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Lying face-down with high-flow oxygen may help COVID-19 patients avoid breathing tubes

NCT ID NCT05178212

Knowledge-focused Sponsor: Hospital Privado de Comunidad de Mar del Plata Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at 600 COVID-19 patients with severe breathing problems who were treated with high-flow nasal oxygen and asked to lie face-down (awake prone position). The goal was to see if this combination reduced the need for a breathing tube and lowered death rates. Researchers also wanted to find out which patients were most likely to need a breathing tube despite this treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could confirm that combining high-flow oxygen with awake prone positioning reduces the need for breathing tubes in COVID-19 patients.
What could go wrong
This is an observational study, not a controlled trial, so it cannot prove cause and effect. Results may not apply to all patients or settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

600 people

The number who actually took part.

Started

Apr 2020

Finished

Dec 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

We included patients older than 17 years admitted to the ICU with a confirmed diagnosis of COVID-19 (real-time PCR) and receiving HFNO for at least 4 hours. Patients received HFNO when any of the following criteria were present: a) peripheral oxygen saturation (SpO2) \< 92% with oxygen \> 4 liters/minute; b) increased work of breathing with use of accessory respiratory muscles, and a respiratory rate \> 30/min; c) PaO2/FiO2ratio \< 200 mmHg. Patients with respiratory failure secondary to a different etiology, decreased level of consciousness, presence of shock requiring vasopressors, immediate need for intubation, use of positive-pressure ventilation prior to HFNO, and with do-not intubate orders were excluded.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Older than 17 years, admitted to the ICU * Confirmed diagnosis of COVID-19 (real-time PCR) * Receiving HFNO for at least 4 hours. Patients received HFNO when any of the following criteria were present: peripheral oxygen saturation (SpO2) \< 92% with oxygen \> 4 liters/minute; increased work of breathing with use of accessory respiratory muscles, and a respiratory rate \> 30/min; PaO2/FiO2ratio \< 200 mmHg. Exclusion Criteria: * Patients with respiratory failure secondary to a different etiology, * Decreased level of consciousness, * Presence of shock requiring vasopressors, * Immediate need for intubation. * Use of positive-pressure ventilation prior to HFNO, and f) with do-not intubate orders.

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Conditions

The condition(s) this trial relates to.

acute respiratory failure COVID-19 respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID -19 Endotracheal intubation Mortality Prone position Respiratory failure

Contacts and locations

Locations

  • Mariano Esperatti

    Mar del Plata, Buenos Aires, 7600, Argentina

More trials for these conditions

Other studies related to the condition(s) this trial covers.