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Why does COVID-19 steal your sense of smell? scientists investigate

NCT ID NCT04366934

Knowledge-focused Sponsor: Institut Pasteur Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study looked at why some COVID-19 patients lose their sense of smell. Researchers compared nasal cell samples from 26 people—some with COVID-19 and smell loss, and some healthy controls. They aimed to find molecular and cellular differences in the nose that might explain the symptom.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help explain why some people lose their sense of smell from COVID-19 and point toward future treatments.
What could go wrong
This is a small, completed observational study with only 26 participants, so findings may not apply broadly and do not test any treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

26 people

The number who actually took part.

Started

May 2020

Finished

Oct 2020

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

COVID-19 patients and control subjects

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: COVID-19 patients * Age \> 18 years * Subject consulting in the context of the COVID-19 screening care for a suspected SARS-CoV-2 infection Controls * Age \> 18 years * Subject consulting in the ear, nose and throat department with no biologically confirmed COVID-19 or suspected COVID-19 in the past 8 weeks, and no symptoms suggestive of COVID-19 or another respiratory disease and therefore no recent anosmia or ageusia Exclusion Criteria (both COVID-19 patients and controls): * Refusal or contraindication to nasal swab * Presence of nasal sinus pathology

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Conditions

The condition(s) this trial relates to.

Anosmia Coronavinae infectious disease COVID-19 severe acute respiratory syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Coronavirus infection SARS-COV2 Severe acute respiratory syndrome

Contacts and locations

Locations

  • Hôpital Lariboisière, Policlinique

    Paris, France

  • Hôpital Lariboisière, Service ORL

    Paris, France

More trials for these conditions

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