthy adults aged 18 and older will receive either a combined vaccine, separate flu and COVID shots, or a placebo. The study will monitor safety and immune response over about six mo…

This study tested whether getting a different COVID-19 vaccine for the second shot (instead of the same one) is safe and boosts immunity. 100 healthy adults who had already received one dose of the AZD1222 vaccine were randomly assigned to get either the same vaccine or a differe…

This large, final-stage study tested a new combination vaccine that aims to protect against both COVID-19 and the flu with a single shot. About 9,300 adults aged 65 and older took part, receiving either the combo vaccine or a standard high-dose flu vaccine. Researchers checked ho…

This study tested a new vaccine designed to protect against the Omicron JN.1 variant of COVID-19. About 120 adults aged 65 and older, and teens and adults aged 12 to 64 with health conditions that increase COVID-19 risk, received one dose. Researchers checked how well the vaccine…

This large study tested the Pfizer-BioNTech COVID-19 vaccine in over 11,800 healthy children aged 6 months to 12 years. Researchers looked at side effects and immune responses after different doses. The goal was to find the right dose that is safe and triggers strong protection. …

This study tested Novavax's COVID-19 vaccine in 3,600 children aged 6 months to 12 years. The goal was to see if the vaccine is safe and triggers a strong immune response. Children received two doses 21 days apart, with some getting a placebo. The trial is complete, and results w…

This study tested whether a third dose of either the CoronaVac or Comirnaty vaccine boosts immunity better in adults who had two prior doses at least six months earlier. Researchers measured antibody levels in 451 participants from Hong Kong 28 days after the booster. The goal wa…

This study tested an experimental vaccine called VBI-2901a in 103 healthy adults aged 18-64 who had already received at least two doses of a licensed COVID-19 vaccine. The vaccine is designed to protect against three coronaviruses: SARS-CoV-2 (which causes COVID-19), SARS-CoV-1, …

This study tested a single combination vaccine that aims to protect against both COVID-19 and influenza at the same time. About 980 adults aged 50 and older received either the combo shot, a flu shot alone, a COVID-19 shot alone, or both shots separately. Researchers monitored sa…

This study tested a single combination vaccine that targets both COVID-19 and influenza in adults aged 50 and older. About 980 participants received either the combo shot, the flu vaccine alone, the COVID-19 vaccine alone, or separate shots in each arm. Researchers monitored safe…

This study tested updated versions of the Pfizer-BioNTech COVID-19 vaccine designed to target newer Omicron variants (XBB.1.5, JN.1, and KP.2). Over 1,000 healthy people aged 12 and older received a single dose. The main goals were to check safety and measure the immune response.…

This large study tested Moderna's COVID-19 mRNA vaccine in over 14,000 people living with HIV or other conditions that increase the risk of severe COVID-19. The goal was to see how well different vaccine doses prevent COVID-19. Participants received either the original or an upda…

This study tested whether a vaccine called VPM1002 could help healthcare workers miss fewer days of work due to respiratory illnesses, including COVID-19. About 1,200 doctors, nurses, and other hospital staff received either the vaccine or a placebo. The goal was to see if the va…

This study tested whether three different manufacturing batches (lots) of Novavax's COVID-19 vaccine produce the same immune response and safety in adults. About 900 healthy adults aged 18 to 49 who had already been vaccinated received one of the three lots. The results help ensu…

This study looked at whether people who had COVID-19 more than 5 months ago need only one dose of the Pfizer mRNA vaccine, instead of the usual two. It included 267 healthy adults aged 18-45 or 65 and older, some with prior infection and some without. Researchers measured antibod…

This large study tested the safety and effectiveness of the Pfizer-BioNTech mRNA vaccine (BNT162b2) against COVID-19 in nearly 47,000 healthy volunteers aged 12 and older. Participants received two doses of the vaccine or a placebo, and the trial also explored booster doses and p…

This study looked at whether a smaller (fractional) dose of the Pfizer-BioNTech COVID-19 booster works as well as the standard dose. It involved 601 healthy adults in Mongolia who had already received two doses of Sinopharm, AstraZeneca, or Sputnik vaccines 6 to 9 months earlier.…

This Phase 2 trial tested the BNT162b2 mRNA vaccine in 960 healthy Chinese adults aged 18 to 85. Participants received two doses of either the vaccine or a placebo, 21 days apart. The main goal was to check safety and measure the immune response, specifically neutralizing antibod…

This study tested the CoviVac COVID-19 vaccine in 200 healthy adults aged 60 and older. Researchers checked how safe the vaccine was and how well it boosted the immune system. The goal was to see if the vaccine could help prevent COVID-19 in this age group.

This study tested a new booster vaccine called PHH-1V81, designed to target recent COVID-19 variants. About 900 adults who had already received mRNA vaccines got either the new booster or an existing one. Researchers checked for side effects and measured immune responses to see i…

This study tested a new booster vaccine called PHH-1V in 887 adults who had already received two doses of the Pfizer COVID-19 vaccine. The goal was to see if the new booster was as safe and effective as a third Pfizer dose. The trial also looked at the effects of a fourth dose of…

This study tested the safety and immune response of several Moderna mRNA vaccines for COVID-19, seasonal flu, RSV, and CMV in 308 healthy adults aged 18 to 75. Researchers monitored side effects and measured antibody levels after vaccination. The goal was to ensure the vaccines a…

This early-stage trial tested a new COVID-19 vaccine called ABNCoV2 in 45 healthy adults who had never had COVID-19. The vaccine uses a virus-like particle to train the immune system, and some doses included an adjuvant to boost response. The main goals were to check safety and m…

This study tested different COVID-19 booster vaccines (Janssen, Moderna, Pfizer, Novavax) in about 1,900 adolescents and adults aged 12 to 64 in Kenya, Democratic Republic of Congo, and Rwanda. Some participants had HIV, and others did not. The goal was to see if mixing vaccine t…

This study looked at whether giving the HPV vaccine and the Moderna COVID-19 vaccine at the same time is safe and works well for children aged 9 to 11. About 165 boys and girls took part. The researchers compared kids who got both vaccines on the same day to those who got them on…

This completed Phase 1/2 trial tested a new DNA booster vaccine called Covigenix VAX-002 in 46 healthy adults aged 18 and older. The vaccine is designed to protect against newer COVID-19 variants like Omicron. Participants had already received a primary COVID-19 vaccine or booste…

This completed Phase 1 trial tested a nasal COVID-19 vaccine called COV2 in 40 healthy adults aged 18-75. The study compared two dose levels (low and high) and two administration methods (nasal drops vs. spray) to see which is safest and best at boosting immunity. Participants in…

This study looked at how well the Pfizer mRNA vaccine triggers an immune response in people with weakened immune systems compared to healthy individuals. About 539 adults received two doses of the vaccine, and researchers measured antibody levels and side effects. The goal was to…

This study tested a new type of COVID-19 vaccine called ARCT-154, which uses self-amplifying RNA technology to potentially provide stronger protection. Nearly 20,000 adults in Vietnam, including those with health conditions, received the vaccine or a placebo. Researchers measured…

This study tested a new COVID-19 booster vaccine called SpiN-Tec in 432 healthy adults aged 18 to 85 who had already received full vaccination and at least one booster. The vaccine was compared to approved boosters like Covishield and Comirnaty. The goal was to check safety and w…

This completed Moderna trial tested the mRNA-1273 COVID-19 vaccine in over 4,300 healthy adolescents aged 12 to 17. The study looked at safety, side effects, and how well the vaccine works to prevent COVID-19. Participants received either the vaccine or a placebo, and some later …

This completed Phase 2 study tested an oral antiviral drug called S-892216 in 282 adults with mild-to-moderate COVID-19. Participants took either the drug or a placebo tablet for a short time. The main goal was to see if the drug could lower the amount of virus in the nose and th…

This study uses health records from over 1.8 million adults in the Czech Republic to see if the antiviral drug molnupiravir lowers the risk of dying from COVID-19 during the Omicron wave. Researchers compare people who received molnupiravir plus standard care with similar patient…

Researchers are testing an experimental oral drug called sabizabulin (VERU-111) in hospitalized adults with confirmed SARS-CoV-2 infection who are at high risk for acute respiratory distress syndrome (ARDS). Participants receive either sabizabulin plus standard care or a placebo …

This phase 2 trial tests a new COVID-19 booster vaccine (GEO-CM04S1) in 80 people with chronic lymphocytic leukemia (CLL). The goal is to see if this vaccine triggers a stronger immune response than standard mRNA boosters. Participants will receive either the new vaccine or a sta…

This study tested whether the immune-modulating drug abatacept, given early to hospitalized COVID-19 patients on low-flow oxygen, helps them recover faster compared to a placebo. A total of 285 adults participated. The goal was to see if adding abatacept to standard care improves…

This trial tests whether a 12-week telerehabilitation program—combining aerobic walking and progressive relaxation exercises—can improve blood sugar control, stress, anxiety, and physical function in adults with type-2 diabetes, both with and without a prior COVID-19 infection. P…

This large Phase 3 study tested an antiviral pill called S-217622 in over 2,000 adults with mild to moderate COVID-19 who were not hospitalized. Participants started the drug within 3 days of symptoms. The main goal was to see if the drug shortens symptom duration compared to a p…

This study looks at whether the antiviral medication Paxlovid can reduce the risk of severe illness, death, and loss of daily functioning in older adults living in long-term care hospitals in Korea. Researchers will compare health outcomes of residents aged 60 and older who recei…

This study tests whether intravenous immunoglobulin (IVIG) can reduce symptoms of autonomic dysfunction—such as dizziness, rapid heartbeat, and fatigue—in people with long COVID. Two hundred participants will receive either IVIG or a placebo (saline) for 9 months, plus coordinate…

This study tests a treatment called LB-DTK-COV19, made from a patient's own immune cells, for people who have had COVID-19 symptoms or a positive test for more than 21 days. Participants receive two infusions of their personalized T cells, two weeks apart, and are followed for si…

This large, completed trial tested several potential COVID-19 treatments in over 1,500 hospitalized adults across Europe. Earlier drugs like remdesivir and hydroxychloroquine were dropped after showing no benefit. The current phase is testing a new antibody combination called AZD…

This study tests an experimental drug called SPI-1005 (ebselen) in adults hospitalized with severe COVID-19. Participants receive either the drug or a placebo to see if the drug is safe and helps improve recovery. The trial is randomized and double-blind, meaning neither patients…

This study investigates whether respiratory muscle training and walking exercises can improve lung function, reduce breathlessness, and enhance quality of life in women who have recovered from COVID-19 pneumonia. Eighty women aged 20 to 45 are divided into four groups: a combinat…

This trial investigates whether famotidine, the active ingredient in Pepcid, can help relieve COVID-19 symptoms in adults who are not sick enough to be hospitalized. Participants receive either famotidine or a placebo, along with standard care, and report their symptoms remotely.…

This study looked at whether giving plasma (the liquid part of blood) from people who recovered from COVID-19 could help critically ill patients fight the virus. The plan was to collect plasma from up to 240 recovered donors and give it to sick patients. However, the plasma donat…

This study tested whether giving early treatment to adults with COVID-19 who have risk factors (like age over 60 or high blood pressure) could prevent them from needing oxygen, hospitalization, or dying. About 412 people took part. The goal was to see if these treatments are safe…

This early-stage study tested a single dose of mesenchymal stromal cells in 7 COVID-19 patients with severe acute respiratory distress syndrome (ARDS) who were on ventilators. The main goal was to check safety, looking for serious side effects like heart problems or blood clots w…

This study tested whether nintedanib, a drug used for other lung diseases, can slow down lung damage in people who had severe COVID-19. It included 103 adults who still had lung problems more than 30 days after their COVID diagnosis. The main goal was to see if the drug helped ma…

This small pilot study tested whether adding pegylated interferon lambda to standard care helps hospitalized adults with mild-to-moderate COVID-19 recover faster. Nine participants were randomly assigned to receive the drug or standard care alone. The study measured how long the …

This study tested whether giving plasma from people who recovered from COVID-19 to those with severe or critical COVID-19 is safe and helps them get better. 350 adults received the plasma treatment. The main goals were to track serious side effects and see if fewer people died wi…

This study tested whether three common drugs—metformin, ivermectin, and fluvoxamine—could prevent severe illness and long COVID in 1,323 adults with early COVID-19. Participants were overweight or obese and not hospitalized. The key finding was that metformin reduced the risk of …

This study looked at whether giving an extra dose of the mRNA COVID-19 vaccine (Pfizer or Moderna) to kidney and liver transplant recipients could boost their antibody levels. Some participants also temporarily reduced their immunosuppressive medications to see if that helped the…

This study tested a treatment called INM005, made from antibodies produced in horses, for adults hospitalized with moderate to severe COVID-19. The goal was to see if it could help patients recover faster, measured by improvement on a standard health scale 28 days after treatment…

This study tested whether early treatment or preventive medication can help adults with COVID-19 feel better faster. 92 participants took part, and researchers tracked their symptoms daily for 28 days. The goal was to see if the treatments could reduce how long symptoms last and …

This study tracked over 4,200 immunocompromised patients who received monoclonal antibodies to prevent or treat severe COVID-19. Researchers measured how many were hospitalized or died from the virus. The goal was to see if these antibody treatments help protect people whose immu…

This early-stage trial tested the safety and tolerability of a new drug called PA-001 in 47 healthy and elderly volunteers. Participants received either PA-001 or a placebo through an IV. The main goal was to see if the drug causes any side effects and to understand how the body …

This study tested whether giving the oral polio vaccine (OPV) to adults over 50 in Guinea-Bissau could reduce their risk of getting sick or dying from COVID-19 and other infections. Researchers enrolled about 3,700 people and gave half the vaccine plus COVID-19 advice, while the …

This study tested whether breathing in nitric oxide gas can improve oxygen levels in severely ill COVID-19 patients who are on ventilators. Researchers enrolled 200 adults in the ICU with confirmed COVID-19 and severe breathing problems. Patients received either standard care plu…

This completed study in Brazil looked at whether a fourth dose of a COVID-19 vaccine helps protect people aged 60 and older from hospitalization and death. Researchers tracked 260 elderly participants who received a second booster and compared their immune responses to samples fr…

This study tested whether a single dose of stem cells (mesenchymal stromal cells) could help patients with severe COVID-19 lung inflammation breathe better. Twenty adults with confirmed COVID-19 and acute respiratory distress syndrome were randomly assigned to receive either the …

This study tested whether a steroid (beclomethasone) placed directly in the nose using a tiny sponge could help people who lost their sense of smell after COVID-19. Sixteen adults with smell loss lasting over 3 months received either the steroid or a placebo sponge twice, two wee…

This study looked at 84 hospitalized adults with severe COVID-19 who received the drug remdesivir. Researchers analyzed their recovery over 15 days to see how the drug affected their clinical course. The goal was to understand if remdesivir helps improve outcomes in severe cases.

This study tested two smartphone apps designed to reduce risky drinking and its effects during the COVID-19 pandemic. One app focused on the drinker, the other on their family partner. About 400 pairs (a drinker and a family member) joined the 12-month study. The goal was to see …

This early-stage study tested the safety of an experimental oral drug called MSP008-22 in 64 healthy adults aged 18-50. The goal was to see if the drug is safe and how the body processes it. This is a first step toward possibly using it to control COVID-19, but it does not aim to…

This study tested whether common blood pressure medications (ACE inhibitors or ARBs) could improve outcomes for high-risk COVID-19 patients. Researchers enrolled 372 adults with confirmed COVID-19 who were either over 40 (outpatients) or over 18 (hospitalized). The goal was to se…

This study tested whether low-dose hydrocortisone, a common steroid, can help people with severe community-acquired pneumonia survive. Over 950 critically ill adults in intensive care received either the steroid or a placebo, alongside standard antibiotics and support. The goal w…

This study tested whether using very small breaths (ultraprotective ventilation) on a breathing machine, without a heart-lung bypass machine, could improve survival and reduce time on the ventilator for COVID-19 patients with severe lung injury. About 220 adults with confirmed CO…

This small pilot study tested whether a sustained-release ammonium chloride formula (with vitamin D) can reduce virus levels in adults with mild or moderate COVID-19 or influenza. 32 participants took either the active formula or a vitamin D-only control twice daily for 10 days. …

This study tested two drugs, ruxolitinib and fostamatinib, in hospitalized adults with mild to moderate COVID-19 pneumonia. The goal was to see if either drug could prevent the disease from becoming severe. 185 patients were randomly assigned to receive one of the drugs or standa…

This study looked at whether giving nebulised heparin (a blood thinner delivered as a mist) to COVID-19 patients on mechanical ventilation could help them get off the breathing machine sooner and reduce deaths. The trial combined data from several smaller studies in Australia, Ir…

This study tested two drugs—remdesivir and aviptadil—in hospitalized COVID-19 patients with severe breathing failure. About 473 participants received either a study drug plus standard care or a placebo plus standard care. The goal was to see if these drugs could safely improve ou…

This completed Phase 4 trial tested a herbal supplement called AntiCov-220 in 82 people with underlying health conditions, including HIV and cancer. The goal was to see if it could prevent and treat COVID-19 by boosting the immune system and fighting the virus. The study compared…

This completed trial tested whether colchicine, a cheap anti-inflammatory drug used for gout, can help patients with mild to moderate COVID-19 pneumonia. Sixty-six patients in Lahore were given the drug to see if it shortens hospital stays and reduces oxygen needs. The goal is to…

This study tested whether filtering the blood (therapeutic plasma exchange) could help severe COVID-19 patients by removing harmful immune molecules that cause lung damage. Twenty-one adults in intensive care with COVID-19 and lung failure were randomly assigned to receive either…

Researchers are studying whether lung ultrasound can reliably show the patterns of COVID-19 pneumonia in hospitalized patients. The trial enrolls adults admitted with confirmed COVID-19 and respiratory symptoms who need a chest CT scan. By comparing ultrasound images with CT scan…

Researchers are studying whether adding rapid antigen testing for SARS-CoV-2 to HIV, maternal and child health, and tuberculosis clinics in Cameroon and Kenya increases the number of people tested and diagnosed with COVID-19. The study compares clinic activity before and after th…

Researchers are testing a portable device called Truenat MTB Plus/COVID-19 to see if it can accurately detect both tuberculosis and COVID-19 from the same sample. The study will enroll about 2,000 adults who have symptoms like a long-lasting cough, fever, or weight loss, which co…

This study is testing a new diagnostic panel called the BioFire ECoV Panel, designed to detect coronaviruses from leftover nose swab samples. Researchers will enroll 1,500 people and compare the panel's results to standard tests to see how accurate it is. The test is not being us…

This study checked whether 3D-printed nasal swabs work as well as standard swabs for diagnosing COVID-19. About 1,179 people who had COVID-19 symptoms or were recently exposed took part. Researchers compared the new swabs' accuracy and safety, like nosebleed risk, to the usual on…

This study tests two new devices (imPulse Una and TOR) that use sound waves to detect COVID-19, flu, and RSV without needles or swabs. About 300 adults with or without symptoms will have a quick, painless scan. The goal is to see if these e-stethoscopes can accurately identify th…

This study tested a quick finger-prick blood test to see if cancer patients had been infected with COVID-19 in the past. Researchers enrolled 214 adults being treated for cancer. The goal was to find out how many had antibodies, including those without symptoms, to help clinics k…

This study looked at whether PET-CT scans can detect unique signs of COVID-19 in the lungs. Researchers scanned 22 patients suspected of having lung infections and compared the images to their COVID-19 test results. The goal was to find patterns that could help diagnose COVID-19 …

This study tested two new rapid tests that use a single nose swab to detect COVID-19, influenza A/B, and RSV. Researchers checked how accurate the tests are compared to standard lab methods and whether healthcare workers find them easy to use. The study involved 589 people with s…

This study collected nasal swabs, throat swabs, and saliva samples from 79 people with symptoms of flu, RSV, or COVID-19. The samples were used to help evaluate a point-of-care device called LumiraDx, which aims to quickly and accurately detect these viruses. The study focused on…

This study evaluates how well the LumiraDx SARS-CoV-2 Ag ULTRA test detects COVID-19 when used at point-of-care locations like clinics or pharmacies. Participants with COVID-19 symptoms provide nasal and nasopharyngeal swabs, and the test results are compared to a standard lab re…

This study checks whether a fingerstick blood test for COVID-19 antibodies gives the same results as standard lab tests using blood from a vein. About 42 people who recently had a positive COVID-19 PCR test will provide both fingerstick and venous blood samples. The goal is to se…

This study collected nose, throat, and blood samples from 523 adults with COVID-19 symptoms or a past positive test. The goal was to help develop and check the accuracy of a new rapid test for detecting COVID-19 antibodies and viral proteins. The test is designed to be used at th…

This study checked how well a new rapid test (LumiraDx) detects COVID-19 and flu A/B from a simple nose swab. Over 1,000 people with symptoms took part at clinics. The test aims to give fast results at the point of care, helping doctors tell these illnesses apart quickly.

This study checked how accurate two rapid tests (LumiraDx SARS-CoV-2 Ag Ultra and LumiraDx SARS-CoV-2 & Flu A/B) are at detecting COVID-19 and flu in people with symptoms. 716 participants provided nasal swabs at clinics. The results were compared to standard lab tests to measure…

This study tested a quick COVID-19 antigen test called LumiraDx at various point-of-care sites, like clinics. Over 1,100 people with COVID-19 symptoms took part. The test's accuracy was compared to standard lab methods to see how well it detects the virus.

This study tested a new saliva-based test for SARS-CoV-2 that gives results in less than an hour, without needing lab equipment. Researchers compared it to the standard PCR method using samples from 627 people, including healthcare workers and patients. The goal was to see if thi…

This study tested whether a shallow (2 cm) or deeper (4 cm) nasal swab is better at detecting COVID-19 using rapid antigen tests. Over 300 adults in Denmark each received both swab depths, and results were compared to a standard throat PCR test. The goal was to find the best bala…

This study checked how well a new rapid test, TestNPass, can detect COVID-19 using a nose swab. It involved 400 adults at a hospital in France. The goal was to see if the test is accurate enough to replace slower PCR tests and provide a digital health pass.

This study tested a new way to diagnose COVID-19 using a saliva sample instead of the standard nose/throat swab. Researchers compared the new method to the usual one in 130 adults at a hospital in France. The goal was to see if the saliva test works just as well, which could make…

This study checked how well a new test called VitaSIRO solo™ detects COVID-19, flu, and RSV in people with respiratory symptoms. Over 1,200 participants provided nose and throat swabs. The test's accuracy was compared to standard lab methods.

This study tested whether saliva samples can detect the COVID-19 virus as well as the standard nose swab test. Over 5,000 people provided both nose swabs and saliva samples, which were compared using different detection methods. The goal was to see if a simpler, less invasive spi…

This study looked at CT scans from over 10,000 people to see if they can help diagnose COVID-19 more accurately. Researchers compared CT results with standard PCR tests and also used AI to predict which patients might need a ventilator. The goal is to make diagnosis faster and he…

This study tested 949 adults with COVID-19 symptoms to see how well saliva samples work compared to standard nasopharyngeal swabs. Each participant gave four samples: saliva for a rapid test and for PCR, and a nasal swab for both tests. The goal was to find out which combination …

This study tested two new tools for diagnosing tuberculosis (TB): a software that analyzes chest X-rays (CAD4TB) and a blood test that measures C-reactive protein (CRP). Researchers enrolled 1,400 adults with TB symptoms in Lesotho and South Africa. They compared these tests to s…

This study tests whether a pill called mitoquinone can prevent COVID-19 in healthy adults who have had close contact with someone who has COVID-19. About 112 participants will receive either the pill or a placebo. The goal is to see if it stops infection and reduces symptoms.

Researchers are testing whether an antiviral tablet called S-217622 can prevent symptomatic COVID-19 in people who live with someone who has symptoms. The trial enrolls household contacts of a person with symptomatic COVID-19 and gives them either the antiviral or a placebo for a…

Researchers test whether a community-based health education program helps Hong Kong residents get tested early for COVID-19, accept vaccination, and follow self-protection measures like hand washing and mask wearing. The trial enrolls about 1,200 residents, including adults and s…

Researchers in St. Louis are studying whether the order of offers in a text message changes how people respond to COVID-19 testing and vaccination help. Participants are adults applying for rent or utility assistance in St. Louis City or County. Each person gets a survey with two…

This study tests whether community health workers can help increase COVID-19 testing among vulnerable adults. Participants receive either education and rapid antigen test kits or guidance on where to get tested. The goal is to see which approach leads to more people getting teste…

This trial tests whether a community health worker-led program can increase the use of rapid COVID-19 self-test kits among diverse Asian Americans in Philadelphia and New York City. Participants receive group education sessions covering COVID-19 basics, the importance of testing,…

This study tests whether a brief self-affirmation exercise, where people reflect on a proud moment, can make health messages more acceptable and increase the uptake of COVID-19 rapid tests. Researchers are working with community health workers and the Mexican Consulate to reach L…

This trial tests whether a brief online game can help Canadian adults better identify COVID-19 vaccine misinformation. Participants judge true/false statements and get instant feedback in a game-like format, compared to reading the same information as a blog post or doing nothing…

This trial tests whether a brief online game can help adults better identify COVID-19 and vaccine misinformation. Participants judge true or false statements and get instant corrections in a game-like format. The study compares this approach to reading the same information as pla…

This completed study looked at whether lupus patients already taking hydroxychloroquine long-term had a lower risk of catching COVID-19 or developing severe symptoms. Researchers compared 552 patients who either took the drug or did not, using blood tests and questionnaires. The …

This trial tests whether a self-administered, tablet-based exercise game, guided by foot-worn sensors, can help hospitalized COVID-19 patients maintain strength and mobility without in-person contact. The program aims to prevent physical decline (deconditioning) during hospital s…

This study compares two strategies to increase COVID-19 vaccination among unvaccinated students, school staff, and their household members. One group receives a text message with a website link about vaccination, while the other group gets a phone call from a peer. The goal is to…

This study tests whether a brief vaccine education session given to unvaccinated adults when they come for COVID-19 testing can increase the number of people who get vaccinated. The education includes a 15-minute counseling session, printed materials, and a referral to a vaccine …

This study tested an experimental antibody called AZD3152 to see if it can safely prevent COVID-19 in people with weakened immune systems. About 3,882 adults received either the antibody or a placebo/comparator. The goal was to measure how well the antibody neutralizes the virus …

This study tested a nose spray containing heparin, a common and safe medicine, to see if it could stop the spread of COVID-19 within households. Over 500 people who lived with someone who tested positive for COVID-19 used the spray or a dummy spray three times a day for 10 days. …

This large Phase 3 trial compared a new experimental mRNA COVID-19 vaccine (mRNA-1283) with Moderna's original vaccine (mRNA-1273) in over 13,500 people aged 12 and older. The goal was to see if the new vaccine is safer, triggers a better immune response, and prevents COVID-19 at…

This Phase 2 trial tested whether thymalfasin, a synthetic version of a natural immune-boosting protein, could prevent COVID-19 infection in 189 kidney dialysis patients. These patients are at high risk due to weakened immune systems and frequent clinic visits. The study measured…

This study looked at whether a medicine called Evusheld can prevent COVID-19 in people with weakened immune systems who did not get protection from vaccines. The study included 88 adults who were at high risk. Researchers tracked how many got sick with COVID-19 symptoms to see if…

This study tested whether using box fans with special filters and improving home ventilation could lower the chance of COVID-19 spreading from one infected person to others living in the same home. Researchers studied 214 people living in households with at least 3 members. The g…

This study tested how well two different 2023-2024 updated COVID-19 vaccines (Novavax and Pfizer mRNA) protect adults from getting sick with COVID-19. About 1,200 adults who had already received at least two mRNA vaccine doses were randomly assigned to get either the Novavax or P…

This study tested whether far-UVC light, a safe type of ultraviolet light, can reduce respiratory infections like flu and COVID-19 in long-term care facilities. The trial involved 550 elderly residents who are at higher risk due to age and health conditions. The light was used as…

This phase 3 trial tested whether a biologic called IMM-101 could reduce severe respiratory infections, including COVID-19, in cancer patients at higher risk. 195 participants either received three doses of IMM-101 or were simply observed. The goal was to see if the treatment cou…

This study tested whether hydroxychloroquine or azithromycin could prevent COVID-19 infection in hospital workers who were regularly exposed to the virus. 122 participants took one of the drugs or a placebo for 40 days. The study found no significant difference in infection rates…

This study looked at whether testing people for COVID-19 just before a large indoor concert could keep the event from causing new infections. Over 6,600 healthy adults aged 18-45 either attended the concert after a negative test or stayed home. The goal was to see if the concert …

This large study tested whether high-dose vitamin D3 supplements could help people recently diagnosed with COVID-19 avoid severe illness and also prevent the virus from spreading to their household members. Over 2,000 participants across the U.S. and Mongolia took either vitamin …

This study tested whether brief videos, handouts, or a short talk from ER staff could increase COVID-19 booster vaccination within 30 days. Over 900 adults from emergency departments took part. The goal was to see if simple, low-cost messaging can improve vaccine uptake.

This large phase 3 trial tested whether a daily statin (pitavastatin) can reduce the risk of heart attacks, strokes, and other cardiovascular events in adults with HIV who are on antiretroviral therapy. Over 7,700 participants from multiple countries took either the statin or a p…

This study tested a device called Cereset Research that plays tones in response to a person's brainwaves, aiming to reduce stress and improve sleep. 94 stressed healthcare workers used the device for several sessions and were followed for a year. The goal was to see if the device…

Researchers are testing whether a 12-week online rehabilitation program helps people with long COVID manage their own health, fatigue, and quality of life. The program combines personalized exercise with education sessions and a mobile app for daily tracking. Participants attend …

This study looks at whether online psychotherapy, a physical activity program, or a combination of both can reduce fatigue in people with Post-COVID syndrome. 195 adults with fatigue will be assigned to one of three groups for 3 months of treatment. The goal is to find which appr…

This study tested whether monthly 45-minute psychological interviews over 6 months could reduce post-traumatic stress symptoms in cancer patients affected by the COVID-19 pandemic. It included 29 adults with solid tumors who had moderate to high PTSD symptoms. The goal was to see…

This trial tests whether an internet-based self-help program called Couple HOPES can reduce PTSD symptoms and improve relationship satisfaction in couples where one partner is a military member, veteran, first responder, or healthcare worker with COVID-19-related PTSD. Participan…

This trial investigates whether ginkgo biloba, piracetam, or a combination of both can help people recover from persistent symptoms after COVID-19, such as memory problems and fatigue. The study enrolls adults aged 18 to 70 who had COVID-19 within the past three months. Participa…

This phase 2 trial tests whether a Chinese herbal formula, COVID Rehab Formula, can reduce fatigue and other lingering symptoms in people who have recovered from COVID-19. Participants take the herbal granules or a placebo daily for 8 weeks. The study focuses on those with ongoin…

This study explores whether a non-invasive brain training technique called qEEG-neurofeedback can help adults with long COVID who struggle with attention, memory, and self-reflection. Participants will undergo 10 sessions of neurofeedback aimed at normalizing brain wave patterns.…

This study tests whether two dietary supplements—eicosapentaenoic acid (EPA), an omega-3 fatty acid, and specialized pro-resolving lipid mediators (SPMs)—can reduce depressive symptoms in adults with long COVID. Participants take either EPA, SPMs, or a placebo daily for 12 weeks.…

This trial tests whether a virtual white board — an e-ink screen that shows patient status, care team information, and pending tests — can improve how satisfied patients feel during their emergency department stay. The study includes adults expected to stay at least four hours in…

This study tests a 16-week program that combines mindfulness with gentle qigong exercises, delivered through a mobile app. It aims to reduce stress, depression, and anxiety in COVID-19 survivors, their caregivers, and the general public. Participants are randomly assigned to eith…

This study tested whether transcranial magnetic stimulation (TMS) can reduce apathy—a severe lack of motivation—in older veterans with mild cognitive impairment (MCI). About 103 participants received either real or fake TMS over 20 sessions. The goal was to see if TMS could impro…

This study tested whether a low-sugar diet, eating only during a 8-12 hour window each day, and periodic water fasts could reduce Long COVID symptoms. 77 adults with at least five Long COVID symptoms participated. The goal was to see if these dietary changes could lower symptom s…

This study looked at whether lying face down (prone positioning) helps hospitalized COVID-19 patients who have low oxygen levels but are not candidates for breathing machines. About 596 adults took part. The goal was to see if this simple position change could lower the chance of…

This study tested whether a simple home program of breathing exercises and walking at least 6000 steps daily could ease long COVID symptoms like cough, breathlessness, and fatigue. Forty adults with long COVID followed the program for six weeks. Researchers tracked changes in sym…

This study tested whether showing children a visual guide about the dentist's office could lower their anxiety. 70 kids aged 5 to 14 were split into two groups: one got the picture-based lesson, the other got standard care. The children who saw the pictures reported less fear and…

This study tested a breathing exercise program for people with long COVID who still feel short of breath. 40 adults took part to see if the exercises could improve their breathing and daily activities compared to usual care. The goal was to find a simple way to help manage this c…

This study tested whether a gentle, noninvasive microcurrent treatment can reduce muscle pain in people who had COVID-19. Forty adults with post-COVID musculoskeletal pain were randomly assigned to receive either real or sham microcurrent therapy for 12 sessions. Researchers meas…

This completed study tested a digital rehab program combining cognitive training, physical exercise, and mindfulness for people with long COVID who have memory and thinking problems. 172 adults with persistent cognitive symptoms at least 12 weeks after COVID-19 took part. The pro…

This study tested Pycnogenol, a natural pine bark extract, against a placebo in 153 adults with Long COVID. The goal was to see if it improves overall health and reduces symptoms like fatigue and brain fog. Participants took the supplement for 12 weeks and reported their health s…

This study tested whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) helps moderate-to-severe COVID-19 patients with low oxygen levels. Thirty adults who needed extra oxygen and had risk factors like diabetes or heart disease were enrolled. The goa…

This study tested whether an online exercise and education program could help cancer patients and survivors feel better during the COVID-19 pandemic. Thirty adults with metastatic breast or gynecological cancer, or breast cancer survivors, took part. The program aimed to reduce f…

This study tested two remotely delivered programs—mindfulness-based cognitive therapy and internet-based cognitive behavioral therapy—against standard remote monitoring alone for reducing depression and substance use related to COVID-19 stress. 113 adults from a health system par…

This study tested a virtual attention training program for 58 adults with Long-Covid brain fog. The goal was to see if the program is feasible and improves focus and thinking. Participants completed sessions online, and researchers measured attention changes before and after trai…

This study tested whether low-dose naltrexone (LDN) can reduce fatigue and improve related symptoms in people with post-COVID fatigue syndrome. 160 adults who had confirmed COVID-19 and met criteria for post-COVID fatigue took either LDN or a placebo for 16 weeks. The main goal w…

This small study tested whether sitting under a bright light for 30 minutes a day for two weeks could help people with long-lasting fatigue after COVID-19. Twelve adults who had been tired for months after their infection took part. The goal was to see if the light therapy could …

This study tested whether the Ghostly app, which guides patients through strength exercises, could help hospitalized people with stroke, COVID-19, frailty, or muscle weakness. Fifteen participants used the app during their hospital stay. The goal was to see if it was practical an…

This study tested whether the antiviral drug remdesivir could help people with Long COVID. 73 adults with confirmed Long COVID received five daily doses of the drug through an IV. Researchers measured how many people completed the treatment and tests, and how well they tolerated …

This early-phase study tested whether high doses of vitamin E (alpha-tocopherol) could reduce C-reactive protein (CRP), a marker of inflammation, in 56 adults with COVID-19. Participants were randomly assigned to receive vitamin E or a placebo. The results suggest that vitamin E …

This pilot study tested whether a stellate ganglion block—a numbing injection near a nerve cluster in the neck—can help people who lost their sense of smell after COVID-19. Twenty adults with smell problems lasting at least a year received the injection. Researchers measured chan…

This study tested a 6-week program called Heart Up! that uses text messages and social support to help adults with heart disease become more physically active and feel less hopeless. About 224 patients who had a heart attack or related procedure took part. The program aimed to im…

This study looked at whether 6 weeks of special breathing exercises (inspiratory muscle training) can improve diaphragm strength and reduce shortness of breath in 18 COVID-19 survivors who still had trouble breathing. Participants had proven diaphragm weakness and no other explan…

This study tested two therapies—low-level laser (light) therapy and myofascial release (a hands-on muscle technique)—against standard chest physiotherapy in 102 moderate COVID-19 patients in the ICU. All patients also received a 12-week home telerehabilitation program after disch…

This study tested a rehabilitation program to help adults with Post-COVID-19 syndrome who suffer from ongoing fatigue. 54 participants completed the program, which aimed to reduce tiredness and improve daily life. The study measured fatigue using several scales to see if the reha…

This study tested whether a budesonide nasal rinse (a steroid) could improve smell loss in 120 adults who still had trouble smelling 30 days after a mild COVID-19 infection. Participants used the rinse twice daily for 30 days, along with smell training. The goal was to see if mor…

This completed pilot study tested a daily ultrasound device applied to the spleen for 8 weeks in 15 adults with Long COVID. The goal was to see if it safely improves symptoms like fatigue, pain, and brain fog. Researchers measured walking endurance and fatigue levels before and a…

This study tested an oral drug called LAU-7b (fenretinide) in 272 adults with moderate to severe Long COVID symptoms lasting at least 12 weeks. Participants took the drug or a placebo in cycles of 14 days on, 14 days off, for 12 weeks. The main goal was to see if LAU-7b improves …

This study tested an internet-based therapy program for adults still struggling with depression or anxiety after the COVID-19 pandemic. 24 participants in Sweden completed 8 weeks of online therapy with a therapist's support. The goal was to see if this approach could reduce ling…

This study tested whether adding functional electrical stimulation (FES) to cycling exercises helps people who survived severe COVID-19 recover more quickly. Twenty-two patients who had been on ventilators in the ICU took part in a 4-week rehab program. Half did cycling with FES,…

This study tested a 10-week group program that teaches self-help strategies from European, Chinese, and Indian traditional medicine for people with post-COVID syndrome. 86 adults with persistent symptoms after COVID-19 took part. The goal was to see if these techniques, added to …

This study tested whether a stellate ganglion block (an injection near nerves in the neck) can improve distorted sense of smell (parosmia) caused by COVID-19. 48 adults with long-term smell issues after COVID took part. Half received the nerve block, half got a placebo (saline). …

This study tested whether two months of smell training can help people who lost their sense of smell or taste due to COVID-19. Forty adults were split into two groups: one did smell training, the other did not. Researchers measured changes using smell tests and daily diaries to s…

This study tested whether a daily breathing exercise program can help people with long COVID who have weak respiratory muscles. 44 adults with long COVID and reduced inspiratory muscle strength were randomly assigned to either breathing exercises plus physical exercise, or physic…

This study tested a 21-herb formula called modified Qing Fei Pai Du Tang (mQFPD) in 60 adults with mild-to-moderate COVID-19. Participants took either the herb capsules or a placebo for 14 days. The main goal was to see if the formula is safe and feasible to use, not yet to prove…

Researchers in the Ile-de-France region are following adults hospitalized with COVID-19 or suspected of having it. They collect blood samples at admission and, for severe cases, at several later points, and they track health outcomes over time. The goal is to identify which facto…

Researchers are comparing serious health events, such as death and unplanned hospital stays, between elderly residents of retirement homes and long-term care units who received a COVID-19 vaccination and those who did not. The study includes about 3,300 residents in the Ile-de-Fr…

This study followed 293 people with autoimmune diseases and healthy volunteers to see how COVID-19 infection or vaccination affects their immune system, inflammation, and blood vessels. Participants were grouped based on their COVID-19 history and had up to 5 visits over 12-18 mo…

Researchers at the University of Malaya are studying how COVID-19 affects muscle loss and strength in critically ill patients. They will compare quadricep muscle thickness and cross-sectional area, along with handgrip and knee extension strength, between COVID-19 and non-COVID-19…

Researchers at Jacobs University Bremen are running a three-phase study to understand how environmentally friendly behaviors relate to eco-anxiety, well-being, and loneliness. About 1,684 adults complete surveys about their food choices, consumption habits, and feelings of social…

This study asks over 1,600 African American women aged 23-35 about their experiences during the COVID-19 pandemic. Participants fill out a short online or paper survey covering infection, vaccination, childcare, job loss, and emotional stress. The goal is to understand how the pa…

This study tested whether weekly community-led group discussions about health topics could change how people feel about COVID-19 testing and vaccines. 49 adults from housing authority agencies took part in Zoom meetings and completed surveys over 18 weeks. The goal was to see if …

This large observational study looks at whether getting an mRNA COVID-19 vaccine shortly before or after starting immune checkpoint inhibitor therapy is linked to longer survival in adults with cancer. Using data from nearly 100,000 patients in France, researchers are comparing t…

This study looked at how the virus that causes COVID-19 reduces the number of infection-fighting white blood cells (lymphocytes) in the blood. Researchers collected blood samples and medical records from 240 adults with or recovering from COVID-19. The goal was to learn more abou…

This study looks at whether people can reliably collect their own blood and saliva samples at home to measure how well COVID-19 vaccines work. About 4,000 adults who recently got a COVID-19 vaccine will either do everything remotely or visit a clinic. Researchers will compare the…

This completed study looked at how COVID-19 affects the heart, lungs, brain, and kidneys in 202 people aged 18 to 80. Participants had imaging scans, blood tests, and other procedures to track inflammation and organ function over time. The goal was to understand why some people g…

Researchers are asking whether isotretinoin, a drug used for severe acne, might increase the chance of catching COVID-19 or having a worse outcome. The drug can dry out the nasal lining, which may reduce the mucus and cilia that help trap viruses. The study compares about 148 peo…

This study looked at how stress from the COVID-19 pandemic affected eating behaviors and weight in over 5,000 English-speaking adults. Participants completed online surveys about their mental health, eating habits, and weight changes. The goal was to understand the link between p…

This study collected blood, saliva, and eye fluid samples from 343 people with uveitis, an inflammatory eye disease that can cause vision loss. Researchers aimed to learn which genes and other factors might lead to the disease and affect treatment response. Participants were foll…

This study followed 132 healthy smokers and non-smokers aged 30-55 to see how smoking history affects immune cells and COVID-19 risk. Participants provided blood, saliva, and nasal swab samples over up to six monthly visits. The goal is to understand why smokers may have more sev…

This study tested whether training healthcare providers on HPV and its vaccine improves their knowledge, attitudes, and communication with patients. Researchers recruited 178 providers in the El Paso border region and compared two types of education programs. The goal was to see …

This early study tests how the experimental COVID-19 drug ALG-097558 moves through the body in people with severe kidney problems compared to healthy volunteers. Twelve adults will take multiple doses of the drug. The goal is to see if kidney function affects drug levels and safe…

This study aims to understand the lived experiences of family caregivers who provide unpaid care to people with mental health conditions like depression, anxiety, and trauma in Zambia during the COVID-19 pandemic. Researchers will interview caregivers and mental health experts to…

This study looks at how lipoproteins, like HDL (good cholesterol) and LDL (bad cholesterol), change in patients with severe COVID-19 in the intensive care unit. Researchers will measure specific proteins on these particles to see if they can predict which patients are at higher r…

This study will use artificial intelligence to analyze data from 400 COVID-19 patients treated in intensive care units. The goal is to see if machine learning models, including deep learning, can predict which patients are most likely to die from the disease. The AI's performance…

This early-stage study looked at how the experimental drug ALG-097558 behaves in 16 people with moderate liver impairment compared to healthy volunteers. The goal was to measure drug levels and safety, not to treat COVID-19. Results will help guide future dosing for patients with…

This study looks at whether post-traumatic stress disorder (PTSD) in surgeons and anesthesiologists is linked to higher rates of complications in the patients they operate on. Researchers will screen surgical staff for PTSD using questionnaires and then track the recovery of thei…

This study looks at whether the virus that causes COVID-19 can be found in the semen of men with cancer who are storing sperm before treatment. Researchers will test both the fluid and the sperm cells for the virus and compare results with nasal swabs and blood tests. The goal is…

This early-stage study is testing a new tablet version of the COVID-19 drug ibuzatrelvir in 18 healthy adults. Researchers want to see how much of the drug gets into the blood when taken as a whole tablet, dispersed in water, or with food. The goal is to compare the new tablet to…

This study looks at how COVID-19 and acute surgical conditions (like appendicitis or internal bleeding) affect each other in hospitalized adults. Researchers will analyze real-world data from a large hospital to understand treatment outcomes and develop models to predict in-hospi…

This study tested two methods to encourage COVID-19 testing among people who use opioids: having friends refer others (chain referral) and using trusted community members (credible messengers). About 500 people took part. The goal was to see which method got more people tested an…

This study follows 6,000 pregnant women worldwide to compare health outcomes for those who received a COVID-19 vaccine during pregnancy versus those who did not. Researchers will track pregnancy complications, newborn health, and infant development up to 12 months old. The goal i…

This study aims to estimate how many people in various US communities have or have had the SARS-CoV-2 virus. Researchers will test blood and nasal swab samples from over 26,000 adults and children living in senior facilities, attending outpatient clinics, or residing in select ne…

This study uses a nationwide health database in South Korea to track the safety of the BNT162b2 (Pfizer-BioNTech) COVID-19 vaccine in over 14 million people. Researchers will look for rare adverse events and severe COVID-19 outcomes after vaccination. The goal is to better unders…

This study invites thousands of adults across the U.S. to share their health records and complete monthly surveys about anxiety, stress, and access to COVID-19 resources. Researchers aim to understand how shelter-in-place policies and containment strategies impacted people's well…

This study investigates why COVID-19 causes severe lung injury (ARDS) by looking at tiny blood vessels in the lungs. Researchers will compare 39 patients with COVID-19 ARDS to those with ARDS from other causes. They measure 'alveolar dead space' — lung areas that get air but not …

This study follows thousands of people with multiple sclerosis (MS) in the UK to see how COVID-19 affects them. Researchers track infections, hospital stays, and deaths using questionnaires and national health data. The goal is to understand the risks and outcomes for this group,…

This study investigates how the immune system responds to COVID-19 in people with chronic lung conditions like asthma, COPD, or cystic fibrosis, compared to those without lung disease. Researchers collect blood, sputum, and nasal samples to measure immune signals and gene activit…

This study looks at tiny nerve fibers in the skin of people with Long COVID, POTS, diabetic neuropathy, and those who had COVID-19 without lasting symptoms. By comparing skin samples, researchers hope to find unique patterns that help explain ongoing symptoms like pain and dizzin…

This study follows thousands of pregnant women in France who had or likely had COVID-19 during pregnancy or shortly after giving birth. Researchers track health problems in both mothers and newborns up to 12 weeks after delivery, using medical records and questionnaires about men…

This study follows people aged 70 and older who were hospitalized with severe COVID-19 for one year after their diagnosis. Researchers aim to describe how many survive and how well they recover, including physical and mental function. The goal is to better understand the long-ter…

This study tests a program called SINCERE that screens people for social needs like food or housing help, then connects them to free community services with follow-up calls. Researchers want to see if this improves overall health, depression, and anxiety in 1500 adults at risk fo…

This study investigates how often cancer patients with COVID-19 develop dangerous blood clots (venous thromboembolism). Researchers will screen participants using ultrasound and blood tests to detect clots, whether or not they cause symptoms. The goal is to understand the true ra…

This study looked at the best way to test for COVID-19 in K-12 schools serving underserved communities. Researchers compared two strategies: testing only people with symptoms versus weekly testing of everyone plus symptom testing. The goal was to see which approach reduced COVID-…

This study looked at the emotional well-being of healthcare workers treating COVID-19 patients at two French hospitals. 78 staff members completed questionnaires about anxiety, depression, resilience, and empathy at different times during the pandemic. The goal was to understand …

This study followed 92 people who had mild COVID and were treated at home. Two years after their diagnosis, they answered a questionnaire by mail about any hospital visits or other health events. The goal was to learn how outpatients fare over time and find patterns that could he…

This study tested whether community health workers with lived experience of incarceration could help people recently released from jail or prison get COVID-19 tests and adopt safety measures like mask-wearing and social distancing. The program included education, on-site testing,…

This study followed 380 people who had COVID-19 pneumonia for one year after they left the hospital. Researchers used heart ultrasounds, lab tests, and CT scans to check for heart problems. The goal was to understand how COVID-19 affects the heart over time.

This completed study looked at 25 young adults (ages 18-65) who had severe COVID-19 and now have thinking or memory problems. Researchers used a special PET-CT scan to see if there are changes in brain activity and how that relates to lung damage. The goal was to better understan…

This study followed 324 people who had close contact with a confirmed COVID-19 case to see how long they shed the virus. Participants provided nasal swabs and reported symptoms over 12 days. The goal was to understand transmission risks and help shape public health policies.

This study looked at 37 critically ill COVID-19 patients who were moved by train from overcrowded ICUs in Paris to less busy ICUs in western France. Researchers tracked how many died, got infections, needed breathing machines, and how long they stayed in the hospital. The goal wa…

This study looked at whether ECMO, a machine that does the work of the heart and lungs, helps people with severe COVID-19 who have lung failure or heart failure. Researchers tracked 761 patients across France to see how many survived and how quickly they recovered. The goal was t…

This study looked at 21 adults with COVID-19 who had neurological symptoms like loss of smell, headache, or memory problems. Researchers used MRI scans to find brain changes linked to the virus. The goal was to better understand how COVID-19 can affect the brain, not to test a tr…

This study screens women who gave birth in four French hospitals for postpartum depression and anxiety during the COVID-19 pandemic. Participants fill out three questionnaires shortly after delivery and again about a month later. The goal is to measure how common postpartum depre…

This study followed 163 people with chronic inflammatory rheumatism (like rheumatoid arthritis) who had a recent COVID-19 infection. Researchers measured their antibody levels over two years to see how immunosuppressive drugs affect antibody persistence. The goal was to better un…

This completed study used advanced MRI and CT scans to look for lasting damage in the brain, heart, lungs, and liver of 206 people who had COVID-19. Researchers compared those who were hospitalized with those who were not, to understand how the virus affects organs over time. The…

This completed pilot study scanned the brains of 30 people who were hospitalized with COVID-19 and later reported memory, concentration, or organizational problems—often called 'brain fog.' Researchers used MRI and spectroscopy to look for changes in brain structure and chemistry…

This completed study looked at how the COVID-19 pandemic and social distancing impacted the mental health of 259 adults with chronic inflammatory rheumatism (like rheumatoid arthritis or ankylosing spondylitis). Researchers used questionnaires to measure stress, depression, anxie…

This study tested whether taking daily probiotic capsules for 4-5 weeks after a COVID-19 vaccine could improve the body's immune response. 138 healthy adults received either probiotics or a placebo. Researchers measured antibody levels and T-cell activity to see if probiotics mad…

This completed study looked at nearly 29,000 adults who had non-cardiac surgery under general anesthesia in a large Canadian health region. Researchers wanted to see how often doctors used lung protective ventilation, a technique that uses smaller breaths and gentle pressure to r…

This completed study looked at how often healthcare workers and first responders experienced short-term side effects (like fever or sore arm) after getting either the updated Novavax or Pfizer COVID-19 vaccine. About 660 adults who had at least one prior COVID-19 shot took part. …

This completed study followed 5 people with cystic fibrosis over two years to track COVID-19 antibodies from infection or vaccination. Researchers collected blood samples every six months to see how antibodies develop and last. The goal was to understand if people with CF have di…

This study tracked 204 patients with blood cancers or those on certain immune-suppressing treatments to see how often COVID-19 infection persists for 21 days or more. Researchers also looked for factors that make a long infection more likely. The goal was to better understand who…

This study followed 122 COVID-19 patients who were in the ICU, along with their family members, for up to a year after leaving the hospital. Researchers measured physical health, mental well-being, and how well people returned to work and daily life. The goal was to learn about t…

This study looked at whether neck muscle activity during sleep affects breathing recovery in 17 COVID-19 patients who were on ventilators in the ICU. Researchers used sleep tests and activity monitors to track sleep quality and breathing patterns. The goal was to understand why s…

This study looked at over 13,000 people with chronic inflammatory rheumatism or autoimmune diseases who had or were suspected to have COVID-19. Researchers tracked how many developed severe COVID-19 requiring intensive care or leading to death. They also examined risk factors lik…

This study looked at how the COVID-19 lockdown changed blood sugar control and self-care in 77 young people aged 13 to 25 with type 1 diabetes. Researchers used data from a glucose monitoring platform to compare blood sugar levels before, during, and after the two-month lockdown …

This study involved over 2,500 people of all ages to find out which immune responses best predict protection against COVID-19 after vaccination. Researchers also tested whether local pharmacies could collect blood and nasal samples effectively. The goal is to improve future vacci…

This study followed 610 adults who had heart surgery to see how often they develop postoperative delirium—a sudden state of confusion that can come and go. Researchers collected information on known risk factors like age, high blood pressure, and diabetes, and tracked outcomes su…

This study looked at whether having COVID-19 makes people more likely to develop a pulmonary embolism (a blood clot in the lungs). Researchers reviewed medical records of 347 patients who had a CT scan of their lungs. They compared those who tested positive for COVID-19 with thos…

This study collected information from 550 adults treated for COVID-19 at Methodist Health System facilities. Researchers looked at patient details, treatments given, and how well patients recovered. The goal was to better understand COVID-19 and improve future care, not to test a…

This study monitored 201 people with multiple myeloma to see how well COVID-19 vaccines and boosters work for them. Since their immune systems are weaker, researchers wanted to learn if vaccines still provide good protection. The goal was to find better ways to keep this vulnerab…

This study tested how a potential COVID-19 drug, ALG-097558, interacts with other medicines and food in 51 healthy adults. It also compared two tablet forms of the drug. The goal was to gather safety and dosing information, not to treat the disease. Results will help guide future…

This study looked at how the COVID-19 pandemic and related public health measures changed asthma control in children aged 3 to 16. Researchers compared asthma control and flare-ups in 577 children during the pandemic to data from before the pandemic. The goal was to see if lockdo…

This completed study followed 829 people, including healthcare workers and a comparison group, over several years to understand how SARS-CoV-2 spreads and who gets sicker. Researchers collected swabs, blood, and saliva samples along with survey data. The goal was to identify risk…

This study tested whether one-on-one support from a resource navigator helps long-term care and retirement home staff access health and wellness resources. 123 staff members took part, with some getting a navigator and others not. Researchers measured changes in wellness, burnout…

This study looked at how many people in Punta Arenas, Chile, have persistent COVID-19 (long COVID) — symptoms lasting more than 4 weeks after infection. Researchers surveyed and tested 282 adults who had COVID-19, checking their physical and mental health, and looking for risk fa…

This study looked at whether lying face down (prone position) while awake can improve how air moves through the lungs in COVID-19 patients with breathing failure. Twenty adults with COVID-19 and low oxygen levels were monitored using a special imaging technique (EIT) to measure l…

This study checks on 137 COVID-19 patients who were in the ICU and used awake prone positioning (lying on their belly) while on high-flow oxygen. Researchers want to see if this technique affects quality of life and survival more than two years later. Participants answer a phone …

This completed study looked at 4000 COVID-19 patients in Swedish ICUs who needed a breathing machine. Researchers compared outcomes based on how soon after starting ventilation a tracheostomy was performed. The goal was to see if earlier or later timing affects how many days pati…

This study looked at 176 people who had COVID-19 and were having problems with smell, taste, or saliva. Researchers tested their senses and tried smell training as a way to help. The goal was to better understand these long-lasting symptoms and how to manage them.

This study looked at how the COVID-19 pandemic affected children with eating disorders and their families in Canada. Researchers tested virtual support groups led by parents who have been through similar experiences. They interviewed parents, youth, and healthcare workers to see …

This completed Phase 1 study looked at how much of the COVID-19 treatment nirmatrelvir/ritonavir (Paxlovid) gets into breast milk. Eight healthy breastfeeding women took the drug by mouth three times over two days. Researchers collected breast milk samples to measure drug levels,…

This study aimed to increase COVID-19 vaccination among African American and Latinx communities in four Michigan counties. Researchers worked with community partners to understand why some people were hesitant to get the vaccine and tested ways to encourage uptake. Over 1,100 adu…

This study surveyed over 3,400 university students and staff to learn what factors influence their decision to get a COVID-19 vaccine. Participants answered questions about vaccine effectiveness, side effects, costs, and incentives. The goal was to better understand preferences a…

This completed study looked at lung function in 42 people recovering from COVID-19. Participants inhaled a special form of xenon gas that shows up on MRI scans, allowing researchers to see how well different parts of the lungs were working. The goal was to understand how mild, mo…

This study followed 201 adults with diabetes who were hospitalized for COVID-19 in Algeria. Researchers tracked their blood sugar, weight, and kidney function for up to a year after leaving the hospital. The goal was to learn how COVID-19 affects long-term diabetes control and to…

This study looked at how well CPAP therapy works for COVID-19 patients who have trouble breathing. Researchers collected data from 250 patients in a hospital to see how they responded to treatment. The goal was to learn more about managing severe COVID-19 in real-life settings.

This completed study enrolled 818 adults hospitalized with COVID-19 to examine how genetic, inflammatory, and other blood markers relate to disease severity and death. Researchers tracked outcomes like recovery or death and analyzed risk factors using statistical models. The goal…

This completed study followed 917 adults with COVID-19 who were prescribed Paxlovid. Researchers wanted to see how often people test positive again after finishing the 5-day treatment. The goal is to better understand the so-called 'Paxlovid rebound' and help guide future care.

This study examined whether being in the ICU with COVID-19 made patients more likely to pick up dangerous, drug-resistant bacteria. Researchers tracked 368 critically ill adults to compare infection rates before and during the pandemic. The goal was to understand if COVID-19 chan…

This completed study from France compared over 1,500 ICU patients on ventilators to see if those with COVID-19 develop more lung infections than patients with influenza or no viral pneumonia. Researchers tracked cases of ventilator-associated pneumonia and tracheobronchitis. The …

This completed study tested whether phenelzine, a drug used for depression, could change how immune cells behave in people with COVID-19. Researchers took blood samples from 51 patients and exposed the cells to phenelzine in the lab. The goal was to see if the drug could reduce o…

This study looked at how the immune system of people with COVID-19 responds, comparing those who had symptoms to those who did not. Researchers tested over 200 adults from households with a confirmed COVID-19 case to see if asymptomatic carriers develop antibodies. The goal was t…

This completed study collected blood, urine, and kidney tissue from 90 COVID-19 patients with acute kidney injury. Researchers aimed to build a biorepository and analyze samples to better understand how COVID-19 affects the kidneys. The goal is to speed up discoveries and improve…

This study tested a fast COVID-19 test-and-treat program in Ghana, Malawi, Rwanda, Zambia, and Zimbabwe. Researchers interviewed health officials, workers, and patients to see if the program was practical and well-liked. The goal was to learn how to set up similar programs in the…

This early-stage trial tested the safety and tolerability of an experimental drug called Benfo-Oxythiamine (B-OT) in 48 healthy male volunteers. Researchers gave the drug as single or multiple daily doses and monitored participants closely for side effects, blood levels, and lab …

This completed study followed 360 adults and children with chronic respiratory and other medical conditions to see how their immune systems responded to COVID-19 vaccines over 18 months. Researchers measured antibody, T cell, and B cell levels before vaccination and every 3 month…

This study followed 51 adults who survived severe COVID-19 pneumonia and needed a breathing tube for more than 72 hours. Researchers measured their quality of life, ability to perform daily activities, muscle strength, and nutrition at 1, 6, and 12 months after leaving the hospit…

This completed Phase 1 trial enrolled 16 healthy Chinese men to see how the body processes MK-4482 after single and multiple doses. Participants took 800 mg of MK-4482 by mouth, first as a single dose and then every 12 hours for several days. The study measured drug levels in the…

This study reviewed medical records of 200 adults from an endocrinology clinic to see if taking vitamin D3 supplements lowered their chances of developing Long COVID after a COVID-19 infection or getting COVID-19 after vaccination. Researchers compared patients who took vitamin D…

This study looked at how the thymus gland, which produces immune cells called T cells, might influence COVID-19 severity. Researchers compared 85 hospitalized patients with and without COVID-19 to see if genetic differences in thymus function were linked to worse lung damage. The…

This completed study looked at how a COVID-19 infection during pregnancy, along with related stress, might affect a baby's brain development. Researchers followed 62 mothers and their infants, using surveys, brain scans (MRI and EEG), and developmental tests. The goal is to bette…

This completed study from the National Institute of Mental Health surveyed over 3,600 English-speaking adults online every two weeks for six months. Researchers asked about mental health symptoms, stress, and behaviors during the COVID-19 pandemic. The goal was to understand how …

This completed study followed 530 working-age adults (18–70) who were hospitalized for COVID-19. Researchers measured disability using WHO checklists at 12 and 36 months after hospitalization. The goal was to understand how severe COVID-19 affects people's ability to function and…

This study looked at how doctors, nurses, and physiotherapists in community health teams were affected by the COVID-19 pandemic. Researchers interviewed 62 healthcare workers about their work and personal challenges. The goal was to understand their experiences and identify what …

This study looked at how wearing surgical masks, N95 masks, and face shields affects speech perception and listening effort in operating rooms. Researchers tested 35 people with normal hearing and surveyed 184 operating room professionals. The goal was to understand communication…

This study looked at whether it is safe to give another dose of a COVID-19 mRNA vaccine to people who had a bad reaction to a previous dose, or to people with a history of allergies. It also included people with long COVID. A total of 137 adults took part and received either the …

This study looked at 51 young adults to see if their physical activity level is related to how strong their cough is and how well they can balance. Participants answered a questionnaire about their activity and used a device to measure cough strength. The goal was to understand t…

This study examined how people with mild or no COVID-19 symptoms respond to the virus. Researchers measured immune markers in the blood of 57 adults who tested positive. The goal was to understand why some people clear the virus quickly while others develop severe illness.

This study tested whether a blood sample can predict how severe COVID-19 will become in kidney transplant patients with mild to moderate symptoms. Researchers measured a protein called IL-6 after stimulating the blood sample. They followed 52 patients to see if IL-6 levels were l…

This study looked at how the COVID-19 pandemic affected the supply of blood products for emergency surgeries at one hospital. Researchers tracked delays and shortages from March 2020 to March 2021. The goal is to use this information to create better policies for handling blood s…

This study tracked 100 fully vaccinated adults to see how many later caught COVID-19 (called a breakthrough infection). It also compared infection rates in people who got a booster shot. The goal was to understand how well vaccines and boosters protect against infection, not to t…

This study tested a blood test called ELISpot to see if it can detect the body's immune response to the COVID-19 virus. The test aims to find infections that standard swab tests might miss and help predict whether a person will develop mild or severe illness. Researchers enrolled…

This study reviewed medical records of 417 adults hospitalized with COVID-19 at four hospitals. Researchers wanted to find out how many patients also had other infections (co-infections) or developed new infections later. They also looked at how these infections affected death ra…

This completed study analyzed blood samples from 304 COVID-19 patients in France to find early immune markers that predict whether someone will become severely ill. Researchers looked at T-cells and inflammatory chemicals in the blood to understand why some people worsen while ot…

This study looked at whether a blood test measuring suPAR levels can predict which adults hospitalized with COVID-19 will develop severe breathing failure requiring a breathing tube. Researchers analyzed stored blood samples from about 367 patients. The goal was to see if a suPAR…

This study looked at how the COVID-19 pandemic changed the way people with multiple sclerosis (MS) reported and managed their relapses. Researchers compared 51 patients who had a relapse during the first wave of the pandemic (April–June 2020) with those who had a relapse during t…

This study looked at whether wearing FFP2/N95 masks changes oxygen levels and pulse rate in dental professionals. Sixty dental workers took part, and researchers measured oxygen saturation and pulse while they wore the masks. The goal was to understand any short-term effects on b…

This study used advanced total-body PET scans to look at how COVID-19 affects the lungs' blood-air barrier. Thirteen adults who had COVID-19 and healthy volunteers each had two scans, one at the start and one four months later. The goal was to measure changes in lung function ove…

This study looked back at 60 adult blood cancer patients who had stem cell transplants and later developed a rare fungal infection called mucormycosis. Researchers compared cases before COVID-19 (2015-2020) to during the pandemic (2020-2024) to see if the virus, new tests, or new…

This study looked at how often brainstem problems occur in COVID-19 patients who are on a ventilator and deeply sedated in the ICU. Researchers checked brainstem reflexes using a simple scoring system, both during sedation and a few days after sedation stopped. The goal was to un…

This study tested whether measuring a protein called MxA in the blood can help doctors decide when to stop antiviral drugs in patients with flu or COVID-19. Researchers enrolled 86 adults and compared standard care to MxA-guided treatment. The goal was to see if the test could re…

This completed study followed 200 adults who had COVID-19 to see if the virus causes long-term heart problems or mental health issues. Participants wore health-tracking devices and answered surveys about anxiety, depression, and substance use. The goal was to better understand th…

This completed study looked at anxiety about COVID-19 in 200 adults with rheumatic diseases who were already taking either biologic or conventional disease-modifying drugs. Researchers called participants and asked them to fill out a questionnaire about their coronavirus-related …

This completed study measured specific blood proteins in 75 adults with COVID-19 to see if they are linked to severe outcomes like ICU admission, breathing support, or organ failure. Researchers analyzed stored blood samples to look at markers that affect blood vessel health. The…

This study looked at placentas from 68 women who had COVID-19 during pregnancy to see if the virus changes the placenta's structure or gene activity. Researchers also checked umbilical cord blood for signs of inflammation. The goal is to better understand how the infection might …

This study followed 75 people with cystic fibrosis (CF) for two years to see how many developed COVID-19 antibodies from infection or vaccination. Researchers wanted to know if CF patients are naturally protected or just avoiding the virus. The study collected blood samples and h…

This completed study looked at whether an artificial neural network (a type of AI) could predict how long COVID-19 patients in the ICU would need a breathing machine and whether they would survive. Researchers analyzed medical records from 113 ICU patients. No new treatment was g…

This completed study tested whether a telemedicine-based program could improve quality of life for adults who needed a breathing machine (ventilator) due to acute respiratory failure. The program included rehabilitation strategies during the ICU stay, hospital ward, and for two m…

This study looked at ways to encourage COVID-19 testing and prevention habits among people with diabetes or at risk for it. About 290 participants in Georgia were split into two groups to compare the effects of a 16-week program. The goal was to see if the program increased testi…

This study looked at the best ways to encourage COVID-19 testing for children with intellectual and developmental disabilities and their teachers. Over 1,100 participants from two special school districts took part. The goal was to find what messages and strategies work best to k…

This study looked at whether people with cystic fibrosis (CF) have COVID-19 antibodies in their blood over two years. Researchers wanted to see if CF patients get infected less often or have milder symptoms. About 331 children and adults with CF from Europe gave blood samples and…

This study looked at 3820 adults with cancer who also had COVID-19. Researchers collected routine medical data to describe symptoms and identify factors affecting survival. The goal was to learn more about how COVID-19 affects cancer patients, not to test a new treatment.

This study looked at 30 cancer patients with COVID-19 pneumonia to see if lung ultrasound could work as well as CT scans for diagnosis. Researchers compared the imaging results and checked if they matched the patients' symptoms and lab tests. The goal was to find a cheaper, easie…

This study looked at how the COVID-19 pandemic affected the quality of life of 200 adults with asthma. Researchers wanted to understand what caused extra stress—like staying home, using more disinfectants, or worrying that asthma symptoms might be COVID-19. The goal was to find o…

This study followed 283 adults who needed intensive care for severe COVID-19 lung damage (ARDS) in Poland. Researchers tracked who survived up to 4 years later and asked survivors about their quality of life, breathing, and daily function. No new treatment was tested—the goal was…

This study looked at nearly 2,000 adults with lung cancer who caught COVID-19. Researchers tracked their health and checked for antibodies (immune system markers) right after infection and again 6 months after vaccination. The goal was to understand how lung cancer affects the bo…

This completed study looked at whether vitamin D levels in the blood are linked to how severe COVID-19 gets. Researchers measured vitamin D in 1,100 COVID-19 patients in Turkey. The goal was to see if current vitamin D thresholds reflect real clinical risk. This is an observation…

This completed study looked at 355 adults with Long COVID in Suffolk and North Essex to understand their symptoms and rehabilitation needs up to 36 months after infection. The goal was to better diagnose and manage the condition, focusing on helping people return to everyday acti…

This study looked at whether people with cystic fibrosis (CF) have COVID-19 antibodies from infection or vaccination. Researchers followed 152 adults and children with CF for two years, taking blood samples every six months. They aimed to understand how many had antibodies, how l…

This study looked at nearly 2,500 adults in the Olomouc region to find out how many had antibodies or cellular immunity against the SARS-CoV-2 virus, either from a past infection or from vaccination. Participants gave blood samples and answered a questionnaire. The goal was to un…

This completed Phase 4 study tested whether an updated COVID-19 vaccine (mRNA-1273.712) affects heart muscle in healthy people aged 12 to 30. Researchers measured a heart enzyme called troponin in 1,000 participants who received either the vaccine or a placebo. The goal was to se…

This study looked at 39 hospitalized COVID-19 patients to see if a strong T-cell immune response is linked to worse symptoms. Researchers measured specific immune cells and chemicals in the blood. The goal was to understand why some patients get much sicker, not to test a treatme…

This completed study looked at 543 people who survived severe COVID-19 with lung failure (ARDS) to see if their socioeconomic status affected their recovery. Researchers checked breathing, mental health, and quality of life six months after leaving the ICU. The goal is to use thi…

This study compared two methods to increase COVID-19 testing among patients at Utah community health centers: text message reminders alone versus text messages plus a patient navigator who helped with logistics. Over 44,000 English- or Spanish-speaking adults with a working cell …

This study looked at how fat (lipid) metabolism is linked to severe pneumonia caused by COVID-19 versus other germs. Researchers measured cholesterol and other fat-related substances in 62 adults with severe pneumonia. The goal was to understand these differences, not to test a t…

This study looked at whether nutritional status affects the risk of death in people aged 70 and older with COVID-19. Researchers followed 426 hospitalized patients, comparing those with and without the virus. The goal was to understand if poor nutrition makes COVID-19 more danger…

This study followed 113 people with cystic fibrosis (CF) over two years to see how many developed antibodies against COVID-19, either from infection or vaccination. Researchers collected blood samples and health data to understand if CF patients have a lower infection rate and ho…

This completed study looked at 25 people who had COVID-19 but were not hospitalized, yet still felt short of breath and tired. Researchers measured their diaphragm strength using advanced breathing tests and ultrasound. The goal was to see if diaphragm weakness is a hidden cause …

This study looked at 600 COVID-19 patients with severe breathing problems who were treated with high-flow nasal oxygen and asked to lie face-down (awake prone position). The goal was to see if this combination reduced the need for a breathing tube and lowered death rates. Researc…

This completed study looked at breathing muscle function in 50 people who were hospitalized for COVID-19. Half had been on a ventilator, half only needed extra oxygen. Researchers used advanced tests to measure diaphragm strength and movement. The goal was to understand why many …

This study looked at how two different COVID-19 booster vaccines affect immune cells in the lymph nodes. Researchers used a needle to take samples from the lymph nodes of 12 adults who had already received at least three doses of an mRNA COVID-19 vaccine. The goal was to understa…

This study looked at 622 veterans with chronic lung disease who had COVID-19. Researchers tracked their health outcomes, recovery, and need for rehabilitation services. The goal was to understand which factors lead to more severe illness and what support patients need after recov…

This study looked at how T-cells, a key part of the immune system, respond to the COVID-19 virus in 51 people—hospitalized patients and healthy hospital staff. Researchers measured T-cell activity at several time points using a blood test called ELISPOT. The goal was to better un…

This study looked at how many hospital workers in Strasbourg, France, had antibodies against the virus that causes COVID-19. About 1,466 staff members were tested to see if they had been infected, especially after a large outbreak linked to a religious event. The goal was to unde…

This study monitored 219 adults with severe COVID-19 who needed a ventilator for at least 72 hours. Researchers checked for serious fungal infections, especially aspergillosis, using standard diagnostic methods. The goal was to learn how common these infections are and what puts …

This study looked at 380 adults in the intensive care unit with suspected or confirmed COVID-19. Researchers tracked organ problems like kidney injury and lung failure, and measured survival rates at 30 days and one year. The goal was to learn how COVID-19 causes organ damage, no…

This early-stage study looked at how the drug Ibuzatrelvir (PF-07817883) is absorbed and processed in the body of 12 healthy Chinese adults after a single dose. The goal was to measure drug levels in the blood and check for any side effects. Since participants were healthy, this …

This study looked at eye problems in 23 COVID-19 patients in intensive care. Doctors checked for damage to the cornea, retina, and optic nerve at several time points. The goal was to find and treat eye issues early to prevent vision loss.

This study asked 714 breast cancer survivors about their experiences with the COVID-19 vaccine. Researchers wanted to understand if lymph node swelling—a common vaccine side effect—caused worry or raised the risk of lymphedema (arm swelling) in these patients. The study collected…

This study looked at 32 adults in the ICU on ECMO life support who had severe influenza or COVID-19 and a serious fungal lung infection called aspergillosis. Researchers measured how the antifungal drug voriconazole behaves in the body to find the best dose for these very ill pat…

This study tested over 1,000 children and their parents for COVID-19 antibodies to find out how many had been infected. Researchers also checked for active virus in nose, saliva, and stool samples. The goal was to better understand infection rates and immune responses in families…

This study looked at eye damage in 34 people who were hospitalized for severe COVID-19. Researchers used many eye exams and scans to find problems like inflammation, dry eye, and blood vessel damage. The goal was to better understand what eye issues can happen after a serious COV…

This study explored how changes in healthcare during the COVID-19 pandemic (2020-2021) impacted the quality of life and experiences of over 5,000 Dutch patients who had surgery or another medical procedure. Researchers first held focus groups to understand key themes, then create…

This completed study looked at over 6,000 adults admitted to Italian cardiac intensive care units during the COVID-19 pandemic. Researchers aimed to describe the types of patients admitted, how they were managed, and their short-term outcomes. The goal was to understand the pande…

This study followed 187 people who had COVID-19 to see how their antibody levels changed over 24 months. Researchers took blood samples and, in some cases, nasal swabs to measure both general and neutralizing antibodies. They also looked at how the severity of the initial infecti…

This study aimed to understand how COVID-19 affected cancer patients and healthcare workers in cancer centers. Over 1,100 participants were followed for a year to track infections, severity, and emotional impacts. No treatments or vaccines were tested; instead, researchers collec…

This study tested whether a systematic phone call from a medical student, supervised by a general practitioner, could reduce hospitalizations in patients with chronic heart or mental health conditions during the COVID-19 lockdown in France. Over 22,000 patients aged 70 and older …

This study examined whether strict COVID-19 rules in nursing homes (like banning visitors and confining residents) saved lives or caused harm. Researchers tracked over 12,000 residents for one year, comparing death rates in homes that followed guidelines closely versus those that…

This study looked at how well the Pfizer COVID-19 vaccine works in people over 65 living in nursing homes compared to younger adults aged 40-65. Researchers measured immune cells and antibodies at 3 and 9 months after vaccination. The goal was to understand if older adults get th…

This completed study from France enrolled 373 people who came to the emergency room with suspected COVID-19. Researchers checked routine blood markers to see if any could predict which patients would later get worse and need intensive care. The goal was to find simple, low-risk t…

This study looked at how well the Pfizer COVID-19 vaccine triggers an immune response in 196 adults with weakened immune systems (due to conditions like kidney transplant, cancer, or HIV) compared to healthy adults. Researchers measured antibody levels and their ability to neutra…

This pilot study looked at whether the COVID-19 virus can spread through the air during surgery on infected patients. Researchers took air samples and swabbed surfaces in the operating room during two surgeries. The goal was to understand contamination risks so that healthcare wo…

This study looked at 757 adult patients treated for COVID-19 at Lille University Hospital to find out which factors best predict death within 28 days. Researchers collected medical, lab, and imaging data to understand why some patients die and others recover. The goal is to help …

This study looked at adults who received a COVID-19 vaccine through local programs in 7 countries. Researchers measured the immune response and how long protection lasts. About 5,400 people took part, providing blood and nose samples. The goal was to understand how well different…

This study looked at 51 adults who had COVID-19 2 to 12 months earlier and still had brain fog or other thinking problems. Researchers checked if the virus was still hiding in the nose's smell center. They compared these patients to a control group to see if lingering virus is li…

This study followed over 1,100 high-risk COVID-19 patients in the Netherlands who received new antiviral drugs or monoclonal antibodies. Researchers collected blood samples and nasal swabs over 90 days to see how the virus and the body's immune response changed during treatment. …

This completed registry study collected data from 500 COVID-19 patients to learn how the virus affects kidney function. Researchers aimed to identify risk factors and track outcomes. The findings may help guide future treatment and care for kidney complications in COVID-19.

This study examined how the COVID-19 pandemic impacted skin allergy visits among healthcare workers. Researchers analyzed records from 341 healthcare workers who visited skin clinics before and after the pandemic. The goal was to understand if increased use of masks, gloves, and …

This completed study observed 199 adults hospitalized with confirmed COVID-19. Researchers tracked patient characteristics, treatments used, and how the disease progressed over time. The goal was to answer important questions about the natural history of COVID-19 to help guide fu…

This study looked at how COVID-19 spread among patients and healthcare workers in four hospitals in Bamako, Mali. Researchers used molecular tests to find active infections and blood tests to check for past infections and immunity. The goal was to understand infection rates, incl…

This study looked at the psychological impact of the COVID-19 pandemic on healthcare workers in intensive care units. Over 700 doctors, nurses, and aides completed questionnaires about post-traumatic stress, anxiety, depression, and burnout. The goal was to measure how common the…

This completed study enrolled nearly 97,000 adults from long-running French health studies to track how many people had been infected with the coronavirus. Participants provided blood samples and answered questionnaires. The goal was to measure infection rates and understand what…

This study examined the immune systems of 120 COVID-19 patients who had trouble breathing. Researchers measured many immune markers in the blood to see if an overactive immune response causes lung damage. They also compared these markers to healthy people and looked for patterns …

This study used advanced MRI scans to look for organ damage in 693 adults who had recovered from COVID-19. Researchers focused on the heart, kidneys, and liver to see how often and how severely these organs were affected. The goal was to better understand the long-term health imp…

This study examined whether a blood test parameter called NEU-SFL, which reflects neutrophil activation, could predict the risk of death in patients hospitalized for COVID-19 in 2021. Researchers compared NEU-SFL levels between those who survived and those who died. The goal was …

This completed early-phase study looked at how mRNA COVID-19 vaccines (Pfizer or Moderna) affect certain immune cells called monocytes in people of different ages. Researchers measured changes in reactive oxygen species (a type of cell activity) and a blood protein called AngII b…

This completed study followed 105 pregnant women who had COVID-19 or received a COVID-19 vaccine. Researchers measured antibodies in the mothers' blood and breast milk, as well as in the umbilical cord blood at delivery, to see how immunity transfers to the baby. The goal was to …

This study looked at how the COVID-19 pandemic impacted the mental health of 501 nursing home workers in Occitanie, France. Researchers measured rates of post-traumatic stress disorder (PTSD), depression, and burnout using standard questionnaires. The goal was to understand how c…

This study looked back at how French hospitals created more intensive care unit (ICU) beds and found extra healthcare workers during the COVID-19 pandemic. Researchers gathered information from nearly 10,000 hospitals across France. The goal was to understand where the new beds c…

This completed study looked at blood clotting in 175 hospitalized COVID-19 patients. Researchers used a special test to measure how quickly and strongly blood clots form, and whether a protein called thrombomodulin can slow this process. The goal was to understand why some COVID-…

This study followed over 1,000 adults with confirmed or suspected COVID-19 who were admitted to intensive care units (ICUs) across France. Researchers tracked their treatments, complications, and survival at 28 days. The goal was to learn how these patients are managed and what f…

This study looked at 73 people who were hospitalized with severe COVID-19 pneumonia to see if their lungs still had problems 4 months later. The main focus was on how well oxygen moves from the lungs into the blood. The goal was to better understand these lasting issues so doctor…

This completed study from Ankara University looked at 146 severe COVID-19 patients in the ICU. Researchers measured red blood cell distribution width (RDW), a marker of variation in red blood cell size, to see if it could predict whether patients would need a breathing tube or di…

This study looked at how many children of hospital workers had antibodies against the virus that causes COVID-19. Researchers tested blood and saliva samples from 563 family members to see if a parent's infection status affected the child's risk. The goal was to better understand…

This study tested over 1,000 healthcare workers for COVID-19 and tracked their antibody levels over time. The goal was to understand how the virus spreads among hospital staff and how the immune system responds. No treatment was given; the focus was on gathering information to gu…

This study looked at over 2,300 children aged 0-12 who had mild cold symptoms before elective non-cardiac surgery. Researchers wanted to see if the COVID-19 pandemic changed the risks of complications like breathing problems or infections. The goal is to help doctors decide the s…

This study looked at how many police officers in Bern, Switzerland had antibodies against COVID-19 over one year. About 1,024 officers volunteered to give blood samples at five different times. Researchers also asked about their work and home life to understand infection risks an…

This study looked at why antibiotics often fail to treat pneumonia in COVID-19 patients on ventilators. Researchers measured how much of the antibiotic piperacillin reaches the lungs in 34 adults with severe COVID-19 pneumonia. The goal was to understand if poor lung penetration …

This completed study followed 332 adults who were hospitalized with severe COVID-19 pneumonia and needed oxygen. Researchers used CT scans and breathing tests to check for lasting lung damage. The goal was to understand how the lungs recover after a serious infection.

This completed study followed 6,000 adults who had COVID-19 symptoms and were tested for the virus. Participants completed online surveys every 3 months for 18 months to track long-term health issues like fatigue, brain fog, and heart problems. The goal was to better understand t…

This study aimed to make COVID-19 rapid testing easier and more effective for Latino communities in San Diego County, especially near the US-Mexico border. Over 6,500 English- or Spanish-speaking adults who were patients at certain clinics or lived nearby took part. Researchers w…

This study looked at how COVID-19 infection relates to tinnitus (ringing in the ears). Researchers in Brazil followed 233 people who had COVID-19 between 2020 and 2024, comparing those who developed new tinnitus, those who had it before, and those without it. The goal was to unde…

This study followed over 4,200 Dutch COVID-19 patients for up to two years to learn about long COVID symptoms like exhaustion, breathing problems, and mental health issues. Researchers also looked at how these symptoms affect quality of life and what factors might predict who get…

This completed study looked at how the COVID-19 pandemic affected online gambling in France and Sweden, using data from 120,000 gamblers. Researchers compared gambling behaviors before and during the pandemic, including money spent and types of games played. They also examined di…

This completed study used a special imaging method called electrical impedance tomography (EIT) to look at lung function in 100 people with long COVID who have trouble breathing, compared to 50 healthy volunteers. The goal was to see if EIT can detect changes in how air moves thr…

This study followed 211 older adults who were hospitalized with COVID-19 to see how their mobility and daily function changed over time. Researchers measured physical abilities like walking, balance, and thinking skills. The goal is to understand recovery patterns so doctors can …

This study looked at why some COVID-19 patients lose their sense of smell. Researchers compared nasal cell samples from 26 people—some with COVID-19 and smell loss, and some healthy controls. They aimed to find molecular and cellular differences in the nose that might explain the…

This study tested a patient engagement tool (PET) designed to encourage COVID-19 and flu vaccination among underserved populations in East London, including minority ethnic groups, migrants, and low-income individuals. Over 5,900 adults from six GP practices were randomly assigne…

This study looked at whether chronic stress before catching COVID-19 makes long COVID more likely. Researchers followed 380 adults who tested positive for SARS-CoV-2 and had symptoms. They measured stress levels and tracked whether symptoms lasted beyond four weeks. The goal is t…

This completed study collected blood, urine, and nasal swab samples from 249 adults—some with COVID-19, some with the flu, and healthy controls—at two time points. Researchers used a systems biology approach to analyze the data, aiming to understand why people respond differently…

This completed study looked back at data from over 361,000 people hospitalized with COVID-19 in Brazil. Researchers used a public health database to describe patient characteristics and outcomes, such as death rates. They also compared the impact of vaccination on immunocompromis…

This completed study looked at 11,000 COVID-19 patients to understand how often they develop dangerous blood clots in arteries or veins. Researchers tracked clot rates, risk factors, and outcomes over 30 and 90 days. The goal was to learn more about these complications to improve…

This completed study looked at 552 adults with myeloproliferative neoplasms (MPN) who also had COVID-19. Researchers wanted to see how often these patients developed blood clots, like pulmonary embolism. The goal was to understand what factors make COVID-19 worse for people with …

This completed study looked at whether smoking or using nicotine products changes the risk of catching COVID-19. Researchers surveyed over 600 healthcare workers who had been tested for the virus. The goal was to see if there is a connection between tobacco or nicotine use and te…

This study looked at how the COVID-19 pandemic and related measures like lockdowns and mask-wearing affected severe Group A Strep infections in children in Paris. Researchers reviewed medical records of 269 children under 18 admitted to a Paris hospital between 2018 and 2023. The…

This study looked back at 20 children under 18 who were in intensive care with heart inflammation (myocarditis) and a possible COVID-19 infection. The goal was to describe their symptoms, lab results, and heart function, and to figure out whether the virus directly damages the he…

This completed study followed 85 COVID-19 survivors who needed a breathing machine in the ICU. Researchers tracked their physical, thinking, and emotional recovery from the hospital until they returned home. They compared walking patterns to healthy people to understand the chall…

This completed study followed 1,366 adults in Luxembourg who tested positive for COVID-19. Researchers tracked symptoms and took blood, swab, and stool samples to identify factors linked to severe disease. The goal was to better predict patient outcomes and improve care.

This study followed 153 people with cancer who had or were suspected of having COVID-19. Researchers collected throat swabs and saliva samples over several weeks to see how well antibody and antigen tests work in this group. The goal was to learn more about the course of COVID-19…

This completed study followed 300 adults who had mild to moderate COVID-19 but were not hospitalized. Researchers tracked their symptoms for up to a year to see how long it took to fully recover and how lingering symptoms affected daily life. The goal was to better understand lon…

This completed study looked at whether COVID-19 patients treated with steroids might have a reactivation of hepatitis B virus (HBV). Researchers followed 1,793 hospitalized adults who needed oxygen and received steroids for COVID-19 pneumonia. The goal was to see how well doctors…

This completed study tested nearly 2,800 primary care health workers (like doctors, pharmacists, and dentists) and their household members in France for COVID-19 antibodies. The goal was to find out how many had been exposed to the virus and to understand risk factors. Participan…

This completed study looked at how the SARS-CoV-2 virus spreads within hospitals, involving over 2,000 patients, caregivers, and healthcare workers. Researchers tracked suspected and confirmed cases to identify risk factors and the effectiveness of infection control measures. The…

This completed study looked at how COVID-19 infection changes hormone levels and markers of inflammation in 220 hospitalized patients. Researchers measured things like thyroid hormones, testosterone, cortisol, and vitamin D at several points during and after hospitalization. They…

This completed study looked at how the COVID-19 pandemic changed the health and daily lives of people aged 75 and older and their caregivers. Researchers analyzed medical records and interviewed participants to understand the impact of lockdowns, reduced physical activity, and so…

This study looked at how many hospital workers had COVID-19 antibodies and how long they lasted. Over 500 staff at a French cancer center gave blood samples and answered questionnaires at the start, 3 months, and 12 months. The goal was to understand immune response in people who…

This completed study enrolled over 1,000 vaccinated adults who later tested positive for COVID-19. Researchers analyzed the virus's genetic code and measured antibody levels to understand which variants cause breakthrough infections and how well the immune system responds. The go…