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Probiotics may supercharge COVID-19 shots, study finds

NCT ID NCT07610512

Knowledge-focused Sponsor: Grape King Bio Ltd. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether taking daily probiotic capsules for 4-5 weeks after a COVID-19 vaccine could improve the body's immune response. 138 healthy adults received either probiotics or a placebo. Researchers measured antibody levels and T-cell activity to see if probiotics made the vaccine work better or reduced side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Probiotics (Lactobacillus spp.)
What this could lead to
If probiotics enhance vaccine immunity, this could point toward a simple way to improve vaccine effectiveness.
What could go wrong
This is a small, completed study with no results posted yet. Probiotics may not meaningfully change immune responses, and effects may vary by individual.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

138 people

The number who actually took part.

Started

Oct 2021

Finished

Mar 2022

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Male or female subject ≥ 20 to ≤ 65 years of age at the time signing informed consent form. 2. Body weight ≥50 kgs 3. Must be scheduling to receive a BNT162b2 mRNA COVID-19 vaccine 4. Being able to comply with the study protocol 5. Being able to independently provide written informed consent Exclusion Criteria: 1. Taking antibiotic at enrollment 2. Taking immunomodulatory (e.g., steroid) or anti-histamine drugs 3. Took pre- or probiotics within the past 30 days 4. Being to expected to take other probiotic supplement during the study period 5. Being expected to take antibiotic during the study period 6. A history of hypersensitivity or severe allergic reaction to any components of the probiotics or placebo supplement 7. Pregnant or breastfeeding 8. Having a severe immunocompromised disorder (e.g. HIV infection) 9. Solid organ or bone marrow transplant recipients 10. Major gastrointestinal surgery within 3 months before enrollment 11. Having severe active gastrointestinal conditions, including inflammatory bowel disease or diverticulitis 12. No self-reported symptoms of an upper airway infection with the past 2 weeks 13. A history of SARS-CoV-2 infection 14. Previously participated in investigational study involving SARS-CoV-2 vaccines or therapies

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Conditions

The condition(s) this trial relates to.

COVID-19

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID -19 Immune response

Contacts and locations

Locations

  • Taipei Medical University Hospital.

    Taipei, Taiwan

More trials for these conditions

Other studies related to the condition(s) this trial covers.