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Face-Down therapy could save COVID patients who refuse ventilators

NCT ID NCT04402879

Symptom relief Sponsor: University of Calgary Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether lying face down (prone positioning) helps hospitalized COVID-19 patients who have low oxygen levels but are not candidates for breathing machines. About 596 adults took part. The goal was to see if this simple position change could lower the chance of death or needing hospice care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

596 people

The number who actually took part.

Started

Nov 2020

Finished

Jun 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Hospitalized patients with probable COVID-19. Probable is defined as Influenza like illness (ILI) symptoms OR confirmed COVID-19 exposure AND COVID-19 testing performed. ILI is defined as any one of the following symptoms including: fever, new or worsening cough, coryza, new or worsening dyspnea, or sore throat. * Goals of care are do-not-intubate (R3 or M1/M2 in Alberta). * Need for oxygen ≥2 L to maintain SpO2 ≥92%. If the patient is on long-term oxygen, the O2 requirements must be ≥2 L above their baseline. * Patient can be positioned to and from prone to supine with minimal assistance (maximum one person assistance). Exclusion Criteria: * Decreased level of consciousness (Glasgow Coma Scale \< 10) or precluding ability to self-reposition. * Hemodynamic instability (Systolic Blood Pressure \< 90 mmHg and or Lactate \>5 mmol/L or HR \>120, not responsive to fluid resuscitation). * Complete bowel obstruction. * Active upper gastrointestinal bleeding. * Poor neck mobility or patient inability to lie prone comfortably. * Unstable spine, femur, or pelvic fractures. * Pregnancy - third trimester. * Full resuscitation status including ICU and willingness to accept invasive mechanical ventilation (i.e. R1/R2 goals of care). * Imminent palliation or end of life expected on admission (i.e. C1/C2 goals of care).

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Conditions

The condition(s) this trial relates to.

acute respiratory distress syndrome adult acute respiratory distress syndrome COVID-19 respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute respiratory distress syndrome ARDS COVID -19 Hypoxemic respiratory failure Severe acute respiratory syndrome coronavirus 2

Contacts and locations

Locations

  • Foothills Hospital Intensive Care Unit

    Calgary, Alberta, T2N 2T9, Canada

  • Peter Lougheed Centre (PLC)

    Calgary, Alberta, T1Y 6J4, Canada

  • Rockyview General Hospital

    Calgary, Alberta, T2V 1P9, Canada

  • South Health Campus

    Calgary, Alberta, T3M 1M4, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.