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COVID-19 may wreak havoc on hormones, new study suggests

NCT ID NCT05749770

Knowledge-focused Sponsor: Istituto Auxologico Italiano Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This completed study looked at how COVID-19 infection changes hormone levels and markers of inflammation in 220 hospitalized patients. Researchers measured things like thyroid hormones, testosterone, cortisol, and vitamin D at several points during and after hospitalization. They also checked if people with pre-existing endocrine problems had worse outcomes. The goal was to understand if COVID-19 causes hormone imbalances and whether treating those imbalances could improve recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help doctors understand how COVID-19 disrupts hormones and identify patients who may need extra care.
What could go wrong
This is an observational study, not a treatment trial. It cannot prove cause and effect, and results may not apply to all COVID-19 patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

220 people

The number who actually took part.

Started

May 2020

Finished

Jun 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This is a pilot study aiming at evaluating all the subjects with COVID-19 admitted to the Istituto Auxologico during pandemic. It is expected to recruit at least 220 COVID-19 subjects and 440 controls subjects collected retrospectively at the other centers.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Nasal swab positive for Sars-CoV-2 * Moderate to severe respiratory dysfunction due to COVID-19, requiring hospitalization. Exclusion Criteria: * History of thyroid diseases before admission * History of adrenal diseases * History of hypogonadism (primary/secondary) * History of pituitary diseases

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Conditions

The condition(s) this trial relates to.

COVID-19 endocrine system disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID-19 pandemic Endocrine system diseases

Contacts and locations

Locations

  • Istituto Auxologico Italiano IRCCS

    Milan, 20145, Italy

More trials for these conditions

Other studies related to the condition(s) this trial covers.